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    Method of embolization using polyvinyl alcohol microspheres
    63.
    发明授权
    Method of embolization using polyvinyl alcohol microspheres 有权
    使用聚乙烯醇微球栓塞的方法

    公开(公告)号：US06680046B1

    公开(公告)日：2004-01-20

    申请号：US09419114

    申请日：1999-10-15

    Applicant: Egisto Boschetti

    Inventor： Egisto Boschetti

    IPC: A61K4900

    CPC classification number: A61K9/1635 ,  A61K47/6927

    Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present, invention relates to a process for producing the polyvinylalcbhol microspheres.

    Abstract translation: 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及一种生产聚乙烯基苯乙醇微球的方法。

    Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
    65.
    发明授权
    Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates 失效
    使用在高流速下具有高动态吸附容量的复合色谱介质从稀溶液中分离分子

    公开(公告)号：US5906747A

    公开(公告)日：1999-05-25

    申请号：US556313

    申请日：1995-11-13

    Applicant: Jonathan L. Coffman ,  Pierre Girot ,  Egisto Boschetti

    Inventor： Jonathan L. Coffman ,  Pierre Girot ,  Egisto Boschetti

    IPC: B01D15/08 ,  C07K1/18

    CPC classification number: B01D15/08 ,  B01D15/361 ,  C07K1/18

    Abstract: This invention relates generally to modified porous solid chromatographic media and processes for the preparation and use of same. In particular, chromatographic media of porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity and high intraparticle mass transfer rates. In order to prevent non-specific adsorption of or interaction with biomolecules, these supports may be passivated by use of a passivation mixture comprising a main monomer, a passivating monomer, and a crosslinking agent, which mixture upon polymerization results in substantial elimination of the undesirable non-specific interaction with biomolecules.

    Abstract translation: 本发明一般涉及改性多孔固体色谱介质及其制备和使用方法。 特别地，公开了多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体的色谱介质，其特征在于可逆的高吸附能力和高的颗粒内传质速率。 为了防止非特异性吸附或与生物分子的相互作用，这些载体可以通过使用包含主单体，钝化单体和交联剂的钝化混合物进行钝化，该聚合物上的该混合物导致基本上不需要的 与生物分子的非特异性相互作用。

    Automatic installation for liquid chromatography
    67.
    发明授权
    Automatic installation for liquid chromatography 失效
    自动安装液相色谱仪

    公开(公告)号：US4478713A

    公开(公告)日：1984-10-23

    申请号：US535308

    申请日：1983-09-23

    Applicant: Pierre Girot ,  Egisto Boschetti

    Inventor： Pierre Girot ,  Egisto Boschetti

    IPC: B01D15/08 ,  G01N30/24 ,  G01N30/82

    CPC classification number: B01D15/08 ,  B01D15/14 ,  B01D15/247 ,  G01N30/24 ,  G01N30/82

    Abstract: In the automatic installation for liquid chromatography according to the invention, the container of product to be fractionated is associated to a measuring container and is provided, as are the containers of eluents, with low level detector means; feed valves are interposed between said containers and the injection pump whereas output valves are interposed between the outlet from the column and the collector containers; a control unit comprises a safety device connected to the low level detectors to control the stoppage of the pump whenever necessary, and a control device receiving the signals from detection means connected to the output of the column and controlling the measuring container and said valves to perform successive cycles of chromatography each one including the steps of injecting a quantity of product, admitting at least one eluent and collecting the or each corresponding fraction.

    Abstract translation: 在根据本发明的液相色谱的自动安装中，要分级的产品的容器与测量容器相关联，并且与洗涤液的容器一样设置有低水平检测器装置; 进料阀介于所述容器和注射泵之间，而输出阀插入在塔的出口和收集容器之间; 控制单元包括连接到低电平检测器的安全装置，以在必要时控制泵的停止;以及控制装置，其接收来自连接到列的输出的检测装置的信号，并控制测量容器和所述阀执行 连续的色谱层析每个包括以下步骤：注入一定数量的产物，允许至少一种洗脱剂并收集或相应的部分。

    Dried rehydratable film containing agarose or gelose and process for preparing same
    68.
    发明授权
    Dried rehydratable film containing agarose or gelose and process for preparing same 失效
    含有琼脂糖或果胶的干燥可再水化膜及其制备方法

    公开(公告)号：US4048377A

    公开(公告)日：1977-09-13

    申请号：US648084

    申请日：1976-01-12

    Applicant: Egisto Boschetti ,  Yvette Paule Nicole Moroux ,  Rene Tixier

    Inventor： Egisto Boschetti ,  Yvette Paule Nicole Moroux ,  Rene Tixier

    IPC: C08L5/12 ,  G01N27/447 ,  B32B27/08 ,  C08L5/00

    CPC classification number: G01N27/44747 ,  C08L5/12 ,  Y10T428/31725 ,  Y10T428/31736 ,  Y10T428/31797

    Abstract: Dried agarose or gelose-containing films which are rehydratable into aqueous gel films are disclosed. The dried films are prepared by first forming, on a support, an aqueous gel film containing at most 5% by weight of agarose or gelose and a water-soluble linear polymer or copolymer of acrylamide or methacrylamide. The viscosity of such polymer and copolymer in a 5% aqueous solution at 22.degree. C is about 17000 centipoises or less and preferably about 6000 centipoises or less. The aqueous gel film is then dried according to known techniques, with the linear polymer or copolymer of acrylamide or methacrylamide being included in the dried film.

    Abstract translation: 公开了可再水化成水性凝胶膜的干琼脂糖或含有糖的胶囊。 干燥的膜通过首先在载体上形成含有至多5重量％的琼脂糖或谷蛋白的水凝胶膜和丙烯酰胺或甲基丙烯酰胺的水溶性线性聚合物或共聚物来制备。 这种聚合物和共聚物在22℃的5％水溶液中的粘度为约17000厘泊或更低，优选约6000厘泊或更小。 然后根据已知技术干燥水性凝胶膜，其中包括丙烯酰胺或甲基丙烯酰胺的直链聚合物或共聚物。

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