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    Drug delivery compositions and medical devices containing block copolymer
    61.
    发明申请
    Drug delivery compositions and medical devices containing block copolymer 有权
    药物输送组合物和含有嵌段共聚物的医疗器械

    公开(公告)号：US20050215722A1

    公开(公告)日：2005-09-29

    申请号：US11057870

    申请日：2005-02-14

    Applicant: Leonard Pinchunk ,  Sepideh Hashemi ,  Marlene Schwarz ,  Kalpana Kamath ,  Ni Ding

    Inventor： Leonard Pinchunk ,  Sepideh Hashemi ,  Marlene Schwarz ,  Kalpana Kamath ,  Ni Ding

    IPC: A61K47/32 ,  A61K9/22 ,  A61K31/337 ,  A61K35/12 ,  A61K45/00 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K48/00 ,  A61L27/16 ,  A61L27/54 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61M37/00 ,  C08F2/00 ,  C08F293/00 ,  C08F297/00 ,  C08F297/04 ,  C08L53/00 ,  C08L53/02 ,  C09D153/00 ,  C09D153/02

    CPC classification number: C08L53/00 ,  A61L27/16 ,  A61L27/54 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  C08F293/005 ,  C08F297/00 ,  C08F297/04 ,  C08L53/02 ,  C09D153/00 ,  C09D153/02 ,  C08L2666/02

    Abstract: A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.

    Abstract translation: 提供了用于递送治疗剂的组合物。 所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。 嵌段共聚物优选为式X-（AB）n N，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。 弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。 根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。 医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。 根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。 根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层 包括上述生物相容性嵌段共聚物。

    Vascular sealing device and method of use
    65.
    发明授权
    Vascular sealing device and method of use 失效
    血管密封装置及其使用方法

    公开(公告)号：US06547806B1

    公开(公告)日：2003-04-15

    申请号：US09498542

    申请日：2000-02-04

    Applicant: Ni Ding

    Inventor： Ni Ding

    IPC: A61B1704

    CPC classification number: A61B17/0057 ,  A61B17/34 ,  A61B2017/00637 ,  A61B2017/00659

    Abstract: A collapsible medical device for use, e.g., as a vascular sealer. The device includes a sheath adapted to be positioned such that a distal end thereof is adjacent the opening. A mandrel is disposed within a lumen of the sheath and is adapted to be positioned such that a distal length thereof is adjacent the distal end of the sheath. A collapsible sealing member comprises a fluid-impervious film carried by a plurality of wires. The wires are attached to the mandrel and expand radially outward therefrom. In one method of using such a device, the sealing member is held in a collapsed position within the sheath. The sealing member is advanced through the sheath and beyond the distal end thereof, whereby the sealing member resiliently expands. The sealing member is positioned against the inner wall of the blood vessel adjacent the opening, thereby affecting a temporary seal of the opening. The sealant is introduced into the tissue tract. After hardening, the sealing member is collapsed within the sheath. The sheath the sealing member collapsed therein (together with any existing introducer) are then withdrawn proximally from the patient.

    Abstract translation: 用于使用的可折叠医疗装置，例如用作血管封闭器。 该装置包括适于定位成使其远端邻近开口的护套。 心轴设置在护套的内腔内，并且适于被定位成使得其远端长度邻近护套的远端。 可折叠密封构件包括由多条导线承载的不透液膜。 电线连接到心轴并从其径向向外扩张。 在使用这种装置的一种方法中，密封构件保持在护套内的折叠位置。 密封构件通过护套前进并超过其远端，由此密封构件弹性膨胀。 密封构件抵靠靠近开口的血管的内壁定位，从而影响开口的临时密封。 将密封剂引入组织道。 硬化后，密封件在护套内折叠。 在其中折叠的密封构件的护套（连同任何现有的导引器）然后从患者的近侧撤回。

    Medical device with sponge coating for controlled drug release
    66.
    发明授权
    Medical device with sponge coating for controlled drug release 失效
    具有海绵涂层的医疗设备，用于控制药物释放

    公开(公告)号：US06364856B1

    公开(公告)日：2002-04-02

    申请号：US09060071

    申请日：1998-04-14

    Applicant: Ni Ding ,  W. Scott Andrus

    Inventor： Ni Ding ,  W. Scott Andrus

    IPC: A61M3100

    CPC classification number: A61F2/86 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1081

    Abstract: The medical devices of the invention comprise an expandable portion which is covered with a sponge coating for release of at least one biologically active material. The sponge coating is made of a non-hydrogel polymer having a plurality of voids. The device can further include means for infusing or expelling the biologically active material or drug into the voids. The drug is delivered to the body lumen of a patient by expelling the drug and inflating or expanding the expandable portion of the catheter or device.

    Abstract translation: 本发明的医疗装置包括可膨胀部分，其被海绵涂层覆盖以释放至少一种生物活性材料。 海绵涂层由具有多个空隙的非水凝胶聚合物制成。 该装置还可以包括用于将生物活性材料或药物注入或排出到空隙中的装置。 通过排出药物并使导管或装置的可扩张部分膨胀或膨胀，将药物输送到患者的体腔。

    Method of bonding polymers and medical devices comprising materials bonded by said method
    68.
    发明授权
    Method of bonding polymers and medical devices comprising materials bonded by said method 有权
    粘合聚合物和医疗器械的方法包括通过所述方法结合的材料

    公开(公告)号：US06299596B1

    公开(公告)日：2001-10-09

    申请号：US09148389

    申请日：1998-09-04

    Applicant: Ni Ding

    Inventor： Ni Ding

    IPC: A61M2900

    CPC classification number: C08J7/123 ,  A61L29/12 ,  A61M25/0009 ,  C08J5/124 ,  C08J2383/04 ,  C08L67/00 ,  C08L77/00 ,  C08L83/04

    Abstract: A method of bonding polymeric materials, in particular, polymeric materials comprising silicone, is provided along with medical devices comprising materials bonded together by said method. More specifically, the method of the present invention involves surface treating the surface of a polymeric material, preferably a polymeric material comprising silicone, such that the character of the surface of the material changes in a manner such that bondability of the material is enhanced. The surface of the surface treated polymeric material is then brought into contact with the surface of a second polymeric material and optionally, an adhesive, under conditions effective to bond the surfaces together. The bond so formed is stronger than a corresponding bond between untreated polymeric materials.

    Abstract translation: 提供粘合聚合物材料，特别是包含硅酮的聚合物材料的方法与包括通过所述方法粘合在一起的材料的医疗装置一起提供。 更具体地说，本发明的方法包括对聚合物材料的表面进行表面处理，优选包括硅氧烷的聚合材料，使得材料表面的特性以提高材料的粘合性的方式改变。 然后在有效地将表面粘合在一起的条件下，使表面处理的聚合物材料的表面与第二聚合物材料的表面和任选的粘合剂接触。 如此形成的粘结剂比未处理的聚合物材料之间的相应粘结强。

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