公开(公告)号：US11078208B1

公开(公告)日：2021-08-03

申请号：US16805933

申请日：2020-03-02

申请人： Gilead Sciences, Inc.

发明人： Elizabeth M. Bacon ,  Elbert Chin ,  Jeromy J. Cottell ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Teresa Alejandra Trejo Martin ,  Zheng-Yu Yang

IPC分类号： C07D405/14 ,  C07D487/08 ,  C07D491/04 ,  A61P31/18 ,  A61K45/06 ,  C07C275/16 ,  C07D401/12 ,  C07D471/08 ,  C07D487/10 ,  C07C243/28 ,  A61K31/52 ,  A61K31/55 ,  A61K31/553 ,  A61K31/685 ,  A61K31/688 ,  C07D403/12

摘要： The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

公开(公告)号：US20210205405A1

公开(公告)日：2021-07-08

申请号：US17192494

申请日：2021-03-04

申请人： Alastin Skincare, Inc.

发明人： John A. GARRUTO ,  Alan David WIDGEROW

IPC分类号： A61K38/08 ,  A61K8/58 ,  A61K31/01 ,  A61K31/047 ,  A61K31/231 ,  A61K31/47 ,  A61K31/685 ,  A61K31/695 ,  A61K31/74 ,  A61K8/26 ,  A61K8/37 ,  A61K8/41 ,  A61K8/42 ,  A61K8/49 ,  A61K8/55 ,  A61K8/60 ,  A61K8/64 ,  A61K8/891 ,  A61K8/894 ,  A61K8/97 ,  A61K9/00 ,  A61K31/16 ,  A61K31/353 ,  A61K31/7048 ,  A61K36/05 ,  A61K36/28 ,  A61K38/06 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/24 ,  A61K47/34 ,  A61Q19/00 ,  A61Q19/08

摘要： Compositions and methods for skincare treatment are provided. The invention relates more generally to skin care treatment and more particularly, to compositions and methods for promoting healthy skin, skin regeneration, skin repair, skin bed preparation, and enhanced wound healing.

公开(公告)号：US11045546B1

公开(公告)日：2021-06-29

申请号：US16902212

申请日：2020-06-15

申请人： CytoDyn Inc.

发明人： Scott Kelly ,  Nader Pourhassan ,  Bruce K. Patterson ,  Jacob B. Lalezari

IPC分类号： A61K39/395 ,  A61P31/14 ,  A61K45/06 ,  A61K39/00 ,  A61K31/351 ,  A61K31/215 ,  A61K31/196 ,  A61K31/685

摘要： Provided herein are methods of preventing and treating viral infections (e.g., coronavirus infection) using a CCR5 binding agent.

公开(公告)号：US11000514B2

公开(公告)日：2021-05-11

申请号：US16796609

申请日：2020-02-20

申请人： Duke University

发明人： Jonathan A. Covel ,  Mitchell Mutz ,  Peter J. Webb ,  Robert Remme Webb, II

IPC分类号： A61K31/436 ,  A61K31/01 ,  A61K31/131 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/425 ,  A61K31/437 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/685 ,  A61K31/695 ,  A61K45/06

摘要： The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.

公开(公告)号：US20210052613A1

公开(公告)日：2021-02-25

申请号：US16881419

申请日：2020-05-22

申请人： GILEAD SCIENCES, INC.

发明人： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC分类号： A61K31/685 ,  A61K31/706 ,  A61K31/7056 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20210046023A1

公开(公告)日：2021-02-18

申请号：US17013024

申请日：2020-09-04

申请人： Bluewillow Biologics, Inc.

发明人： Susan Ciotti

IPC分类号： A61K31/14 ,  A61P31/14 ,  A61K9/00 ,  A61K9/107 ,  A61K31/34 ,  A61K31/427 ,  A61K31/4706 ,  A61K31/513 ,  A61K31/53 ,  A61K31/685 ,  A61K31/7064 ,  A61K38/21 ,  A61K45/06 ,  A61K47/26 ,  A61K47/34 ,  A61K47/44

摘要： The present disclosure relates to nanoemulsion compositions with certain surfactant blend ratios that impart enhanced permeability. Such compositions are useful for topical, mucosal and intranasal applications and allow for the greater delivery of one or more active agents to the application site to prevent infection by a microorganism.

