公开(公告)号：US11874252B2

公开(公告)日：2024-01-16

申请号：US17337733

申请日：2021-06-03

申请人： MOBILion Systems, Inc.

发明人： John Daniel DeBord ,  Liulin Deng ,  Nathan Paul Roehr

IPC分类号： G01N27/623 ,  H01J49/02 ,  H01J49/06 ,  H01J49/00 ,  H01J49/10

CPC分类号： G01N27/623 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/061 ,  H01J49/062 ,  H01J49/10

摘要： An apparatus for ion manipulation having improved duty cycle includes first and second separation regions separated by a switch that alternates between guiding ions to each of the separation regions. The separation regions separate the ions based on mobility over respective time periods that at least partially overlap. The apparatus can additionally or alternatively include a pre-separation region that filters ions prior to accumulating ions, thus allowing an accumulation region to accumulate for a longer time period. The apparatus can additionally or alternatively include a plurality of gates along the separation region(s) to simultaneously filter a plurality of ion packets sequentially released into the separation region(s). Methods for ion manipulation having improved duty cycle involve separating ions on two separation regions over first and second time periods that at least partially overlap, pre-filtering ions prior to accumulation and separation, and/or simultaneously filtering a plurality of ions packets are also provided.

公开(公告)号：US11862448B2

公开(公告)日：2024-01-02

申请号：US18149743

申请日：2023-01-04

申请人： THE TRUSTEES OF INDIANA UNIVERSITY

发明人： Martin F. Jarrold ,  Andrew W. Alexander ,  Aaron R. Todd

IPC分类号： H01J49/02 ,  H01J49/42 ,  H01J49/00

CPC分类号： H01J49/025 ,  H01J49/0009 ,  H01J49/022 ,  H01J49/4245

摘要： A CDMS may include an ion source to generate ions from a sample, a mass spectrometer to separate the generated ions as a function of ion mass-to-charge ratio, an electrostatic linear ion trap (ELIT) having a charge detection cylinder disposed between first and second ion mirrors, wherein ions exiting the mass spectrometer are supplied to the ELIT, a charge generator for generating free charges, a field free region between the charge generator and the charge detection cylinder, and a processor configured to control the charge generator, with no ions in the charge detection cylinder, to generate a target number of free charges and cause the target number of free charges to travel across the field-free region and into contact with the charge detection cylinder to deposit the target number of free charges thereon and thereby calibrate or reset the charge detection cylinder to a corresponding target charge level.

公开(公告)号：US11862445B2

公开(公告)日：2024-01-02

申请号：US17312502

申请日：2019-02-14

申请人： SHIMADZU CORPORATION

发明人： Shinichi Yamaguchi

IPC分类号： H01J49/00

CPC分类号： H01J49/0004 ,  H01J49/0036

摘要： An imaging mass spectrometer includes: a storage configured to acquire and store data constituting a first imaging graphic indicating an ion intensity distribution in a specific one or plurality of m/z or m/z ranges based on data obtained by mass spectrometry for a sample; a Raman imaging data acquisition unit configured to acquire and store data constituting one or plurality of second imaging graphics obtained by Raman analysis that is a type different from mass spectrometry for the sample; a signal intensity normalization processor configured to perform data conversion processing of normalizing signal intensity in one or plurality of first and second imaging graphics; an adjustment processor configured to perform data processing of aligning spatial resolutions of the one or plurality of first and second imaging graphics; and a statistical analysis processor configured to execute statistical analysis processing on images and to classify the first and second imaging graphics.

公开(公告)号：US20230420234A1

公开(公告)日：2023-12-28

申请号：US18037458

申请日：2021-11-16

申请人： MOBILion Systems, Inc.

发明人： James Russel Arndt ,  John Daniel DeBord

IPC分类号： H01J49/00 ,  G01N27/623 ,  G06T11/20

CPC分类号： H01J49/0004 ,  H01J49/0036 ,  G01N27/623 ,  G06T11/206

摘要： Systems and methods for image and/or video processing of mass spectrometry data comprise a processor in communication with a storage device, and computer system code executed by the processor that causes the processor to perform an image or video analysis comparison between a second data plot image or video to a first data plot image or video, and generate a delta dataset based on the comparison. The delta dataset is representative of the differences between the first and second data plots. In additional systems and methods the computer system code can perform an image or video analysis comparison between the first and second data plots and a reference data plot, generate first and second delta datasets based on the comparisons, which are representative of the differences between the first and second data plots and the reference data plot, and perform a statistical analysis on the first and second delta datasets.

公开(公告)号：US11854778B2

公开(公告)日：2023-12-26

申请号：US18149189

申请日：2023-01-03

申请人： Bruker Scientific LLC

发明人： Michael Easterling

IPC分类号： H01J49/00 ,  G01N27/622 ,  G01N30/72 ,  G01N33/50 ,  G01N33/68 ,  H01J49/16 ,  G01N33/483

CPC分类号： H01J49/0004 ,  G01N27/622 ,  G01N30/7233 ,  G01N33/50 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/164 ,  H01J49/165 ,  G01N33/4833 ,  G01N2560/00

摘要： A method for the identification and localization of small molecule species in a histologic thin tissue section comprises the steps of: a) acquiring a mass/mobility image of the tissue section and generating a mass/mobility map of the small molecule species of interest for each pixel of the image; b) providing a second sample of the same tissue and extracting the small molecules of interest, separating them, and acquiring mass and ion mobility spectra from the separated small molecules; c) identifying the small molecules of interest using corresponding reference databases; and d) assigning identified small molecules to entries in the mass/mobility maps of the first tissue section by comparison of ion masses and mobilities of the identified species to those of the second thin tissue section.

