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    INSTRUMENT AND METHODS FOR FILLING AN IMPLANTED DRUG PUMP
    71.
    发明申请
    INSTRUMENT AND METHODS FOR FILLING AN IMPLANTED DRUG PUMP 审中-公开
    用于填充植入式药液泵的仪器和方法

    公开(公告)号：US20120234433A1

    公开(公告)日：2012-09-20

    申请号：US13419968

    申请日：2012-03-14

    申请人： Jason Shih ,  Sean Caffey ,  Mark Humayun ,  Fukang Jiang ,  Changlin Pang ,  Raymond Peck ,  Yu-Chong Tai

    发明人： Jason Shih ,  Sean Caffey ,  Mark Humayun ,  Fukang Jiang ,  Changlin Pang ,  Raymond Peck ,  Yu-Chong Tai

    IPC分类号： B65B31/00

    CPC分类号： A61M5/14276

    摘要： A tool for refilling an implantable pump having at least one reservoir. The tool includes a plurality of independent fluid channels; a fluid reservoir in fluid communication with a first one of the fluid channels; at least one pump fluidly coupled to the fluid channels, the at least one pump and the independent fluid channels differing from each other in number, wherein (i) a pump is configured to apply positive pressure to the first fluid channel so as to drive fluid from the fluid reservoir therethrough, and (ii) a pump is configured to apply negative pressure to the second fluid channel; and a connector for removably connecting the fluid channels to the at least one reservoir.

    摘要翻译： 一种用于重新填充具有至少一个储存器的可植入泵的工具。 该工具包括多个独立的流体通道; 流体储存器，其与所述流体通道中的第一流体流体连通; 流体地联接到流体通道的至少一个泵，所述至少一个泵和独立流体通道在数量上彼此不同，其中（i）泵构造成对第一流体通道施加正压以驱动流体 并且（ii）泵构造成对第二流体通道施加负压; 以及用于将所述流体通道可移除地连接到所述至少一个储存器的连接器。

    Method for integrating micro and nanoparticles into MEMS and apparatus including the same
    74.
    发明授权
    Method for integrating micro and nanoparticles into MEMS and apparatus including the same 有权
    将微纳米颗粒与微纳米颗粒整合到MEMS中的方法及包括其的设备

    公开(公告)号：US07994592B2

    公开(公告)日：2011-08-09

    申请号：US11182906

    申请日：2005-07-18

    申请人： Yu-Chong Tai ,  Qing He

    发明人： Yu-Chong Tai ,  Qing He

    IPC分类号： H01L27/14

    CPC分类号： B81C1/00333 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0896 ,  B81C1/00182 ,  B81C1/00476 ,  B81C2201/0108 ,  B82Y30/00 ,  G01N30/6095 ,  G01N2030/562 ,  G01N2030/6056

    摘要： MEMs devices are integrally fabricated with included micro or nanoparticles by providing a mixture of a sacrificial material and a multiplicity of particles, disposing the mixture onto a substrate, fabricating a MEMs structure on the substrate including at least part of the mixture, so that at least some of the mixture is enclosed in the MEMs structure, removing the sacrificial material, and leaving at least some of the multiplicity of particles substantially free and enclosed in the MEMs structure. The step of fabricating a MEMs structure is quite general and is contemplated as including one or a multiplicity of additional steps for creating some type of structure in which the particles, which may be microbeads or nanobeads, are included. A wide variety of useful applications for MEMs integrated with micro or nanoparticles are available.

    摘要翻译： 通过提供牺牲材料和多个颗粒的混合物将MEM装置与包含的微型或纳米颗粒整体制造，将混合物设置在衬底上，在包括至少部分混合物的衬底上制造MEM结构，使得至少 一些混合物被包封在MEMs结构中，去除牺牲材料，并且使至少一些多个颗粒基本上自由并且封闭在MEM结构中。 制造MEMs结构的步骤是相当普遍的，并且被设想为包括用于产生某些类型的结构的一个或多个附加步骤，其中可以包括可以是微珠或纳米珠的颗粒。 可以使用与微型或纳米颗粒集成的MEM的各种有用的应用。

    Integrated LC-ESI on a chip
    75.
    发明授权
    Integrated LC-ESI on a chip 有权
    集成LC-ESI芯片

