公开(公告)号：US20150183928A1

公开(公告)日：2015-07-02

申请号：US14659791

申请日：2015-03-17

Applicant: Toray Industries, Inc.

Inventor： Hiroshi Takezaki ,  Hiroshi Kobayashi ,  Makiko Saito ,  Itaru Asano

IPC: C08G63/81

CPC classification number: C08G63/81 ,  A61K8/0241 ,  A61K8/0279 ,  A61K8/85 ,  A61K2800/412 ,  A61Q1/02 ,  A61Q1/10 ,  C08G63/08 ,  C08J3/14 ,  C08J9/26 ,  C08J9/28 ,  C08J2367/04 ,  G03G9/0802 ,  G03G9/0804 ,  G03G9/0821 ,  G03G9/08722 ,  G03G9/08762 ,  G03G9/08775 ,  Y10T428/2982

Abstract: A process of producing polylactic acid-based resin microparticles includes a dissolving step that forms a system, which can cause phase separation into two phases of a solution phase mainly composed of polylactic acid-based resin (A) having an enthalpy of fusion of less than 5 J/g and a solution phase mainly composed of polymer (B) different from polylactic acid-based resin, by dissolving the polylactic acid-based resin (A) and the polymer (B) different from polylactic acid-based resin in an ether-based organic solvent (C); an emulsion-forming step that forms an emulsion by applying a shear force to the system; and a microparticle-forming step that precipitates polylactic acid-based resin microparticles by contacting the emulsion with a poor solvent which has lower solubility of the polylactic acid-based resin (A) than the ether-based organic solvent (C).

Abstract translation: 制造聚乳酸类树脂微粒的方法包括形成系统的溶解步骤，其能够相分离成主相由熔融焓小于等于的聚乳酸类树脂（A）构成的溶液相的两相 5J / g和主要由不同于聚乳酸类树脂的聚合物（B）组成的溶液相，通过将不同于聚乳酸类树脂的聚乳酸类树脂（A）和聚合物（B）溶解在醚中 的有机溶剂（C）; 通过向系统施加剪切力而形成乳液的乳液形成步骤; 以及通过使所述乳液与所述聚乳酸类树脂（A）比所述醚系有机溶剂（C）的溶解性低的不良溶剂接触来使聚乳酸类树脂微粒析出的微粒形成工序。

公开(公告)号：US09062147B2

公开(公告)日：2015-06-23

申请号：US14095647

申请日：2013-12-03

Applicant: LG CHEM, LTD.

Inventor： Jung-Min Sohn ,  Seung Young Park ,  Sung-Cheol Yoon ,  Do-Yong Shim

IPC: C08G18/42 ,  C08G18/40 ,  C08L75/06 ,  C08L75/08 ,  C08G18/48 ,  C08G18/72 ,  C08G18/79 ,  C08G63/08 ,  C08G63/664 ,  C08G63/685 ,  C08G63/91 ,  C08G63/82

CPC classification number: C08G18/428 ,  C08G18/4009 ,  C08G18/4072 ,  C08G18/4244 ,  C08G18/4252 ,  C08G18/4266 ,  C08G18/4286 ,  C08G18/4887 ,  C08G18/725 ,  C08G18/792 ,  C08G63/08 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/823 ,  C08G63/912 ,  C08L75/06 ,  C08L75/08

Abstract: The present invention relates to a lactide copolymer having good flexibility in addition to excellent properties such as mechanical properties and processability and preferably being applicable as a packaging material, a preparation method thereof, and a resin composition including the same. The lactide copolymer includes two or more specific block copolymerized repeating units that the hard segments of polylactide repeating units are connected to both ends of the soft segments of polyether polyol repeating unit, and the block copolymerized repeating units are connected to each other through the intermediation of urethane connecting groups derived from polyvalent isocyanate compound of which the average equivalent of isocyanate group per a molecule is more than 2 and less than 3.

