公开(公告)号：US20070165380A1

公开(公告)日：2007-07-19

申请号：US11306896

申请日：2006-01-16

Applicant: Cheng-Tien Lai ,  Zhi-Yong Zhou ,  Qiao-Li Ding

Inventor： Cheng-Tien Lai ,  Zhi-Yong Zhou ,  Qiao-Li Ding

IPC: H05K7/20

CPC classification number: H01L23/4093 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A memory module assembly (1) includes a printed circuit board (30) having an electronic heat-generating component (40) thereon, a heat sink (20) and a clip (10) for securing the heat sink onto the heat-generating component mounted on the printed circuit board. The heat sink includes a base (22) and a plurality of fins (24) arranged on the base. A recess (28) is defined extending across the fins. The clip includes a retaining portion (12) resting against a face of the printed circuit board opposite the heat sink and an elastic pressing portion (16) spaced from the retaining portion. The pressing portion is received in the recess of the heat sink and resiliently presses the base of the heat sink toward the heat-generating component, whereby the clip clamps the heat sink and the printed circuit board therebetween.

Abstract translation: 存储模块组件（1）包括其上具有电子发热部件（40）的印刷电路板（30），散热器（20）和夹子（10），用于将散热器固定到发热部件 安装在印刷电路板上。 散热器包括基座（22）和布置在基座上的多个翅片（24）。 限定延伸穿过翅片的凹部（28）。 夹子包括一个保持部分（12），该保持部分靠在与散热器相对的印刷电路板的表面上，以及与保持部分间隔的弹性按压部分（16）。 按压部分被容纳在散热器的凹部中，并将散热片的基座弹性地压向发热部件，由此夹子将散热片和印刷电路板夹在其间。

公开(公告)号：US20070010981A1

公开(公告)日：2007-01-11

申请号：US11166659

申请日：2005-06-23

Applicant: Li Ding ,  Peivand Fallah-Tehrani ,  Alireza Kasnavi

Inventor： Li Ding ,  Peivand Fallah-Tehrani ,  Alireza Kasnavi

IPC: G06F17/50

CPC classification number: G06F17/5031

Abstract: A model for a circuit cell used in timing and signal integrity analysis in an integrated circuit design is automatically generated. A behavioral model, such as a gate current model is used in which the current in the circuit cell is determined as a function of the input voltage and the output voltage of the circuit cell as well as the history of at least one of the current, voltage, and charge values of the circuit cell. For example, the current in the circuit cell may be a function of the history of the current, which may be calculated incrementally using recursive convolution at each time step when using the model.

Abstract translation: 自动生成用于集成电路设计中的时序和信号完整性分析的电路单元的模型。 使用诸如栅极电流模型的行为模型，其中电路单元中的电流被确定为电路单元的输入电压和输出电压的函数以及电流单元中的至少一个的历史， 电压和电荷值。 例如，电路单元中的电流可以是电流的历史的函数，其可以在使用该模型时在每个时间步长处使用递归卷积来逐渐计算。

公开(公告)号：US20060277528A1

公开(公告)日：2006-12-07

申请号：US11144092

申请日：2005-06-03

Applicant: Xuan Chen ,  Kushal Munir ,  David McKnight ,  Li Ding ,  Vadim Berestetsky

Inventor： Xuan Chen ,  Kushal Munir ,  David McKnight ,  Li Ding ,  Vadim Berestetsky

IPC: G06F9/44

CPC classification number: G06F11/3624

Abstract: A source container for use in a computer system executing problem determination tools in an integrated environment across a computer network, the source container comprising a list of pathways to a plurality of source files and module objects. A software development may create the source container independently or within the front end of a problem determination tool. The front end of the problem determination tools sends the source container to its engine, and only source files and module objects having a pathway in the source container are analyzed within the engine of the problem determination tool. Furthermore, the results of the analysis of only those source files and module objects having a pathway in the source container are returned to the front end of the problem determination tool for viewing by the software developer. The front ends of the tools of the integrated development environment, the source files, the module objects, the engines of the tools, and different tools may all be located on different servers and/or clients across a computer network.

Abstract translation: 一种用于计算机系统的源容器，用于在跨计算机网络的集成环境中执行问题确定工具，所述源容器包括到多个源文件和模块对象的路径列表。 软件开发可以独立地或在问题确定工具的前端创建源容器。 问题确定工具的前端将源容器发送到其引擎，并且在问题确定工具的引擎内仅分析在源容器中具有路径的源文件和模块对象。 此外，只有具有在源容器中的路径的源文件和模块对象的分析结果被返回到问题确定工具的前端，以供软件开发者查看。 集成开发环境的工具的前端，源文件，模块对象，工具的引擎和不同的工具可能都位于跨计算机网络的不同服务器和/或客户端上。

