公开(公告)号：US4968715A

公开(公告)日：1990-11-06

申请号：US343865

申请日：1989-04-26

Applicant: Thomas J. Dougherty ,  Ravindra K. Pandey

Inventor： Thomas J. Dougherty ,  Ravindra K. Pandey

IPC: C07D487/22 ,  A61K31/40 ,  A61K39/44 ,  A61K41/00 ,  A61P35/00 ,  C07D519/00

CPC classification number: C07D519/00 ,  A61K31/40 ,  A61K41/0071

Abstract: Pure dimer and trimer compounds of hematoporphyrin are prepared and shown to be effective agents in photodynamic therapy. The compounds of the invention are of the formula ##STR1## wherein each X is independently 1-hydroxyethyl or vinyl and wherein R is H or lower alkyl. The compounds of the invention can be conjugated to targeting substances such as immunoglobulins or to labels.

Abstract translation: 制备血卟啉的纯二聚体和三聚体化合物，并显示为光动力学治疗中的有效试剂。 本发明的化合物具有下式：其中每个X独立地为1-（4-羟基苯基） 羟乙基或乙烯基，其中R为H或低级烷基。 本发明的化合物可以与靶向物质例如免疫球蛋白缀合，或与标记缀合。

公开(公告)号：USD311373S

公开(公告)日：1990-10-16

申请号：US87756

申请日：1987-08-21

Applicant: Jeffrey A. Morisse ,  Gregg A. Herde ,  David W. Saari ,  Edward N. Mrotek ,  Thomas J. Dougherty

Designer： Jeffrey A. Morisse ,  Gregg A. Herde ,  David W. Saari ,  Edward N. Mrotek ,  Thomas J. Dougherty

公开(公告)号：US4649151A

公开(公告)日：1987-03-10

申请号：US609991

申请日：1984-05-14

Applicant: Thomas J. Dougherty ,  William R. Potter ,  Kenneth R. Weishaupt

Inventor： Thomas J. Dougherty ,  William R. Potter ,  Kenneth R. Weishaupt

IPC: A61B5/00 ,  A61K31/40 ,  A61K41/00 ,  A61K49/00 ,  A61K51/00 ,  A61N5/06 ,  A61P35/00 ,  A61P43/00 ,  C07D487/22 ,  C07D519/00 ,  C09B47/00 ,  G02B6/04 ,  G02B6/26 ,  G02B6/42

CPC classification number: A61K31/40 ,  A61B5/411 ,  A61B5/416 ,  A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  C07D519/00 ,  G02B6/262 ,  G02B6/4204 ,  A61B5/0071 ,  A61B5/0084 ,  G02B6/4298 ,  Y10S607/901

Abstract: To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.5 kilocalories per mole; (2) are soluble in water, forming an aggregate of over 10,000 molecular weight in water and have an affinity for each other compared to serum protein such that 10 to 100 percent remain self aggregated in serum protein; and (3) are lipophyllic and able to disaggregate and attach to cell plasma, nuclear membrane, mitochondria, lysosomes and tissue. The drug obtained by the first method has an empirical formula of approximately C.sub.68 H.sub.70 N.sub.8 O.sub.11 or C.sub.68 H.sub.66 N.sub.8 O.sub.11 Na.sub.4.

Abstract translation: 为了获得肿瘤选择性的光敏药物，可用于肿瘤组织的定位和治疗异常肿瘤组织如肿瘤，使用两种方法之一。 在第一种方法中，血卟啉与乙酸和硫酸的反应产物的水解混合物循环通过微孔膜系统以排除低分子量产物。 在第二种方法中，合成或衍生自其他吡咯化合物的药物。 药物：（1）包括两个共价结合的基团，每个具有四个环，其中一些是吡咯，例如卟啉，卟啉，二氢卟酚，取代的吡咯，取代的二氢卟酚或取代的藜芦烯，每个组排列成环结构，共价连接 到另一组，并具有高于每摩尔37.5千卡的三线态能量状态; （2）可溶于水，与血清蛋白质相比，在水中形成了超过10,000分子量的聚集体，并且与血清蛋白质具有亲和力，使得10％至100％在血清蛋白中保持自我聚集; 和（3）是脂蛋白的并且能够解聚并附着于细胞血浆，核膜，线粒体，溶酶体和组织。 通过第一种方法获得的药物具有约C68H70N8O11或C68H66N8O11Na4的经验式。

公开(公告)号：US09172067B2

公开(公告)日：2015-10-27

申请号：US12497502

申请日：2009-07-02

Applicant: Thomas J. Dougherty ,  Steven J. Wood ,  John P. Dinkelman ,  Dale B. Trester ,  Gerald K. Bowen ,  Gary P. Houchin-Miller

