公开(公告)号：US07072700B2

公开(公告)日：2006-07-04

申请号：US10148991

申请日：2000-11-29

申请人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Michiyuki Fujiwara ,  Mikihiro Kaga

发明人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Michiyuki Fujiwara ,  Mikihiro Kaga

IPC分类号： A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/046

摘要： The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.

公开(公告)号：US07047149B1

公开(公告)日：2006-05-16

申请号：US09674008

申请日：1999-04-26

申请人： Atsushi Maki ,  Yuuichi Yamashita ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi

发明人： Atsushi Maki ,  Yuuichi Yamashita ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi

IPC分类号： G01C17/00

CPC分类号： G01N21/49 ,  A61B5/0042 ,  A61B5/14553 ,  A61B5/7435

摘要： An optical measurement system for optically measuring a body to be inspected and obtaining an image of a desired item based on information obtained by the measurement includes means for displaying a number of measurement points, means for indicating a light irradiation position and a light detecting position and means for displaying a measurement position and a state of allocating a number to the measurement position. The system further includes means for displaying measuring time sequence data, means for setting a condition of acquiring data, means for displaying a status of acquiring the data, means for instructing control of measurement and means for marking a mark at a position measuring time sequence data.

摘要翻译： 一种光学测量系统，用于光学测量待检查的物体，并且基于通过测量获得的信息获得期望项目的图像，包括显示多个测量点的装置，用于指示光照射位置和光检测位置的装置，以及 用于显示测量位置和向测量位置分配数字的状态的装置。 该系统还包括用于显示测量时间序列数据的装置，用于设置获取数据的条件的装置，用于显示获取数据的状态的装置，用于指示测量的控制的装置和用于在测量时间序列数据的位置处标记标记的装置 。

公开(公告)号：US06901284B1

公开(公告)日：2005-05-31

申请号：US09913323

申请日：2000-02-18

申请人： Atsushi Maki ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi ,  Yuichi Yamashita

发明人： Atsushi Maki ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi ,  Yuichi Yamashita

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B6/00 ,  G01N21/17

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/7445 ,  A61B2562/0233 ,  A61B2562/046

摘要： An optical measuring apparatus for optically measuring a sample includes a plurality of parts for applying light beams to the sample, a plurality of detecting parts for detecting light beams from the light applying parts which come through the sample, a memory part which receives signals from the detecting parts, converts them into digital signals and stores the digital signals as measuring positions between the light applying part and the light detecting part. Further, there is provided a first display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts on the sample, and a second display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts which are shown on the first display part.

摘要翻译： 用于光学测量样品的光学测量装置包括用于向样品施加光束的多个部件，用于检测来自样品的光施加部分的光束的多个检测部分， 检测部件将它们转换为数字信号，并将数字信号存储在光施加部分和光检测部分之间的测量位置。 此外，提供了示出样品上的位置与样品上检测部位的位置对应的测量位置之间的关系的第一显示部分和示出样品和测量位置之间的关系的第二显示部分 对应于在第一显示部分上示出的检测部件的位置。

公开(公告)号：US06787017B1

公开(公告)日：2004-09-07

申请号：US09806913

申请日：2001-04-06

申请人： Atsumu Hirabayashi ,  Yukiko Hirabayashi ,  Akihiko Okumura ,  Hideaki Koizumi

发明人： Atsumu Hirabayashi ,  Yukiko Hirabayashi ,  Akihiko Okumura ,  Hideaki Koizumi

IPC分类号： G01N27447

CPC分类号： G01N27/44791 ,  G01N27/44704

摘要： The capillary electrophoresis system includes a wafer-shaped part having passages filled with a buffer solution for introducing sample solutions; a body having a configuration suitable to removably hold and to move the wafer-shaped part. The body includes first and second electrodes for applying a voltage across both ends of passages of the wafer-shaped part to separate and remove the sample solution. The body also includes first and second buffer reservoirs conductive to passages of the wafer-shaped part at specific positions for filling buffer solution around the first and second electrodes. The system according to the present invention facilitates washing of electrophoresis passages and reduces the time and labor costs required for replacement of the fused-silica wafers and simplifies operation by allowing a plurality of sample solutions to be analyzed more quickly.

摘要翻译： 毛细管电泳系统包括具有填充有用于引入样品溶液的缓冲溶液的通道的晶片状部件; 具有适于可移除地保持和移动晶片形部分的构造的本体。 本体包括第一和第二电极，用于跨晶片形部分的通道的两端施加电压以分离和去除样品溶液。 身体还包括第一和第二缓冲储存器，其导电到晶片状部分在特定位置处的通道，用于在第一和第二电极周围填充缓冲溶液。 根据本发明的系统有助于电泳通道的洗涤，并且减少了更换熔凝石英晶片所需的时间和人力成本，并且通过允许更快速地分析多个样品溶液来简化操作。

公开(公告)号：US06774359B1

公开(公告)日：2004-08-10

申请号：US09762276

申请日：2001-02-06

申请人： Yukiko Hirabayashi ,  Atsumu Hirabayashi ,  Akihiko Okumura ,  Hideaki Koizumi

