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公开(公告)号：US06403358B1
公开(公告)日：2002-06-11
申请号：US09412210
申请日：1999-10-05
IPC分类号： C12N988
CPC分类号： C12N9/88
摘要： Novel adenylate cyclase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length adenylate cyclase proteins, the invention further provides isolated adenylate cyclase fusion proteins, antigenic peptides, and anti-adenylate cyclase antibodies. The invention also provides adenylate cyclase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an adenylate cyclase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
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62.发明授权Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 有权人二酰基甘油酰基转移酶2（DGAT2）家族成员及其用途公开(公告)号：US08334111B2
公开(公告)日：2012-12-18
申请号：US13015635
申请日：2011-01-28
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US20120149648A1
公开(公告)日：2012-06-14
申请号：US13352223
申请日：2012-01-17
申请人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
发明人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Jiawen Han
CPC分类号： C07K7/64 , A61K38/12 , A61K38/1761 , A61K45/06
摘要： The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
摘要翻译： 本发明提供用于治疗细胞增殖性疾病如癌症和免疫增殖性疾病的生物活性的拟肽大环化合物。
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公开(公告)号：US20120115793A1
公开(公告)日：2012-05-10
申请号：US13120386
申请日：2009-09-22
CPC分类号： C07K14/47
摘要： The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
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公开(公告)号：US07977059B2
公开(公告)日：2011-07-12
申请号：US12129509
申请日：2008-05-29
IPC分类号： C12Q1/00 , G01N33/00 , G01N33/53 , G01N33/567 , G01N33/573
CPC分类号： C12Q1/37 , A61K38/00 , C12N9/48 , G01N2500/00 , Y02A50/475
摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。
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公开(公告)号：US07820403B2
公开(公告)日：2010-10-26
申请号：US12217258
申请日：2008-07-02
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。 本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。 本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07704711B1
公开(公告)日：2010-04-27
申请号：US11901873
申请日：2007-09-19
CPC分类号： C12N9/1205 , A61K38/00 , C07C51/215 , C07C57/04
摘要： The invention relates to novel kinase nucleic acid sequences and proteins. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
摘要翻译： 本发明涉及新型激酶核酸序列和蛋白质。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。
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公开(公告)号：US07527962B2
公开(公告)日：2009-05-05
申请号：US11296615
申请日：2005-12-07
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
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公开(公告)号：US20080108093A1
公开(公告)日：2008-05-08
申请号：US11981786
申请日：2007-10-31
申请人： Rosana Kapeller-Libermann , David White , Keith Robison , Kyle MacBeth , Joseph Carroll , William Cook , Rachel Meyers , Miyoung Chun , Mark Williamson
发明人： Rosana Kapeller-Libermann , David White , Keith Robison , Kyle MacBeth , Joseph Carroll , William Cook , Rachel Meyers , Miyoung Chun , Mark Williamson
CPC分类号： G01N33/5008 , A61K38/00 , C12N9/1007 , C12N9/16 , C12N9/6489 , C12Q1/37 , C12Q1/6883 , C12Q2600/158 , C12Y301/04017 , G01N33/5011 , G01N33/502 , G01N33/56983 , G01N33/56994 , G01N33/57426 , G01N33/5761 , G01N33/5767 , G01N33/68 , G01N2333/916 , G01N2333/96486 , G01N2500/04
摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
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公开(公告)号：US07329529B2
公开(公告)日：2008-02-12
申请号：US10165231
申请日：2002-06-06
IPC分类号： C12N9/64 , G01N33/53 , G01N33/00 , C12Q1/37 , C07K14/00 , C12P21/06 , C12N15/00 , C12N5/10 , C12N1/20 , C07H21/04
CPC分类号： C12N9/6472
摘要： The invention provides isolated nucleic acids molecules that encode novel ubiquitin protease polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the ubiquitin protease nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a ubiquitin protease sequence of the invention has been introduced or disrupted. The invention still further provides isolated ubiquitin protease proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的泛素蛋白酶多肽的分离的核酸分子。 本发明还提供了反义核酸分子，含有本发明的泛素蛋白酶核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入了本发明的泛素蛋白酶序列的非人类转基因动物 或中断。 本发明还提供了分离的泛素蛋白酶蛋白，融合蛋白，抗原肽和抗体。 还提供了利用本发明组合物的诊断方法。
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