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    REDUCER OF IMMUNOSUPPRESSION BY TUMOR CELL AND ANTITUMOR AGENT USING THE SAME
    62.
    发明申请
    REDUCER OF IMMUNOSUPPRESSION BY TUMOR CELL AND ANTITUMOR AGENT USING THE SAME 审中-公开
    使用肿瘤细胞和抗肿瘤药物免疫的免疫抑制剂

    公开(公告)号：US20100291677A1

    公开(公告)日：2010-11-18

    申请号：US12674881

    申请日：2008-08-22

    申请人： Chie Kudo ,  Yutaka Kawakami

    发明人： Chie Kudo ,  Yutaka Kawakami

    IPC分类号： C12N5/071 ,  C07K14/47 ,  C07K16/26

    CPC分类号： C07K16/2866 ,  A61K31/00 ,  A61K38/1709 ,  A61K38/1793 ,  A61K38/195 ,  A61K2039/505 ,  C07K14/4702 ,  C07K16/18 ,  C07K16/24 ,  C07K16/30 ,  C07K2317/73 ,  C12N5/0693 ,  C12N15/113 ,  C12N2310/14 ,  C12N2501/148 ,  C12N2502/1114 ,  C12N2502/1157 ,  C12N2502/30 ,  C12N2510/00

    摘要： In order to provide a gene expression enhancer for enhancing expression of FoxP3 gene in a cell; a cell differentiation inducer for inducing differentiation of a cell into a regulatory T cell; an immunosuppressor for suppressing immunity and an agent for treating hyperimmune diseases based on the abovementioned actions; an inhibitor of enhancement of gene expression for inhibiting enhancement of expression of FoxP3 gene in a cell; an inhibitor of induction of cell differentiation for inhibiting induction of differentiation of a cell into a regulatory T cell; a reducer of immunosuppression for reducing immunosuppression, a stimulator of tumor immunity and an antitumor agent based on the abovementioned actions; and the like, for example, an agent containing at least one of a cell expressing Snail protein, MCP1 protein, FSTL1 protein, membrane IL-13Ra2 protein or secretory IL-13Ra2 protein, or MCP1 protein, FSTL1 protein or secretory IL-13Ra2 protein, is used as a gene expression enhancer for FoxP3, an inducer of regulatory T cell differentiation, an immunosuppressor or an agent for treating hyperimmune diseases; and an agent containing an anti-MCP1 antibody, an anti-FSTL1 antibody or an anti-IL-13Ra2 antibody is used as an inhibitor of enhancement of FoxP3 gene expression, a reducer of immunosuppression, a stimulator of tumor immunity, an antitumor agent, or the like.

    摘要翻译： 为了提供用于增强细胞中FoxP3基因表达的基因表达增强子; 用于诱导细胞分化成调节性T细胞的细胞分化诱导物; 用于抑制免疫的免疫抑制剂和基于上述作用的用于治疗超免疫疾病的药剂; 用于抑制细胞中FoxP3基因表达增强的基因表达增强抑制剂; 用于抑制诱导细胞分化成调节性T细胞的细胞分化诱导抑制剂; 基于上述作用的减少免疫抑制的减少剂，免疫抑制的刺激剂和抗肿瘤剂; 例如含有表达Snail蛋白，MCP1蛋白，FSTL1蛋白，膜IL-13Ra2蛋白或分泌型IL-13Ra2蛋白的细胞或MCP1蛋白，FSTL1蛋白或分泌型IL-13Ra2蛋白中的至少一种的药剂 用作FoxP3的基因表达增强子，FoxP3是调节性T细胞分化的诱导剂，免疫抑制剂或治疗超免疫疾病的药剂; 使用含有抗MCP1抗体，抗FSTL1抗体或抗IL-13Ra2抗体的药剂作为FoxP3基因表达增强抑制剂，免疫抑制剂的减少剂，肿瘤免疫刺激剂，抗肿瘤剂， 或类似物。

    Medium for culturing tumor cells
    66.
    发明授权
    Medium for culturing tumor cells 失效
    用于培养肿瘤细胞的培养基

