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公开(公告)号：US10959987B2
公开(公告)日：2021-03-30
申请号：US16384472
申请日：2019-04-15
发明人： Moustafa E. El-Araby , Abdelsattar Mansour Omar , Mahmoud Abdelkhalek El-Faky , Sameh Hamdy Abdelmageed Soror , Maan Talaat Khayat , Hani Zakariah Asfour , Faida Hassan Bamane
IPC分类号： A61K31/4164 , A61K31/55 , C07D233/64 , C07D233/54 , C07C279/04 , C07C279/10 , C07C279/12 , C07C279/16 , A61P31/14
摘要： Imidazole-based compounds as hepatitis C virus (HCV) inhibitors. The compounds have an imidazole core that is disubstituted via amide links. Also described are a pharmaceutical composition incorporating the imidazole-based compound, a method of preparing these compounds, and a method for using the pharmaceutical composition in the treatment of HCV infection.
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公开(公告)号：US10894765B2
公开(公告)日：2021-01-19
申请号：US16286094
申请日：2019-02-26
IPC分类号： C07C277/08 , C07C279/12 , C08F220/36 , C09D133/14 , C07C277/02 , D06M14/30 , G01N33/53 , C08F26/00 , C08F126/02 , G01N33/545 , C08F120/36 , C09D4/00 , G01N1/40 , B01J20/26 , B01J20/32 , B01J20/28
摘要： Solar energy device comprising at least one of a photovoltaic cell or a solar thermal collector having an absorption bandwidth in the infrared wavelength region of the solar spectrum; a visible light-transmitting reflector; and at least one of a graphic film or lighted display. The graphic film or a lighted display present is visible through the visible light-transmitting reflector. The solar energy devices can be used, for example, as a sign (e.g., an advertising sign or a traffic sign), on the side and/or roof, as well as in a window, of a building.
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公开(公告)号：US10662211B2
公开(公告)日：2020-05-26
申请号：US15901517
申请日：2018-02-21
发明人： Scott D. Allen , Anna E. Cherian , Chris A. Simoneau , Jay J. Farmer , Geoffrey W. Coates , Alexei A. Gridnev , Robert E. LaPointe
IPC分类号： C08G64/34 , C07F15/06 , B01J31/18 , C07C251/24 , C07C279/12 , C07D213/53 , C07D487/04 , C07D487/22 , C07F9/535 , C07F9/6561 , C08F4/80 , C07F19/00 , B01J31/02 , B01J31/22
摘要： The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.
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公开(公告)号：US20190185423A1
公开(公告)日：2019-06-20
申请号：US16286094
申请日：2019-02-26
IPC分类号： C07C277/08 , G01N1/40 , C08F220/36 , C09D4/00 , B01J20/28 , C08F26/00 , G01N33/53 , D06M14/30 , C07C277/02 , G01N33/545 , C08F126/02 , B01J20/32 , B01J20/26 , C07C279/12 , C09D133/14 , C08F120/36
CPC分类号： C07C277/08 , B01J20/261 , B01J20/28033 , B01J20/327 , C07C277/02 , C07C279/12 , C08F26/00 , C08F120/36 , C08F126/02 , C08F220/36 , C09D4/00 , C09D133/14 , D06M14/30 , G01N1/405 , G01N33/53 , G01N33/545 , C07C279/08
摘要： Solar energy device comprising at least one of a photovoltaic cell or a solar thermal collector having an absorption bandwidth in the infrared wavelength region of the solar spectrum; a visible light-transmitting reflector; and at least one of a graphic film or lighted display. The graphic film or a lighted display present is visible through the visible light-transmitting reflector. The solar energy devices can be used, for example, as a sign (e.g., an advertising sign or a traffic sign), on the side and/or roof, as well as in a window, of a building.
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公开(公告)号：US20180345207A1
公开(公告)日：2018-12-06
申请号：US15978323
申请日：2018-05-14
申请人： UT-Battelle, LLC
IPC分类号： B01D53/14 , C07C279/12
CPC分类号： B01D53/1475 , B01D53/1493 , B01D2252/20415 , B01D2252/20442 , B01D2252/2053 , B01D2257/504 , C07C279/12
摘要： A method for removing carbon dioxide from a gaseous source, the method comprising: (i) contacting said gaseous source with an aqueous solution of a carbon dioxide sorbent that reacts with carbon dioxide to form an aqueous-soluble carbonate or bicarbonate salt of said carbon dioxide sorbent; (ii) contacting the aqueous solution from step (i) with a bis-iminoguanidine carbon dioxide complexing compound, which is different from the carbon dioxide sorbent, to result in precipitation of a carbonate or bicarbonate salt of said carbon dioxide complexing compound and regeneration of the carbon dioxide sorbent; and (iii) removing the precipitated carbonate or bicarbonate salt from the aqueous solution in step (ii) to result in a solid form of said carbonate or bicarbonate salt of the carbon dioxide complexing compound. The method may further include a step (iv) of regenerating the carbon dioxide complexing compound by subjecting the precipitated salt to sufficient heat and/or vacuum.