    公开(公告)号：US07976779B2

    公开(公告)日：2011-07-12

    申请号：US11177505

    申请日：2005-07-11

    申请人： Yu-Chong Tai ,  Jun Xie ,  Jason Shih ,  Terry Lee ,  Yunan Miao

    发明人： Yu-Chong Tai ,  Jun Xie ,  Jason Shih ,  Terry Lee ,  Yunan Miao

    IPC分类号： B01L3/00 ,  G01N30/02 ,  F04F99/00 ,  C02F11/00 ,  C02F1/469

    CPC分类号： G01N30/34 ,  G01N30/16 ,  G01N30/6095 ,  G01N30/7266

    摘要： A microfluidic system with on-chip pumping which can be used for liquid chromatography and also electrospray ionization mass spectrometry and which provides improved efficiency, better integration with sensors, improved portability, reduced power consumption, and reduced cost. The system can include (A) a main chip comprising: a substrate having a front face and a back face; a chromatography column on the front face of said substrate, wherein said column has an inlet and an outlet; an electrospray ionization (ESI) nozzle on the front face of said substrate, wherein said nozzle has an inlet and an outlet, and wherein the inlet of the nozzle is microfluidically coupled to the outlet of the column; one or more pump systems on the front face of said substrate comprising a pump chamber, one or more electrodes, and an outlet microfluidically coupled to the inlet of said column; and (B) a reservoir chip comprising a front surface and a back surface, wherein the reservoir chip has one or more cavities in the back surface which when disposed next to the front surface of the main chip extends the volume of the pump chamber of one of the pump system. Microfabrication can be used to prepare the chips, which can be assembled with a cover and inserted into a testing jig for electronic control and mass spectral analysis. Peptide separations are demonstrated which compete with present commercial systems.

    摘要翻译： 具有片上泵浦的微流体系统，其可用于液相色谱和电喷雾离子化质谱，并且其提供更高的效率，更好地与传感器的集成，改进的便携性，降低的功率消耗和降低的成本。 该系统可以包括（A）主芯片，其包括：具有正面和背面的基板; 所述基板前表面上的色谱柱，其中所述色谱柱具有入口和出口; 在所述基板的前表面上的电喷雾离子化（ESI）喷嘴，其中所述喷嘴具有入口和出口，并且其中所述喷嘴的入口微流体耦合到所述塔的出口; 所述衬底的前表面上的一个或多个泵系统包括泵室，一个或多个电极和微流体耦合到所述塔的入口的出口; 和（B）包括前表面和后表面的储存器芯片，其中所述储存器芯片在所述后表面中具有一个或多个空腔，当所述储存器芯片靠近所述主芯片的前表面设置时，所述泵室的体积将一个 的泵系统。 可以使用微加工来制备芯片，其可以与盖组装并插入用于电子控制和质谱分析的测试夹具中。 展示了与现有商业系统竞争的肽分离。

    RESONANCE-INDUCED SENSITIVITY ENHANCEMENT METHOD FOR CONDUCTIVITY SENSORS
    78.
    发明申请
    RESONANCE-INDUCED SENSITIVITY ENHANCEMENT METHOD FOR CONDUCTIVITY SENSORS 失效
    用于电导率传感器的谐振感应灵敏度增强方法

    公开(公告)号：US20070247173A1

    公开(公告)日：2007-10-25

    申请号：US11697060

    申请日：2007-04-05

    申请人： Yu-Chong Tai ,  Chi-yuan Shih ,  Wei Li ,  Siyang Zheng

    发明人： Yu-Chong Tai ,  Chi-yuan Shih ,  Wei Li ,  Siyang Zheng

    IPC分类号： G01R27/08

    CPC分类号： G01N27/023 ,  G01N15/1056 ,  G01N15/12 ,  G01N27/4473 ,  G01N2030/645 ,  G01R27/22

    摘要： Methods and systems for improving the sensitivity of a variety of conductivity sensing devices, in particular capacitively-coupled contactless conductivity detectors. A parallel inductor is added to the conductivity sensor. The sensor with the parallel inductor is operated at a resonant frequency of the equivalent circuit model. At the resonant frequency, parasitic capacitances that are either in series or in parallel with the conductance (and possibly a series resistance) is substantially removed from the equivalent circuit, leaving a purely resistive impedance. An appreciably higher sensor sensitivity results. Experimental verification shows that sensitivity improvements of the order of 10,000-fold are possible. Examples of detecting particulates with high precision by application of the apparatus and methods of operation are described.