Abstract translation: 本发明涉及具有良好的柔韧性的丙交酯共聚物，除了具有优异的性能如机械性能和加工性，并且优选适用于包装材料，其制备方法和包含其的树脂组合物。 丙交酯共聚物包括两个或更多个特定的嵌段共聚重复单元，其中聚丙交酯重复单元的硬链段连接到聚醚多元醇重复单元的软链段的两端，并且嵌段共聚重复单元通过以下方式彼此连接： 衍生自每分子的异氰酸酯基平均当量大于2且小于3的多价异氰酸酯化合物的氨基甲酸酯连接基团。

公开(公告)号：US20150166722A1

公开(公告)日：2015-06-18

申请号：US14407834

申请日：2013-06-13

Applicant: TOTAL RESERCH & TECHNOLOGY FELUY

Inventor： Jean-François Carpentier ,  Sophie Guillaume ,  William Guerin

IPC: C08G63/64 ,  C08G63/83

CPC classification number: C08G63/64 ,  C07D317/36 ,  C08G63/08 ,  C08G63/823 ,  C08G63/83 ,  C08G64/18

Abstract: A process for copolymerizing selectively i) ethylene carbonate with ii) one or more cyclic esters can include contacting the ethylene carbonate with the one or more cyclic esters in the presence of a catalyst. The catalyst can be a Zn-complex with a diaminophenolate ligand (NNO) or a β-diiminate ligand (BDI).

Abstract translation: 选择性地共聚合i）碳酸亚乙酯与ii）一种或多种环酯的方法可以包括在催化剂存在下使碳酸亚乙酯与一种或多种环状酯接触。 该催化剂可以是与二氨基苯酚酸盐配体（NNO）或二胺配体（BDI）的Zn络合物。

公开(公告)号：US09029497B2

公开(公告)日：2015-05-12

申请号：US13034119

申请日：2011-02-24

Applicant: Zhenjiang Li ,  Pingkai Ouyang ,  He Huang

Inventor： Zhenjiang Li ,  Pingkai Ouyang ,  He Huang

IPC: C08G63/08 ,  C08G63/81 ,  C08G63/82 ,  B01J31/40 ,  B01J31/04

CPC classification number: C08G63/08 ,  B01J31/04 ,  B01J31/40 ,  C08G63/81 ,  C08G63/823

Abstract: This disclosure provides a method of making polylactic acid using carbon dioxide adducts of carbenes, wherein the adducts of carbenes have a structure represented by formula (I) as follows:

Abstract translation: 本公开提供了使用卡宾的二氧化碳加合物制备聚乳酸的方法，其中卡宾的加成物具有如下式（I）所示的结构：

公开(公告)号：US09017812B2

公开(公告)日：2015-04-28

申请号：US13982804

申请日：2011-12-22

Applicant: Hiroshi Takezaki ,  Hiroshi Kobayashi ,  Makiko Saito ,  Itaru Asano

Inventor： Hiroshi Takezaki ,  Hiroshi Kobayashi ,  Makiko Saito ,  Itaru Asano

IPC: B32B5/16 ,  A61K9/14 ,  A61K8/85 ,  C08J3/14 ,  C08J9/26 ,  C08J9/28 ,  G03G9/08 ,  G03G9/087 ,  A61Q1/02 ,  A61Q1/10 ,  A61K8/02 ,  C08G63/08

CPC classification number: C08G63/81 ,  A61K8/0241 ,  A61K8/0279 ,  A61K8/85 ,  A61K2800/412 ,  A61Q1/02 ,  A61Q1/10 ,  C08G63/08 ,  C08J3/14 ,  C08J9/26 ,  C08J9/28 ,  C08J2367/04 ,  G03G9/0802 ,  G03G9/0804 ,  G03G9/0821 ,  G03G9/08722 ,  G03G9/08762 ,  G03G9/08775 ,  Y10T428/2982

Abstract: A process of producing polylactic acid-based resin microparticles includes a dissolving process that forms a system, which can cause phase separation into two phases of a solution phase mainly composed of polylactic acid-based resin (A) and a solution phase mainly composed of polymer (B) different from polylactic acid-based resin, by dissolving the polylactic acid-based resin (A) and the polymer (B) different from polylactic acid-based resin in an ether-based organic solvent (C), an emulsion-forming process that forms an emulsion by applying a shear force to the system, and a microparticle-forming process that precipitates polylactic acid-based resin microparticles by contacting the emulsion with a poor solvent which has lower solubility of the polylactic acid-based resin (A) than the ether-based organic solvent (C).

