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公开(公告)号:US11909401B2
公开(公告)日:2024-02-20
申请号:US17766689
申请日:2020-10-09
Applicant: University of Washington
Inventor: Samrat Dey , Thomas Lewellen , Jacques Christophe Rudell
CPC classification number: H03K5/24 , H03K5/2427 , H03K19/20
Abstract: An input driven self-clocked dynamic comparator, and associated systems and methods are described herein. In one embodiment, self-clocked dynamic comparator, includes a latch configured to receive an input voltage (VIN), a reference voltage (VREF) and a clocking (CLKsf) signal, and configured to output a first rail-to-rail output (OUT+) signal and a second rail-to-rail output (OUT−) signal. The self-clocked dynamic comparator also includes a pre-amplifier (PRE-AMP) configured to output an enable (TRI) signal based on a comparison between the VIN and an adjusted VREF. The self-clocked dynamic comparator further includes a pre-amplifier (PRE-AMP) configured to output an enable (TRI) signal based on a comparison between the VIN and an adjusted VREF, and a logic gate configured to receive the TRI signal and one of the OUT+ signal and OUT− signal, and configured to output the CLKsf signal. The cycles of the CLKsf signal cause the latch to dissipate energy.
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公开(公告)号:US20240047098A1
公开(公告)日:2024-02-08
申请号:US18484587
申请日:2023-10-11
Applicant: University of Washington
Inventor: Daniel T. CHIU , Jiangbo YU , Yu RONG , Changfeng WU
CPC classification number: H01B1/18 , C07K14/00 , C07K16/00 , C08K3/36 , C08L83/04 , G02F1/015 , C08K2201/001 , C08L2203/20
Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号:US20240042018A1
公开(公告)日:2024-02-08
申请号:US18360190
申请日:2023-07-27
Applicant: University of Washington
Inventor: John Cavin KRAFT II , Isaac SAPPINGTON , Neil P. KING
IPC: A61K39/385 , C07K14/00 , A61K39/145
CPC classification number: A61K39/385 , C07K14/00 , A61K39/145 , C07K2319/735 , C07K2319/40 , A61K2039/6031
Abstract: Polypeptides including the amino acid sequence of SEQ ID NO:78-80, substituted with one or more sequon, are provided, as are fusion proteins and nanoparticles formed from such polypeptides, and methods for their use.
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公开(公告)号:US20240041358A1
公开(公告)日:2024-02-08
申请号:US18094206
申请日:2023-01-06
Inventor: John R. Chevillet , Tatiana D. Khokhlova , George R. Schade , Joo Ha Hwang , Muneesh Tewari
CPC classification number: A61B5/14546 , A61B8/08 , A61B8/5223 , A61B5/145 , C12Q1/6886 , A61B5/14507 , A61B5/15 , A61B5/4836 , A61B10/0038 , A61B10/007 , A61N7/022 , A61N7/02 , C12Q2600/118 , C12Q2600/158 , A61B2010/0077
Abstract: The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.
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公开(公告)号:US11884649B2
公开(公告)日:2024-01-30
申请号:US17525778
申请日:2021-11-12
Inventor: Feroz R. Papa , Bradley J. Backes , Dustin J. Maly
IPC: C07D401/14 , C07D401/04
CPC classification number: C07D401/14 , C07D401/04
Abstract: Disclosed herein, inter alia, are compounds for inhibiting IRE1α and uses thereof.
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公开(公告)号:US20240027325A1
公开(公告)日:2024-01-25
申请号:US18250613
申请日:2021-11-10
Applicant: University of Washington
Inventor: Daniel T. Chiu , Yifei Jiang , Mengxia Zhao , Yuanhua Cheng
IPC: G01N15/14
CPC classification number: G01N15/1434 , G01N2015/0065
Abstract: Systems and methods for analyzing particles flowing in a channel are described. In an embodiment, the channel is configured to flow a particle through a lumen of the channel, the channel defining an interrogation window configured to allow light to pass into and out of the lumen; a light engine comprising: a first light source positioned to output first excitation light onto a first portion of the channel in the interrogation window; and a second light source positioned to output second excitation light onto a second portion of the channel in the interrogation window separate from the first portion. In an embodiment, the systems include an emission fiber bundle comprising a first emission optical fiber and a second emission optical fiber, wherein a proximal end of first emission optical fiber and second emission optical fiber are arranged in an emission fiber bundle head.
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公开(公告)号:US20230408851A1
公开(公告)日:2023-12-21
申请号:US18333113
申请日:2023-06-12
Applicant: UNIVERSITY OF WASHINGTON
Inventor: Mo Li , Han Zhao , Bingzhao Li
CPC classification number: G02F1/0072 , G02F2203/15 , G02F1/0356 , G02F1/0311
Abstract: Systems and methods for optical computation and acousto-optic modulation are described. The systems and methods comprise acousto-optic modulators with reflectors and transducers used for actuation and modulation of mechanical waves. The systems further comprise multilayer optical computing systems incorporating arrays of acousto-optic modulators. In an embodiment, the acousto-optic modulator comprises a substrate; an optical layer coupled to a first portion of the substrate, the optical layer comprising: a free-standing portion shaped and positioned to define a gap between the free-standing portion of the optical layer and the substrate; and a rib waveguide comprising a photonic crystal, formed in the free-standing portion; and a piezoelectric transducer mechanically coupled to the free-standing portion, wherein the piezoelectric transducer comprises a piezoelectric material and a plurality of conductive electrodes disposed in electrically conductive contact with the piezoelectric material, the plurality of conductive electrodes extending from a base portion of the piezoelectric transducer.
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公开(公告)号:US11840523B2
公开(公告)日:2023-12-12
申请号:US17525764
申请日:2021-11-12
Inventor: Feroz R. Papa , Bradley J. Backes , Dustin J. Maly
IPC: C07D239/84 , C07D401/10
CPC classification number: C07D401/10
Abstract: Disclosed herein, inter alia, are substituted quinazolin-2-amines and isoquinolin-3-amines for inhibiting IRE1α and uses thereof.
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公开(公告)号:US11823809B2
公开(公告)日:2023-11-21
申请号:US17368078
申请日:2021-07-06
Applicant: University of Washington
Inventor: Daniel T. Chiu , Jiangbo Yu , Yu Rong , Changfeng Wu
CPC classification number: H01B1/18 , C07K14/00 , C07K16/00 , C08K3/36 , C08L83/04 , G02F1/015 , C08K2201/001 , C08L2203/20
Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号:US20230369083A1
公开(公告)日:2023-11-16
申请号:US17740785
申请日:2022-05-10
Applicant: University of Washington
Inventor: David Bergsman , Yuri Choe , Duncan Reece
IPC: G05B19/4155
CPC classification number: G05B19/4155 , G05B2219/49021
Abstract: A reactor system includes a first reaction chamber, a second reaction chamber, a resource, one or more processors, and a computer readable medium storing instructions that, when executed by the one or more processors, cause the one or more processors to perform functions. The functions include making a first determination that providing a first reaction chamber access to a resource of a reactor system requires that the first reaction chamber have exclusive access to the resource. The resource includes a reactant source and/or a vacuum pump. The functions also include making a second determination that a second reaction chamber does not require access to the resource. The functions also includes providing the first reaction chamber exclusive access to the resource in response to making the second determination.
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