公开(公告)号：US20130071319A1

公开(公告)日：2013-03-21

申请号：US13646880

申请日：2012-10-08

Applicant: Searete LLC

Inventor： Edward S. Boyden ,  Daniel B. Cook ,  Roderick A. Hyde ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

IPC: A61K9/14 ,  A61K51/12 ,  A61K33/00

CPC classification number: A61K9/14 ,  A61K9/0021 ,  A61K9/08 ,  A61K9/1611 ,  A61K9/1641 ,  A61K9/1664 ,  A61K9/1688 ,  A61K9/19 ,  A61K31/00 ,  A61K31/10 ,  A61K31/337 ,  A61K31/70 ,  A61K31/7088 ,  A61K33/00 ,  A61K39/00 ,  A61K41/0004 ,  A61K45/06 ,  A61K49/1818 ,  A61K51/12 ,  A61K51/1244 ,  A61K2300/00

Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Abstract translation: 本文公开的某些实施方案涉及关于冷冻颗粒的组合物，方法，装置，系统和产品。 在某些实施方案中，冷冻颗粒包括低温下的材料。 在某些实施方案中，冷冻颗粒提供用于递送特定试剂的载体。 在某些实施方案中，将冷冻颗粒施用于至少一种生物组织。

公开(公告)号：US20130041253A1

公开(公告)日：2013-02-14

申请号：US13648752

申请日：2012-10-10

Applicant: SEARETE LLC

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Michael A. Smith ,  Leif T. Stordal ,  Lowell L. Wood, Jr. ,  Victoria Y.H. Wood

IPC: A61B6/12

CPC classification number: A61M5/3287 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150106 ,  A61B5/150167 ,  A61B5/150229 ,  A61B5/150748 ,  A61B5/15087 ,  A61B5/15109 ,  A61B5/15117 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/153 ,  A61B6/00 ,  A61B10/0283 ,  A61B17/3403 ,  A61B34/30 ,  A61B90/11 ,  A61B90/361 ,  A61B2017/00199 ,  A61B2017/00398 ,  A61B2017/00402 ,  A61B2017/00539 ,  A61B2017/00544 ,  A61B2017/3409 ,  A61B2090/376 ,  A61B2090/378 ,  A61M5/427 ,  A61M2005/14252 ,  A61M2005/1585 ,  A61M2205/59

Abstract: Embodiments disclosed herein are directed to systems and methods for automatically inserting a needle into an insertion-target region of a living subject in response to a machine-vision system locating the insertion-target region. In an embodiment, a needle insertion system includes a moveable needle configured to be inserted into a living subject, a machine-vision system configured to locate an insertion-target region of the living subject, control electrical circuitry, and an actuator coupled to the control electrical circuitry. The control electrical circuitry may be coupled to the machine-vision system to receive location information therefrom about the insertion-target region, and configured to output needle targeting instructions. The actuator may be coupled to the control electrical circuitry to receive the needle targeting instructions therefrom and coupled to the moveable needle. The actuator may be configured to move the moveable needle to the insertion-target region automatically in response to receiving the needle targeting instructions from the control electrical circuitry.

Abstract translation: 本文公开的实施例涉及用于响应于定位插入目标区域的机器视觉系统而自动将针插入活体的插入目标区域的系统和方法。 在一个实施例中，针插入系统包括构造成插入生物体的可移动针，被配置为定位活体的插入目标区域，控制电路和耦合到控制器的致动器的机器视觉系统 电路。 控制电路可以耦合到机器视觉系统以从其接收关于插入目标区域的位置信息，并且被配置为输出针瞄准指令。 致动器可以联接到控制电路以从其接收针头指令并且联接到可移动的针。 致动器可以被配置为响应于接收到来自控制电路的针瞄准指令而自动地将可移动针移动到插入目标区域。

公开(公告)号：US20130034288A1

公开(公告)日：2013-02-07

申请号：US13645359

申请日：2012-10-04

Applicant: SEARETE LLC

Inventor： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Michael A. Smith ,  Clarence T. Tegreene ,  Thomas A. Weaver ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Victoria Y.H. Wood

IPC: G06K9/40

CPC classification number: G06T5/006 ,  G06T2207/30012

Abstract: Certain aspects can relate to responsive to the at least some input compensating information, imaging the at least the portion of the individual in a manner to limit at least some distorting effects of the at least the portion of the at least one distorting feature associated with the at least the portion of the individual at least partially by modifying a non-optical electromagnetic output from an imaging modality as applied to the at least the portion of the at least one distorting feature associated with the at least the portion of the individual. Certain aspects can relate to creating at least one conformal absence of a non-optical electromagnetic output to limit distortion to an imaging of an at least a portion of an individual resulting at least partially from at least one distorting feature associated with the at least the portion of the individual.