Abstract translation: 制备聚乳酸类树脂微粒的方法包括形成系统的溶解过程，其可以相分离成主要由聚乳酸类树脂（A）和主要由聚合物组成的溶液相的两相的相分离 （B）与聚乳酸类树脂不同，通过将与聚乳酸类树脂不同的聚乳酸类树脂（A）和聚合物（B）溶解在醚系有机溶剂（C）中，形成乳液 通过对系统施加剪切力而形成乳液的方法，以及通过使乳液与聚乳酸类树脂（A）的溶解性较差的不良溶剂接触而使聚乳酸类树脂微粒析出的微粒形成方法， 比醚类有机溶剂（C）。

公开(公告)号：US09006254B2

公开(公告)日：2015-04-14

申请号：US14138601

申请日：2013-12-23

Applicant: Selecta Biosciences, Inc.

Inventor： Charles Zepp ,  Grayson B. Lipford ,  Yun Gao ,  Lloyd Johnston ,  Fen-ni Fu ,  Mark J. Keegan ,  Sam Baldwin

IPC: A01N43/90 ,  A61K39/385 ,  A61K9/51 ,  A61K39/00 ,  A61K47/48 ,  B82Y5/00 ,  C08G63/06 ,  C08G63/91 ,  C08G64/42 ,  A61K39/39

CPC classification number: A61K39/385 ,  A61K9/5138 ,  A61K39/0013 ,  A61K39/39 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6925 ,  A61K47/6935 ,  A61K47/6937 ,  A61K2039/55511 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093 ,  A61K2039/62 ,  A61K2039/627 ,  B82Y5/00 ,  C07D471/04 ,  C07D473/34 ,  C08G63/06 ,  C08G63/08 ,  C08G63/912 ,  C08G64/42 ,  C08J3/24 ,  C08J2367/04

Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.

Abstract translation: 本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。 缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

公开(公告)号：US20150093444A1

公开(公告)日：2015-04-02

申请号：US14354496

申请日：2012-10-23

Applicant: Suzhou Ribo Life Science Co., Ltd.

Inventor： Hongyan Zhang ,  Jun Wang

IPC: A61K47/34 ,  C12N15/113 ,  C08G79/04

CPC classification number: A61K47/34 ,  A61K9/1075 ,  A61K9/5153 ,  A61K31/7105 ,  A61K31/713 ,  C08G63/08 ,  C08G79/04 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: Provided are a polycaprolactone-polyphosphate block copolymer, a liquid composite formed by the block copolymer, a nucleic acid preparation, preparation methods for the copolymer and the liquid composite, and the use of the copolymer and the liquid composite in a nucleic acid medicine delivery system. The block copolymer prepared using the present invention has good biocompatibility, low cytotoxicity, and good biodegradability. The micelles provided in the present invention self-assemble into nano-particles in an aqueous solution, and have good stability, biocompatibility, and biodegradability, and low cytotoxicity. The preparation method is simple, has high repeatability, as a vector can protect small nucleic acids such as siRNA from biodegradation, can combine with the scale effect of nano-particles, and can be used for treating different diseases. Additionally, bonding targeting groups enable specificity recognition of different cancer cells.

Abstract translation: 提供了聚己内酯 - 聚磷酸酯嵌段共聚物，通过嵌段共聚物形成的液体复合物，核酸制剂，共聚物和液体复合物的制备方法，以及在核酸药物递送系统中使用共聚物和液体复合物 。 使用本发明制备的嵌段共聚物具有良好的生物相容性，低细胞毒性和良好的生物降解性。 本发明提供的胶束在水溶液中自组装成纳米颗粒，具有良好的稳定性，生物相容性和生物降解性以及低的细胞毒性。 制备方法简单，重复性高，载体可以保护小核酸如siRNA免受生物降解，可与纳米颗粒的鳞屑结合，可用于治疗不同疾病。 另外，结合靶向组能够特异性识别不同的癌细胞。

公开(公告)号：US20150087799A1

公开(公告)日：2015-03-26

申请号：US14343912

申请日：2012-09-11

Applicant: Hisanori Kishida ,  Takashi Hasegawa ,  Nobuyoshi Nomura ,  Makoto Takahashi ,  Joseph Schroeder ,  Manuel Natal

