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    Ion trap analyzer and ion trap mass spectrometry analysis method
    62.
    发明授权
    Ion trap analyzer and ion trap mass spectrometry analysis method 有权
    离子阱分析仪和离子阱质谱分析方法

    公开(公告)号：US09502228B2

    公开(公告)日：2016-11-22

    申请号：US14389516

    申请日：2013-03-26

    申请人： SHIMADZU CORPORATION

    发明人： Gongyu Jiang ,  Wenjian Sun

    IPC分类号： H01J49/42

    CPC分类号： H01J49/4225 ,  H01J49/422 ,  H01J49/423 ,  H01J49/424 ,  H01J49/4245 ,  H01J49/427 ,  H01J49/4285

    摘要： An ion trap analyzer, an ion trap mass spectrometry analysis method, and an ion fragmentation method are provided. The ion trap analyzer includes an ion trapping space enclosed by multiple electrodes (101, 102, 103, 11, 12, 214), where a high-frequency voltage is applied on at least a part of the electrodes, so as to generate, within the trapping space, a trapping electric field dominated by a quadratic field. The apparatus is provided with an ion ejection outlet (200) in at least one direction away from the center of the trap; an alternating voltage signal used for resonant excitation of ion motions is overlaid on an electrode part that is on a side of the ion ejection outlet and closest to the ejection outlet, while no voltage signal that is identical in range and phase with the alternating voltage is applied on at least one remaining electrode part in said direction. With the method, or by further applying, to the remaining electrode part in said direction, a voltage signal that is inverted to the alternating voltage, the orientation of an alternating electric field induced by the excitation alternating voltage signal can be limited, thereby improving the resonance ejection efficiency of the ion trap, reducing, in ion motions, motion coupling between an ejection direction and a non-ejection direction, and improving the viability of selecting the ion trap as a mass analyzer.

    摘要翻译： 提供离子阱分析仪，离子阱质谱分析方法和离子碎片化方法。 离子阱分析仪包括由多个电极（101,102,103,11,12,214）包围的离子捕获空间，其中在至少一部分电极上施加高频电压，从而在 捕获空间，由二次场主导的捕获电场。 该设备在远离捕集器中心的至少一个方向上设置有离子喷射出口（200）; 用于离子运动的共振激发的交流电压信号覆盖在离子喷射出口侧并且最靠近喷射出口的电极部分上，而在交变电压范围和相位上没有相同的电压信号是 施加在所述方向上的至少一个剩余电极部分上。 通过该方法，或者通过进一步向所述方向上的剩余电极部分施加反向交流电压的电压信号，可以限制由激励交流电压信号感应的交变电场的取向，从而改善 离子阱的共振喷射效率，减少离子运动，喷射方向和非喷射方向之间的运动耦合，以及提高作为质量分析器选择离子阱的可行性。

    High Frequency Voltage Supply Control Method for Multipole or Monopole Analysers
    63.
    发明申请
    High Frequency Voltage Supply Control Method for Multipole or Monopole Analysers 审中-公开
    用于多极或单极分析仪的高频电源控制方法

    公开(公告)号：US20160293393A1

    公开(公告)日：2016-10-06

    申请号：US15022705

    申请日：2014-09-17

    申请人： MICROMASS UK LIMITED

    发明人： David Gordon ,  Richard Barrington Moulds ,  Kenneth Russell Worthington

    IPC分类号： H01J49/00 ,  H01J49/42

    CPC分类号： H01J49/0036 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/4215 ,  H01J49/422 ,  H01J49/4275

    摘要： A voltage supply system for supplying an RF voltage to an RF resonant load comprising an ion-optical component of a mass spectrometer is disclosed. The system comprises a Direct Digital Synthesiser (“DDS”) arranged and adapted to output an RF voltage. The voltage supply system is arranged and adapted: (i) to vary the frequency of the RF voltage output by the Direct Digital Synthesiser, (ii) to determine a first resonant frequency of the RF resonant load comprising the ion-optical component, and (iii) to determine whether or not the generation of an RF voltage at the first resonant frequency by the Direct Digital Synthesiser would also result in the generation of a spur frequency close to the first resonant frequency. If it is determined that a spur frequency would be generated close to the first resonant frequency then the voltage supply system is further arranged and adapted: (iv) to consult a look-up table comprising one or more preferred frequencies, and (v) to direct the Direct Digital Synthesiser to generate an RF voltage at a second frequency which corresponds with one of the preferred frequencies from the look-up table, wherein the second frequency is different to said first resonant frequency.

    摘要翻译： 公开了一种用于向包括质谱仪的离子光学部件的RF谐振负载提供RF电压的电压供应系统。 该系统包括布置并适于输出RF电压的直接数字合成器（“DDS”）。 电压供应系统被布置和适应：（i）改变由直接数字合成器输出的RF电压的频率，（ii）确定包括离子光学部件的RF谐振负载的第一谐振频率和（ iii）确定直接数字合成器在第一谐振频率下的RF电压的产生是否也将导致接近于第一谐振频率的杂散频率的产生。 如果确定将产生接近第一共振频率的杂散频率，则电压供应系统被进一步布置和适配：（iv）查阅包括一个或多个优选频率的查找表，以及（v）至 指导直接数字合成器以产生与来自查找表的优选频率之一相对应的第二频率的RF电压，其中第二频率不同于所述第一谐振频率。