Abstract translation: 某些方面可以涉及响应于至少一些输入补偿信息，以至少限制与至少一个失真特征相关联的至少一个失真特征的至少一部分的至少一些失真效应的方式成像该个体的至少一部分 所述个体的至少一部分至少部分地通过当应用于与所述个体的至少一部分相关联的所述至少一个失真特征的所述至少一部分时，从成像模态修改非光学电磁输出。 某些方面可以涉及产生非光学电磁输出的至少一个共形缺失，以将失真限制到个体的至少一部分的成像，至少部分地由至少一个与至少部分相关联的变形特征 的个人。

公开(公告)号：US09649425B2

公开(公告)日：2017-05-16

申请号：US14291435

申请日：2014-05-30

Applicant: Searete LLC

Inventor： Roderick A. Hyde ,  Lowell L. Wood, Jr.

IPC: G01N33/50 ,  A61M1/36 ,  B82Y20/00 ,  C12Q3/00

CPC classification number: A61M1/3689 ,  A61B17/435 ,  B82Y20/00 ,  C12Q3/00 ,  G01N33/505 ,  G01N33/5091 ,  Y10T436/115831

Abstract: Devices, systems, or methods are disclosed herein for treatment of disease in a vertebrate subject. The device can include a quasi-planar substrate; and one or more laterally-mobile effector molecule types at least partially embedded within the quasi-planar substrate, wherein the one or more laterally-mobile effector molecule types is configured to interact with one or more cell types. The device can further include one or more sensors configured to detect at least one aspect of an interaction between the at least one of the one or more laterally-mobile effector molecule types and the one or more cell types; and a controller in communication with the one or more sensors, wherein the controller is configured to responsively initiate modification of at least one of the one or more laterally-mobile effector molecule types, the quasi-planar substrate, and the one or more cell types.

公开(公告)号：US09358374B2

公开(公告)日：2016-06-07

申请号：US14683198

申请日：2015-04-10

Applicant: Searete LLC

Inventor： Ralph G. Dacey, Jr. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood ,  Gregory J. Zipfel

IPC: A61N1/18 ,  A61M35/00 ,  A61B5/11 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61N1/04 ,  A61N7/00 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/145 ,  A61F7/00 ,  A61M5/168 ,  A61M37/00 ,  A61N1/30 ,  A61N1/32 ,  A61N1/36 ,  A61N1/372 ,  A61N2/00

CPC classification number: A61M5/14276 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/1118 ,  A61B5/14539 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/411 ,  A61B5/441 ,  A61B5/4821 ,  A61B5/4839 ,  A61F7/00 ,  A61F7/0085 ,  A61F2007/0075 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/16827 ,  A61M5/1723 ,  A61M35/00 ,  A61M37/00 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2037/0007 ,  A61M2205/0244 ,  A61M2210/1003 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/303 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/37252 ,  A61N2/002 ,  A61N2/006 ,  A61N7/00 ,  A61N2007/0026

Abstract: Methods and related systems for modulating neural activity by cyclical blocking of conduction in peripheral neural structures are disclosed. Neural activity may blocked cyclically by blocking stimuli delivered via various types of blocking stimulus sources. In an aspect, a conduction block is produced in a sensory nerve. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of blocking stimuli may be controlled in part in response to an input from a user input device.

Abstract translation: 公开了通过循环阻断外周神经结构传导来调节神经活动的方法和相关系统。 通过阻断通过各种类型的阻断刺激源递送的刺激，神经活动可能会周期性阻断。 在一方面，在感觉神经中产生传导阻滞。 例如，可以使用神经调节来调节不期望的感觉，例如疼痛，或免疫或炎症反应或过程。 可以部分地响应于来自用户输入设备的输入来控制传递阻塞刺激。

公开(公告)号：US09337659B2

公开(公告)日：2016-05-10

申请号：US13710158

申请日：2012-12-10

Applicant: SEARETE LLC

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC: A61N1/37 ,  H02J4/00 ,  A61N1/378 ,  A61N1/372 ,  H02J17/00 ,  H04B10/114 ,  H04B13/00

CPC classification number: H02J4/00 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/3785 ,  H02J17/00 ,  H02J50/30 ,  H02J50/40 ,  H02J50/90 ,  H04B10/1141 ,  H04B13/005

Abstract: In an embodiment, a system includes an internal optical power transmitter configured to be disposed within a living subject. The internal optical power transmitter includes a power source configured to provide electrical energy and an electrical-optical converter operably coupled to the power source. The electrical-optical converter may be configured to convert at least a portion of the electrical energy into one or more optical power signals transdermally transmittable out of the living subject. The system further includes an external optical-electrical converter configured to convert the one or more optical power signals into one or more electrical power signals and at least one external device configured to be operably coupled to the external optical-electrical converter and powered by the one or more electrical power signals. Embodiments of methods, biocompatible electrical-optical converters, and internal optical power transmitters are also disclosed.

