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公开(公告)号：US11542539B2
公开(公告)日：2023-01-03
申请号：US16307363
申请日：2017-06-05
Applicant: UNIVERSITY OF WASHINGTON , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US20220082566A1
公开(公告)日：2022-03-17
申请号：US17538447
申请日：2021-11-30
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US11249086B2
公开(公告)日：2022-02-15
申请号：US16209729
申请日：2018-12-04
Inventor： Daniel T. Chiu , Changfeng Wu , Jason McNeill , Jiangbo Yu
Abstract: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.
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公开(公告)号：US20220025111A1
公开(公告)日：2022-01-27
申请号：US17276690
申请日：2019-09-16
Applicant: University of Washington
Inventor： Daniel T. Chiu , Lei Chen , Jiangbo Yu
IPC: C08G61/12 , G01N33/543 , C08G79/08 , C08G61/02 , G01N21/64
Abstract: Polymers, monomers, narrow-band absorbing polymers, narrow-band absorbing monomers, absorbing units, polymer dots, and related methods are provided. Bright, luminescent polymer nanoparticles with narrow-band absorptions are provided. Methods for synthesizing absorbing monomers, methods for synthesizing the polymers, preparation methods for forming the polymer nanoparticles, and applications for using the polymer nanoparticles are also provided.
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公开(公告)号：US11221336B2
公开(公告)日：2022-01-11
申请号：US16556006
申请日：2019-08-29
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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Patent Agency Ranking
公开(公告)号：US10955419B2
公开(公告)日：2021-03-23
申请号：US14772608
申请日：2014-03-05
Applicant: University of Washington
Inventor： Daniel T. Chiu
Abstract: Methods, systems, compositions and kits are provided for the analysis of target molecules using chromophoric polymer dots conjugated to biomolecules. The use of chromophoric polymer dots improves detection sensitivity and stability when compared with existing techniques. In some aspects, methods, systems, and kits are provided for detecting a target protein using chromophoric polymer dots conjugated to biomolecules in a Western blot analysis. Related methods, systems, compositions and kits are also provided.
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公开(公告)号：US20200371109A1
公开(公告)日：2020-11-26
申请号：US16989491
申请日：2020-08-10
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , B82Y30/00 , B82Y40/00 , C08G61/12 , C08J3/11 , C09K11/02 , C09K11/06 , H01L51/00 , B82Y15/00
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US10739349B2
公开(公告)日：2020-08-11
申请号：US15167513
申请日：2016-05-27
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: C09K11/06 , G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H01L51/00 , C08G61/12 , C08J3/11 , C09K11/02
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US20190284601A1
公开(公告)日：2019-09-19
申请号：US16307363
申请日：2017-06-05
Applicant: UNIVERSITY OF WASHINGTON , LAMPROGEN, INC.
Inventor： Daniel T. Chiu , Jiangbo Yu , Changfeng Wu , Kai Sun
Abstract: The present disclosure provides nanoparticle transducers and methods of use thereof for the detection of analyte concentrations in a fluid. Nanoparticle transducers can comprise a nanoparticle, such as a Pdot, coupled to an enzyme that catalyzes a reaction with the analyte. The nanoparticle transducers further comprise chromophores that emit fluorescence that varies as a function of the concentration of one of the elements of the reaction. The nanoparticle transducer thus changes fluorescence as the analyte concentration changes, transforming analyte concentration values into fluorescence intensities. The measurement of these intensities provides a measurement of the analyte concentration. The nanoparticle transducers are biocompatible, allowing for use in vivo, for the monitoring of analyte blood concentrations such as blood glucose concentrations.
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公开(公告)号：US20180364270A1
公开(公告)日：2018-12-20
申请号：US15741462
申请日：2016-07-07
Applicant: University of Washington
Inventor： Daniel T. Chiu , Bryant S. Fujimoto , Jason E. Kreutz
IPC: G01N35/10 , G01N15/14 , G01N21/64 , G01N35/00 , G01N35/04 , G01N35/02 , C12Q1/686 , B01L3/00 , B01L7/00 , B01L9/00
CPC classification number: G01N35/1016 , B01L3/5025 , B01L3/502746 , B01L7/52 , B01L9/523 , B01L2200/027 , B01L2200/0673 , B01L2300/0809 , B01L2300/0816 , B01L2300/0864 , B01L2300/18 , B01L2300/1894 , B01L2400/0409 , C12Q1/686 , G01N15/1463 , G01N21/6456 , G01N35/00069 , G01N35/025 , G01N35/04 , G01N2015/1006 , G01N2035/00158 , G01N2035/00356 , G01N2035/00366 , G01N2035/0449 , G01N2035/1034
Abstract: Systems, methods, and devices for discretizing and analyzing fluidic samples are provided. In one aspect, a microfluidic array for discretizing a fluidic sample comprises one or more flow channels and a plurality of fluidic compartments in fluidic communication with the one or more flow channels. In another aspect, a system for discretizing and analyzing fluidic samples comprises a rotor assembly shaped to receive a microfluidic device.
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