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131 条记录 (耗时 0.028 秒)

    NON-INVASIVE DEVICE FOR DIAGNOSING GASTROESPHAGEAL REFLUX
    62.
    发明申请
    NON-INVASIVE DEVICE FOR DIAGNOSING GASTROESPHAGEAL REFLUX 审中-公开
    非侵入式装置，用于诊断胃肠道反流镜

    公开(公告)号：US20140031720A1

    公开(公告)日：2014-01-30

    申请号：US14042035

    申请日：2013-09-30

    申请人： Board of Trustees of Michigan State University

    发明人： Ira H. Gewolb ,  Frank L. Vice

    IPC分类号： A61B7/00

    CPC分类号： A61B7/008 ,  A61B5/11 ,  A61B5/4211 ,  A61B5/6823 ,  A61B5/7257 ,  A61B5/726 ,  A61B2562/0204 ,  A61B2562/0219

    摘要： The present invention provides compositions and methods useful in the diagnosis and management of Gastroesophageal Reflux. Specifically, the inventions provide a device and methods of using the device for accurately, quantitatively, and non-invasively diagnosing Gastroesophageal reflux disease (GERD) in both patients at risk for GERD and patients demonstrating reflux-like symptoms. In particular, the inventions relate to detecting and analyzing upward esophageal movements in patients, such as human infants, children, and adults.

    摘要翻译： 本发明提供了用于诊断和治疗胃食管反流的组合物和方法。 具体地说，本发明提供了一种使用该装置的装置和方法，用于准确，定量和非侵入性地诊断患有GERD风险的患者和表现出类似反流症状的患者的胃食管反流病（GERD）。 特别地，本发明涉及检测和分析患者（例如人类婴儿，儿童和成人）中的向上食管运动。

    DIAGNOSIS OF ENTRY OF GASTROINTESTINAL CONTENTS INTO RESPIRATORY TRACT OF HUMANS AND ANIMALS
    65.
    发明申请
    DIAGNOSIS OF ENTRY OF GASTROINTESTINAL CONTENTS INTO RESPIRATORY TRACT OF HUMANS AND ANIMALS 有权
    胃肠道内含物进入人体和动物呼吸道的诊断

    公开(公告)号：US20110312017A1

    公开(公告)日：2011-12-22

    申请号：US13162344

    申请日：2011-06-16

    申请人： Igor GONDA

    发明人： Igor GONDA

    IPC分类号： C12Q1/02 ,  A61B5/00

    CPC分类号： G01N33/94 ,  A61B5/082 ,  A61B5/14 ,  A61B5/150022 ,  A61B5/411 ,  A61B5/4211 ,  G01N21/6486 ,  G01N33/6893 ,  G01N2800/06

    摘要： A method of diagnosing respiratory fluid in a patient suffering from gastro esophageal reflux disease (GERD) is disclosed. The method comprises (1) orally administering to a subject suspected of suffering from gastro esophageal reflux disease (GERD), a formulation comprised of a plurality of particles comprised of a biocompatible polymer (e.g. carnauba wax) and a detectable, non-radioactive label (e.g. a fluorescent label), (2) allowing the formulation to remain in the subject over a period of time during which the subject would be expected to aspirate the formulation, (3) collecting respiratory fluid from the subject, and (4) analyzing the respiratory fluid to determine if the fluid contains the detectable label, and thereby determining if the subject regurgitates fluid into the respiratory tract. Alternatively, or additionally, a subject swallows a label that is not destroyed in the respiratory tract, or in the gastrointestinal tract, which further has the property that it is absorbed from the respiratory tract but not from the gastrointestinal tract. The presence of the label is then analyzed in blood, or, if the substance is excreted from blood to urine, in urine samples. The qualitative analysis can be also expanded into quantitative analysis, enabling the estimation of either the concentration, or the amount, or both, of the gastrointestinal contents that entered the respiratory tract.

