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    Apparatus & method for ion beam implantation using scanning and spot beams with improved high dose beam quality
    61.
    发明申请
    Apparatus & method for ion beam implantation using scanning and spot beams with improved high dose beam quality 有权
    使用改进的高剂量光束质量的扫描和点光束进行离子束注入的装置和方法

    公开(公告)号：US20100237232A1

    公开(公告)日：2010-09-23

    申请号：US12661522

    申请日：2010-03-18

    Applicant: Jiong Chen

    Inventor： Jiong Chen

    IPC: H01J37/317 ,  H01J49/26 ,  H01J37/147

    CPC classification number: H01J37/3171 ,  H01J49/00 ,  H01J2237/057 ,  H01J2237/1526 ,  H01J2237/153 ,  H01J2237/166 ,  H01J2237/24528 ,  H01J2237/24542 ,  H01J2237/30472

    Abstract: An ion implantation apparatus with multiple operating modes is disclosed. The ion implantation apparatus has an ion source and an ion extraction means for forming a converging beam on AMU-non-dispersive plane therefrom. The ion implantation apparatus includes magnetic scanner prior to a magnetic analyzer for scanning the beam on the non-dispersive plane, the magnetic analyzer for selecting ions with specific mass-to-charge ratio to pass through a mass slit to project onto a substrate. A rectangular quadruple magnet is provided to collimate the scanned ion beam and fine corrections of the beam incident angles onto a target. A deceleration or acceleration system incorporating energy filtering is at downstream of the beam collimator. A two-dimensional mechanical scanning system for scanning the target is disclosed, in which a beam diagnostic means is built in.

    Abstract translation: 公开了一种具有多种工作模式的离子注入装置。 离子注入装置具有离子源和用于在其AMU非分散平面上形成会聚束的离子提取装置。 离子注入装置包括在用于扫描非分散平面上的束的磁分析仪之前的磁扫描器，用于选择具有特定质荷比的离子的磁分析器通过质量狭缝以投射到基底上。 提供矩形四极磁体以准直扫描的离子束并将光束入射角精细校正到目标上。 结合能量过滤的减速或加速系统位于射束准直仪的下游。 公开了一种用于扫描目标的二维机械扫描系统，其中内置了光束诊断装置。

    Optimizing Selection of SRM Transitions for Analysis of Biomolecules by Tandem Mass Spectrometry
    63.
    发明申请
    Optimizing Selection of SRM Transitions for Analysis of Biomolecules by Tandem Mass Spectrometry 审中-公开
    通过串联质谱法优化SRM转换选择分析生物分子

    公开(公告)号：US20090326828A1

    公开(公告)日：2009-12-31

    申请号：US12163928

    申请日：2008-06-27

    Applicant: Amol Prakash

    Inventor： Amol Prakash

    IPC: G01N33/68

    CPC classification number: G01N33/6848 ,  G01N2500/00 ,  H01J49/00

    Abstract: Methods for selecting a set of SRM transitions for a peptide of interest include selecting a first transition based on sensitivity criteria and selecting at least a second transition based on selectivity criteria. A determination of the uniqueness of the first transition combined with the at least a second transition is made. When the combination of the first transition and the at least a second transition is determined to be unique to the peptide of interest, a sample containing the peptide of interest is subjected to a SRM workflow by monitoring the first transition and the second transition. Also described is an apparatus for carrying out the methods.

    Abstract translation: 用于选择感兴趣的肽的一组SRM转换的方法包括基于灵敏度标准选择第一转换并基于选择性标准选择至少第二转换。 进行与至少第二过渡组合的第一过渡的唯一性的确定。 当确定第一转变和至少第二转化的组合对感兴趣的肽是唯一的时，通过监测第一转化和第二转化，将含有感兴趣肽的样品经受SRM工作流程。 还描述了一种用于执行这些方法的装置。

    SYSTEM AND METHOD FOR SEQUENCE VARIATION/PREDICTION AND GENETIC ENGINEERING DETECTION USING DOCUMENTED CODON/AMINO ACID MUTATION AND/OR SUBSTITUTION PATTERNS
    64.
    发明申请
    SYSTEM AND METHOD FOR SEQUENCE VARIATION/PREDICTION AND GENETIC ENGINEERING DETECTION USING DOCUMENTED CODON/AMINO ACID MUTATION AND/OR SUBSTITUTION PATTERNS 审中-公开
    使用文献CODON /氨基酸突变和/或替代模式进行序列变异/预测和遗传工程检测的系统和方法

    公开(公告)号：US20090210207A1

    公开(公告)日：2009-08-20

    申请号：US11911495

    申请日：2005-11-14

    Applicant: John Andrew Keightley ,  Gerald J. Wyckoff

    Inventor： John Andrew Keightley ,  Gerald J. Wyckoff

    IPC: G06G7/58

    CPC classification number: G16B30/00 ,  G16B35/00 ,  G16B50/00 ,  G16C20/60 ,  H01J49/00

    Abstract: The present invention primarily relates to protein identification and can be particularly useful for bioinformaticists employing a mass spectrometry analysis. The present invention provides systems and methods to produce virtual databases, virtual database entries, or virtual amino acid sequences that can be used to improve the identification of unknown proteins and facilitate recognizing engineered proteins and distinguishing between natural and engineered genes and proteins. The present invention uses variations, such as mutation or substitution patterns, evident in and derived from known DNA, RNA, and protein sequences to predict and generate virtual DNA, RNA, and amino acid sequences that may not be represented in the current databases but that are likely to occur in nature. Substitution patterns may be derived from either the chemical, physical, and biological patterns of mutation or the derived, observable patterns of evolutionary fixation of such mutations between or within species. These virtual sequences (or databases/datafiles of such virtual sequences) contain novel, but statistically likely sequences for use in comparing to unknown proteins (peptides) for protein identification. The use of such synthetic sequences and/or databases facilitate the recognition and distinction between naturally occurring and genetically engineered DNA, RNA, and protein sequences.

