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公开(公告)号：US09871472B2
公开(公告)日：2018-01-16
申请号：US14402670
申请日：2013-05-24
Applicant: Cambridge Enterprise Limited
Inventor： Yu Jia , Jize Yan , Ashwin Arunkumar Seshia , Kenichi Soga
IPC: H02N2/18 , H01L41/113 , F03G7/08 , H02K35/02
CPC classification number: H02N2/188 , F03G7/08 , H01L41/1136 , H02K35/02 , Y10T74/18856
Abstract: An energy harvester is provided for harvesting energy, and in particular electrical energy from an input vibration such as an ambient vibration. The energy harvester comprises a first mechanical amplifier responsive to the input vibration and a second mechanical amplifier coupled to the first mechanical amplifier. At least one of the first and second mechanical amplifiers comprises a parametric resonator, and a power output of the energy harvester is generated by damping the second mechanical amplifier.
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公开(公告)号：US20180010187A1
公开(公告)日：2018-01-11
申请号：US15642252
申请日：2017-07-05
Applicant: Cambridge Enterprise Limited
Inventor： Paul A. Lyons , Kenneth G.C. Smith , Eoin F. McKinney , Daniele Biasci , James Lee
CPC classification number: C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G16B25/00
Abstract: The present invention provides a method of assessing whether an individual is at high risk or low risk of inflammatory bowel disease (IBD) progression by determining the expression level of two or more genes in a whole blood sample. Also provided are methods for treating IBD in an individual who is determined to be at high risk or low risk for IBD progression, and kits for assessing whether an individual is at high risk or low risk for IBD progression. Arrays, and methods of providing arrays, of patient-identified selected gene expression products from a whole blood sample of a patient are also provided.
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公开(公告)号：US20170363589A1
公开(公告)日：2017-12-21
申请号：US15529944
申请日：2015-11-27
Applicant: Cambridge Enterprise Limited
Inventor： Vasant Ramachandran Kumar , Sohab Sarfraz , Florin Udrea
IPC: G01N30/66 , G01N30/60 , G01N27/18 , G01N33/497 , G01N25/18
CPC classification number: G01N30/66 , G01N25/18 , G01N27/18 , G01N30/6095 , G01N33/497
Abstract: A thermal conductivity sensing device (1) is disclosed, along with a method for operation of the thermal conductivity sensing device and use of the thermal conductivity sensing device in a system for gas chromatography and a method of carrying out gas chromatography. The thermal conductivity sensing device is for use in sensing one or more gaseous components in a flowing gaseous environment. The device has a first sensor (4B) and a second sensor (4A) for exposure to the same flowing gaseous environment (G). The first sensor has an associated flow altering means (20) to affect gas flow at least at part of the surface of the first sensor, to be different to gas flow at the surface of the second sensor. Each sensor provides an output relating to heat transfer between a surface of the sensor and the gaseous environment. The device is operable to compare outputs of the first and second sensors. The sensor is able to reduce the effects of bulk convection of the flowing gas on thermal conductivity measurements.
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公开(公告)号：US20170360809A1
公开(公告)日：2017-12-21
申请号：US15624299
申请日：2017-06-15
Applicant: Cambridge Enterprise Limited , King's College London
Inventor： Melinda Duer , David Reid , Catherine Shanahan
IPC: A61K31/65 , A61K31/522 , A61K31/506 , A61K31/166 , A61K31/473 , A61K31/4709 , A61K31/554 , A61K31/519
CPC classification number: A61K31/65 , A61K31/166 , A61K31/4184 , A61K31/454 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/50 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/554 , A61K45/06 , A61K2300/00
Abstract: The invention relates to the use of a poly(ADP ribose) polymerase (PARP) inhibitor and/or a tetracycline, for treating, preventing or ameliorating medial vascular calcification, and to pharmaceutical compositions comprising PARP inhibitors or tetracycline.
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公开(公告)号：US09821248B2
公开(公告)日：2017-11-21
申请号：US13834901
申请日：2013-03-15
Applicant: Cambridge Enterprise Limited
Inventor： Yii Leng Chua
IPC: B01D15/00 , B01D15/02 , B01D15/08 , B01D15/10 , B01D15/18 , B01D15/42 , B01D15/20 , B01D15/24 , B01D15/26 , B01D11/02 , B01D17/02 , C12N15/10
CPC classification number: B01D15/20 , B01D11/02 , B01D11/0219 , B01D15/00 , B01D15/02 , B01D15/24 , B01D15/245 , B01D15/26 , B01D17/02 , B01D17/0202 , C12N15/1006 , C12N15/101 , C12N15/1017
Abstract: A method for obtaining a liquid from a porous solid phase is described. The method comprises forming a liquid seal at a first end of a porous solid phase to which a liquid is bound, wherein liquid of the liquid seal is immiscible with the liquid bound to the solid phase, and applying a pressure differential across the porous solid phase to cause the immiscible liquid to move through the porous solid phase towards a second end of the porous solid phase, thereby displacing the liquid bound to the porous solid phase towards the second end and releasing this liquid from the second end. Recovery of liquid from the solid phase using such methods is increased compared with corresponding methods in which no liquid seal is formed. In preferred embodiments, the liquid used to form the liquid seal is a mineral oil. The methods have particular application in nucleic acid extractions which utilize capture of nucleic acid to a solid phase. Kits and apparatus for performing the methods are also described.
