公开(公告)号：US10399924B2

公开(公告)日：2019-09-03

申请号：US14201380

申请日：2014-03-07

申请人： Biogen MA Inc.

发明人： Jianhua Chao

IPC分类号： A61K31/22 ,  C07C69/60 ,  C07C69/533 ,  A61K31/225 ,  A61K31/235 ,  A61K31/24 ,  A61K31/5375 ,  A61K45/06 ,  C07C69/76 ,  C07C229/36 ,  C07D295/145 ,  C07B59/00

摘要： Provided herein are deuterium substituted fumarate derivatives and pharmaceutical compositions comprising deuterium substituted fumarate derivatives. Also provided is a method of treating, prophylaxis, or amelioration of a disease, comprising administering to a subject in need of treatment for the disease an effective amount of a deuterium substituted fumarate derivative or a pharmaceutical composition comprising a deuterium substituted fumarate derivative. In one embodiment, the method is a neurodegenerative disease, such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, or Alzheimer's disease.

公开(公告)号：US20190031594A1

公开(公告)日：2019-01-31

申请号：US15954451

申请日：2018-04-16

申请人： REG Life Sciences, LLC

发明人： Zhihao Hu ,  Fernando Valle

IPC分类号： C07C69/533 ,  C12N1/12 ,  C10L1/02 ,  C12N1/16 ,  C12N1/20 ,  C07C69/52 ,  C07C69/34 ,  C12N9/10 ,  C12N9/02 ,  C12N9/16 ,  C12P7/64 ,  C12N9/00 ,  C11C3/00 ,  C10L1/19 ,  C12N1/14

摘要： Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.

公开(公告)号：US20190023680A1

公开(公告)日：2019-01-24

申请号：US16024368

申请日：2018-06-29

申请人： James William Leahy ,  Zachary Paul Shultz ,  Grant Alexander Lawrence

发明人： James William Leahy ,  Zachary Paul Shultz ,  Grant Alexander Lawrence

IPC分类号： C07D311/80 ,  C07C45/67 ,  C07C45/41 ,  C07C67/08 ,  C07C45/68 ,  C07C29/143 ,  C07C29/132 ,  C07C69/533 ,  C07C49/248

摘要： Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.

公开(公告)号：US20180208866A1

公开(公告)日：2018-07-26

申请号：US15826334

申请日：2017-11-29

申请人： Elevance Renewable Sciences, Inc.

发明人： Paul A. Bertin ,  Courtnay Shaner ,  Na Liu ,  Monika Mujkic ,  Kristine Counter ,  Jonathan Brekan

IPC分类号： C10M105/38 ,  C07C69/533

CPC分类号： C10M105/38 ,  C07C69/533 ,  C10M2207/2835 ,  C10N2220/02 ,  C10N2220/022 ,  C10N2220/024 ,  C10N2230/02 ,  C10N2230/06 ,  C10N2230/10 ,  C10N2230/66 ,  C10N2240/08

摘要： This invention relates to unsaturated polyol esters that can be used in hydraulic fluid applications, including fire-resistant hydraulic fluid applications, marine hydraulic fluid applications, metalworking fluid applications, food grade fluid applications, and transformer fluid applications, and methods for making the same.

公开(公告)号：US20180194714A1

公开(公告)日：2018-07-12

申请号：US15915957

申请日：2018-03-08

申请人： Beth Israel Deaconess Medical Center, Inc. ,  President and Fellows of Harvard College

发明人： Barbara B. Kahn ,  Mark A. Herman ,  Alan Saghatelian ,  Edwin Homan ,  Mark M. Yore ,  Ismail Syed ,  Pedro M.M. Moraes Vieira

IPC分类号： C07C69/22 ,  G01N33/543 ,  G01N33/92 ,  C07C69/58 ,  C07C69/533 ,  C07C69/24 ,  C07D495/04

CPC分类号： C07C69/22 ,  C07C69/24 ,  C07C69/533 ,  C07C69/58 ,  C07D495/04 ,  G01N33/54306 ,  G01N33/92 ,  G01N2500/04

摘要： The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders—including diabetes-related disorders, Metabolic Syndrome, polycyctic ovarian syndrome, cancer, and inflammatory disorders—using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

公开(公告)号：US09988654B2

公开(公告)日：2018-06-05

申请号：US14740749

申请日：2015-06-16

申请人： INVISTA North America S.á r.l.

