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61.
公开(公告)号:US20060241109A1
公开(公告)日:2006-10-26
申请号:US11360885
申请日:2006-02-23
申请人: Jeremy Little , Shomir Ghosh , Sean Harrison , Amy Elder , Christelle Renou , Kenneth Carson
发明人: Jeremy Little , Shomir Ghosh , Sean Harrison , Amy Elder , Christelle Renou , Kenneth Carson
IPC分类号: A61K31/538 , A61K31/498 , A61K31/4709 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号: C07D413/12 , C07D215/50 , C07D401/06 , C07D401/12 , C07D409/06 , C07D413/06 , C07D471/04 , C07D495/04
摘要: Disclosed are CRTH2 inhibitors represented by Structural Formula (I): The values for the variables of Structural Formula (I) are provided herein.
摘要翻译: 公开了由结构式(I)表示的CRTH2抑制剂:本文提供了结构式(I)的变量的值。
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62.
公开(公告)号:US20050256158A1
公开(公告)日:2005-11-17
申请号:US11101208
申请日:2005-04-07
申请人: Shomir Ghosh , Amy Elder , Kenneth Carson , Kevin Sprott , Sean Harrison , Frederick Hicks , Christelle Renou , Dominic Reynolds
发明人: Shomir Ghosh , Amy Elder , Kenneth Carson , Kevin Sprott , Sean Harrison , Frederick Hicks , Christelle Renou , Dominic Reynolds
IPC分类号: A61K31/47 , A61K31/4709 , C07D215/38 , C07D215/42 , C07D215/44 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06 , C07D413/10 , C07D417/06
CPC分类号: C07D405/06 , C07D215/42 , C07D215/44 , C07D401/04 , C07D401/06 , C07D401/12 , C07D413/06 , C07D413/10 , C07D417/06
摘要: Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
摘要翻译: 本文公开的是由结构式(I)和(IA)表示的化合物:还公开了这样的化合物用于抑制称为Th2上表达的化学引诱物受体同源分子的G-蛋白偶联受体,或简称为“CRTH2”,用于 治疗炎症性疾病。 结构式(I)和(I-A)中的变量在本文中定义。
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公开(公告)号:US20050070549A1
公开(公告)日:2005-03-31
申请号:US10487168
申请日:2002-11-13
申请人: Jay Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine Harriman , Kenneth Carson , Shomir Ghosh , Amy Elder , Karen Mattia
发明人: Jay Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine Harriman , Kenneth Carson , Shomir Ghosh , Amy Elder , Karen Mattia
IPC分类号: A61P1/00 , A61P3/10 , A61P29/00 , C07D211/46 , C07D211/52 , C07D313/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04 , C07D519/00 , A61K31/495 , A61K31/445 , C07D211/18 , C07D241/04
CPC分类号: C07D211/46 , C07D211/52 , C07D313/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由式(1)表示的化合物或其生理学上可接受的盐。
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公开(公告)号:US08653096B2
公开(公告)日:2014-02-18
申请号:US13245436
申请日:2011-09-26
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: C07D491/00 , C07D498/00 , C07D515/00 , A01N43/42 , A61K31/44
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号:US08067457B2
公开(公告)日:2011-11-29
申请号:US12084356
申请日:2006-10-26
申请人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
发明人: Shomir Ghosh , Prakash Raman , Kevin Sprott , Amy M. Elder , Sian Griffiths , Francois Soucy , Qing Ye
IPC分类号: C07D487/04 , C07D413/14 , C07D405/14 , C07D405/04 , A61K31/517 , A61K31/4725 , A61K31/4439 , A61K31/4375 , A61K31/423 , A61K31/4184 , A61K31/416 , A61K31/4025
CPC分类号: C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/14 , C07D471/04
摘要: The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
摘要翻译: 本发明提供通式I的化合物或其药学上可接受的盐,其中X,n,Y和R 1通常在本文中定义并在亚组中。 本发明的化合物是CCR2的抑制剂,因此可用于治疗各种炎症,过敏和自身免疫疾病,病症或病症。
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公开(公告)号:US08058287B2
公开(公告)日:2011-11-15
申请号:US12436271
申请日:2009-05-06
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine C. B. Harriman , Kenneth G. Carson , Shomir Ghosh , Amy M. Elder , Karen M. Mattia
IPC分类号: C07D491/00 , C07D498/00 , C07D515/00 , A01N43/42 , A61K31/44
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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公开(公告)号:US20110263588A1
公开(公告)日:2011-10-27
申请号:US13126118
申请日:2009-10-23
申请人: Peter Bertinato , Merav Fichman , Shomir Ghosh , Jian Lin , Dalia Segal , Zhaoda Zhang
发明人: Peter Bertinato , Merav Fichman , Shomir Ghosh , Jian Lin , Dalia Segal , Zhaoda Zhang
IPC分类号: A61K31/5377 , C07D471/04 , A61K31/4162 , A61K31/4439 , A61K31/437 , A61K31/454 , A61P25/28 , A61P25/14 , A61P25/22 , A61P25/24 , A61P29/00 , A61P25/06 , A61P1/04 , A61P25/34 , A61P25/00 , C07D491/052
CPC分类号: C07D491/052 , C07D231/54 , C07D471/04
摘要: The present invention relates to compounds that may be negative allosteric modulators of metabotropic receptors-subtype 5, and methods of making and using same.