公开(公告)号：US10918658B2

公开(公告)日：2021-02-16

申请号：US16564537

申请日：2019-09-09

申请人： The Trustees of The University of Pennsylvania

发明人： James M. Wilson ,  Christie L. Bell ,  Luc H. Vandenberghe

IPC分类号： A61K48/00 ,  C12N15/86 ,  C12N7/00 ,  C07K14/005 ,  A61K38/17 ,  A61K31/7088 ,  A61K31/685 ,  A61K38/47

摘要： A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (AAV) viral vector having a capsid containing an AAV9 cell surface binding domain is described. The method involves modifying a clade F cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate β-galactose residue. The modification may involve retargeting the vector by temporarily functionally ablate AAV9 binding in a subset of cells, thereby redirecting the vector to another subset of cells. Alternatively, the modification may involve increasing cellular update efficiency by treating the cells with a neuraminidase to expose cell surface β-galactose. Also provided are compositions containing the AAV9 vector and a neuraminidase. Also provided is a method for purifying AAV9 using β-galactose linked to solid support. Also provided are mutant vectors which have been modified to alter their targeting specificity, including mutant AAV9 in which the galactose binding domain is mutated and AAV in which an AAV9 galactose binding domain is engineered.

公开(公告)号：US20210038619A1

公开(公告)日：2021-02-11

申请号：US17071538

申请日：2020-10-15

申请人： CIPLA LIMITED

发明人： Geena Malhotra ,  Kalpana Joshi ,  Jeevan Ghosalkar ,  Preeti Raut

IPC分类号： A61K31/685 ,  A61K45/06 ,  A61K31/675 ,  A61K9/24 ,  A61K47/22 ,  A61K9/20 ,  A61K31/34 ,  A61K31/4525 ,  A61K9/00 ,  A61K31/47 ,  A61K31/506 ,  A61K31/5365 ,  A61K31/635

摘要： An oral or injectable pharmaceutical composition is provided for treating diseases caused by retroviruses or hepatitis B viruses. The composition comprises a therapeutically effective amount of at least one anti-retroviral drug and a therapeutically effective amount of at least one pharmacokinetic booster or enhancer or derivative thereof. Methods and kits are also provided.

公开(公告)号：US20210023223A1

公开(公告)日：2021-01-28

申请号：US16967843

申请日：2019-02-07

申请人： IP SCIENCE LIMITED

发明人： Ivan PETYAEV

IPC分类号： A61K47/06 ,  A61K31/202 ,  A23D9/007 ,  A23G9/32 ,  A61K9/10 ,  A61K9/107 ,  A23L33/115 ,  A23P10/35 ,  A23L25/10 ,  A61K8/04 ,  A23C9/13 ,  A61Q19/06 ,  A61K31/122 ,  A23G1/36 ,  A61K8/31 ,  C10L1/185 ,  A61K31/685 ,  A61Q19/00 ,  A23L5/44 ,  A23C15/12 ,  A23C9/152 ,  A61K8/35 ,  A61K9/06 ,  C10L1/16 ,  A61K31/01 ,  A61K8/06

摘要： The invention relates to uses of hydrocarbon/lipid complexes with carotenoids for improvement properties of hydrocarbon-based products as well as related methods and uses.

公开(公告)号：US10881640B2

公开(公告)日：2021-01-05

申请号：US15234084

申请日：2016-08-11

申请人： S.L.A. PHARMA AG

发明人： David Nigel Armstrong ,  Justin Slagel

IPC分类号： A61K31/685 ,  A61K31/4164 ,  A61K9/00 ,  A61K31/192 ,  A61K31/24 ,  A61K31/245 ,  A61K31/355 ,  A61K31/407 ,  A61K31/4166 ,  A61K31/545 ,  A61K31/573 ,  A61K31/60 ,  A61K31/65 ,  A61K33/30 ,  A61K45/06 ,  A61K9/06 ,  A61K47/06 ,  A61K47/44

摘要： A topical composition comprising about 5 wt % to about 12.5 wt % of metronidazole or a pharmacologically acceptable salt thereof in a non-aqueous vehicle. The composition may be used in the treatment of skin damage due to inflammatory skin conditions; thermal, chemical or electrical burns; infections or radiation treatment. One advantage of the composition is that topical administration of metronidazole results in a primarily local effect, and thus, side effects observed from systemic administration are avoided.