发明人： Alex Van Eck Conradie ,  Adriana Leonora Botes

IPC分类号： C12P7/62 ,  C12P7/44 ,  C12P13/00 ,  C12P7/42 ,  C12P7/18 ,  C12P11/00 ,  C12N9/16 ,  C12N9/10 ,  C12N9/02 ,  C12N9/18 ,  C07C69/533 ,  C12P7/24 ,  C12P7/40 ,  C12P17/10

CPC分类号： C12P7/62 ,  C07C69/533 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/18 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P11/00 ,  C12P13/001 ,  C12P13/005 ,  C12P17/10 ,  C12Y102/99006 ,  C12Y203/01016 ,  C12Y206/01018 ,  C12Y206/01019 ,  C12Y206/01029 ,  C12Y206/01048 ,  C12Y206/01082 ,  C12Y301/01085 ,  C12Y301/02

摘要： This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol.

公开(公告)号：US09834626B2

公开(公告)日：2017-12-05

申请号：US14761082

申请日：2014-01-13

申请人： Bret Ja Chisholm ,  Harjyoti Kalita ,  Samim Alam ,  Andrey Chernykh

发明人： Bret Ja Chisholm ,  Harjyoti Kalita ,  Samim Alam ,  Andrey Chernykh

IPC分类号： C08F16/26 ,  C07C69/533 ,  C07D303/42 ,  C09D133/14 ,  C07C69/604 ,  C08G77/38 ,  C08F20/68 ,  C09D129/10 ,  C07C69/587 ,  C07D301/00 ,  C08L75/04

CPC分类号： C08F16/26 ,  C07C69/533 ,  C07C69/587 ,  C07C69/604 ,  C07D301/00 ,  C07D303/42 ,  C08F20/68 ,  C08G77/38 ,  C08L75/04 ,  C09D129/10 ,  C09D133/14

摘要： Plant oil-based compounds are provided which possess both low viscosity and high reactive functionality. These compounds are useful in coating and composite applications, as well as related methods. Exemplary compounds can be produced by transesterification of a plant oil triglyceride with a nucleophile reactant, such as a vinyl-functional alcohol, to yield reactive fatty acid-containing monomers.

公开(公告)号：US20170144954A1

公开(公告)日：2017-05-25

申请号：US15309758

申请日：2015-05-08

申请人： Mitsubishi Gas Chemical Company, Inc.

发明人： Takashi MAKINOSHIMA ,  Masatoshi ECHIGO

IPC分类号： C07C39/12 ,  C09D161/06 ,  C07C25/22 ,  C07C205/06 ,  C07C211/61 ,  C07D303/36 ,  C07D303/18 ,  C07C69/52 ,  C07C69/533 ,  C07C321/26 ,  C07C43/285 ,  G03F7/004 ,  G03F7/16 ,  G03F7/11 ,  G03F7/039 ,  G03F7/20 ,  G03F7/38 ,  G03F7/32 ,  H01L21/308 ,  H01L21/306 ,  C08G8/08

CPC分类号： C07C39/12 ,  C07C25/22 ,  C07C43/285 ,  C07C69/52 ,  C07C69/533 ,  C07C205/06 ,  C07C211/61 ,  C07C321/26 ,  C07C2603/54 ,  C07D303/18 ,  C07D303/36 ,  C08G8/08 ,  C09D161/06 ,  G03F7/0045 ,  G03F7/039 ,  G03F7/11 ,  G03F7/162 ,  G03F7/168 ,  G03F7/2037 ,  G03F7/26 ,  G03F7/322 ,  G03F7/38 ,  H01L21/027 ,  H01L21/30604 ,  H01L21/3081 ,  H01L21/3086

摘要： The material for forming a film for lithography according to the present invention contains a compound represented by the following formula (1): wherein, each R0 independently represents a monovalent group having an oxygen atom, a monovalent group having a sulfur atom, a monovalent group having a nitrogen atom, a hydrocarbon group or a halogen atom, and each p is independently an integer of 0 to 4.

