公开(公告)号：US20180353644A1

公开(公告)日：2018-12-13

申请号：US16108581

申请日：2018-08-22

申请人： LifeCell Corporation

发明人： Wenquan Sun ,  Melissa Richter Bowley ,  Goel Raghav

IPC分类号： A61L27/24 ,  A61K35/545 ,  A61K38/19 ,  A61K38/18 ,  A61K35/35 ,  A61L27/36 ,  A61L27/54 ,  A61L27/38 ,  A61L27/26 ,  A61L27/20

CPC分类号： A61L27/24 ,  A61F2/02 ,  A61K35/35 ,  A61K35/545 ,  A61K38/18 ,  A61K38/19 ,  A61L2/081 ,  A61L2/087 ,  A61L2/206 ,  A61L27/20 ,  A61L27/26 ,  A61L27/362 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/34 ,  C08L5/02

摘要： Methods of making tissue fillers are provided. In certain embodiments, the tissue is flake-like and has regenerative properties.

公开(公告)号：US10137224B2

公开(公告)日：2018-11-27

申请号：US14698763

申请日：2015-04-28

申请人： MicroVascular Tissues, Inc.

发明人： Dale R. Peterson ,  Richard B. Emmitt

IPC分类号： A61L27/36 ,  A61K35/12 ,  A61K35/35 ,  C12N5/077 ,  A61K35/28 ,  A61L27/54 ,  A61L27/56 ,  A61L27/38

摘要： Disclosed are products and methods for treating soft tissue injuries. The provided methods include the production of processed or cryopreserved microvascular tissue. Also provided are products and methods of using processed or cryopreserved microvascular tissue for the treatment of soft tissue injuries.

公开(公告)号：US10092677B2

公开(公告)日：2018-10-09

申请号：US15344855

申请日：2016-11-07

申请人： LifeCell Corporation

发明人： Hui Xu ,  Wenquan Sun ,  Hua Wan ,  Rick T. Owens

IPC分类号： A61K35/35 ,  A61K31/728 ,  A61K38/18 ,  A61L27/36 ,  A61K38/17 ,  A61L27/20 ,  A61L27/54 ,  C08L5/08 ,  A61L27/34 ,  A61L27/22

摘要： Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

公开(公告)号：US10092598B2

公开(公告)日：2018-10-09

申请号：US15044498

申请日：2016-02-16

申请人： RegenLab USA LLC

发明人： Antoine Turzi ,  Donald Francois Du Toit

IPC分类号： A61L24/00 ,  A61L24/10 ,  A61L26/00 ,  A61M1/36 ,  A61K35/14 ,  A61K35/16 ,  A61K38/18 ,  A61K35/18 ,  A61K35/36 ,  A61Q19/00 ,  A61K8/98 ,  A61K35/19 ,  A61K38/36 ,  A61K35/15 ,  A61K35/28 ,  A61K35/30 ,  A61K35/32 ,  A61K35/34 ,  A61K35/35 ,  A61K35/38 ,  A61K35/39 ,  A61K35/51 ,  A61K38/48 ,  A61L27/36 ,  A61L27/38 ,  A61Q19/08

摘要： The present invention relates to new plasma or new platelet-rich plasma preparations, new cell dissociation methods, new cell associations or compositions, a method of preparation thereof, a use thereof, devices for the preparation thereof and preparations containing such a platelet-rich plasma preparation and cell associations or compositions. Specifically, the invention provides plasma or platelet-rich plasma alone or in cell combinasons preparations for use in tissue regeneration and bone regeneration and pain reduction.

公开(公告)号：US10085963B2

公开(公告)日：2018-10-02

申请号：US14936830

申请日：2015-11-10

申请人： SAMI LABS LIMITED

发明人： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Sarang Bani ,  Anjali Pandey

IPC分类号： A61K31/352 ,  A61K35/35 ,  C12N5/077 ,  G01N33/50

摘要： Disclosed is a method of achieving optimal mammalian energy balance using forskolin on a particular physiological and developmental stage of the mammalian cellular system.

公开(公告)号：US20180216070A1

公开(公告)日：2018-08-02

申请号：US15743062

申请日：2016-07-08

申请人： ETABLISSEMENT FRANCAIS DU SANG ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITE TOULOUSE III - PAUL SABATIER ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： FREDERIC DESCHASEAUX ,  FABIEN GUILLOTON ,  SANDRA MULLER ,  LUC SENSEBE ,  LOUIS CASTEILLA ,  AUDREY CARRIERE-PAZAT

IPC分类号： C12N5/077 ,  A61K35/35 ,  G01N33/50

CPC分类号： C12N5/0653 ,  A61K35/35 ,  C12N5/0663 ,  C12N5/0667 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/33 ,  C12N2501/999 ,  C12N2502/115 ,  C12N2506/13 ,  C12N2506/1346 ,  C12N2513/00 ,  G01N33/50 ,  G01N33/5044

摘要： The present invention concerns a method of producing brown/beige adipocytes from white adipose tissue cells and/or mesenchymal stem cells, in particular from subcutaneous white adipose tissue cells, and the use of said brown/beige adipocytes in a cell based therapy of a subject or in screening platforms.

