公开(公告)号：US20160320304A1

公开(公告)日：2016-11-03

申请号：US15209640

申请日：2016-07-13

Applicant: Becton, Dickinson and Company

Inventor： Pierce O. Norton ,  Yong Qin Chen

IPC: G01N21/64 ,  G01N15/14

CPC classification number: G01N21/6428 ,  G01N15/1434 ,  G01N15/1436 ,  G01N15/1459 ,  G01N21/64 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/144 ,  G01N2015/1477 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/068

Abstract: The present invention provides systems and methods for analyzing the excitation spectra of fluorescent particles in a flowing stream. The system uses a white light laser and color separation optics to provide a spatially-distributed, continuous color-spectrum excitation light system that is used to illuminate a region of a flowing stream. A particle that passes through the detection region traverses the full dispersed spectrum of excitation light, and the fluorescence emissions from the particle are continuously measured as it passes through the detection region. The measured fluorescence emissions at each wavelength of excitation light, which changes through full spectrum of the excitation light as the particle passes through the detection region, provides the excitation spectrum of the particle.

Abstract translation: 本发明提供了用于分析流动流中的荧光颗粒的激发光谱的系统和方法。 该系统使用白光激光器和分色光学器件来提供用于照亮流动区域的空间分布的连续色谱激发光系统。 通过检测区域的粒子穿过激发光的全部分散光谱，并且当粒子通过检测区域时，粒子的荧光发射被连续地测量。 在颗粒通过检测区域时，通过激发光的全谱变化的激发光的每个波长处的测量的荧光发射提供了颗粒的激发光谱。

公开(公告)号：US20160313252A1

公开(公告)日：2016-10-27

申请号：US15200126

申请日：2016-07-01

Applicant: SamanTree Medical SA

Inventor： Bastien Rachet ,  Davor Kosanic ,  Etienne Shaffer

IPC: G01N21/77 ,  G01N33/483

CPC classification number: G01N21/77 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/7786 ,  G01N2201/0633 ,  G01N2201/068 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0044 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/24 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361

Abstract: The disclosed technology brings histopathology into the operating theatre, to enable real-time intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, “optical slices” of fresh tissue—without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin “optical section” of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

Abstract translation: 所公开的技术将组织病理学带入手术室，以实现实时的手术中数字病理学。 所公开的技术在手术室中利用共聚焦成像装置，在新鲜组织的“光学切片”中，而不需要根据冷冻切片分析（FSA）的要求对切除的组织进行物理切片和处理。 在某些实施例中，所公开的技术包括简单的操作台式数字组织学扫描仪，具有快速扫描组织样本的所有外部边缘（例如，切除肿块，去除的组织块）的能力。 使用点扫描显微镜技术，在某些实施例中，所公开的技术精确地扫描被切除的组织的薄的“光学部分”，并将数字图像发送到病理学家而不是真实的组织，从而为病理学家提供机会 术中分析组织。 因此，所公开的技术提供具有与FSA相似的信息内容的数字图像，但是更快地提供并且不破坏组织样本本身的数字图像。

公开(公告)号：US09448168B2

公开(公告)日：2016-09-20

申请号：US14738371

申请日：2015-06-12

Applicant: Xtralis Technologies Ltd

Inventor： Ronald Knox ,  Kate Cooper ,  Kemal Ajay

IPC: G01N21/00 ,  G01N21/53 ,  G01N15/02 ,  G01N15/14 ,  F21K99/00 ,  G01N15/10

CPC classification number: G01N21/53 ,  F21K9/00 ,  G01N15/0205 ,  G01N15/10 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/538 ,  G01N2201/061 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0627 ,  G01N2201/0633 ,  G01N2201/0696

Abstract: A beam detector including a light source, a receiver, and a target, acting in cooperation to detect particles in a monitored area. The target reflects incident light, resulting in reflected light being returned to receiver. The receiver is capable of recording and reporting light intensity at a plurality of points across its field of view. In the preferred form the detector emits a first light beam in a first wavelength band; a second light beam in a second wavelength band; and a third light beam in a third wavelength band, wherein the first and second wavelengths bands are substantially equal and are different to the third wavelength band.

公开(公告)号：US09448166B1

公开(公告)日：2016-09-20

申请号：US14676483

申请日：2015-04-01

Applicant: Michael D. Rainer

Inventor： Michael D. Rainer

IPC: G01N21/41

CPC classification number: G01N21/4133 ,  G01N2021/414 ,  G01N2021/435 ,  G01N2201/062 ,  G01N2201/0633

Abstract: A method is provided for determining a physical property of a malt beverage sample. The method includes measuring a refractive index of the malt beverage sample. The method further includes determining a temperature-compensated measured refractive index by temperature correcting the measured refractive index relative to a predetermined reference temperature. The temperature correcting is specific to the total dissolved solids of the malt beverage sample. The method also includes converting the temperature-compensated measured refractive index to a unit of measurement. The unit of measurement relates to a physical property of the malt beverage sample. Apparatus are also provided.