发明人： Yukiko Hirabayashi ,  Atsumu Hirabayashi ,  Akihiko Okumura ,  Hideaki Koizumi

IPC分类号： G01N2306

CPC分类号： H01J49/04 ,  B01F5/0413 ,  B01F13/0059 ,  B01L3/5027 ,  G01N35/085

摘要： In a sample-introduction tool in which an end of a passage is connected to a reservoir for storing a mobile phase solution, a sample-dropping orifice is provided at the passage and the mobile phase solution and a sample running off from the other end of the passage are introduced into a mass spectrometer by generating a high-speed gas stream around the other end of the passage. The mobile phase solution and the sample are nebulized by the high-speed gas stream, and the injected sample is ionized.

摘要翻译： 在其中通道的端部连接到用于存储流动相溶液的储存器的样品引入工具中，在通道和流动相溶液处提供了一个抽样孔，并且从另一端流出的样品 通过在通道的另一端周围产生高速气流将通道引入质谱仪。 流动相溶液和样品被高速气流雾化，注入的样品离子化。

公开(公告)号：US06542763B1

公开(公告)日：2003-04-01

申请号：US09697327

申请日：2000-10-27

申请人： Yuichi Yamashita ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi ,  Fumio Kawaguchi

发明人： Yuichi Yamashita ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi ,  Fumio Kawaguchi

IPC分类号： A61B500

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/0059 ,  A61B2562/02 ,  A61B2562/0233 ,  A61B2562/046

摘要： In a system for performing imaging measurement of a test object by mounting many optical fibers to the test object, incident positions of the test object on which to illuminate light, detection positions of the test object from which to detect light and measurement positions which are determined from a positional relationship between the incident positions and the detection positions are displayed as graphic elements on a display unit. A state of detection signal level or a change in the state is displayed as a change in color or in pattern of the graphic element. Further, incident optical fibers for illuminating light to the test object and detection optical fibers for detecting light from the test object are mounted to the test object, and light emitting elements are mounted to probes to be mounted to the test object and interlocked with the change of the graphic elements.

摘要翻译： 在用于通过将许多光纤安装到测试对象上来进行测试对象的成像测量的系统中，用于照亮光的测试对象的入射位置，检测光的测试对象的检测位置和确定的测量位置 根据入射位置与检测位置之间的位置关系在显示单元上显示为图形元素。 检测信号电平状态或状态变化被显示为图形元素的颜色或图案的变化。 此外，将用于向测试对象照射光的入射光纤和用于检测来自测试对象的光的检测光纤安装在测试对象上，并且将发光元件安装到要安装到测试对象上的探针并与变化互锁 的图形元素。

公开(公告)号：US06465779B2

公开(公告)日：2002-10-15

申请号：US09968928

申请日：2001-10-03

申请人： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

发明人： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

IPC分类号： H01J4942

CPC分类号： H01J49/067 ,  H01J49/04

摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectroscopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.

摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于在大气压下对质谱进行质谱分析的样品化合物进行离子化;将含有所述样品化合物的溶液供给到所述电离装置的样品溶液供给装置，将由所述电离装置形成的离子供给 将设置在电极中的孔设置在真空区域中，以及离子阱型质谱分析装置，用于对通过孔进入真空区域的离子进行质谱分析，其中离子减速电场形成装置设置在 孔和设置有离子入口的电极，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。

公开(公告)号：US06316769B2

公开(公告)日：2001-11-13

申请号：US09739217

申请日：2000-12-19

申请人： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

发明人： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

IPC分类号： H01J4942

CPC分类号： H01J49/067 ,  H01J49/04

摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.

摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分散分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域和离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置有 所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，以及注入离子阱质谱分析装置的离子。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。

公开(公告)号：US06252225B1

公开(公告)日：2001-06-26

申请号：US09492352

申请日：2000-01-27

申请人： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

发明人： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

IPC分类号： H01J4910

CPC分类号： H01J49/165 ,  G01N30/7266 ,  H01J49/168

摘要： A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to a center axis of the aperture and a tip of the needle is disposed facing to an electrode having the aperture.

摘要翻译： 一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔 设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。 由喷雾器引起的喷雾方向几乎垂直于孔的中心轴线，并且针的尖端面向具有孔的电极设置。

公开(公告)号：US6011260A

公开(公告)日：2000-01-04

申请号：US114945

申请日：1998-07-14

申请人： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

发明人： Yasuaki Takada ,  Minoru Sakairi ,  Takayuki Nabeshima ,  Yukiko Hirabayashi ,  Hideaki Koizumi

IPC分类号： G01N27/62 ,  H01J49/04 ,  H01J49/06 ,  H01J49/34 ,  H01J49/42

CPC分类号： H01J49/067 ,  H01J49/04

摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and anion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.

摘要翻译： 一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分散分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置， 意味着通过设置在电极中的孔进入真空区域，以及阴离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置有 所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，以及注入离子阱质谱分析装置的离子。 即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。