公开(公告)号：US20140250669A1

公开(公告)日：2014-09-11

申请号：US14281428

申请日：2014-05-19

Applicant: EMD Millipore Corporation

Inventor： John Charkoudian ,  John P. Puglia ,  Nicole Fox

IPC: B01D39/16 ,  B01D39/18

CPC classification number: B01D39/1676 ,  B01D39/18 ,  B01D67/0093 ,  B01D71/10 ,  B01D2323/283 ,  B01D2323/30 ,  B01D2325/36 ,  C08B15/005 ,  C08L1/02 ,  Y10T29/49885

Abstract: The present invention relates to a nanofilter formed by using a porous ultrafiltration membrane as a precursor, and carefully controlling reaction conditions so as to maintain sufficient hydrophilic nature of the membrane while causing the pore structure to close to a nanofilter range (less than 400 Daltons). This produces a solvent stable cellulose nanofiltration membrane capable of operating at satisfactory flux in aqueous solutions, and being low binding to organic biomaterials.

Abstract translation: 本发明涉及通过使用多孔超滤膜作为前体形成的纳米过滤器，并仔细控制反应条件，以便在使孔结构接近纳米过滤范围（小于400道尔顿）的同时保持膜的充分亲水性， 。 这产生了能够在水溶液中以令人满意的助熔剂操作并且与有机生物材料结合低的溶剂稳定的纤维素纳米过滤膜。

公开(公告)号：US20140231371A1

公开(公告)日：2014-08-21

申请号：US14265429

申请日：2014-04-30

Applicant: EMD Millipore Corporation

Inventor： Rene Reinbigler ,  Jean-Louis Weissenbach

IPC: A47B81/00 ,  A47B91/00

CPC classification number: A47B81/00 ,  A47B57/04 ,  A47B91/002 ,  A47F5/0037 ,  A61G12/001 ,  B62B3/006

Abstract: A device for supporting a plurality of flexible containers (1) for liquid; characterized in that it comprises a plurality of baskets (10), each adapted to contain at least one said flexible container (1), a magazine (60) to receive said baskets (10), able to adopt an operating configuration in which said baskets (10) are disposed inclined one above the other, which magazine (60) comprises support means (75) for said baskets (10), able to adopt a loading/unloading position in which they are adapted such that each said basket (10) can be loaded/unloaded along a horizontal path, and able to adopt an operating position in which they are adapted to maintain each said basket (10) in inclined position to make said magazine (60) adopt said operating configuration, and means (83) for driving said support means (75) between said loading/unloading position and said operating position.

Abstract translation: 一种用于支撑用于液体的多个柔性容器（1）的装置; 其特征在于，它包括多个筐（10），每个筐（10）适于容纳至少一个所述柔性容器（1），用于容纳所述筐（10）的料仓（60），能够采用操作构型，其中所述筐 （10）彼此倾斜地布置，所述仓库（60）包括用于所述篮子（10）的支撑装置（75），能够采用它们被适配的装载/卸载位置，使得每个所述篮子（10） 可以沿着水平路径装载/卸载，并且能够采用它们适于将每个所述筐（10）保持在倾斜位置的操作位置，以使所述仓（60）采用所述操作构型，以及装置（83） 用于在所述装载/卸载位置和所述操作位置之间驱动所述支撑装置（75）。

公开(公告)号：US08798954B2

公开(公告)日：2014-08-05

申请号：US13414886

申请日：2012-03-08

Applicant: Aaron Burke

Inventor： Aaron Burke

IPC: A61L2/08

CPC classification number: A61L2/081 ,  A61L2/087 ,  A61L2202/24

Abstract: A system and method for implementing embedded electronics in environments where radiation or extreme temperatures are used is disclosed. Embedded electronics are affixed to various components of a pharmaceutical system, thereby enabling the customer to download pertinent information about the component, such as lot number, date of manufacturer, test parameters, etc. Additionally, these electronics allow an array of functions and features to be implemented, such as integrity tests and diagnostics. The electronics in the pharmaceutical components utilize a technology that is not as susceptible to radiation and extreme temperatures as traditional electronics.