    摘要翻译： 用于提高各种电导率传感装置的灵敏度的方法和系统，特别是电容耦合的非接触电导检测器。 并联电感器被添加到电导率传感器。 具有并联电感器的传感器以等效电路模型的谐振频率工作。 在谐振频率下，与电导串联或并联的寄生电容（和可能的串联电阻）基本上从等效电路中去除，留下纯电阻阻抗。 传感器敏感度会更高。 实验验证表明灵敏度提高可达10,000倍。 描述了通过应用该装置和操作方法检测高精度的微粒的实例。

    Pyrolyzed-parylene based sensors and method of manufacture
    79.
    发明授权
    Pyrolyzed-parylene based sensors and method of manufacture 失效
    基于热解 - 聚对二甲苯的传感器和制造方法

    公开(公告)号：US07238941B2

    公开(公告)日：2007-07-03

    申请号：US10973938

    申请日：2004-10-25

    申请人： Yu-Chong Tai ,  Matthieu Liger ,  Scott Miserendino ,  Satoshi Konishi

    发明人： Yu-Chong Tai ,  Matthieu Liger ,  Scott Miserendino ,  Satoshi Konishi

    IPC分类号： G01J5/00

    CPC分类号： G01J5/20

    摘要： A method (and resulting structure) for fabricating a sensing device. The method includes providing a substrate comprising a surface region and forming an insulating material overlying the surface region. The method also includes forming a film of carbon based material overlying the insulating material and treating to the film of carbon based material to pyrolyzed the carbon based material to cause formation of a film of substantially carbon based material having a resistivity ranging within a predetermined range. The method also provides at least a portion of the pyrolyzed carbon based material in a sensor application and uses the portion of the pyrolyzed carbon based material in the sensing application. In a specific embodiment, the sensing application is selected from chemical, humidity, piezoelectric, radiation, mechanical strain or temperature.

    摘要翻译： 一种用于制造感测装置的方法（和结果）。 该方法包括提供包括表面区域并形成覆盖表面区域的绝缘材料的基板。 该方法还包括形成覆盖绝缘材料的碳基材料薄膜，并处理碳基材料薄膜以热解碳基材料，以形成电阻率范围在预定范围内的基本上碳基材料的薄膜。 该方法还在传感器应用中提供热解碳基材料的至少一部分，并且在感测应用中使用部分热解碳基材料。 在具体实施例中，感测应用选自化学，湿度，压电，辐射，机械应变或温度。

    Micromachined polymer beam structure method and resulting device for spring applications
    80.
    发明申请
    Micromachined polymer beam structure method and resulting device for spring applications 有权
    微加工聚合物梁结构方法和弹簧应用的结果装置

    公开(公告)号：US20070052322A1

    公开(公告)日：2007-03-08

    申请号：US11492836

    申请日：2006-07-26

    申请人： Yu-Chong Tai ,  Yuji Suzuki

    发明人： Yu-Chong Tai ,  Yuji Suzuki

    IPC分类号： H02N10/00

    CPC分类号： B81B3/0078 ,  B81B2201/0235 ,  B81B2203/033 ,  B81C1/0015 ,  B81C1/0019 ,  B81C1/00484 ,  Y10T29/49126 ,  Y10T29/49165

    摘要： An integrated composite beam structure. The structure has a substrate, which includes a surface and a thickness defined underlying the surface. The substrate is composed of a first material. A thickness of polymer based material includes a first portion, a length, and a second portion. The second is coupled to a portion of the substrate. The length is defined between the first portion and the second portion. The structure also has a spring constant (K) of less than a predetermined amount (e.g., 10 N/m, 1 N/m) characterizing the length of the polymer based beam structure. The first portion is capable of moving in a first direction characterized by the spring constant upon application of an externally applied force and is substantially fixed in a second direction, which is normal to the first direction. The second end is capable of returning to a predetermined state when the externally applied force has been removed. The second portion includes a selected geometric configuration to secure the second portion to the portion of the substrate.

    摘要翻译： 一体化复合梁结构。 该结构具有基底，其包括表面和在该表面下方限定的厚度。 基板由第一材料构成。 聚合物基材料的厚度包括第一部分，长度和第二部分。 第二个耦合到衬底的一部分。 长度限定在第一部分和第二部分之间。 该结构还具有小于基于聚合物的梁结构的长度的小于预定量（例如，10N / m，1N / m）的弹簧常数（K）。 第一部分能够在施加外部施加的力的情况下沿着特征为弹簧常数的第一方向移动，并且基本上固定在与第一方向垂直的第二方向上。 当外部施加的力被去除时，第二端能够返回到预定状态。 第二部分包括选定的几何构型，以将第二部分固定到基底的该部分。