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公开(公告)号：US20110054084A1
公开(公告)日：2011-03-03
申请号：US12908095
申请日：2010-10-20
申请人： Brent R. Constantz , Cecily Ryan , Laurence Clodic
发明人： Brent R. Constantz , Cecily Ryan , Laurence Clodic
CPC分类号： C04B28/04 , C04B14/26 , Y02W10/33 , Y02W10/37 , Y10T428/2982
摘要： Hydraulic cement compositions that include a carbonate compound composition, e.g., a salt-water derived carbonate compound composition containing crystalline and/or amorphous carbonate compounds, are provided. Also provided are methods of making and using the hydraulic cements, as well as settable compositions, such as concretes and mortars, prepared therefrom. The cements and compositions produced therefrom find use in a variety of applications, including use in a variety of building materials and building applications.
摘要翻译： 提供了包含碳酸盐化合物组合物的液压水泥组合物，例如含有结晶和/或无定形碳酸酯化合物的盐水衍生的碳酸盐化合物组合物。 还提供了制备和使用水硬性水泥的方法，以及由其制备的可固化组合物，例如混凝土和砂浆。 由此产生的水泥和组合物可用于各种应用，包括用于各种建筑材料和建筑应用中。
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62.发明申请PRODUCTION OF CARBONATE-CONTAINING COMPOSITIONS FROM MATERIAL COMPRISING METAL SILICATES 审中-公开从含有金属硅酸盐的材料生产含碳酸盐的组合物公开(公告)号：US20100313794A1
公开(公告)日：2010-12-16
申请号：US12788255
申请日：2010-05-26
申请人： Brent R. Constantz , Laurence Clodic , Cecily Ryan , Miguel Fernandez , Kasra Farsad , Sidney Omelon , Philip Tuet , Paulo Monteiro , Gordon E. Brown, JR. , Katharine Geramita
发明人： Brent R. Constantz , Laurence Clodic , Cecily Ryan , Miguel Fernandez , Kasra Farsad , Sidney Omelon , Philip Tuet , Paulo Monteiro , Gordon E. Brown, JR. , Katharine Geramita
CPC分类号： C25B1/22 , B01D2251/404 , B01D2257/504 , C04B14/04 , C04B28/04 , Y02P20/129 , C04B14/28 , C04B2103/0088 , C04B20/023
摘要： Provided are methods for producing carbonate-containing compositions comprising silicon-based material (e.g., pozzolanic material) from a source of carbon dioxide, a divalent cation-containing solution, and a source of proton-removing agents. In such methods, divalent cations of the divalent cation-containing solution are provided by digestion of material comprising metal silicates. Also provided are methods for producing carbonate-containing compositions comprising little or no silicon-based material. In such methods, silicon-based material (e.g., silica, unreacted or undigested silicates, aluminosilicates, etc.) may be separated and processed separately from carbonate-containing compositions. Silicon-based material and carbonate-containing material may be blended at a later stage to produce a pozzolanic material, which may be further processed and blended with, for example, Portland cement.
摘要翻译： 提供了用于生产含有二氧化碳源的二氧化硅（含阳离子）溶液和质子去除剂源的含硅基材料（例如火山灰材料）的含碳酸盐组合物的方法。 在这种方法中，通过消化包含金属硅酸盐的材料提供含二价阳离子的溶液的二价阳离子。 还提供了用于生产包含很少或不含硅基材料的含碳酸盐组合物的方法。 在这种方法中，硅基材料（例如二氧化硅，未反应或未消化的硅酸盐，铝硅酸盐等）可以与含碳酸盐的组合物分离和加工。 硅基材料和含碳酸盐的材料可以在稍后阶段混合以制备火山灰材料，其可以进一步加工并与例如波特兰水泥混合。
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公开(公告)号：US20100132591A1
公开(公告)日：2010-06-03
申请号：US12700076
申请日：2010-02-04
申请人： Brent R. Constantz , Cecily Ryan , Laurence Clodic
发明人： Brent R. Constantz , Cecily Ryan , Laurence Clodic
CPC分类号： C04B28/04 , C04B14/26 , Y02W10/33 , Y02W10/37 , Y10T428/2982
摘要： Hydraulic cement compositions that include a carbonate compound composition, e.g., a salt-water derived carbonate compound composition containing crystalline and/or amorphous carbonate compounds, are provided. Also provided are methods of making and using the hydraulic cements, as well as settable compositions, such as concretes and mortars, prepared therefrom. The cements and compositions produced therefrom find use in a variety of applications, including use in a variety of building materials and building applications.
