摘要:
This invention relates generally to the field of moiety or molecule manipulation in a chip format. In particular, the invention provides a method for manipulating a moiety in a microfluidic application, which method comprises: a) coupling a moiety to be manipulated onto surface of a binding partner of said moiety to form a moiety-binding partner complex; and b) manipulating said moiety-binding partner complex with a physical force in a chip format, wherein said manipulation is effected through a combination of a structure that is external to said chip and a structure that is built-in in said chip, thereby said moiety is manipulated.
摘要:
Circuits, architectures, a system and methods for protecting against overvoltages in a high-speed differential signal or circuit. The circuit generally includes (a) a differential signal transmission line, (b) a common mode circuit coupled to and configured to reduce a swing of the differential signal transmission line, and (c) an overvoltage protection circuit coupled to the common mode circuit, wherein the common mode circuit is electrically interposed between the overvoltage protection circuit and the differential signal transmission line. The architectures and/or systems generally include an integrated circuit that embodies one or more of the inventive concepts disclosed herein. The method generally includes shunting the overvoltage to a ground potential through the termination circuit when the differential circuit receives the overvoltage, but otherwise processing the differential signal through circuitry coupled to the differential circuit. The present invention advantageously provides a satisfactory level of overvoltage protection for nearly all applications in which conventional CMOS circuitry can be used, while at the same time, having very little, if any, adverse effect on differential data signal transmission speed.
摘要:
The present invention relates to methods of identifying modulators of angiogenesis utilizing human cells. The methods of the invention can be employed to assay compounds and small molecules for their ability to modulate human angiogenesis utilizing human pluripotent stem cells in an in vitro assay system. The present invention further relates to methods of identifying modulators of human angiogenesis by determining the ability of a test compound to modulate spontaneous vasogenesis in an in vitro assay system utilizing nonembryonic pluripotent stem cells. The present invention relates to in vitro assay systems utilizing nonembryonic pluripotent stem cells for the identification of compounds that modulate human angiogenesis or human vasogenesis. The present invention also relates to methods of treatment which require modulation of human angiogenesis or vasogenesis comprising administering to patients in need of such treatment compounds or small molecules which have been identified to be inhibitors of human angiogenesis or vasogenesis.
摘要:
Circuits, architectures, systems and methods for facilitating data communications and/or reducing latency in data communications. The architecture includes a clock recovery loop receiving data from a host device and providing a recovered clock signal, a filter circuit receiving recovered clock signal information and providing a control signal that adjusts the transmitter clock in response to recovered clock signal information and the two clock signals, and a transmitter receiving the control signal and transmitting data to a destination device in accordance with the transmitter clock. The circuitry generally includes a clock alignment block receiving first and second periodic signals and providing a control signal in response thereto, a filter for first periodic signal information, and a logic circuit configured to combine the control signal and the filtered information, thereby providing an adjustment signal for the second periodic signal. The systems generally relate to those that include the present architecture and/or circuit. The method generally includes determining a phase difference between first and second periodic signals, one of the periodic signals being recovered from a data stream; adjusting the other periodic signal in response to the phase difference and filtered information from the recovered periodic signal; and transmitting the data stream in accordance with said adjusted periodic signal. The present invention advantageously eliminates a FIFO memory in the data path, thereby reducing transceiver latency and improving system performance.
摘要:
The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles. The high throughput electrorotation chip and chamber may be used for cell-based screening for leading drug candidate molecules from a compound library, for high-throughput characterizing particle electric properties, and for high-throughput assaying molecular compositions of unknown solutions.
摘要:
The present disclosure relates to a FMCW Light Detection and Ranging system, a wave train of carrier frequency is modulated in narrow-band sequence, an delay interferometer with in-phase and quadrature outputs extracts the phase of this frequency modulation, and a coherent receiver with in-phase and quadrature outputs detects the phase of reflected light from a remote object, the ratio between two phases determines the distance of the remote object.
摘要:
The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.
摘要:
A microactuator for displacing a platform vertically with respect to a substrate includes a first rigid frame, a first flexible bimorph beam connecting the first frame to the substrate, a second rigid frame, a second flexible bimorph beam connecting the second frame to the first frame, and a third flexible bimorph beam connecting a platform to the second frame. Activation of the first, second, and third flexible bimorph beams allows vertical displacement of the platform with respect to the substrate, with negligible lateral shift. A microactuator assembly includes a substrate, a plurality of first rigid frames, a plurality of first flexible bimorph beams, a plurality of second rigid frames, a plurality of second flexible bimorph beams, a platform, and a plurality of third flexible bimorph beams. Activation of the first, second, and third bimorph beams allows vertical displacement of the platform with respect to the substrate, with negligible lateral shift. A further embodiment with four identical such microactuators oriented at four sides of the platform, can achieve 1D or 2D angular scanning of the mirror plate by the activation of 1 or 2 adjacent microactuators.
摘要:
A transmitter including an analog front end configured to receive a serial signal; a control circuit configured to generate a first gain signal and a second gain signal based on a characteristic of a serial channel; a first amplifier is configured to amplify the serial signal to generate a first amplified signal based on the first gain signal; a first delay device configured to delay the serial signal to generate a first delayed signal; a second amplifier configured to amplify the first delayed signal to generate a second amplified signal based on the second gain signal; and at least one summer is configured to sum the first amplified signal and the second amplified signal to generate an output signal. The output signal is transmitted on the serial channel.
摘要:
The present invention relates to prepaid services in the communication field. A method for charging a prepaid account includes: delivering the available traffic to the NAS based on the available balance of an account shared by the user and other users in response to a successful authentication of a user's access request; and delivering the available traffic to the NAS based on the available balance of the account shared by the user and other users in response to a receipt of an Accounting-Request-Interim message from the NAS. The solution provided by the invention may deliver the available traffic to a user every accounting period so that an account can be used by multiple users concurrently, whereas overdraft does not occur. The present invention also provides a system and an AAA server for charging a prepaid account.