Abstract translation: 公开了一种在使用辐射或极端温度的环境中实现嵌入式电子设备的系统和方法。 嵌入式电子设备固定在药物系统的各种组件上，从而使客户能够下载有关组件的相关信息，例如批号，制造商日期，测试参数等。此外，这些电子装置允许一系列功能和特征 实施，如​​完整性测试和诊断。 药物部件中的电子元件利用了不像传统电子产品那样易受辐射和极端温度影响的技术。

公开(公告)号：US20140091020A1

公开(公告)日：2014-04-03

申请号：US14053891

申请日：2013-10-15

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

IPC: B01D65/02

CPC classification number: B01D53/22 ,  B01D61/22 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/103 ,  B01D2311/16 ,  B01D2313/22 ,  B01D2321/40 ,  G01F1/6888 ,  G01F1/69 ,  G01F15/125

Abstract: An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.

Abstract translation: 公开了一种自主的过滤装置和改善过滤器寿命和性能的方法。 过滤器元件配备有适于测量一个或多个特性的一个或多个传感器。 响应于测量的特性，滤波器元件内的控制逻辑能够确定适当的响应。 例如，控制逻辑可以确定在过滤膜中已经发生突然而暂时的堵塞。 作为响应，控制逻辑可以启动旨在减轻阻塞的特定响应。 然后，控制逻辑将确定响应的成功，基于监测流体特性的任何变化。 基于此，控制逻辑可以警告操作者必须更换过滤元件。 或者，如果响应成功地纠正堵塞，则控制逻辑不需要通知操作者，因为过滤器元件已经回到正常的操作操作。

公开(公告)号：US20140090738A1

公开(公告)日：2014-04-03

申请号：US14074815

申请日：2013-11-08

Applicant: EMD Millipore Corporation

Inventor： Martin Morrissey ,  Neil Schauer

IPC: F16L9/127

CPC classification number: F16L9/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00808 ,  B01J2219/00813 ,  B01J2219/00833 ,  B01J2219/00968 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/561 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0887 ,  F16L9/127 ,  F16L9/133 ,  F16L9/22 ,  Y10T137/87153

Abstract: A disposable flow path having a manifold system that provides pressure resistance for the disposable device. The disposable device is comprised of a first rigid plastic sheet and a second rigid plastic sheet. Each sheet has two major surfaces and a thickness between them. At least one sheet surface has flow channels formed in it. The flow channels extend away from a first major surface and beyond the normal plane of a second major surface of the sheet. The sheets are liquid tightly sealed to each other at their adjoining first major surfaces. When each sheet contains a flow channel, the flow channels are aligned and in register with each other. One or more fittings can be secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets. Alternatively, tubing is placed in the channels before the sheets are secured to one another.

公开(公告)号：US20140051564A1

公开(公告)日：2014-02-20

申请号：US14003833

申请日：2012-03-28

Applicant: Luc Felden ,  Sebastien Jouette

Inventor： Luc Felden ,  Sebastien Jouette

IPC: B01D21/26

CPC classification number: B01D21/262 ,  B01D17/0217 ,  B01D17/085 ,  B01D61/18 ,  B01D63/16 ,  B01D71/34 ,  B01D2315/02 ,  B04B5/04 ,  B04B5/0407 ,  B04B2005/0435 ,  B04B2005/0478 ,  B04B2005/0485

Abstract: The invention provides a filtering and centrifugation device, comprising a barrel, a volume in the barrel for receiving a fluid sample to be processed, a filter medium, at least one piston movable in the barrel to force fluid in the volume through the filter medium to produce a filtrate, and a space for pelleting particulate material. The device is centrifugeable, and said space is located in or communicates with the volume and is located preferably away from the filter medium such that the particulate material does not or at least not completely clog the filter medium during such centrifugation of the device. The invention also provides a method for the sterile filtration of a sample, comprising the steps of introducing the sample into the volume of such a device, subjecting the device to centrifugation to pellet particulate material contained in the sample at the space away from the filter medium, and applying force to the piston(s) to force fluid of the sample in the volume through the filter medium to produce a filtrate. By providing the space for pelleting the particulate material under the influence of the centrifugation force, the clogging of the filter medium can be avoided or considerably delayed. Further, the entire process can be performed in the same device without having to remove the sample for any intermediate clarification steps.