摘要翻译: 本发明涉及可以是代谢型受体 - 亚型5的负变构调节剂的化合物及其制备和使用方法。
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公开(公告)号:US20110230516A1
公开(公告)日:2011-09-22
申请号:US13151701
申请日:2011-06-02
IPC分类号: A61K31/4545 , A61P29/00 , A61P9/10 , A61P3/10 , A61P1/00 , A61P37/06 , A61P17/06 , A61P37/08 , A61P11/06
CPC分类号: C07D491/044 , C07D491/04
摘要: The invention provides compounds having the formula: wherein R1 is halogen. The invention also provides compositions comprising the compounds, and methods of treating diseases or disorders that comprise administering one or more of the compounds to a subject in need thereof. The disclosed compounds have CCR1 antagonist activity.
摘要翻译: 本发明提供具有下式的化合物:其中R1是卤素。 本发明还提供包含该化合物的组合物,以及治疗疾病或病症的方法,其包括向有需要的受试者施用一种或多种化合物。 所公开的化合物具有CCR1拮抗剂活性。
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69.
公开(公告)号:US07951950B2
公开(公告)日:2011-05-31
申请号:US11360885
申请日:2006-02-23
申请人: Jeremy D. Little , Shomir Ghosh , Sean Harrison , Amy M. Elder , Christelle C. Renou , Kenneth G. Carson
发明人: Jeremy D. Little , Shomir Ghosh , Sean Harrison , Amy M. Elder , Christelle C. Renou , Kenneth G. Carson
IPC分类号: C07D215/38
CPC分类号: C07D413/12 , C07D215/50 , C07D401/06 , C07D401/12 , C07D409/06 , C07D413/06 , C07D471/04 , C07D495/04
摘要: Disclosed are CRTH2 inhibitors represented by Structural Formula (I): The values for the variables of Structural Formula (I) are provided herein.
摘要翻译: 公开了由结构式(I)表示的CRTH2抑制剂:本文提供了结构式(I)的变量的值。
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公开(公告)号:US20110117073A1
公开(公告)日:2011-05-19
申请号:US12882484
申请日:2010-09-15
申请人: Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
发明人: Juswinder Singh , Russell Colyn Petter , Deqiang Niu , Lixin Qiao , Arthur Kluge , Roy Lobb , Shomir Ghosh , Zhendong Zhu
IPC分类号: A61K38/45 , C12N9/12 , C07D403/14 , A61K31/497 , C07D213/66 , C07D239/42 , C07D487/04 , A61K31/502 , A61K31/44 , A61K31/506 , A61P9/00 , A61P35/00 , A61P25/28 , A61P19/00 , A61P11/06 , A61P37/02
CPC分类号: C07D487/04 , A61K47/545 , A61K47/62 , C07D213/72 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/22 , C07D231/12 , C07D239/42 , C07D239/48 , C07D333/68 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D495/04 , C07D498/04 , C12N9/1205 , C12N9/96
摘要: The invention relates to protein conjugates that contain a protein kinase containg a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.
摘要翻译: 本发明涉及蛋白质缀合物,其含有包含ATP结合位点中的半胱氨酸残基的蛋白激酶和与所述半胱氨酸残基共价和不可逆地结合的抑制剂,使得蛋白激酶的活性不可逆地被抑制。 本发明还涉及不可逆地抑制蛋白激酶的化合物。
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