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公开(公告)号：US10111437B2
公开(公告)日：2018-10-30
申请号：US15576425
申请日：2016-06-03
发明人： Yoichi Ihori , Shuuji Inoue , Kotaro Shibayama , Chang-Kyung Kang , Yasuyuki Shiinoki , Takuya Kamada , Hiroaki Naito , Satoshi Nishimura
IPC分类号： A61K31/155 , C07C291/00 , A01N47/40 , C07D401/14 , A01N43/50 , A01N43/52 , A01N47/12 , A01N47/44 , A01N51/00 , C07C279/08 , C07C279/12 , C07C279/24 , C07D333/22 , C07D233/46 , C07D233/52 , C07D233/88 , C07D235/30 , C07D237/14 , C07D277/28 , C07D213/64 , C07D307/81 , A01N47/28 , C07C335/02 , C07D213/78 , C07D233/48 , C07D237/24 , C07D239/06 , C07D243/04 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/04
摘要： A novel guanidine compound having excellent fungicidal activity is represented by formula [I]. (In the formula, Y represents a divalent group represented by formula [II] (wherein each of R7-R9 independently represents a hydrogen atom or the like) or the like; each of X and Z independently represents an unsubstituted or substituted alkylene group or the like; each of Q1 and Q2 independently represents a single bond or the like; each of A1 and A2 independently represents an unsubstituted or substituted divalent heterocyclic compound residue or the like; and each of R1-R6 independently represents a hydrogen atom or the like.)
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公开(公告)号：US10100068B2
公开(公告)日：2018-10-16
申请号：US15300842
申请日：2015-04-16
申请人： SIKA TECHNOLOGY AG
发明人： Urs Burckhardt , Rita Cannas
IPC分类号： C07F7/18 , C08G77/26 , C08G77/388 , B01J31/00 , C07C279/04 , C07C279/12 , C07C279/16 , C07C279/18 , C08G65/00 , C08G77/08 , C09D183/08 , C09J183/08
摘要： A silane of the formula (I) containing at least one aliphatic amidine group- or guanidine group-containing alkoxy group, to a method for producing same, to conversion products thereof, and to the use thereof as a catalyst in curable compositions, in particular based on silane group-containing polymers. The silane of the formula (I) is largely odorless and non-volatile at room temperature. The silane accelerates the hydrolysis and condensation reaction of silane groups very effectively without impairing the storage stability of silane group-containing polymers. Additionally, the silane is very tolerable in silane group-containing compositions, whereby such compositions are not prone to separate, migrate, or evaporate the catalyst.
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公开(公告)号：US20180273467A1
公开(公告)日：2018-09-27
申请号：US16005286
申请日：2018-06-11
申请人： ModernaTX, Inc.
发明人： Kerry E. Benenato
IPC分类号： C07C229/12 , A61K9/127 , C07C335/08 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/09 , C07K14/505 , A61K9/00 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , A61K9/16 , A61K38/18 , A61K47/54 , A61K47/69 , A61K48/00 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C311/05
CPC分类号： A61K48/0033 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/12 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
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公开(公告)号：US20180044299A1
公开(公告)日：2018-02-15
申请号：US15556657
申请日：2016-03-11
申请人： Lumos Pharma, Inc.
IPC分类号： C07D239/14 , C07C279/14 , C07C277/02 , C07C279/12
CPC分类号： C07D239/14 , A61K31/4172 , C07C277/02 , C07C279/12 , C07C279/14
摘要： Provided herein is a process an intermediates for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction.
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公开(公告)号：US20170349538A1
公开(公告)日：2017-12-07
申请号：US15683739
申请日：2017-08-22
发明人： John R. Cashman , Jaroslaw Kalisiak
IPC分类号： C07C251/40 , C07D239/06 , C07C279/12 , C07C257/12 , C07C257/18 , C07C257/14 , C07D249/04 , C07D233/24
CPC分类号： C07C251/40 , C07C257/12 , C07C257/14 , C07C257/18 , C07C279/12 , C07D233/24 , C07D239/06 , C07D249/04
摘要： The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.
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