    摘要翻译： 公开了一种诊断患有胃食管反流病（GERD）患者呼吸道液体的方法。 该方法包括（1）口服给予怀疑患有胃食管反流病（GERD）的受试者，由多种由生物相容性聚合物（例如巴西棕榈蜡）和可检测的非放射性标记组成的颗粒 例如荧光标签），（2）允许制剂在预期受试者吸出制剂的一段时间内保留在受试者中，（3）从受试者收集呼吸液体，和（4）分析 呼吸流体以确定流体是否含有可检测标记，从而确定受试者是否将流体反流进入呼吸道。 或者或另外，受试者吞咽在呼吸道或胃肠道中未被破坏的标签，其进一步具有从呼吸道而不是从胃肠道吸收的性质。 然后在血液中分析标签的存在，或者如果物质从尿液中排泄到尿液中。 定性分析也可以扩展到定量分析中，从而能够估计进入呼吸道的胃肠道内容物的浓度或量，或两者。

    System for displaying esophageal function
    66.
    发明授权
    System for displaying esophageal function 有权
    食管功能显示系统

    公开(公告)号：US08079965B2

    公开(公告)日：2011-12-20

    申请号：US12372553

    申请日：2009-02-17

    申请人： Thomas D. Stuebe ,  Timothy Paul Stewart ,  Lisa Roos Stewart

    发明人： Thomas D. Stuebe ,  Timothy Paul Stewart ,  Lisa Roos Stewart

    IPC分类号： A61B5/103 ,  A61B5/117

    CPC分类号： A61B5/4205 ,  A61B5/037 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/11 ,  A61B5/1126 ,  A61B5/14539 ,  A61B5/4211 ,  A61B5/4233 ,  A61B5/6852

    摘要： A system for displaying an esophageal operation includes a display device, an interface capable of receiving esophageal impedance and pressure measurements, and a processing system in communication with the display device, the interface, and an esophageal operation model. The processing system is configured to receive a plurality of impedance values from a first plurality of spaced-apart esophageal locations, receive a plurality of pressure values from a second plurality of spaced-apart esophageal locations, process the plurality of impedance values and the plurality of pressure values with the esophageal operation model, display the plurality of impedance values on the display device as a bolus transit, and display the plurality of pressure values on the display device as operational esophagus movement.

    摘要翻译： 用于显示食管手术的系统包括显示装置，能够接收食道阻抗和压力测量的接口，以及与显示装置，界面和食道操作模型通信的处理系统。 处理系统被配置为从第一多个间隔开的食道位置接收多个阻抗值，从第二多个间隔开的食道位置接收多个压力值，处理多个阻抗值，并且多个 使用食管手术模型的压力值，在显示装置上显示多个阻抗值作为推注运输，并将显示装置上的多个压力值显示为可操作的食道运动。

    Ambulatory reflux monitoring system
    69.
    发明授权
    Ambulatory reflux monitoring system 失效
    动态回流监测系统

    公开(公告)号：US5479935A

    公开(公告)日：1996-01-02

    申请号：US139117

    申请日：1993-10-21

    申请人： Anders Essen-Moller

    发明人： Anders Essen-Moller

    IPC分类号： A61B5/00 ,  A61B5/03 ,  A61B5/053 ,  A61B5/05

    CPC分类号： A61B5/14542 ,  A61B5/037 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/4211

    摘要： An ambulatory system for recording and analyzing gastroesophageal reflux is presented. The system comprises a digital recorder, an analysis software package and a catheter for measurement of changes in esophageal impedance. For the first time, gastroesophageal reflux can be detected with a pH above 4 (called alkaline reflux), which is the normal pH environment of the healthy esophagus. In addition, one embodiment of the invention allows for the determination of the direction of flow of the detected material in the esophagus, thus enabling the system to distinguish between swallowed saliva and alkaline gastroesophageal reflux. In yet a further embodiment, the present invention allows for recording and analysis of reflux on a non-invasive basis, by using pairs of externally worn impedance sensors. In another embodiment, the invention measures impedance simultaneously with other bio-parameters, such as pH or pressure.

    摘要翻译： 提出了记录和分析胃食管反流的动态系统。 该系统包括数字记录器，分析软件包和用于测量食管阻抗变化的导管。 可以首次检测到胃食管反流，pH高于4（称为碱性回流），这是健康食管的正常pH环境。 此外，本发明的一个实施例允许确定食道中检测到的材料的流动方向，从而使系统能够区分吞咽的唾液和碱性胃食管反流。 在又一个实施例中，本发明允许通过使用一对外部磨损的阻抗传感器在非侵入性的基础上记录和分析回流。 在另一个实施方案中，本发明与其他生物参数如pH或压力同时测量阻抗。