公开(公告)号：US07029897B2

公开(公告)日：2006-04-18

申请号：US10433794

申请日：2001-12-04

Applicant: Henry Yue ,  Li Ding ,  Preeti G. Lal ,  Jennifer A. Griffin ,  Rajagopal Gururajan ,  Mariah R. Baughn ,  Craig H. Ison ,  Jayalaxmi Ramkumar ,  Catherine M. Tribouley ,  Anita Swarnakar ,  Neil Burford ,  Olga Bandman ,  Michael Thornton ,  Farrah A. Khan ,  Narinder K. Chawla ,  Danniel B. Nguyen ,  Vicki S. Elliott ,  Yuming Xu ,  Yan Lu ,  April J. A. Hafalia ,  Monique G. Yao ,  Ameena R. Gandhi ,  Chandra S. Arvizu ,  Ian J. Forsythe

Inventor： Henry Yue ,  Li Ding ,  Preeti G. Lal ,  Jennifer A. Griffin ,  Rajagopal Gururajan ,  Mariah R. Baughn ,  Craig H. Ison ,  Jayalaxmi Ramkumar ,  Catherine M. Tribouley ,  Anita Swarnakar ,  Neil Burford ,  Olga Bandman ,  Michael Thornton ,  Farrah A. Khan ,  Narinder K. Chawla ,  Danniel B. Nguyen ,  Vicki S. Elliott ,  Yuming Xu ,  Yan Lu ,  April J. A. Hafalia ,  Monique G. Yao ,  Ameena R. Gandhi ,  Chandra S. Arvizu ,  Ian J. Forsythe

IPC: C12N9/16 ,  C12N15/00 ,  C12N1/20 ,  C07K1/00 ,  C07H21/04

CPC classification number: C12N9/1205 ,  C07H21/04 ,  C12N9/16

Abstract: The invention provides human kinases and phosphatases (KAP) and polnucleotides which identify and encode KAP. The invention also provides expresson vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KAP.

Abstract translation: 本发明提供鉴定和编码KAP的人激酶和磷酸酶（KAP）和核苷酸。 本发明还提供了表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与KAP的异常表达相关的疾病的方法。

公开(公告)号：US20060063170A1

公开(公告)日：2006-03-23

申请号：US11084582

申请日：2005-03-18

Applicant: Mark Erlander ,  Li Ding

Inventor： Mark Erlander ,  Li Ding

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6851 ,  C12Q1/68 ,  C12Q2545/101 ,  C12Q2545/114 ,  C12Q2531/113 ,  C12Q2525/161

Abstract: This invention relates to the determination of RNA quality, or RNA integrity, in a biological sample. The extent of RNA degradation, or retention of RNA integrity, is determined based upon the comparison of the relative amount of two sequences of a representative RNA molecule in the sample. Compositions and methods related to the determination are provided to assess RNA quality.

Abstract translation: 本发明涉及生物样品中RNA质量或RNA完整性的确定。 基于样品中代表性的RNA分子的两个序列的相对量的比较来确定RNA降解的程度或RNA完整性的保留。 提供与测定有关的组合物和方法以评估RNA质量。

公开(公告)号：US20050239126A1

公开(公告)日：2005-10-27

申请号：US11167040

申请日：2005-06-27

Applicant: Stephen Todd ,  Angelo Delegeane ,  Ameena Gandhi ,  Danniel Nguyen ,  April Hafalia ,  Liam Kearney ,  Yan Lu ,  Ernestine Lee ,  Narinder Chawla ,  Debopriya Das ,  Chandra Arvizu ,  Monique Yao ,  Deborah Kallick ,  Vicki Elliott ,  Li Ding ,  Henry Yue ,  Roopa Reddy ,  Dyung Lu ,  Jayalaxmi Ramkumar ,  Junming Yang ,  Catherine Tribouley ,  Neil Burford ,  Mariah Baughn ,  Preeti Lal ,  Mark Borowsky ,  Farrah Khan ,  Rajagopal Gururajan ,  Y. Tang ,  Janice Au-Young ,  Bridget Warren ,  Roberto Hernandez ,  Brendan Duggan

Inventor： Stephen Todd ,  Angelo Delegeane ,  Ameena Gandhi ,  Danniel Nguyen ,  April Hafalia ,  Liam Kearney ,  Yan Lu ,  Ernestine Lee ,  Narinder Chawla ,  Debopriya Das ,  Chandra Arvizu ,  Monique Yao ,  Deborah Kallick ,  Vicki Elliott ,  Li Ding ,  Henry Yue ,  Roopa Reddy ,  Dyung Lu ,  Jayalaxmi Ramkumar ,  Junming Yang ,  Catherine Tribouley ,  Neil Burford ,  Mariah Baughn ,  Preeti Lal ,  Mark Borowsky ,  Farrah Khan ,  Rajagopal Gururajan ,  Y. Tang ,  Janice Au-Young ,  Bridget Warren ,  Roberto Hernandez ,  Brendan Duggan

IPC: A01K67/00 ,  C07H21/04 ,  C12N9/64 ,  C12N15/09 ,  C12P21/06 ,  C12Q1/68

CPC classification number: C12N9/6421 ,  A01K2217/05 ,  A01K2217/075 ,  C07H21/04 ,  C12N9/6472 ,  C12Q1/6837 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  Y02A50/52

Abstract: The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.