摘要翻译： 提供了包含碳酸盐化合物组合物的液压水泥组合物，例如含有结晶和/或无定形碳酸酯化合物的盐水衍生的碳酸盐化合物组合物。 还提供了制备和使用水硬性水泥的方法，以及由其制备的可固化组合物，例如混凝土和砂浆。 由此产生的水泥和组合物可用于各种应用，包括用于各种建筑材料和建筑应用中。
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公开(公告)号：US06719993B2
公开(公告)日：2004-04-13
申请号：US10109994
申请日：2002-03-29
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61F200
CPC分类号： A61L24/02 , A61K6/0612 , A61K6/0643 , A61K6/097 , A61L27/12 , Y10S514/951 , Y10S514/953 , A61K6/087 , C08L89/00
摘要： Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.
摘要翻译： 提供生产可流动组合物的方法，例如 糊剂，即磷酸钙产品。 在本发明的方法中，将包含钙源和磷酸盐源的干燥反应物与可溶性硅酸盐的溶液合并。 并将混合的液体和固体混合以产生可流动的组合物。 还提供了组合物本身以及用于制备它们的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如， 骨缺损。
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65.发明授权Catheter systems and methods for their use in the treatment of calcified vascular occlusions 有权导管系统及其用于治疗钙化血管闭塞的方法公开(公告)号：US06527979B2
公开(公告)日：2003-03-04
申请号：US09384860
申请日：1999-08-27
IPC分类号： A61B1706
CPC分类号： A61M25/1011 , A61M25/0026 , A61M29/02 , A61M2025/0004 , A61M2025/1052 , A61M2025/1095
摘要： Catheter systems and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter systems include at least an aspiration catheter and at least one of a total occlusion insert catheter and a partial occlusion insert catheter, where the insert catheters are capable of being slidably moved in the lumen of the aspiration catheter. In practicing the subject methods, a surface of the vascular occlusion is flushed with an acidic dissolution fluid using the subject catheter systems for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter systems and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
摘要翻译： 提供了用于增强通过血管闭塞所占据的血管部位的流体流动的导管系统和方法。 主题导管系统包括至少一个抽吸导管和全闭塞插入导管和部分闭塞插入导管中的至少一个，其中插入导管能够在抽吸导管的内腔中可滑动地移动。 在实施本发明方法时，使用主题导管系统用酸性溶解流体冲洗血管闭塞的表面一段足以使流体流过血管部位以增强的时间，例如， 增加或建立 主题导管系统和方法可用于治疗各种不同血管疾病，其特征在于存在钙化血管闭塞，包括外周和冠状动脉血管疾病。
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66.发明授权Catheter devices and methods for their use in the treatment of calcified vascular occlusions 有权导管装置及其用于治疗钙化血管闭塞的方法公开(公告)号：US06290689B1
公开(公告)日：2001-09-18
申请号：US09425826
申请日：1999-10-22
IPC分类号： A61M3100
CPC分类号： A61B5/14539 , A61B17/22 , A61B2017/22084 , A61M29/02 , A61M2025/0004 , A61M2025/0034 , A61M2025/1052 , A61M2025/1093 , A61M2025/1095
摘要： Catheter devices and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter devices include at least a first, second and third lumen, where: (a) the first lumen is used for delivery of an acidic dissolution solution to the vascular site; (b) the second lumen is used for delivery of a buffer solution to the vascular site; and (c) the third lumen is used for removal of fluid from the vascular site. In many preferred embodiments, the first, second and third lumens are coaxial. In practicing the subject methods, the vascular site is flushed simultaneously with an acidic dissolution fluid and a buffer solution, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the acidic dissolution fluid and the remainder of the vascular site is not contacted with fluid having a pH that is lower than about 4. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter devices and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
摘要翻译： 提供了用于增强通过血管闭塞占据的血管部位的流体流动的导管装置和方法。 主题导管装置包括至少第一，第二和第三腔，其中：（a）第一腔用于将酸性溶解溶液递送至血管部位; （b）第二管腔用于将缓冲溶液递送至血管部位; 和（c）第三腔用于从血管部位去除流体。 在许多优选实施例中，第一，第二和第三管腔是同轴的。 在实施本发明的方法中，血管部位与酸性溶解液和缓冲溶液同时冲洗，其中以如下方式进行冲洗，使得只有血管闭塞的表面与酸性溶解液接触，其余部分 血管部位不与pH低于约4的液体接触。以这种方式进行冲洗足以使液体流过血管部位以增强的时间，例如 增加或建立 主题导管装置和方法可用于治疗各种不同血管疾病，其特征在于存在钙化血管闭塞，包括外周和冠状动脉血管疾病。
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公开(公告)号：US5968253A
公开(公告)日：1999-10-19
申请号：US127996
申请日：1998-07-31
申请人： Robert Poser , Mark Fulmer , Brent R. Constantz
发明人： Robert Poser , Mark Fulmer , Brent R. Constantz
CPC分类号： C04B28/34 , A61K33/42 , A61K38/14 , C04B2111/00836
摘要： A flowable, paste-like composition capable of setting in a clinically relevant period of time into an antimicrobial agent loaded apatitic product having sufficient compressive strength to serve as a cancellous bone structural material is provided. The subject compositions are prepared by combining dry ingredients with a physiologically acceptable lubricant and an antimicrobial agent, where the dry ingredients comprise at least two different calcium phosphates. The subject compositions find use in a variety of different applications, including orthopaedic, dental and cranio-maxillofacial applications.