    Abstract translation: 本发明主要涉及蛋白质鉴定，并且可以特别适用于采用质谱分析的生物信息学家。 本发明提供用于产生虚拟数据库，虚拟数据库条目或虚拟氨基酸序列的系统和方法，所述虚拟数据库条目或虚拟氨基酸序列可用于改进未知蛋白质的鉴定并促进识别工程改造的蛋白质并区分天然和工程基因和蛋白质。 本发明使用在已知的DNA，RNA和蛋白质序列中明显的衍生而来的突变或替代模式的变异来预测和产生可能在当前数据库中未被表示的虚拟DNA，RNA和氨基酸序列，但是 很可能发生在自然界。 替代模式可以从突变的化学，物理和生物学模式中导出，或衍生的，可观察到的种内或种内突变的进化固定模式。 这些虚拟序列（或这种虚拟序列的数据库/数据文件）包含用于与用于蛋白质鉴定的未知蛋白质（肽）进行比较的新颖但统计上可能的序列。 使用这样的合成序列和/或数据库有助于识别和区分天然存在的和遗传工程化的DNA，RNA和蛋白质序列。

    Method of analysis of amine by mass spectrometry
    67.
    发明申请
    Method of analysis of amine by mass spectrometry 审中-公开

    公开(公告)号：US20070010025A1

    公开(公告)日：2007-01-11

    申请号：US11486417

    申请日：2006-07-12

    Applicant: Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

    Inventor： Hoa Nguyen ,  Trinh Nguyen ,  Duc Nguyen

    IPC: G01N33/00

    CPC classification number: G01N33/6848 ,  H01J49/00 ,  Y10T436/17 ,  Y10T436/173845

    Abstract: Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

    Gas-phase purification of biomolecules by ion mobility for patterning microarrays and protein crystal growth
    69.
    发明申请
    Gas-phase purification of biomolecules by ion mobility for patterning microarrays and protein crystal growth 失效
    通过离子迁移率生物分子的气相纯化用于图案化微阵列和蛋白质晶体生长

    公开(公告)号：US20050189485A1

    公开(公告)日：2005-09-01

    申请号：US11038834

    申请日：2005-01-20

    Applicant: John McLean ,  David Russell ,  J. Schultz

    Inventor： John McLean ,  David Russell ,  J. Schultz

    IPC: H01J49/00

    CPC classification number: G01N27/622 ,  B82Y30/00 ,  C30B7/00 ,  C30B23/00 ,  C30B29/58 ,  H01J49/00

    Abstract: A method and device for the gas-phase separation of ionic biomolecules including peptide, and protein or inorganic cluster ions or nanoparticles by ion mobility and for depositing them intact on a surface in a spatially addressable manner is described. The surface onto which the proteins are deposited can be modified for the purpose of constructing microarrays of biologically relevant materials or for promoting the growth of highly ordered protein crystals.

    Abstract translation: 描述了通过离子迁移率气相分离离子生物分子（包括肽）和蛋白质或无机簇离子或纳米颗粒并用空间可寻址方式在表面上完整沉积它们的方法和装置。 为了构建生物相关材料的微阵列或促进高度有序的蛋白质晶体的生长，可以修饰其上沉积有蛋白质的表面。

    Mass spectrometric screening of catalysts
    70.
    发明授权
    Mass spectrometric screening of catalysts 失效
    催化剂的质谱筛选

    公开(公告)号：US06797516B1

    公开(公告)日：2004-09-28

    申请号：US09489863

    申请日：2000-01-24

    Applicant: Peter Chen ,  Christian Hinderling

    Inventor： Peter Chen ,  Christian Hinderling

    IPC: G01N3110

    CPC classification number: G01N31/10 ,  H01J49/00 ,  Y10T436/24

    Abstract: Screening methods to identify catalysts or to identify improved catalysts using mass spectrometric analysis of products of catalysis, particularly catalyst-bound intermediate products in the catalytic cycle. The methods are applicable, in particular, to screening of organometallic compounds for catalytic function. Moreover, the methods are applicable, in particular, to screening for catalysts for polymerization reactions. More specifically, the methods employ a two stage (or two step) mass spectrometric detection method in which ions formed in a first stage ionization and which are linked to catalyst performance are selected and the catalyst associated with the selected ion is identified in a second stage employing tandem mass spectrometry. In specific embodiments, the screening methods of this invention avoid explicit encoding because the identity of the catalyst is implicitly contained in the product molecular mass (typically an intermediate product), since the catalyst (or a portion thereof) remains attached to the product.

    Abstract translation: 用于鉴定催化剂的筛选方法或使用催化产物的质谱分析来确定改进的催化剂，特别是在催化循环中的催化剂结合的中间产物。 该方法特别适用于筛选有机金属化合物用于催化功能。 此外，该方法特别适用于筛选聚合反应的催化剂。 更具体地说，该方法采用两阶段（或两步）质谱检测方法，其中选择在第一阶段电离中形成的并且与催化剂性能相关的离子，并且在第二阶段中鉴定与所选离子相关的催化剂 采用串联质谱法。 在具体实施方案中，本发明的筛选方法避免了显式编码，因为催化剂的特性（通常为中间产物）隐含地包含在催化剂（通常为中间产物）中），因为催化剂（或其一部分）保持附着于产物。

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