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    Tandem Ion-Trap Time-Of-Flight Mass Spectrometer
    61.
    发明申请
    Tandem Ion-Trap Time-Of-Flight Mass Spectrometer 有权
    串联离子捕获飞行时间质谱仪

    公开(公告)号：US20080035842A1

    公开(公告)日：2008-02-14

    申请号：US10598194

    申请日：2005-02-23

    Applicant: Michael Sudakov ,  Li Ding

    Inventor： Michael Sudakov ,  Li Ding

    IPC: H01J49/40

    CPC classification number: H01J49/40 ,  H01J49/004 ,  H01J49/423

    Abstract: A tandem linear ion trap and time-of-flight mass spectrometer, where the ion trap has a straight central axis orthogonal to the flight path of the mass spectrometer. The ion trap comprises a set of electrodes, (401, 403, 402, 404) at least one of the electrodes has a slit for ejecting ions towards the mass spectrometer; a set of DC voltage supplies (+V, −V, V1, V2) to provide discrete DC levels and a number of fast electronic switches (409) for connecting/disconnecting the DC supplies to at least two of the electrodes; a neutral gas filling the ion trap and a digital controller to provide a switching procedure of ion trapping, manipulation with ions, cooling and including a state at which all ions are ejected from the ion trap towards the mass spectrometer.

    Abstract translation: 串联线性离子阱和飞行时间质谱仪，其中离子阱具有与质谱仪的飞行路径正交的直的中心轴。 离子阱包括一组电极（401,403,402,404），至少一个电极具有用于向质谱仪喷射离子的狭缝; 一组直流电压源（+ V，-V，V 1，V 2）以提供离散DC电平和多个用于将DC电源连接/断开至少两个电极的快速电子开关（409） 填充离子阱的中性气体和数字控制器，以提供离子捕获，用离子的操作，冷却和包括从离子阱向质谱仪喷射所有离子的状态的切换过程。

    Modeling circuit cells for waveform propagation
    62.
    发明申请
    Modeling circuit cells for waveform propagation 有权
    建模用于波形传播的电路单元

    公开(公告)号：US20070010981A1

    公开(公告)日：2007-01-11

    申请号：US11166659

    申请日：2005-06-23

    Applicant: Li Ding ,  Peivand Fallah-Tehrani ,  Alireza Kasnavi

    Inventor： Li Ding ,  Peivand Fallah-Tehrani ,  Alireza Kasnavi

    IPC: G06F17/50

    CPC classification number: G06F17/5031

    Abstract: A model for a circuit cell used in timing and signal integrity analysis in an integrated circuit design is automatically generated. A behavioral model, such as a gate current model is used in which the current in the circuit cell is determined as a function of the input voltage and the output voltage of the circuit cell as well as the history of at least one of the current, voltage, and charge values of the circuit cell. For example, the current in the circuit cell may be a function of the history of the current, which may be calculated incrementally using recursive convolution at each time step when using the model.

    Abstract translation: 自动生成用于集成电路设计中的时序和信号完整性分析的电路单元的模型。 使用诸如栅极电流模型的行为模型，其中电路单元中的电流被确定为电路单元的输入电压和输出电压的函数以及电流单元中的至少一个的历史， 电压和电荷值。 例如，电路单元中的电流可以是电流的历史的函数，其可以在使用该模型时在每个时间步长处使用递归卷积来逐渐计算。

    Constraining source code and objects for analysis tools
    63.
    发明申请
    Constraining source code and objects for analysis tools 有权
    限制源代码和分析工具的对象

    公开(公告)号：US20060277528A1

    公开(公告)日：2006-12-07

    申请号：US11144092

    申请日：2005-06-03

    Applicant: Xuan Chen ,  Kushal Munir ,  David McKnight ,  Li Ding ,  Vadim Berestetsky

    Inventor： Xuan Chen ,  Kushal Munir ,  David McKnight ,  Li Ding ,  Vadim Berestetsky

    IPC: G06F9/44

    CPC classification number: G06F11/3624

    Abstract: A source container for use in a computer system executing problem determination tools in an integrated environment across a computer network, the source container comprising a list of pathways to a plurality of source files and module objects. A software development may create the source container independently or within the front end of a problem determination tool. The front end of the problem determination tools sends the source container to its engine, and only source files and module objects having a pathway in the source container are analyzed within the engine of the problem determination tool. Furthermore, the results of the analysis of only those source files and module objects having a pathway in the source container are returned to the front end of the problem determination tool for viewing by the software developer. The front ends of the tools of the integrated development environment, the source files, the module objects, the engines of the tools, and different tools may all be located on different servers and/or clients across a computer network.

    Abstract translation: 一种用于计算机系统的源容器，用于在跨计算机网络的集成环境中执行问题确定工具，所述源容器包括到多个源文件和模块对象的路径列表。 软件开发可以独立地或在问题确定工具的前端创建源容器。 问题确定工具的前端将源容器发送到其引擎，并且在问题确定工具的引擎内仅分析在源容器中具有路径的源文件和模块对象。 此外，只有具有在源容器中的路径的源文件和模块对象的分析结果被返回到问题确定工具的前端，以供软件开发者查看。 集成开发环境的工具的前端，源文件，模块对象，工具的引擎和不同的工具可能都位于跨计算机网络的不同服务器和/或客户端上。

    Determination of RNA quality
    65.
    发明申请
    Determination of RNA quality 审中-公开
    RNA质量的测定

    公开(公告)号：US20060063170A1

    公开(公告)日：2006-03-23

    申请号：US11084582

    申请日：2005-03-18

    Applicant: Mark Erlander ,  Li Ding

    Inventor： Mark Erlander ,  Li Ding

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6851 ,  C12Q1/68 ,  C12Q2545/101 ,  C12Q2545/114 ,  C12Q2531/113 ,  C12Q2525/161

    Abstract: This invention relates to the determination of RNA quality, or RNA integrity, in a biological sample. The extent of RNA degradation, or retention of RNA integrity, is determined based upon the comparison of the relative amount of two sequences of a representative RNA molecule in the sample. Compositions and methods related to the determination are provided to assess RNA quality.