Abstract translation: 本发明提供了一种过滤和离心装置，其包括筒体，桶中用于容纳要处理的流体样品的容积，过滤介质，至少一个可在筒体中移动的活塞，以迫使体积中的流体通过过滤介质至 产生滤液和颗粒物质造粒的空间。 该装置是可离心的，并且所述空间位于该容积中或与该体积连通，并且优选远离过滤介质，使得该颗粒材料在该装置的离心过程中不会或至少不完全堵塞过滤介质。 本发明还提供了一种用于样品的无菌过滤的方法，包括以下步骤：将样品引入这种装置的体积中，使装置进行离心以将包含在样品中的颗粒材料在远离过滤介质的空间 并且向活塞施加力以迫使体积中的样品的流体通过过滤介质以产生滤液。 通过在离心力的影响下提供用于造粒颗粒材料的空间，可以避免或显着延迟过滤介质的堵塞。 此外，整个过程可以在相同的装置中进行，而不必去除样品用于任何中间澄清步骤。

公开(公告)号：US08652330B2

公开(公告)日：2014-02-18

申请号：US12660715

申请日：2010-03-02

Applicant: Kwok-Shun Cheng ,  Senthilkumar Ramaswamy ,  Chen Wang ,  Nanying Bian ,  Brian Gagnon ,  Joaquin A. Umana ,  Dennis Aquino ,  Neil Soice ,  Andrew Lyddiatt

Inventor： Kwok-Shun Cheng ,  Senthilkumar Ramaswamy ,  Chen Wang ,  Nanying Bian ,  Brian Gagnon ,  Joaquin A. Umana ,  Dennis Aquino ,  Neil Soice ,  Andrew Lyddiatt

IPC: B01D15/08

CPC classification number: C07K16/00 ,  B01J20/262 ,  B01J20/265 ,  B01J20/267 ,  B01J20/28019 ,  B01J20/28092 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3212 ,  B01J20/3244 ,  B01J20/3274 ,  B01J20/328 ,  B01J20/3285 ,  B01J20/3293 ,  B01J39/26 ,  Y10T428/2982

Abstract: The present invention relates to an asymmetric chromatography media suitable for separations applications, particularly as packed bed, fluidized bed or magnetized bed chromatography media. In certain embodiments, the asymmetric chromatography media comprises asymmetric particles, preferably beads, having at least two distinct, controlled pore size distributions. Preferably one of the distinct pore size distributions is in an internal region of the particle, and the other is in an external region or coating on the particle. These distinct pore size distributions can be modified with uniform or alternatively unique functional groups or mixtures of functional groups. The present invention allows for the control over pore size distribution within an asymmetric porous particle by providing a distinct internal region, preferably in the form of a bead, and a distinct external region, preferably in the form of a coating on the bead.

Abstract translation: 本发明涉及适用于分离应用的非对称色谱介质，特别是作为填充床，流化床或磁化床层析介质。 在某些实施方案中，不对称色谱介质包含具有至少两个不同的，受控的孔径分布的不对称颗粒，优选珠粒。 优选地，不同孔径分布中的一个在颗粒的内部区域中，另一个位于颗粒的外部区域或涂层中。 这些不同的孔径分布可以用均匀的或替代地独特的官能团或官能团的混合物进行改性。 本发明允许通过提供不同的内部区域，优选以珠粒的形式和不同的外部区域，优选以珠粒上的涂层的形式来控制不对称多孔颗粒内的孔径分布。

公开(公告)号：US08652315B2

公开(公告)日：2014-02-18

申请号：US13653667

申请日：2012-10-17

Applicant: EMD Millipore Corporation

Inventor： Andrej Grabowski

IPC: B01D61/48 ,  C02F1/469

CPC classification number: B01D57/02 ,  B01D61/48 ,  C02F1/44 ,  C02F1/4695 ,  C02F2001/46119 ,  C02F2201/4611 ,  C02F2201/46115 ,  C02F2301/043