Inventor： Thomas J. Dougherty ,  Steven J. Wood ,  John P. Dinkelman ,  Dale B. Trester ,  Gerald K. Bowen ,  Gary P. Houchin-Miller

IPC: H01M2/02 ,  H01M2/04

CPC classification number: H01M2/021 ,  H01M2/0404 ,  H01M2/0426 ,  Y10T29/49108

Abstract: An electrochemical cell includes a can having a first end and a second end and a first element provided within the can and including an electrode. The cell also includes a first terminal integrally formed as a part of the can and extending from one of the first or second ends. The cell further includes a terminal assembly directly coupled to the first element and including a stud configured to act as a second terminal. The first end includes a boss that defines an aperture through which the stud extends, wherein the boss at least partially surrounds the stud and a bushing coupled to the stud.

Abstract translation: 电化学电池包括具有第一端和第二端的罐和设置在罐内并包括电极的第一元件。 电池还包括一体地形成为罐的一部分并从第一或第二端中的一个延伸的第一端子。 电池还包括直接耦合到第一元件的端子组件，并且包括构造成用作第二端子的螺柱。 第一端包括限定了螺柱延伸穿过的孔的凸台，其中凸台至少部分地围绕螺栓和连接到螺栓的衬套。

公开(公告)号：US08969756B2

公开(公告)日：2015-03-03

申请号：US12637578

申请日：2009-12-14

Applicant: Thomas J. Dougherty

Inventor： Thomas J. Dougherty

IPC: B23K26/00 ,  B23K26/14 ,  B23K26/02 ,  B23K26/12

CPC classification number: B23K26/142 ,  B23K26/037 ,  B23K26/123 ,  B23K2103/10 ,  B23K2103/12

Abstract: A workpiece cutting apparatus includes a laser source, a first suction system, and a first finger configured to guide a workpiece as it moves past the laser source. The first finger includes a first end provided adjacent a point where a laser from the laser source cuts the workpiece, and the first end of the first finger includes an aperture in fluid communication with the first suction system.

Abstract translation: 工件切割装置包括激光源，第一抽吸系统和第一指状物，其构造成当工件移动经过激光源时引导工件。 第一指状物包括邻近激光源的激光切割工件的点附近提供的第一端，并且第一指状物的第一端包括与第一吸入系统流体连通的孔。

公开(公告)号：US08426059B2

公开(公告)日：2013-04-23

申请号：US13080532

申请日：2011-04-05

Applicant: Jason Fuhr ,  Gary Houchin-Miller ,  Thomas J. Dougherty

Inventor： Jason Fuhr ,  Gary Houchin-Miller ,  Thomas J. Dougherty

IPC: H01M2/02 ,  H01M4/00

CPC classification number: H01M2/0272 ,  H01M2/0225 ,  H01M2/0275 ,  H01M2/0295 ,  H01M10/0431 ,  Y10T29/49115

Abstract: An electrochemical cell including a housing configured to receive a cell element. The housing has an electrically-insulating material including metal oxide particles provided on at least a portion of an inner surface thereof to prevent electrical contact between the housing and the cell element. A method of manufacturing an electrochemical cell including applying an electrically-insulating material including metal oxide particles to an inner surface of a housing for an electrochemical cell and inserting a cell element into the housing.

Abstract translation: 一种电化学电池，包括构造成容纳电池元件的壳体。 壳体具有电绝缘材料，其包括设置在其内表面的至少一部分上的金属氧化物颗粒，以防止壳体和电池元件之间的电接触。 一种制造电化学电池的方法，包括将包含金属氧化物颗粒的电绝缘材料施加到用于电化学电池的壳体的内表面并将电池元件插入壳体中。

公开(公告)号：US20130096762A1

公开(公告)日：2013-04-18

申请号：US13806075

申请日：2011-06-21

Applicant: Gary P. Houchin-Miller ,  Craig W. Rigby ,  Thomas J. Dougherty ,  James S. Symanski

Inventor： Gary P. Houchin-Miller ,  Craig W. Rigby ,  Thomas J. Dougherty ,  James S. Symanski

IPC: B60L11/18

CPC classification number: B60L11/1864 ,  B60L11/1879 ,  H02J7/0013 ,  Y02T10/7005 ,  Y02T10/7055 ,  Y02T10/7061 ,  Y10S903/903

Abstract: A battery system includes a plurality of battery modules electrically coupled together in series. The battery system also includes a first electronic control unit (ECU) configured to act as a master ECU. The master ECU is electronically coupled to a first one of the plurality of battery modules. The battery system further includes a plurality of slave ECUs, wherein each slave ECU is electronically coupled to one of the other of the plurality of battery modules. The master ECU is configured to control whether electrical power is provided to each of the plurality of slave ECUs.

