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110 条记录 (耗时 0.039 秒)

    Antibodies to human I-branching beta-1,6-N-acetylglucosaminyltransferase
    61.
    发明授权
    Antibodies to human I-branching beta-1,6-N-acetylglucosaminyltransferase 失效
    人I支链β-1,6-N-乙酰葡糖胺基转移酶的抗体

    公开(公告)号：US5731420A

    公开(公告)日：1998-03-24

    申请号：US486196

    申请日：1995-06-07

    申请人： Minoru Fukuda ,  Marti F. A. Bierhuizen

    发明人： Minoru Fukuda ,  Marti F. A. Bierhuizen

    IPC分类号： A61K38/00 ,  C12N9/10 ,  C12N15/54 ,  C07K16/00 ,  C12P21/08

    CPC分类号： C12N9/1051 ,  A61K38/00

    摘要： The present invention provides an isolated nucleic acid molecule encoding both a soluble and membrane-bound human .beta.-1,6-N-acetylglucosaminyltransferase, the I-branching enzyme (IGnT). The invention also provides vectors containing the isolated nucleic acid molecule encoding human IGnT as well as recombinant host cells transformed with the vectors. The invention further provides a method of preparing a membrane-bound form of human IGnT and methods of preparing and purifying soluble human IGnT and active fragments of either form. Also provided are antisense oligonucleotides complementary to a nucleic acid molecule encoding a human IGnT or an active fragment thereof, antibodies directed to the human IGnT, pharmaceutical compositions related to the human IGnT and transgenic nonhuman mammals expressing DNA encoding normal or mutant human IGnT. Also provided are methods for regulating the expression of human IGnT and methods for modifying a biological function mediated by the regulatory activity of human IGnT. Methods of detecting the presence of linear polylactosaminoglycans expressing i antigenic determinants on a cell surface also are provided.

    摘要翻译： 本发明提供了编码可溶性和膜结合的人β-1,6-N-乙酰葡糖胺基转移酶I-分支酶（IGnT）的分离的核酸分子。 本发明还提供含有编码人IGnT的分离的核酸分子以及用载体转化的重组宿主细胞的载体。 本发明还提供了制备人IGnT的膜结合形式的方法，以及制备和纯化可溶性人IGnT和任一种形式的活性片段的方法。 还提供了与编码人IGnT或其活性片段的核酸分子互补的反义寡核苷酸，针对人IGnT的抗体，与人IGnT相关的药物组合物和表达编码正常或突变型人IGnT的DNA的转基因非人哺乳动物。 还提供了调节人IGnT的表达的方法和用于修饰由人IGnT的调节活性介导的生物功能的方法。 还提供了检测在细胞表面上表达i抗原决定簇的线性多糖胺聚糖存在的方法。

    Human .beta.1-6 n-acetylglucosaminyl transferase
    63.
    发明授权
    Human .beta.1-6 n-acetylglucosaminyl transferase 失效
    新型β1-6正乙酰葡糖胺转移酶

    公开(公告)号：US5360733A

    公开(公告)日：1994-11-01

    申请号：US955041

    申请日：1992-10-01

    申请人： Minoru Fukuda ,  Marti F. A. Bierhuizen

    发明人： Minoru Fukuda ,  Marti F. A. Bierhuizen

    IPC分类号： C12N15/09 ,  C07K14/47 ,  C07K14/705 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/54 ,  C12N15/64 ,  C12P21/02 ,  C12R1/91 ,  C12P19/18

    CPC分类号： C07K16/40 ,  C07K14/705 ,  C07K14/70596 ,  C12N15/64 ,  C12N9/1051

    摘要： The present invention provides a novel .beta.1.fwdarw.6 N-acetylglucosaminyltransferase, which forms core 2 oligosaccharide structures in O-glycans, and a novel acceptor molecule, leukosialin, CD43, for core 2 .beta.1.fwdarw.6 N-acetylglucosaminyltransferase activity. The amino acid sequences and nucleic acid sequences encoding these molecules, as well as active fragments thereof, also are disclosed. A method for isolating nucleic acid sequences encoding proteins having enzymatic activity is disclosed, using CHO cells that support replication of plasmid vectors having a polyoma virus origin of replication. A method to obtain a suitable cell line that expresses an acceptor molecule also is disclosed.

    摘要翻译： 本发明提供了一种在O-聚糖中形成核心寡糖结构的新颖的β1-6N-乙酰氨基葡糖转移酶，以及用于核心2β1-> 6 N-乙酰葡糖胺基转移酶活性的新受体分子白细胞介素，CD43。 还公开了编码这些分子的氨基酸序列和核酸序列，以及其活性片段。 使用支持具有多瘤病毒复制起点的质粒载体的复制的CHO细胞来公开分离编码具有酶活性的蛋白质的核酸序列的方法。 公开了获得表达受体分子的合适细胞系的方法。

    Semiconductor memory
    65.
    发明授权
    Semiconductor memory 失效
    半导体存储器

    公开(公告)号：US4788665A

    公开(公告)日：1988-11-29

    申请号：US75986

    申请日：1987-07-21

    申请人： Minoru Fukuda ,  Hideaki Takahashi ,  June Sugiura ,  Fumio Tsuchiya ,  Toshimasa Kihara

    发明人： Minoru Fukuda ,  Hideaki Takahashi ,  June Sugiura ,  Fumio Tsuchiya ,  Toshimasa Kihara

    IPC分类号： G11C17/00 ,  G11C16/02 ,  G11C16/10 ,  G11C8/00

    CPC分类号： G11C16/10 ,  G11C2216/14

    摘要： An electrically programmable read only memory is equipped with latch circuits for sequentially introducing series signals which are fed through external terminals. The converter includes sequentially operated switch elements and latch circuits in order to convert the series signals into parallel signals. The thus converted parallel signals are written simultaneously in a memory array via address decoder operated selection switch elements. According to this method, the writing operations into the memory array can be conducted at a high speed even when one writing operation is relatively long as a result of the parallel signal action.