Abstract: Method for the removal of ions and ionizable substances from a polar liquid (10) comprising at least one process wherein said polar liquid (10) is split into a first stream (F1) and a second stream (F2), Said first stream (F1) passing through an electrochemically regenerable ion-exchange material (2) located where an electric field between two electrodes (4, 5) is applied, said first stream (F1) flowing from one electrode (4) to the other electrode (5) so that the ions to be removed are migrating in the direction reverse to the first stream flow through said ion-exchange material (2), Said second stream (F2) rinsing said one electrode (4), and said material is regenerated by the ions which are formed at the other electrode (5). Device in particular for the implementation of said method.

Abstract translation: 用于从极性液体（10）中去除离子和可离子化物质的方法，包括至少一种方法，其中所述极性液体（10）被分裂为第一流（F1）和第二流（F2），所述第一流 ）通过位于两个电极（4,5）之间的电场的电化学再生的离子交换材料（2），所述第一流（F1）从一个电极（4）流到另一个电极（5），所以 要除去的离子在与通过所述离子交换材料（2）的第一物流相反的方向上移动，所述第二流（F2）冲洗所述一个电极（4），并且所述材料由离子 形成在另一个电极（5）。 设备特别用于实现所述方法。

公开(公告)号：US20140017151A1

公开(公告)日：2014-01-16

申请号：US14031458

申请日：2013-09-19

Applicant: EMD Millipore Corporation

Inventor： Christopher A. Scott ,  Timothy K. Nadler ,  Kurt Greenizen ,  Louis Bonhomme ,  Sara D. Gutierrez ,  Masaharu Mabuchi ,  David Briggs ,  Phillip Clark ,  Ralph T. Scaduto

IPC: G01N1/34

CPC classification number: G01N1/34 ,  B01D61/18 ,  B01D63/06 ,  B01D63/16 ,  B01D2315/02 ,  B01L3/5021 ,  B01L3/5085 ,  B01L2300/0618 ,  B01L2300/0681 ,  C07K1/16 ,  C07K1/22 ,  G01N1/405 ,  G01N1/4077 ,  G01N2001/4088 ,  Y10T436/25375

Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.

Abstract translation: 允许完全结合，洗涤，洗脱，缓冲交换和浓缩过程的样品制备装置，在多个装置之间没有样品转移的情况下进行。 该装置包括储存器，用于保持色谱介质的柱，用于保持过滤装置的保持器区域和出口。 过滤装置插入到离心装置的保持器区域中，并且组件可以放置在可选的保持器中。 具有或不具有任选的保持器的组件可以放置在用于离心的常规离心管中。 整个结合，洗涤，洗脱，缓冲液交换和浓缩步骤可以在没有任何移液管转移（和相关样品损失）的情况下进行，样品制备装置也可用于结合和洗涤步骤，在这种情况下，过滤 设备不需要，并且用于缓冲区交换和集中步骤，在这种情况下不需要介质。

公开(公告)号：US20140014231A1

公开(公告)日：2014-01-16

申请号：US14032358

申请日：2013-09-20

Applicant: EMD Millipore Corporation

Inventor： Pierre Guedon

IPC: G01N1/10

CPC classification number: C12M33/07 ,  B01L3/567 ,  G01N1/10 ,  G01N35/1097 ,  G01N2001/022

Abstract: The device for the transfer of a medium comprises a magazine having two main faces (17) of which one is adapted to cooperate with a container and a lateral face (18) extending between said main faces (17) as well as at least one sliding valve (3) housed in a cavity of said magazine (2) and in which there is formed a transfer duct (59) for said medium which issues on said face (17) adapted to cooperate with said container, said valve (3) having a closed position in which it sealingly isolates said duct (59) from said container and an open position in which said duct (59) is placed in communication with said container; said valve (3) comprising a valve member (40), an isolation sleeve (41) surrounding at least partially said valve member (40) as well as spring means (58) adapted to be compressed by said valve member (40) when said valve (3) is in its open position.