公开(公告)号：US10017740B2

公开(公告)日：2018-07-10

申请号：US14664441

申请日：2015-03-20

申请人： PLASTICELL LIMITED

发明人： Marina Tarunina ,  Yen Choo ,  Mylvaganam Jeyakumar ,  Thomas Watson ,  Meritxell Rosell ,  Lilian Hook ,  Diana Hernandez

IPC分类号： C12N5/00 ,  C12N5/077 ,  A61K35/35

CPC分类号： C12N5/0653 ,  A61K35/35 ,  C12N2500/24 ,  C12N2500/25 ,  C12N2501/01 ,  C12N2501/04 ,  C12N2501/155 ,  C12N2501/33 ,  C12N2502/1352 ,  C12N2506/1384

摘要： The present invention relates to brown adipose tissue (BAT) cells derived from adult stern or progenitor cells, derived from adult white fat tissue (WAT), as well as to methods for deriving such cells.

公开(公告)号：US20180147241A1

公开(公告)日：2018-05-31

申请号：US15877803

申请日：2018-01-23

申请人： CorMatrix Cardiovascular, Inc.

发明人： Robert G Matheny

IPC分类号： A61K35/35 ,  A61K35/12 ,  A61K38/18 ,  A61K45/06 ,  A61K48/00 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61M1/12

CPC分类号： A61K35/35 ,  A61K35/12 ,  A61K35/28 ,  A61K35/34 ,  A61K35/44 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1866 ,  A61K45/06 ,  A61K48/00 ,  A61L27/3604 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/367 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/64 ,  A61L2430/20 ,  A61M1/122 ,  A61M2205/05 ,  A61P9/10

摘要： Methods for treating cardiovascular disorders that include administration of an ECM based composition to damaged cardiovascular tissue in conjunction with a treatment remedy, such as ventricular assistance and transmyocardial revascularization (TMR), which induces enhanced bioremodeling of the damaged cardiovascular tissue and regeneration of new cardiovascular tissue and associated structures with site-specific structural and functional properties.

公开(公告)号：US20180133366A1

公开(公告)日：2018-05-17

申请号：US15814247

申请日：2017-11-15

申请人： Neil RIORDAN

发明人： Neil RIORDAN

IPC分类号： A61L27/36 ,  A61L27/50 ,  A61L27/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/35 ,  A61K35/50 ,  A61K35/51 ,  A61K9/00

CPC分类号： A61L27/3687 ,  A01N1/021 ,  A61K9/0019 ,  A61K35/35 ,  A61K35/39 ,  A61K35/407 ,  A61K35/50 ,  A61K35/51 ,  A61L27/3604 ,  A61L27/3691 ,  A61L27/3804 ,  A61L27/50 ,  A61L2300/214 ,  A61L2300/232 ,  A61L2300/406 ,  A61L2400/06

摘要： Disclosed are compositions of matter, protocols, and treatment means for generation of tissues capable of administration in a flowable manner through contain with one or more antibiotics, or derivatives of said antibiotics. In one embodiment the invention provides the treatment of morselized amniotic membranes with antibiotics in a manner as to increase buoyancy of morselized components of said amniotic membranes in order to prevent gravity based accumulation of said morselized tissue. In another embodiment buoyancy of morselized tissue is modulated by contacting said tissue with an antibiotic or derivative thereof in a manner to allow for increased uniformity of said morselized tissue components throughout a vessel. In another embodiment, pancreatic islets are isolated and stored in a manner to prevent gravity based aggregation. The invention pertains to all tissues, with emphasize in a preferred embodiment to tissues which are useful when administered in a flowable manner.

公开(公告)号：US09950014B2

公开(公告)日：2018-04-24

申请号：US14425960

申请日：2013-08-31

申请人： Pluristem Ltd.

发明人： Ayelet Chajut ,  Eytan Abraham

IPC分类号： A61K35/50 ,  A61K35/28 ,  A61K35/35 ,  C12N5/073 ,  C12N5/077

CPC分类号： A61K35/35 ,  A61K35/28 ,  A61K35/50 ,  C12N5/0605 ,  C12N5/0653 ,  C12N2513/00

摘要： Methods for treating or preventing preeclampsia or eclampsia by administering adherent stromal cells are described. The adherent stromal cells may be derived from bone marrow, placenta, or adipose tissue. Also described is the use of adherent stromal cells for the manufacture of a medicament, and an article of manufacture comprising a packaging material which comprises a label for use in treating or preventing preeclampsia or eclampsia.