公开(公告)号：US20170088503A1

公开(公告)日：2017-03-30

申请号：US15315955

申请日：2015-05-28

申请人： TAKASAGO INTERNATIONAL CORPORATION

发明人： Kenichiro ADACHI ,  Hiroyuki MATSUDA

IPC分类号： C07C69/533 ,  C07C209/60 ,  C07C209/88 ,  C07C45/41 ,  C07C47/21 ,  C07C251/40 ,  C07C255/07 ,  C07C43/303 ,  C07C47/02 ,  C07C57/03 ,  C07C33/025 ,  C07C69/145 ,  A61Q5/02 ,  A61K8/33 ,  A61K8/40 ,  A61Q19/10 ,  C11D3/50 ,  C11B9/00 ,  A23L27/20 ,  A23L2/56 ,  A23L33/10 ,  C07C211/21

CPC分类号： C07C69/533 ,  A23L2/56 ,  A23L27/2024 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/33 ,  A61K8/36 ,  A61K8/37 ,  A61K8/40 ,  A61Q5/02 ,  A61Q13/00 ,  A61Q19/10 ,  C07B53/00 ,  C07B2200/07 ,  C07C33/025 ,  C07C43/303 ,  C07C45/41 ,  C07C47/02 ,  C07C47/21 ,  C07C57/03 ,  C07C69/145 ,  C07C209/60 ,  C07C209/88 ,  C07C211/21 ,  C07C251/40 ,  C07C255/07 ,  C11B9/0007 ,  C11B9/0015 ,  C11B9/0019 ,  C11B9/0023 ,  C11D3/50

摘要： The present invention addresses the problem of providing a novel compound capable of imparting a highly appealing floral and verdant scent, and a flavor composition and/or fragrance composition containing the same. This compound is a racemic or optically active compound represented by general formula (1). In formula (1), the solid and dotted double line indicates a double bond or a single bond, the definition of Y is the same as described in the specification, and * represents an asymmetric carbon atom.

公开(公告)号：US09550722B2

公开(公告)日：2017-01-24

申请号：US14025176

申请日：2013-09-12

申请人： Biosuccess Biotech Co. Ltd.

发明人： Zheng Tao Han ,  Hung-Fong Chen

IPC分类号： A61K31/215 ,  A61K31/573 ,  A61K31/60 ,  C07C69/33 ,  A61K31/216 ,  A61K31/22 ,  A61K31/23 ,  A61K31/235 ,  A61K45/06 ,  C07C69/18 ,  C07C69/78 ,  C07C69/21 ,  C07C69/533 ,  C07C69/614 ,  C07C69/716 ,  C07C69/612 ,  C07C69/54 ,  C07C69/16

CPC分类号： A61K31/215 ,  A61K31/216 ,  A61K31/22 ,  A61K31/225 ,  A61K31/23 ,  A61K31/235 ,  A61K45/06 ,  C07C69/16 ,  C07C69/18 ,  C07C69/21 ,  C07C69/33 ,  C07C69/533 ,  C07C69/54 ,  C07C69/612 ,  C07C69/614 ,  C07C69/716 ,  C07C69/78 ,  C07C2603/40 ,  A61K2300/00

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.

摘要翻译： 提供含有佛波醇酯或佛波醇酯衍生物的方法和组合物用于治疗和预防中风和中风后遗症。 提供了额外的组合物和方法，其使用佛波醇酯或衍生化合物与至少一种另外的试剂组合以产生治疗或预防中风的更有效的治疗工具以及中风在哺乳动物受试者中的长期作用。