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    Apparatus and method for high throughput electrorotation analysis
    2.
    发明授权
    Apparatus and method for high throughput electrorotation analysis 有权
    用于高通量电磁分析的装置和方法

    公开(公告)号：US06448794B1

    公开(公告)日：2002-09-10

    申请号：US09643362

    申请日：2000-08-22

    申请人： Jing Cheng ,  Junquan Xu ,  Xiaoshan Zhu ,  Litian Liu ,  Xiao-Bo Wang ,  Lei Wu

    发明人： Jing Cheng ,  Junquan Xu ,  Xiaoshan Zhu ,  Litian Liu ,  Xiao-Bo Wang ,  Lei Wu

    IPC分类号： G01R2708

    CPC分类号： G01N33/48707 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/0072 ,  Y10S436/806

    摘要： The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles. The high throughput electrorotation chip and chamber may be used for cell-based screening for leading drug candidate molecules from a compound library, for high-throughput characterizing particle electric properties, and for high-throughput assaying molecular compositions of unknown solutions.

    摘要翻译： 本发明涉及一种具有电极单元阵列的高通量电选机芯及其使用方法。 为了制造高通量电选芯片，在基板或支撑件上制造多个电极单元（EU），并且每个EU在施加适当的电信号时能够产生旋转电场。 示例性实施例包括具有通过两个导电层实现的四个电极元件的EU行的列列配置。 电极元件可以是线性的，凹的或凸的。 具有一个或多个孔的薄板结合到高通量电旋转切片以形成具有一个或多个孔的测定室。 可以将颗粒引入孔中，并且可以对颗粒进行电转化测量。 高通量电刺激芯片和腔室可用于来自化合物文库的主要药物候选分子的基于细胞的筛选，用于高通量表征颗粒电性质，以及用于高通量测定未知溶液的分子组成。

    Apparatus for switching and manipulating particles and method of use thereof
    3.
    发明授权
    Apparatus for switching and manipulating particles and method of use thereof 有权
    用于切换和操纵颗粒的装置及其使用方法

    公开(公告)号：US06596143B1

    公开(公告)日：2003-07-22

    申请号：US09678263

    申请日：2000-10-03

    申请人： Xiao-Bo Wang ,  Weiping Yang ,  Junquan Xu ,  Jing Cheng ,  Lei Wu

    发明人： Xiao-Bo Wang ,  Weiping Yang ,  Junquan Xu ,  Jing Cheng ,  Lei Wu

    IPC分类号： G01N2726

    CPC分类号： H02N11/006 ,  B01D57/02 ,  B03C5/028 ,  H02N1/004

    摘要： A device acts as a particle switch to transport and/or re-direct microparticles which are in a fluid suspension. The switch comprises at least three structural branches and the branches may be connected at a common junction. Particles can be transported along the branches as a result of the forces generated along that branch. Particles are transported into or out of the particle switch via the ends of the branches. Particles can be switched from one branch into one of the other branches. Depending on the properties of the particles, the transportation mechanism may be traveling-wave-dielectrophoresis or traveling-wave-electrophoresis.

    摘要翻译： 装置用作颗粒开关以运输和/或重新引导处于流体悬浮液中的微粒。 开关包括至少三个结构分支，并且分支可以在公共接头处连接。 由于沿该分支产生的力，颗粒可以沿着分支运输。 颗粒通过分支的末端被输送进出颗粒开关。 颗粒可以从一个分支切换到其他分支之一。 根据颗粒的性质，运输机制可以是行波介电电泳或行波电泳。