Abstract translation: 提供了一种用于确定麦芽饮料样品的物理性质的方法。 该方法包括测量麦芽饮料样品的折射率。 该方法还包括通过相对于预定参考温度校正所测量的折射率的温度来确定经温度补偿的测量的折射率。 温度校正特定于麦芽饮料样品的总溶解固体。 该方法还包括将温度补偿的测量的折射率转换为测量单位。 测量单位涉及麦芽饮料样品的物理性质。 还提供了装置。

公开(公告)号：US09423346B2

公开(公告)日：2016-08-23

申请号：US14213064

申请日：2014-03-14

Applicant: DATACOLOR HOLDING AG

Inventor： Zhiling Xu

IPC: G01J1/42 ,  G01N21/59 ,  G01N21/94 ,  G01N21/47

CPC classification number: G01N21/59 ,  G01N21/4738 ,  G01N21/94 ,  G01N2021/4707 ,  G01N2021/4735 ,  G01N2021/4773 ,  G01N2201/0633 ,  G01N2201/0634 ,  G01N2201/065 ,  G01N2201/12746

Abstract: The present invention is directed to an apparatus and method for measuring the haze value of transmissive samples. The apparatus comprises a first light source selectively configurable to emit a first light beam, a second light source selectively configurable to emit a second light beam, an integrating sphere having an outer surface and an inner surface, the inner surface configured to reflect light incident upon the inner surface, the inner surface further enclosing an interior volume. The integrating sphere is further equipped with an exit port configured to emit light from the interior volume of the integrating sphere. The exit port is positioned such that light from the first light source exits the integrating sphere without obstruction, and light from the second light source is diffused on the interior surface of the integrating sphere prior to exiting the exit port. A light detector is also included and is configured to generate a light-intensity signal when light exiting the integrating sphere has passed through a sample and is incident on the light detector. The apparatus further includes a processor configured to receive the light-intensity signal and generate an output signal to a user indicating the haze value. The present invention is also directed to a method of calculating the haze value of a sample using a stored calibration value, a diffuse transmission value (sample-absent diffuse light-intensity value), a direct transmission value (sample-absent direct light-intensity value), a measured diffuse transmission value (sample-present diffuse light-intensity value) and a measured direct transmission value (sample-present direct light-intensity value).

Abstract translation: 本发明涉及一种用于测量透射样品的雾度值的装置和方法。 该装置包括可选择性地配置为发射第一光束的第一光源，可选择地配置为发射第二光束的第二光源，具有外表面和内表面的积分球，所述内表面被配置为反射入射到其上的光 内表面，内表面还包围内部体积。 积分球还配备有出口端口，其被配置为从积分球的内部空间发射光。 出口端口被定位成使得来自第一光源的光不会阻塞地离开积分球，并且来自第二光源的光在离开出口之前扩散到积分球的内表面上。 还包括光检测器，并且被配置为当离开积分球的光已经通过样品并入射到光检测器上时产生光强度信号。 该装置还包括处理器，其被配置为接收光强度信号并且向用户生成指示雾度值的输出信号。 本发明还涉及一种使用存储的校准值，漫射透射值（无采样扩散光强度值），直接透射值（无采样直接光强度）的样品的雾度值来计算雾度值的方法 值），测量的漫射透射值（样品存在的漫射光强度值）和测量的直接透射值（样品存在的直接光强度值）。

公开(公告)号：US20160238525A1

公开(公告)日：2016-08-18

申请号：US14901762

申请日：2013-07-04

Applicant: SHIMADZU CORPORATION

Inventor： Katsuto YAMADA ,  Naoya KONDO

IPC: G01N21/41

CPC classification number: G01N21/4133 ,  G01N2201/061 ,  G01N2201/0633 ,  G01N2201/068

Abstract: A V-block refractometer capable of enhancing measurement accuracy is provided. An incident angle of measurement light incident on a V-block prism 1 from a collimator lens 48 is changed through the rotation of a motor 7, and the measurement light from the V-block prism 1 at each incident angle is detected by a detector 2. This configuration eliminates the need to provide the detector 2 near the motor 7 as in the conventional art, whereby deterioration in measurement accuracy caused by an increase in load to the motor 7 can be prevented, and the measurement accuracy can be enhanced.

Abstract translation: 提供了能够提高测量精度的V型块折射计。 由准直透镜48入射到V形棱镜1上的测量光的入射角通过马达7的转动而改变，并且每个入射角的来自V形棱镜1的测量光由检测器2检测 该结构消除了如现有技术那样在电机7附近设置检测器2的需要，能够防止由电动机7的负荷增加引起的测量精度的劣化，能够提高测量精度。

公开(公告)号：US20160216201A1

公开(公告)日：2016-07-28

申请号：US14915473

申请日：2014-08-29

Applicant: DANMARKS TEKNISKE UNIVERSITET

Inventor： Krzysztof Iwaszczuk ,  Peter Uhd Jepsen

IPC: G01N21/3581

CPC classification number: G01N21/3581 ,  G01J3/28 ,  G01N2201/0633 ,  H01L31/0232

Abstract: The present invention relates to a system for detecting terahertz radiation, a camera device, and a method for detecting terahertz radiation.