Abstract translation: 本发明提供鉴定和编码PRTS的人类蛋白酶（PRTS）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供诊断，治疗或预防与PRTS异常表达相关的疾病的方法。

公开(公告)号：US20050142600A1

公开(公告)日：2005-06-30

申请号：US11046868

申请日：2005-02-01

Applicant: Bridget Warren ,  Cynthia Honchell ,  Yan Lu ,  Narinder Chawla ,  Neil Burford ,  Angelo Delegeane ,  Ameena Gandhi ,  Mariah Baughn ,  Jennifer Griffin ,  Kimberly Gietzen ,  Dyung Lu ,  Craig Ison ,  Jayalaxmi Ramkumar ,  Y. Tang ,  Preeti Lal ,  Mark Borowsky ,  Brendan Duggan ,  April Hafalia ,  Chandra Arvizu ,  Kavitha Thangavelu ,  Monique Yao ,  Vicki Elliott ,  Li Ding ,  Henry Yue ,  Sally Lee ,  Anita Swarnakar ,  Uyen Tran ,  Yuming Xu

Inventor： Bridget Warren ,  Cynthia Honchell ,  Yan Lu ,  Narinder Chawla ,  Neil Burford ,  Angelo Delegeane ,  Ameena Gandhi ,  Mariah Baughn ,  Jennifer Griffin ,  Kimberly Gietzen ,  Dyung Lu ,  Craig Ison ,  Jayalaxmi Ramkumar ,  Y. Tang ,  Preeti Lal ,  Mark Borowsky ,  Brendan Duggan ,  April Hafalia ,  Chandra Arvizu ,  Kavitha Thangavelu ,  Monique Yao ,  Vicki Elliott ,  Li Ding ,  Henry Yue ,  Sally Lee ,  Anita Swarnakar ,  Uyen Tran ,  Yuming Xu

IPC: A61K38/00 ,  C07H21/04 ,  C12N9/64 ,  C12Q1/68

CPC classification number: C12N9/6421 ,  A01K2217/05 ,  A61K38/00 ,  C07H21/04 ,  C12N9/64

Abstract: The invention provides human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMMM.

Abstract translation: 本发明提供了鉴定和编码PMMM的人蛋白质修饰和维持分子（PMMM）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与PMMM的异常表达相关的紊乱的方法。

公开(公告)号：US20050069876A1

公开(公告)日：2005-03-31

申请号：US10473519

申请日：2002-03-29

Applicant: Mariah Baughn ,  Neil Burford ,  Li Ding ,  Brendan Duggan ,  Vicki Elliott ,  Ian Forsythe ,  Ameena Gandhi ,  Kimberly Gietzen ,  Jennifer Griffin ,  Ann He ,  Cynthia Honchell ,  Craig Ison ,  Preeti Lal ,  Ernestine Lee ,  Sally Lee ,  Dyung Alina Lu ,  Patricia Mason ,  Madhusudan Sanjanwala ,  Anita Swarnakar ,  Jayalaxmi Ramkumar ,  Y Tom Tang ,  Kavitha Thangavelu ,  Uyen Tran ,  Narinder Chawla ,  Bridget Warren ,  Monique Yao ,  Yuming Xu ,  Henry Yue

Inventor： Mariah Baughn ,  Neil Burford ,  Li Ding ,  Brendan Duggan ,  Vicki Elliott ,  Ian Forsythe ,  Ameena Gandhi ,  Kimberly Gietzen ,  Jennifer Griffin ,  Ann He ,  Cynthia Honchell ,  Craig Ison ,  Preeti Lal ,  Ernestine Lee ,  Sally Lee ,  Dyung Alina Lu ,  Patricia Mason ,  Madhusudan Sanjanwala ,  Anita Swarnakar ,  Jayalaxmi Ramkumar ,  Y Tom Tang ,  Kavitha Thangavelu ,  Uyen Tran ,  Narinder Chawla ,  Bridget Warren ,  Monique Yao ,  Yuming Xu ,  Henry Yue

IPC: G01N33/50 ,  A01K67/00 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/16 ,  A61P7/00 ,  A61P7/06 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P19/04 ,  A61P19/06 ,  A61P19/10 ,  A61P21/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P27/06 ,  A61P27/12 ,  A61P29/00 ,  A61P31/00 ,  A61P31/18 ,  A61P33/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P37/08 ,  C07H21/04 ,  C07K14/47 ,  C07K16/18 ,  C07K16/46 ,  C07K19/00 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N37/00