Inventor： Hisanori Kishida ,  Takashi Hasegawa ,  Nobuyoshi Nomura ,  Makoto Takahashi ,  Joseph Schroeder ,  Manuel Natal

IPC: C08G63/08

CPC classification number: C08G63/08 ,  C08G63/823

Abstract: This invention provides a method for synthesizing semi-crystalline polylactides (PLA) even from a lactide mixture including meso-LA and rac-LA. According to the invention, when a mixture of racemic lactide and meso-lactide ispolymerized using a catalyst capable of iso-selectively polymerizing L-lactide and D-lactide, an amorphous poly (meso-lactide) block is formed from meso-lactide and a semi-crystalline poly (racemic lactide) block is formed from racemic lactide by separately polymerizing racemic lactide and meso-lactide by taking advantage of a difference in physicochemical properties between racemic lactide and meso-lactide, whereby polylactide which is semi-crystalline as a whole is produced.

Abstract translation: 本发明提供了即使由包括meso-LA和rac-LA的丙交酯混合物合成半结晶聚交酯（PLA）的方法。 根据本发明，当外消旋丙交酯和内消旋丙交酯的混合物使用能够同时选择性聚合L-丙交酯和D-丙交酯的催化剂进行聚合时，由内消旋丙交酯形成无定形的聚（内消旋丙交酯）嵌段， 通过利用外消旋丙交酯和内消旋丙交酯之间的物理化学性质的差异，通过分别外消旋丙交酯和内消旋丙交酯聚合形成半结晶聚（外消旋丙交酯）嵌段，由此作为整体是半结晶的聚丙交酯 生产。

公开(公告)号：US20150045451A1

公开(公告)日：2015-02-12

申请号：US14454073

申请日：2014-08-07

Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

Inventor： Durgadas Bolikal ,  Joachim B. Kohn ,  Lioubov Kabalnova

IPC: C08G63/08 ,  A61L31/16 ,  A61L31/06 ,  C08G63/91 ,  C08G64/02

CPC classification number: C08G63/08 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/416 ,  C08G63/19 ,  C08G63/64 ,  C08G63/912 ,  C08G64/0208 ,  C08G64/0233 ,  C08G64/1608 ,  C08G64/1633 ,  C08L69/00 ,  C08L85/02

Abstract: The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

Abstract translation: 本发明提供新类型的衍生自羟基酸和酪醇或酪醇类似物的酚类化合物，其可用作制备生物相容性聚合物的单体，以及由这些单体羟基酸 - 酚类化合物制备的生物相容性聚合物，包括新的可生物降解和/或生物可再吸收的聚合物。 具有增强的生物可再生性和加工性的这些生物相容性聚合物或聚合物组合物可用于各种医疗应用，例如在医疗装置和控制释放治疗制剂中。 本发明还提供了制备这些单体羟基酸 - 酚类化合物和生物相容性聚合物的方法。

公开(公告)号：US20150031827A1

公开(公告)日：2015-01-29

申请号：US14198775

申请日：2014-03-06

Applicant: Chiyoshi Nozaki ,  Chiaki Tanaka ,  Taichi Nemoto

Inventor： Chiyoshi Nozaki ,  Chiaki Tanaka ,  Taichi Nemoto

IPC: C08G63/08 ,  C08L67/04

CPC classification number: C08G63/08 ,  C08B37/0012 ,  C08B37/0015 ,  C08G63/668 ,  C08G63/78 ,  C08L5/16 ,  C08L67/04 ,  C08L71/02

Abstract: A polymer is provided. The polymer includes a polymer chain; and a saccharide bonded with the polymer chain. The polymer does not substantially include an organic solvent and a metal atom, and includes a residual monomer in an amount of not greater than 1,000 ppm, which is relatively small compared to the amount of residual monomer in a polymer prepared by a conventional method. The polymer is preferably used for a clathrate, a sheet, and an aqueous dispersion of the sheet.

Abstract translation: 提供聚合物。 聚合物包括聚合物链; 和与聚合物链键合的糖。 聚合物基本上不包括有机溶剂和金属原子，并且包括与通过常规方法制备的聚合物中的残留单体的量相比相对小的不大于1,000ppm的残余单体。 聚合物优选用于片材的包合物，片材和水分散体。