    Abstract translation: 本发明涉及生物样品中RNA质量或RNA完整性的确定。 基于样品中代表性的RNA分子的两个序列的相对量的比较来确定RNA降解的程度或RNA完整性的保留。 提供与测定有关的组合物和方法以评估RNA质量。

    Agar gel bead composition and method
    69.
    发明授权
    Agar gel bead composition and method 失效
    琼脂凝胶珠组成及方法

    公开(公告)号：US06319507B1

    公开(公告)日：2001-11-20

    申请号：US09431742

    申请日：1999-11-01

    Applicant: Pascal E. Delrieu ,  Li Ding

    Inventor： Pascal E. Delrieu ,  Li Ding

    IPC: A61K914

    CPC classification number: A61K8/042 ,  A61K8/025 ,  A61K8/11 ,  A61K8/365 ,  A61K8/645 ,  A61K8/676 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/944

    Abstract: Crushable gel beads 10 formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Entrapped in and dispersed randomly throughout each agar bead 10 is a water-soluble, preferably polar, restraining polymer 14, preferably a quaternized cationic polymer, such as polyquaternium 24 or steardimonium hydroxyethylcellulose. Various active agents 16 may be bound to restraining polymer 14, for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.

    Abstract translation: 由琼脂复合物形成的可破碎的凝胶珠10提供用于局部递送生物或化妆活性剂的新型化妆品，药​​物等输送载体。 优选的琼脂珠10是具有抑制性聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。包埋并随机分散在每个琼脂珠10中是水溶性的，优选极性的， 约束聚合物14，优选季铵化阳离子聚合物，例如聚季铵盐24或羟乙基纤维素。 各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸或木瓜蛋白酶。 还描述了制造方法。

    Human diacylglycerol kinase iota
    70.
    发明授权
    Human diacylglycerol kinase iota 有权
    人二酰甘油激酶

    公开(公告)号：US06255095B1

    公开(公告)日：2001-07-03

    申请号：US09412545

    申请日：1999-10-05

    Applicant: Stephen M. Prescott ,  Li Ding ,  Elie Traer

    Inventor： Stephen M. Prescott ,  Li Ding ,  Elie Traer

    IPC: C12N912

    CPC classification number: C12N9/1205

    Abstract: Diacylglycerol (DAG) plays a central role in both the synthesis of complex lipids and in intracellular signaling; diacylglycerol kinase (DGK) catalyzes the phosphorylation of DAG, which yields phosphatidic acid. A family of DGKs has been identified in multicellular organisms over the past few years, but the physiological function(s) of this diversity is not clear. One clue has come from the Drosophila DGK2, rdgA, since mutations in this gene cause retinal degeneration. The present invention relates to a novel DGK, designated DGK&igr;, which was isolated from human retina and brain libraries. DGK&igr; contains two cysteine-rich repeats, a region similar to the phosphorylation site domain of MARCKS, a conserved catalytic domain, and four ankyrin repeats at its C-terminus. By primary structure, DGK&igr; is most similar to human DGK&zgr; and Drosophila rdgA. A>12 kb mRNA for DGK&igr; was detected only in brain and retina among the tissues examined. In cells transfected with the DGK&igr; cDNA, an approximately 130 kDa protein was detected by immunoassay, and activity assays demonstrated that it encodes a functional DAG kinase. The protein was found to be in both the cytoplasm and nucleus, with this localization controlled by PKC isoforms &agr; and &ggr;. The gene encoding DGK&igr; was localized to human chromosome 7q32.3-33, which is known to be a locus for an inherited form of retinitis pigmentosa. These results have defined a novel isoform of DAG kinase, which may have important cellular functions in the retina and brain.

    Abstract translation: 二酰基甘油（DAG）在复合脂质的合成和细胞内信号传导中起重要作用; 二酰基甘油激酶（DGK）催化DAG的磷酸化，其产生磷脂酸。 过去几年，DGKs家族已被鉴定为多细胞生物，但这种多样性的生理功能尚不清楚。 一个线索来自果蝇DGK2，rdgA，因为该基因的突变导致视网膜变性。 本发明涉及一种从人视网膜和脑文库中分离得到的一种称为DGK和igr的新型DGK。 DGK＆igr 含有两个富含半胱氨酸的重复序列，一个与MARCKS的磷酸化位点结构域相似的区域，一个保守的催化结构域，在其C-末端有四个锚蛋白重复序列​​。 通过主要结构，DGK＆igr; 最类似于人类DGK＆zgr; 和果蝇rdgA。 A> 12 kb的mRNA用于DGK和igr; 在所检查的组织中仅在脑和视网膜中检测到。 在用DGK和igr转染的细胞中 cDNA通过免疫测定检测到约130kDa的蛋白质，活性测定证明它编码功能性DAG激酶。 发现蛋白质在细胞质和细胞核两者中，其定位受PKC同种型α和γ的控制。 编码DGK和igr的基因 被定位于人染色体7q32.3-33，其被认为是色素性视网膜炎的遗传形式的基因座。 这些结果定义了DAG激酶的新型同工型，其可能在视网膜和脑中具有重要的细胞功能。

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