Abstract translation: 电池系统包括串联电耦合在一起的多个电池模块。 电池系统还包括被配置为充当主ECU的第一电子控制单元（ECU）。 主ECU电耦合到多个电池模块中的第一个。 电池系统还包括多个从属ECU，其中每个从属ECU电耦合到多个电池模块中的另一个电池模块中的一个。 主ECU被配置为控制是否向多个从ECU中的每一个提供电力。

公开(公告)号：US20120164508A1

公开(公告)日：2012-06-28

申请号：US13339141

申请日：2011-12-28

Applicant: Gary P. Houchin-Miller ,  Steven J. Wood ,  Thomas J. Dougherty

Inventor： Gary P. Houchin-Miller ,  Steven J. Wood ,  Thomas J. Dougherty

IPC: H01M10/50

CPC classification number: B60K6/442 ,  B60K2001/005 ,  B60W2510/246 ,  H01M2/1077 ,  H01M10/613 ,  H01M10/617 ,  H01M10/625 ,  H01M10/633 ,  H01M10/651 ,  H01M10/6563 ,  H01M2010/4271 ,  Y02T10/6234

Abstract: A battery system for use in a vehicle is configured to provide at least a portion of the propulsion power for the vehicle and includes a plurality of battery modules. Each battery module includes a plurality of electrochemical cells configured to store an electrical charge. The battery system also includes a plurality of fan assemblies each having a motor and at least one fan blade. Each fan assembly is associated with one of the plurality of battery modules to regulate the temperature thereof. A first fan assembly of the plurality of fan assemblies has a different configuration than at least one of the other of the plurality of fan assemblies or is configured to provide an output that is different from an output provided by at least one of the other of the plurality of fan assemblies.

Abstract translation: 用于车辆的电池系统被配置为提供用于车辆的推进动力的至少一部分，并且包括多个电池模块。 每个电池模块包括被配置为存储电荷的多个电化学电池。 电池系统还包括多个风扇组件，每个风扇组件具有电动机和至少一个风扇叶片。 每个风扇组件与多个电池模块中的一个相关联以调节其温度。 多个风扇组件的第一风扇组件具有与多个风扇组件中的另一风扇组件中的至少一个不同的构造，或者被配置为提供与由另一个风扇组件中的至少一个 多个风扇组件。

公开(公告)号：USRE43274E1

公开(公告)日：2012-03-27

申请号：US12321729

申请日：2009-01-23

Applicant: Ravindra K. Pandey ,  William R. Potter ,  Thomas J. Dougherty

Inventor： Ravindra K. Pandey ,  William R. Potter ,  Thomas J. Dougherty

IPC: C09B47/04

CPC classification number: C07D471/22 ,  A61K41/0071 ,  A61K41/0076 ,  C09B47/00 ,  C09B69/108

Abstract: Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferative tissue are provided. In another embodiment, compounds that absorb light at a wavelength of from about 700 to about 850 nm are provided. In a further embodiment, compounds that are detectable by magnetic resonance imaging are provided.

Abstract translation: 本文提供了使用光动力学方法检测，诊断和治疗靶组织或靶组合物的化合物，包括过度增殖组织如肿瘤。 特别地，提供了在过度增殖组织中收集的光敏剂化合物。 在另一个实施方案中，提供了吸收波长为约700至约850nm的光的化合物。 在另一个实施方案中，提供了可通过磁共振成像检测的化合物。

公开(公告)号：US20110244330A1

公开(公告)日：2011-10-06

申请号：US13086300

申请日：2011-04-13

Applicant: Jeffrey L. Swoyer ,  Thomas J. Dougherty

Inventor： Jeffrey L. Swoyer ,  Thomas J. Dougherty

IPC: H01M4/50 ,  H01M4/70 ,  H01M4/505 ,  H01M4/52 ,  H01M4/13915 ,  F27D21/00

CPC classification number: H01M4/13 ,  H01M4/485 ,  H01M4/525 ,  H01M4/5825 ,  H01M4/622 ,  H01M4/625 ,  Y10T29/49108 ,  Y10T29/49115

Abstract: An electrode for an electrochemical cell including a polymer substrate, a conductive material in contact with the polymer substrate, a conductive ink in contact with the conductive material, and an active electrode material in contact with the conductive ink. The conductive ink is configured to enhance the adhesion between the conductive material and the active electrode material.

Abstract translation: 一种用于电化学电池的电极，包括聚合物基底，与聚合物基底接触的导电材料，与导电材料接触的导电油墨，以及与导电油墨接触的活性电极材料。 导电油墨被配置为增强导电材料和活性电极材料之间的粘合性。