    公开(公告)号：US07132288B2

    公开(公告)日：2006-11-07

    申请号：US10467982

    申请日：2002-02-14

    申请人： Jakob Izbicki ,  Stefan Hosch ,  Peter Scheunemann

    发明人： Jakob Izbicki ,  Stefan Hosch ,  Peter Scheunemann

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0693 ,  C12N2500/25 ,  C12N2500/32 ,  C12N2501/11 ,  C12N2501/148

    摘要： Disclosed is a medium for cultivating tumor cells, comprising the following constituents, as comprised for example in the medium RPMI 1640: (a) fetal calf serum (FCS), (b) penicillin-streptomycin, (c) L-glutamine, (d) transferrin, (e) insulin, (f) human epidermal growth factor (EGF) and (g) α-TGF. A method for characterizing tumor cells or potential tumor cells, respectively, is also described. Said method includes the culturing of cells in the inventive medium and the two tumor cell lines LNHOS1 and PTHOS1 established by means of the inventive culturing method.

    摘要翻译： 公开了用于培养肿瘤细胞的培养基，其包含例如在培养基RPMI 1640中包含的以下成分：（a）胎牛血清（FCS），（b）青霉素 - 链霉素，（c）L-谷氨酰胺，（d ）转铁蛋白，（e）胰岛素，（f）人表皮生长因子（EGF）和（g）α-TGF。 还描述了分别表征肿瘤细胞或潜在肿瘤细胞的方法。 所述方法包括培养本发明培养基中的细胞和通过本发明培养方法建立的两个肿瘤细胞系LNHOS1和PTHOS1。

    Multipotent neural stem cell cDNA libraries
    67.
    发明授权
    Multipotent neural stem cell cDNA libraries 失效
    多能神经干细胞cDNA文库

    公开(公告)号：US07105342B2

    公开(公告)日：2006-09-12

    申请号：US09925911

    申请日：2001-08-09

    申请人： Samuel Weiss ,  Brent Reynolds

    发明人： Samuel Weiss ,  Brent Reynolds

    IPC分类号： C12N15/63 ,  C12N15/12

    CPC分类号： G01N33/5058 ,  A01K2217/05 ,  A61K48/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/82 ,  C12N5/0623 ,  C12N9/0065 ,  C12N9/2471 ,  C12N2500/25 ,  C12N2500/46 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/148 ,  C12N2501/15 ,  C12N2501/392 ,  C12N2501/91 ,  C12N2503/02 ,  C12N2510/00 ,  C12Y302/01023 ,  G01N33/5008 ,  G01N33/5017 ,  G01N33/5023 ,  G01N33/5073 ,  G01N2500/00 ,  G01N2510/00

    摘要： cDNA libraries may be obtained from neural cell cultures produced by using growth factors to induce the proliferation of multipotent neural stem cells. The libraries may be obtained from both cultured normal and dysfunctional neural cells and from neural cell cultures at various stages of development. This information allows for the identification of the sequence of gene expression during neural development and can be used to reveal the effects of biological agents on gene expression in neural cells. Additionally, nucleic acids derived from dysfunctional tissue can be compared with that of normal tissue to identify genetic material which may be the cause of the dysfunction. This information could then be used in the design of therapies to treat the neurological disorder. A further use of the technology would be in the diagnosis of genetic disorders or for use in identifying neural cells at a particular stage in development.

    摘要翻译： cDNA文库可以从使用生长因子产生的神经细胞培养物获得以诱导多能神经干细胞的增殖。 文库可以从培养的正常和功能障碍的神经细胞和来自神经细胞培养物的不同发展阶段获得。 该信息允许在神经发育期间鉴定基因表达序列，并且可以用于揭示生物剂对神经细胞中的基因表达的影响。 另外，来自功能障碍组织的核酸可以与正常组织的核酸进行比较，以鉴定可能是功能障碍的原因的遗传物质。 然后可以将该信息用于设计治疗神经障碍的治疗。 该技术的进一步使用将在于遗传疾病的诊断或用于在发育的特定阶段鉴定神经细胞。