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Patent Agency Ranking
公开(公告)号：US20170315507A1
公开(公告)日：2017-11-02
申请号：US15384280
申请日：2016-12-19
Applicant: Cambridge Enterprise Limited
Inventor： Neil Collings , Andreas Georgiou , Maura Michelle Redmond , Brian Robertson , Jinsong Liu , William Crossland , John Richard Moore , Daping Chu
CPC classification number: G03H1/0841 , G02B5/32 , G02B6/3558 , G02B6/3588 , G02F1/136277 , G03H1/0808 , G03H1/2294 , G03H2001/0816 , G03H2001/085 , G03H2210/44 , G03H2222/31 , G03H2225/32 , G03H2225/60 , G03H2226/02 , H04Q11/0005
Abstract: A LCOS routing device, comprising: an optical input and plurality of optical outputs; a spatial light modulator (SLM) between said input and output, for displaying a kinoform; a data processor, configured to provide kinoform data for displaying said kinoform on said SLM. Said data processor inputs routing and calculates said kinoform data. Said data processor calculates kinoform data by: determining an initial phase pattern for said kinoform; calculating a replay field of said phase pattern; modifying an amplitude component of said replay field, retaining a phase component of said replay field to provide an updated replay field; performing a space-frequency transform on said updated replay field to determine an updated phase pattern for said kinoform; and repeating said calculating and updating of said replay field and said performing of said space-frequency transform until said kinoform for display is determined; and outputting said kinoform data for display on said LCOS SLM.
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公开(公告)号：US20170212102A1
公开(公告)日：2017-07-27
申请号：US15416789
申请日：2017-01-26
Applicant: Cambridge Enterprise Limited
Inventor： Sabine Bahn , Emanuel Schwarz
IPC: G01N33/53 , G01N33/50 , G01N33/52 , G01N33/573
CPC classification number: G01N33/5308 , G01N33/50 , G01N33/52 , G01N33/573 , G01N33/6893 , G01N33/6896 , G01N2333/96494 , G01N2800/28 , G01N2800/2814 , G01N2800/30 , G01N2800/302 , G01N2800/304
Abstract: The invention relates to a method of differentially diagnosing schizophrenia, bipolar disorder and major depressive disorder.
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公开(公告)号：US20170202779A1
公开(公告)日：2017-07-20
申请号：US15508876
申请日：2015-09-04
Inventor： Tuomas KNOWLES , Ulyana SHIMANOVICH , Christopher DOBSON , David WEITZ
CPC classification number: A61K9/4825 , A61K9/4833 , A61K9/5169 , B01J13/08
Abstract: The present invention provides capsules having a shell of material that comprises an assembly of a protein, and the capsule is optionally provided with a network of material within the shell that is an assembly of the protein. The assembly of the protein is obtained or obtainable by the aggregation of the protein, optionally together with another protein. The assembly is a non-covalent assembly of a protein.
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公开(公告)号：US09707557B2
公开(公告)日：2017-07-18
申请号：US14486290
申请日：2014-09-15
Applicant: Cambridge Enterprise Limited
Inventor： Wolfgang Andreas Bauer , Wilhelm T. S. Huck , Martin Fischlechner
CPC classification number: B01L3/502707 , B01F17/00 , B01J2219/00511 , B01J2219/0059 , B01J2219/00637 , B01J2219/00783 , B01J2219/00788 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/0097 , B01L2200/0636 , B01L2300/0867 , B01L2300/16 , B01L2300/161 , B05C7/04 , B05D7/22 , B05D7/222 , B81B2201/0214 , B81B2201/05 , B81B2201/052 , B81B2201/058 , B81C1/00119 , B81C1/00206 , Y10T137/8593
Abstract: We describe a method of layer-by-layer deposition of a plurality of layers of material onto the wall or walls of a channel of a microfluidic device, the method comprising: loading a tube with a series of segments of solution, a said segment of solution bearing a material to be deposited; coupling said tube to said microfluidic device; and injecting said segments of solution into said microfluidic device such that said segments of solution pass, in turn, through said channel depositing successive layers of material to perform said layer-by-layer deposition onto said wall or walls of said channel. Embodiments of the methods are particularly useful for automated surface modification of plastic, for example PDMS (Poly(dimethylsiloxane)), microchannels. We also describe methods and apparatus for forming double-emulsions.
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公开(公告)号：US20170121383A1
公开(公告)日：2017-05-04
申请号：US15404265
申请日：2017-01-12
Applicant: CAMBRIDGE ENTERPRISE LIMITED
Inventor： Nicholas W. MORRELL , Wei LI , Paul D. UPTON
IPC: C07K14/51
CPC classification number: C07K14/51 , A61K38/00 , A61K38/1875 , A61K48/00
Abstract: The invention relates to a bone morphogenetic protein 9 (BMP9) variant lacking osteogenic activity, and its use in the treatment of a vascular disease or a respiratory disease.
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