Abstract translation: 本发明涉及一种用于检测太赫兹辐射的系统，相机装置和用于检测太赫兹辐射的方法。

公开(公告)号：US20160178516A1

公开(公告)日：2016-06-23

申请号：US14909933

申请日：2014-06-10

Applicant: PHOTONICSYS LTD.

Inventor： Ibrahim ABDULHALIM

IPC: G01N21/552

CPC classification number: G01N21/554 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/648 ,  G01N21/658 ,  G01N21/7703 ,  G01N29/022 ,  G01N29/2418 ,  G01N2021/7709 ,  G01N2021/7776 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/0633 ,  G01N2201/068 ,  Y10S977/954

Abstract: The invention is a SPR sensor that comprises a multi-layered plasmonic structure on a substrate for sensing. The SPR sensor has an enhanced figure of merit and lower limit of detection (system noise divided by the sensitivity) by at least two orders of magnitude than prior art SPR sensors. The plasmonic structure of the invention comprises a Nano-structured Porous Metal Layer (NPML) and at least one of: (a) buried dielectric layer under the nano-porous metal layer; (b) a nano-dimensional high index layer on top of the metal layer; and (c) a molecular layer for bio-functionalization adjacent to an analyte layer. The invention also encompasses many embodiments of measuring systems that comprise the SPR sensors of the invention with improved signal to noise ratio.

Abstract translation: 本发明是一种SPR传感器，其包括用于感测的衬底上的多层等离子体激元结构。 SPR传感器具有增强的品质因数和检测下限（系统噪声除以灵敏度）比现有技术SPR传感器至少两个数量级。 本发明的等离子体结构包括纳米结构的多孔金属层（NPML）和以下至少一种：（a）在纳米多孔金属层下面的掩埋介电层; （b）金属层顶部的纳米尺寸高折射率层; 和（c）与分析物层相邻的用于生物官能化的分子层。 本发明还包括测量系统的许多实施例，其包括具有改善的信噪比的本发明的SPR传感器。

公开(公告)号：US20160054235A1

公开(公告)日：2016-02-25

申请号：US14552188

申请日：2014-11-24

Applicant: KOREA AEROSPACE RESEARCH INSTITUTE

Inventor： Hyun Woo KIM ,  Jeong Hwan KO ,  Eui Seung CHUNG

IPC: G01N21/94 ,  G01N21/88 ,  G01N21/95

CPC classification number: G01N21/94 ,  G01N21/8806 ,  G01N21/95 ,  G01N2021/8829 ,  G01N2201/0633 ,  G01N2201/0638

Abstract: Provided are a surface inspection apparatus and a surface inspection method. More particularly, disclosed are a surface inspection apparatus and a surface inspection method to allow for inspection of a foreign material on non-uniformly colored diffusive surfaces containing a metal or polymer material or the like.

Abstract translation: 提供了表面检查装置和表面检查方法。 更具体地，公开了一种表面检查装置和表面检查方法，以允许在含有金属或聚合物材料等的非均匀着色的漫射表面上检查异物。

公开(公告)号：US20150268163A1

公开(公告)日：2015-09-24

申请号：US14439046

申请日：2013-10-28

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  BIOMERIEUX

Inventor： Mathieu Dupoy ,  Mathieu Debourdeau ,  Frédéric Pinston

IPC: G01N21/47 ,  C12Q1/02

CPC classification number: G01N21/47 ,  C12M23/10 ,  C12M41/36 ,  C12Q1/02 ,  G01N21/4738 ,  G01N2201/022 ,  G01N2201/06113 ,  G01N2201/0633

Abstract: A method for observing biological species on a culture medium contained in a container having at least one translucent face, the method including the steps of: a) directing a light beam onto one portion of the translucent face, so as to define at least one illuminated region and at least one non-illuminated region of the face; and b) acquiring an image of a portion of the surface of the culture medium illuminated by the light beam, the acquisition being carried out through at least one of the non-illuminated regions of the translucent face and along an optical acquisition axis forming a non-zero angle (a) with the direction of propagation of the light beam.

Abstract translation: 一种用于观察包含在具有至少一个半透明面的容器中的培养基上的生物物种的方法，所述方法包括以下步骤：a）将光束引导到半透明面的一部分上，以限定至少一个照明 区域和面部的至少一个非照明区域; 以及b）获取由所述光束照射的所述培养基的表面的一部分的图像，所述获取通过所述半透明面的所述非照明区域中的至少一个并且沿着形成非光照的光学获取轴进行， （a）与光束的传播方向。