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00

Abstract: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

Abstract translation: 本发明提供鉴定和编码SECP的人分泌蛋白（SECP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与SECP异常表达相关的疾病的方法。

公开(公告)号：US06319507B1

公开(公告)日：2001-11-20

申请号：US09431742

申请日：1999-11-01

Applicant: Pascal E. Delrieu ,  Li Ding

Inventor： Pascal E. Delrieu ,  Li Ding

IPC: A61K914

CPC classification number: A61K8/042 ,  A61K8/025 ,  A61K8/11 ,  A61K8/365 ,  A61K8/645 ,  A61K8/676 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/944

Abstract: Crushable gel beads 10 formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Entrapped in and dispersed randomly throughout each agar bead 10 is a water-soluble, preferably polar, restraining polymer 14, preferably a quaternized cationic polymer, such as polyquaternium 24 or steardimonium hydroxyethylcellulose. Various active agents 16 may be bound to restraining polymer 14, for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.

Abstract translation: 由琼脂复合物形成的可破碎的凝胶珠10提供用于局部递送生物或化妆活性剂的新型化妆品，药​​物等输送载体。 优选的琼脂珠10是具有抑制性聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。包埋并随机分散在每个琼脂珠10中是水溶性的，优选极性的， 约束聚合物14，优选季铵化阳离子聚合物，例如聚季铵盐24或羟乙基纤维素。 各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸或木瓜蛋白酶。 还描述了制造方法。

公开(公告)号：US06255095B1

公开(公告)日：2001-07-03

申请号：US09412545

申请日：1999-10-05

Applicant: Stephen M. Prescott ,  Li Ding ,  Elie Traer

Inventor： Stephen M. Prescott ,  Li Ding ,  Elie Traer

IPC: C12N912

CPC classification number: C12N9/1205

Abstract: Diacylglycerol (DAG) plays a central role in both the synthesis of complex lipids and in intracellular signaling; diacylglycerol kinase (DGK) catalyzes the phosphorylation of DAG, which yields phosphatidic acid. A family of DGKs has been identified in multicellular organisms over the past few years, but the physiological function(s) of this diversity is not clear. One clue has come from the Drosophila DGK2, rdgA, since mutations in this gene cause retinal degeneration. The present invention relates to a novel DGK, designated DGK&igr;, which was isolated from human retina and brain libraries. DGK&igr; contains two cysteine-rich repeats, a region similar to the phosphorylation site domain of MARCKS, a conserved catalytic domain, and four ankyrin repeats at its C-terminus. By primary structure, DGK&igr; is most similar to human DGK&zgr; and Drosophila rdgA. A>12 kb mRNA for DGK&igr; was detected only in brain and retina among the tissues examined. In cells transfected with the DGK&igr; cDNA, an approximately 130 kDa protein was detected by immunoassay, and activity assays demonstrated that it encodes a functional DAG kinase. The protein was found to be in both the cytoplasm and nucleus, with this localization controlled by PKC isoforms &agr; and &ggr;. The gene encoding DGK&igr; was localized to human chromosome 7q32.3-33, which is known to be a locus for an inherited form of retinitis pigmentosa. These results have defined a novel isoform of DAG kinase, which may have important cellular functions in the retina and brain.

Abstract translation: 二酰基甘油（DAG）在复合脂质的合成和细胞内信号传导中起重要作用; 二酰基甘油激酶（DGK）催化DAG的磷酸化，其产生磷脂酸。 过去几年，DGKs家族已被鉴定为多细胞生物，但这种多样性的生理功能尚不清楚。 一个线索来自果蝇DGK2，rdgA，因为该基因的突变导致视网膜变性。 本发明涉及一种从人视网膜和脑文库中分离得到的一种称为DGK和igr的新型DGK。 DGK＆igr 含有两个富含半胱氨酸的重复序列，一个与MARCKS的磷酸化位点结构域相似的区域，一个保守的催化结构域，在其C-末端有四个锚蛋白重复序列​​。 通过主要结构，DGK＆igr; 最类似于人类DGK＆zgr; 和果蝇rdgA。 A> 12 kb的mRNA用于DGK和igr; 在所检查的组织中仅在脑和视网膜中检测到。 在用DGK和igr转染的细胞中 cDNA通过免疫测定检测到约130kDa的蛋白质，活性测定证明它编码功能性DAG激酶。 发现蛋白质在细胞质和细胞核两者中，其定位受PKC同种型α和γ的控制。 编码DGK和igr的基因 被定位于人染色体7q32.3-33，其被认为是色素性视网膜炎的遗传形式的基因座。 这些结果定义了DAG激酶的新型同工型，其可能在视网膜和脑中具有重要的细胞功能。