    摘要翻译： 电可编程只读存储器配备有用于顺序地引入通过外部端子馈送的串联信号的锁存电路。 转换器包括顺序操作的开关元件和锁存电路，以将串联信号转换为并行信号。 这样转换的并行信号通过地址译码器操作的选择开关元件同时写入存储器阵列。 根据这种方法，即使当并行信号动作的结果是一个写入操作相对较长时，也可以高速地进行对存储器阵列的写入操作。

    Photosensitive resin containing a combination of diphenyl-imiazolyl dimer and a heterocyclic mercaptan
    67.
    发明授权
    Photosensitive resin containing a combination of diphenyl-imiazolyl dimer and a heterocyclic mercaptan 失效
    含有二苯基 - 亚氨基二聚体和杂环硫醇的组合的光敏树脂

    公开(公告)号：US4410621A

    公开(公告)日：1983-10-18

    申请号：US250805

    申请日：1981-04-03

    申请人： Minoru Wada ,  Minoru Fukuda

    发明人： Minoru Wada ,  Minoru Fukuda

    IPC分类号： G03F7/031 ,  G03C1/68

    CPC分类号： G03F7/031 ,  Y10S430/121 ,  Y10S430/123

    摘要： A photosensitive resin composition which comprises (1) an ethylenically unsaturated compound which can be addition polymerized to form a high molecular compound, said addition polymerization being initiated by a free radical and chain-propagating, (2) a 2-polycyclic aryl-4,5-diphenylimidazolyl dimer wherein the polycyclic aryl group at the 2-position comprises at least two benzene rings condensed each other and (3) a heterocyclic mercaptan compound, said photosensitive resin composition being excellent in having a high photopolymerization initiation potency.

    摘要翻译： 一种感光性树脂组合物，其包含（1）可以加成聚合以形成高分子化合物的烯属不饱和化合物，所述加成聚合由自由基引发和链增长，（2）2-多环芳基-4， 5-二苯基咪唑基二聚体，其中2-位的多环芳基包含至少两个彼此稠合的苯环和（3）杂环硫醇化合物，所述感光性树脂组合物具有优异的光聚合引发效力。

    Field effect transistor Miller integrator oscillator with temperature compensating impedance
    68.
    发明授权
    Field effect transistor Miller integrator oscillator with temperature compensating impedance 失效
    具有温度补偿阻抗的场效应晶体管MILLER积分器振荡器

    公开(公告)号：US4001721A

    公开(公告)日：1977-01-04

    申请号：US627281

    申请日：1975-10-30

    申请人： Minoru Fukuda

    发明人： Minoru Fukuda

    IPC分类号： H03K3/02 ,  H03K3/03 ,  H03K3/354 ,  H03K4/94 ,  H03K3/353

    CPC分类号： H03K3/3545 ,  H03K4/94 ,  Y10S323/907

    摘要： In an oscillation circuit wherein three or a greater odd number of inverters each of which is composed of a load FET and a driving FET are connected in cascade, a capacitor is connected between the input and output of at least one of the inverters so as to construct a Miller integrator, and the output of the final-stage inverter is connected to the input of the first-stage inverter, the improvement comprising the fact that impedance means, such as resistance, which has a positive temperature coefficient is connected in series with the capacitor, whereby the oscillation frequency of the oscillation circuit is prevented from fluctuating due to a change of the ambient temperature.

    Electronic device
    69.
    发明授权
    Electronic device 有权
    电子设备

    公开(公告)号：US08902610B2

    公开(公告)日：2014-12-02

    申请号：US13540618

    申请日：2012-07-03

    申请人： Minoru Fukuda

    发明人： Minoru Fukuda

    IPC分类号： H05K7/02 ,  H05K7/04 ,  H05K5/00 ,  H05K7/00 ,  H05K1/18 ,  H01F27/32 ,  H05K3/30

    CPC分类号： H05K5/0095

    摘要： An electronic device is provided. In the electronic device, a cover is securely fitted to a predetermined positioning hole formed in a printed board using a ready-made cover without using solder when the cover is installed in the printed board, so that the cover is prevented slipping from the printed board. The positioning hole is formed in a predetermined position of the printed board, and a cover claw that can be fitted to the positioning hole of the cover is formed in the cover, so that the cover covers the principal surface of the printed board to provide an electronic device.

    摘要翻译： 提供电子设备。 在电子设备中，当盖被安装在印刷电路板上时，使用现成的盖子将盖子牢固地装配到形成在印刷板上的预定定位孔，而不使用焊料，从而防止盖板从印刷板滑动 。 定位孔形成在印刷电路板的预定位置，并且可以在盖子上形成能够装配到盖的定位孔的盖爪，使得盖子覆盖印刷电路板的主表面， 电子设备。