公开(公告)号：US20230408513A1

公开(公告)日：2023-12-21

申请号：US18235941

申请日：2023-08-21

申请人： SHIMADZU CORPORATION

发明人： Yuko FUKUYAMA

IPC分类号： G01N33/569 ,  G01N33/68 ,  H01J49/00

CPC分类号： G01N33/56916 ,  G01N33/6851 ,  H01J49/0036

摘要： A method for analyzing a microorganism including an identification step for determining which of Abony and Pakistan which are two serotypes of Salmonella bacteria is contained in a sample which contains either Abony or Pakistan, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Minnesota, Infantis and Brandenburg which are three serotypes of Salmonella bacteria is contained in a sample which contains Minnesota, Infantis or Brandenburg, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Schwarzengrund and Montevideo which are two serotypes of Salmonella bacteria is contained in a sample which contains either Schwarzengrund or Montevideo, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample.

公开(公告)号：US20230395363A1

公开(公告)日：2023-12-07

申请号：US18249668

申请日：2020-12-01

申请人： KARSA OY

发明人： Oskari KAUSIALA ,  Aleksei SHCHERBININ

IPC分类号： H01J49/00 ,  G16C20/20 ,  G16C20/70

CPC分类号： H01J49/0036 ,  G16C20/20 ,  G16C20/70

摘要： A signal processing method (100) of a mass spectrometer signal, indicative of mass spectrum of atoms abundant in the mass spectrometer analyzed sample, where the signal processing method comprises: segmentation of the spectra (102), compression of the data points (103), peak finding from the spectra (104), ridge detection (105) at the adjacent peaks represented but the consecutive spectra, peak data processing (106), and identification of peaks (107). The signal processing method is used in a mass spectrometer and a mass spectrometer system.

公开(公告)号：US11837451B2

公开(公告)日：2023-12-05

申请号：US18152684

申请日：2023-01-10

申请人： Thermo Finnigan LLC

发明人： Joshua A. Silveira ,  Michael L. Poltash ,  Wei Wei ,  Eloy R. Wouters

IPC分类号： B08B3/02 ,  H01J49/00 ,  B08B5/02 ,  B08B9/023 ,  H01J49/16 ,  B08B9/032 ,  H01J43/16

CPC分类号： H01J49/0031 ,  B08B3/02 ,  B08B5/02 ,  B08B9/023 ,  B08B9/0323 ,  H01J49/165 ,  H01J49/167 ,  B08B2203/02

摘要： A method for cleaning an electrospray emitter of a mass spectrometer comprises the steps of: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude, |V|, of a voltage applied between a counter electrode and the electrospray emitter; and (b) changing the mode of operation of the electrospray emitter from the dripping mode or the pulsating mode of operation to the stable jet mode of operation by increasing the magnitude, |V|, of the applied voltage; wherein the repetitions are performed at a predetermined frequency that depends on one or more of liquid flow rate, an emitter internal diameter, and liquid properties.

公开(公告)号：US11835499B2

公开(公告)日：2023-12-05

申请号：US16944640

申请日：2020-07-31

申请人： CITY OF HOPE

发明人： Timothy W. Synold ,  John Termini ,  Sarah Shuck

IPC分类号： G01N30/72 ,  G01N1/28 ,  G01N33/483 ,  G01N33/49 ,  G01N33/493 ,  H01J49/00 ,  G01N30/02

CPC分类号： G01N30/7266 ,  G01N1/28 ,  G01N33/4833 ,  G01N33/49 ,  G01N33/493 ,  H01J49/004 ,  G01N2001/2893 ,  G01N2030/027

摘要： Methods of quantifying a N2-(1-carboxyethyl)-2′-deoxyguanosine (CEdG) and N2-(1-carboxyethyl)-guanosine (CEG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG and CEG levels before and after treatment. Measurement of CEdG and CEG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.

公开(公告)号：US20230386814A1

公开(公告)日：2023-11-30

申请号：US18032381

申请日：2021-09-28

申请人： SHIMADZU CORPORATION

发明人： Masaji FURUTA ,  Hidenori TAKAHASHI

IPC分类号： H01J49/00

CPC分类号： H01J49/0072

摘要： Provided is an ion analysis device (10) that irradiates sample component-derived precursor ions with radicals so as to generate product ions and analyzes the product ions, said device comprising: a reaction chamber (142) into which the precursor ions are introduced; a radical generation unit (151) which generates radicals; and a radical transport pipe (152) which connects the radical generation unit (151) and the reaction chamber (142), wherein at least part of the inner wall surface of the radical transport pipe (152) is made of a material having a lesser amount of or lower strength of radical adherence to the inner wall surface of the radical transport pipe (152) in comparison with alumina or quartz. One end (1523) of the radical transport pipe (152) is disposed inside the reaction chamber (142) and preferably faces toward a prescribed region (1424) where ions are localized in the reaction chamber (142).