    METHOD FOR ANALYZING IONIC STRUCTURE
    64.
    发明申请
    METHOD FOR ANALYZING IONIC STRUCTURE 有权
    分析离子结构的方法

    公开(公告)号：US20160247670A1

    公开(公告)日：2016-08-25

    申请号：US14430533

    申请日：2014-09-05

    申请人： BEIJING INSTITUTE OF TECHNOLOGY

    发明人： WEI XU ,  MUYI HE ,  XIANG FANG

    IPC分类号： H01J49/42 ,  H01J49/00

    CPC分类号： H01J49/422 ,  G01N27/68 ,  H01J49/005 ,  H01J49/427

    摘要： A method for analyzing ionic structure, including: applying a radio frequency electric field on an ion mass analyzer to cause sample ions to be excited to a motion amplitude, the motion amplitude at this moment being recorded as a primary motion amplitude; continuously feeding carrier gas into the ion mass analyzer and keeping a certain degree of vacuum in the ion mass analyzer, the sample ions being collided with the carrier gas and the motion amplitude being decreased gradually, and collecting a time domain signal of an image current generated by the sample ions during the process; and analyzing the time domain signal through a time-frequency analysis method and obtaining time-varying characteristic curves indicating corresponding relations between the motion frequencies of the ions having corresponding sizes and the collision cross sectional areas of the ions and the carrier gas, thus distinguishing among ions having different sizes.

    摘要翻译： 一种用于分析离子结构的方法，包括：在离子质量分析仪上施加射频电场，使样品离子被激发到运动幅度，此时的运动幅度被记录为主运动幅度; 将离子质量分析仪中的载气连续送入离子质量分析仪，并在离子质量分析仪中保持一定的真空度，样品离子与载气相撞，运动幅度逐渐减小，并收集产生的图像电流的时域信号 在过程中由样品离子; 并通过时频分析方法对时域信号进行分析，得到时间特性曲线，表示具有相应尺寸的离子的运动频率与离子与载气的碰撞横截面积之间的对应关系，从而区别于 具有不同尺寸的离子

    Mass spectrometer
    68.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US09129787B2

    公开(公告)日：2015-09-08

    申请号：US11571917

    申请日：2005-07-21

    申请人： Robert Harold Bateman ,  Jeffery Brown ,  Martin Green

    发明人： Robert Harold Bateman ,  Jeffery Brown ,  Martin Green

    IPC分类号： H01J49/40 ,  H01J49/06 ,  H01J49/02 ,  H01J49/42

    CPC分类号： H01J49/062 ,  H01J49/027 ,  H01J49/422 ,  H01J49/4245

    摘要： A mass spectrometer is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap by the application of an AC or RF voltage to the electrodes forming the ion guide or ion trap. A quadratic DC potential is applied along the axial length of the ion guide or ion trap in order to cause trapped ions to perform simple harmonic motion within the ion guide or ion trap. The frequency of the oscillations of the ions is detected using one or more inductive detectors. The mass to charge ratio of the ions can then be determined from the determined frequency of oscillations.

    摘要翻译： 公开了一种质谱仪，其包括分段线性离子导向器或离子阱。 通过对形成离子导向器或离子阱的电极施加AC或RF电压，离子导向器或离子阱中的离子被径向限制。 沿着离子导向器或离子阱的轴向长度施加二次直流电位，以使被捕获的离子在离子导向器或离子阱内进行简单的谐波运动。 使用一个或多个感应检测器检测离子振荡的频率。 然后可以从确定的振荡频率确定离子的质荷比。

    Performance improvements for RF-only quadrupole mass filters and linear quadrupole ion traps with axial ejection
    70.
    发明授权
    Performance improvements for RF-only quadrupole mass filters and linear quadrupole ion traps with axial ejection 有权
    仅射频四极杆质量过滤器和具有轴向喷射的线性四极离子阱的性能改进

    公开(公告)号：US08901486B2

    公开(公告)日：2014-12-02

    申请号：US14344938

    申请日：2012-09-17

    申请人： Micromass UK Limited

    发明人： David J. Langridge ,  Daniel James Kenny

    IPC分类号： B01D59/44 ,  H01J49/00 ,  H01J49/06 ,  H01J49/42 ,  H01J49/36

    CPC分类号： H01J49/4215 ,  H01J49/0027 ,  H01J49/06 ,  H01J49/063 ,  H01J49/36 ,  H01J49/422 ,  H01J49/4225

    摘要： A RF only quadrupole rod set mass filter or mass analyzer and a linear quadrupole ion trap with axial ejection are disclosed comprising a first pair of rod electrodes, a second pair of rod electrodes and an energy filter. The first pair of rod electrodes is longer than the second pair of rod electrodes. Ions having desired mass to charge ratios experience fringing fields at an exit region which results in the ions possessing sufficient axial kinetic energy to be transmitted by the energy filter. Other ions possess insufficient axial kinetic energy to be transmitted by the energy filter and are attenuated.

    摘要翻译： 公开了一种射频唯一四极杆组质量过滤器或质量分析器和具有轴向喷射的线性四极离子阱，其包括第一对杆电极，第二对棒电极和能量过滤器。 第一对杆电极比第二对杆电极长。 具有期望的质荷比的离子在出口区域处经历边缘场，导致离子具有足够的轴向动能以被能量过滤器传输。 其他离子具有不足的轴向动能，由能量过滤器传递并被衰减。