公开(公告)号：US09305669B2

公开(公告)日：2016-04-05

申请号：US14251894

申请日：2014-04-14

Applicant: Searete LLC

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Nathan P. Myhrvold ,  Lowell L. Wood, Jr.

IPC: G21C15/243 ,  G21C15/247 ,  G21C15/00 ,  G21C1/02 ,  G21C7/02 ,  G21C7/06 ,  G21C15/04 ,  G21D3/00 ,  G21C15/28

CPC classification number: G21C15/243 ,  G21C1/026 ,  G21C7/02 ,  G21C7/06 ,  G21C15/00 ,  G21C15/04 ,  G21C15/247 ,  G21C15/28 ,  G21D3/00 ,  Y02E30/34 ,  Y02E30/39

Abstract: Exemplary embodiments provide automated nuclear fission reactors and methods for their operation. Exemplary embodiments and aspects include, without limitation, re-use of nuclear fission fuel, alternate fuels and fuel geometries, modular fuel cores, fast fluid cooling, variable burn-up, programmable nuclear thermostats, fast flux irradiation, temperature-driven surface area/volume ratio neutron absorption, low coolant temperature cores, refueling, and the like.

Abstract translation: 示例性实施例提供了自动化核裂变反应器及其操作方法。 示例性实施例和方面包括但不限于重新使用核裂变燃料，替代燃料和燃料几何形状，模块化燃料芯，快速流体冷却，可变燃烧，可编程核恒温器，快速通量照射，温度驱动表面积/ 体积比中子吸收，低冷却剂温度核心，加油等。

公开(公告)号：US20160074583A1

公开(公告)日：2016-03-17

申请号：US14853726

申请日：2015-09-14

Applicant: Searete LLC

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Eric C. Leuthardt ,  Royce A. Levien ,  Robert W. Lord ,  Mark A. Malamud ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

IPC: A61M5/172 ,  G06F19/00 ,  A61M21/02

CPC classification number: A61M5/1723 ,  A61M21/02 ,  A61M2021/005 ,  G06F19/3456 ,  G06F19/3481 ,  G16H50/50

Abstract: Methods, computer program products, and systems are described that include accepting an indication of a schedule for administration of a bioactive agent to an individual and presenting an indication of an artificial sensory experience at least partly based on the accepting an indication of the schedule for administration of the bioactive agent to the individual.

Abstract translation: 描述了方法，计算机程序产品和系统，其包括接受用于向个体施用生物活性剂的时间表的指示，并至少部分地基于接受管理时间表的指示来呈现人造感官体验的指示 的生物活性剂给个体。

公开(公告)号：US09164167B2

公开(公告)日：2015-10-20

申请号：US14656440

申请日：2015-03-12

Applicant: SEARETE LLC

Inventor： Roderick A. Hyde ,  Jordin T. Kare ,  Lowell L. Wood, Jr.

IPC: G01S13/02 ,  G01S13/04 ,  G01S13/52 ,  A61B5/00 ,  A61B5/024 ,  A61B5/05 ,  G01S13/89 ,  G01S7/41 ,  G01S13/50 ,  G01S13/86

CPC classification number: G01S13/0209 ,  G01S7/003 ,  G01S7/412 ,  G01S13/50 ,  G01S13/56 ,  G01S13/867 ,  G01S13/887 ,  G01S13/89

Abstract: A personal electronic device such as a smart phone can include a micro-impulse radar (MIR).

公开(公告)号：US09162057B2

公开(公告)日：2015-10-20

申请号：US13627391

申请日：2012-09-26

Applicant: Searete LLC

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC: A61N1/378 ,  A61N1/08 ,  A61N1/372

CPC classification number: A61N1/08 ,  A61N1/37211 ,  A61N1/37217 ,  A61N1/3787 ,  H02J50/30

Abstract: Embodiments disclosed herein are directed to systems configured to power at least one device disposed in a living subject, apparatuses configured to be disposed in a living subject and export power stored in an energy-storage device, and related methods of powering at least one device disposed in the living subject.

Abstract translation: 本文公开的实施例涉及被配置为对设置在活体中的至少一个装置供电的系统，被配置为设置在活体中的装置和存储在能量存储装置中的输出电力的系统以及为至少一个设置的装置供电的相关方法 在生活中。