摘要翻译： 提供了一种可流动的糊状组合物，其能够在临床相关时间段内将具有足够抗压强度的抗微生物剂的磷灰石产品置于松质骨结构材料中。 通过将干成分与生理上可接受的润滑剂和抗微生物剂组合来制备主题组合物，其中干成分包含至少两种不同的磷酸钙。 主题组合物可用于各种不同的应用，包括矫形，牙科和头颌面应用。
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公开(公告)号：US5952010A
公开(公告)日：1999-09-14
申请号：US987430
申请日：1997-12-09
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455 , A61K33/42 , A61K33/06 , A61K33/10
CPC分类号： A61L24/02 , A61K6/0067 , A61K6/0085 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293
摘要： Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest
摘要翻译： 描述了碳酸化羟基磷灰石组合物及其制备方法。 组合物是生物可吸收的并且被制备成可流动的质量，其可以通过注射器施用以原位置换以用作支撑结构，填充物，假体等。 任选地，组合物可以包括蛋白质或用作用于药理学兴趣的组合物的贮库
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公开(公告)号：US5279831A
公开(公告)日：1994-01-18
申请号：US933877
申请日：1992-08-21
申请人： Brent R. Constantz , Gary C. Osaka
发明人： Brent R. Constantz , Gary C. Osaka
IPC分类号： A61F2/28 , A61F2/00 , A61F2/30 , A61L27/00 , A61L27/32 , C30B5/00 , A61K9/14 , A61K37/02 , A61K37/12
CPC分类号： A61L27/32 , A61F2310/00796 , Y10S514/953 , Y10S623/901
摘要： Methods and compositions are provided for coating a substrate with a strongly adherent hydroxyapatite coating, which allows for ingrowth of natural bone and strong bonding between the coating and the substrate. The procedure provides for repetitive coatings at varying concentrations of coating forming reagents, where the highest concentration is used initially. The coating has particular application for prostheses, where porous areas of the prostheses are completely coated with a thin sturdy coating of hydroxyapatite.
摘要翻译： 提供方法和组合物用于用强粘附羟基磷灰石涂层涂覆基底，其允许天然骨的向内生长和涂层与基底之间的强结合。 该程序提供了不同浓度的涂层形成试剂的重复涂层，其中最初使用最高浓度。 该涂层特别适用于假体，其中假体的多孔区域被完全涂覆有薄的坚固的羟基磷灰石涂层。
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公开(公告)号：US5231169A
公开(公告)日：1993-07-27
申请号：US842788
申请日：1992-02-26
CPC分类号： C08L89/06 , A61L27/46 , C07K14/78 , A61F2310/00365 , Y10S128/08 , Y10S514/801
摘要： Mineralized collagen is prepared by forming calcium phosphate mineral under mild agitation in situ in the presence of dispersed collagen fibrils. A stable composition is obtained with desirable physical characteristics mimicking the characteristics of bone.
摘要翻译： 在分散的胶原纤维存在下，通过在温和搅拌下原位形成磷酸钙矿物来制备矿化胶原蛋白。 获得具有模拟骨特征的理想物理特性的稳定组合物。
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