公开(公告)号：US20030133113A1

公开(公告)日：2003-07-17

申请号：US10331215

申请日：2002-12-30

Applicant: SYMYX TECHNOLOGIES, INC

Inventor： Damian Hajduk ,  Eric Carlson

IPC: G01J004/00

CPC classification number: G01N21/21 ,  B01J2219/00286 ,  B01J2219/00315 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00745 ,  C40B40/18 ,  C40B60/14 ,  G01J4/04 ,  G01N2201/0813

Abstract: A method and apparatus for characterizing and screening an array of material samples is disclosed. The apparatus includes a sample block having a plurality of regions for containing the material samples, a polarized light source to illuminate the materials, an analyzer having a polarization direction different than the polarization direction of the polarized light source, and a detector for analyzing changes in the intensity of the light beams. The light source, together with a polarizer, may include a plurality of light beams to simultaneously illuminate the entire array of materials with linearly polarized light so that characterization and screening can be performed in parallel. In addition, the materials in the sample block maybe subjected to different environmental conditions or mechanical stresses, and the detector analyzes the array as a function of the different environmental conditions or mechanical stresses.

公开(公告)号：US20030108879A1

公开(公告)日：2003-06-12

申请号：US10043394

申请日：2002-01-10

Applicant: Symyx Technologies, Inc.

Inventor： Gerrit Klaerner ,  Didier Benoit ,  Dominique Charmot ,  Srinivas Nomula ,  Marcelo Eduardo Piotti ,  Laura T. Mazzola

IPC: C12Q001/68 ,  C12M001/34

CPC classification number: G01N33/54353 ,  C08F293/005

Abstract: Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.

Abstract translation: 用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包括具有用疏水性聚合物链段修饰的表面的基底，其附着有水分散性或水溶性聚合物链段 具有结合探针的官能团。 合成这种传感器的方法优选包括使用受控的自由基聚合技术，其允许可控结构聚合物改性底物的表面，以及使用具有在探针附着之前不需要活化的官能团的单体。 以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。

公开(公告)号：US20030070917A1

公开(公告)日：2003-04-17

申请号：US09975707

申请日：2001-10-11

Applicant: Symyx Technologies, Inc.

Inventor： Daniel M. Giaquinta ,  Alexander Gorer ,  Martin Devenney ,  Sum Nguyen ,  Leonid Matsiev

IPC: C25B009/00 ,  C25D017/00

CPC classification number: G01N27/403 ,  B01J2219/00274 ,  C25D9/06 ,  C25D13/22 ,  C25D17/02

Abstract: An apparatus including a basis that has a plurality of wells associated therewith for defining a plurality of electrochemical cells; at least two electrodes sealingly disposed in each electrochemical cell; and circuitry for providing an electrical connection between an electrical source and each said cell. A particularly preferred apparatus employs at least one printed circuit board secured to the base. In a preferred method, candidate materials are introduced into the apparatus and their respective performances are analyzed.

Abstract translation: 一种装置，包括具有与其相关联的多个孔的基础，用于限定多个电化学电池; 密封地设置在每个电化学电池中的至少两个电极; 以及用于在电源和每个所述电池之间提供电连接的电路。 特别优选的装置采用固定到基座的至少一个印刷电路板。 在优选的方法中，将候选材料引入到装置中并分析它们各自的性能。

公开(公告)号：US20030041672A1

公开(公告)日：2003-03-06

申请号：US09939404

申请日：2001-08-24

Applicant: Symyx Technologies , Inc.

Inventor： Damian A. Hajduk ,  Eric D. Carlson ,  J. Christopher Freitag ,  Oleg Kolosov ,  James R. Engstrom ,  Adam Safir ,  Ravi Srinivasan ,  Leonid Matsiev

IPC: G01L001/24

CPC classification number: G01N3/18 ,  B01J2219/00274 ,  G01N3/10 ,  G01N2203/0016 ,  G01N2203/0051 ,  G01N2203/0252 ,  G01N2203/0254 ,  G01N2203/0258 ,  G01N2203/0617 ,  G01N2203/0623 ,  G01N2203/0641

Abstract: A method for high throughput mechanical property and bulge testing of materials libraries. A plurality of samples on a substrate are monitored for their response to a force from a fluid.

Abstract translation: 一种材料库高通量机械性能和凸起试验方法。 监测基板上的多个样品对来自流体的力的响应。

公开(公告)号：US20030037601A1

公开(公告)日：2003-02-27

申请号：US09939149

申请日：2001-08-24

Applicant: Symyx Technologies, Inc

Inventor： Paul Mansky ,  Damian A. Hajduk

IPC: G01N011/04

CPC classification number: G01N33/442 ,  B01J2219/00315 ,  B01J2219/00367 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  G01N11/04 ,  G01N35/028 ,  G01N35/109

Abstract: A library of materials is screened for viscosity. A library of materials is provided. The library is contacted with at least one capillary for applying a force through the materials. The relative flow resistance of the materials is measured in response to the force; and the materials in the library are ranked based on the monitored flow resistance.

Abstract translation: 对材料库进行粘度筛选。 提供材料库。 文库与至少一个毛细管接触，以通过材料施加力。 材料的相对流动阻力是响应于力而测量的; 并且图书馆中的材料基于监测的流动阻力进行排名。

公开(公告)号：US20030029229A1

公开(公告)日：2003-02-13

申请号：US10262303

申请日：2002-10-01

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

IPC: G01N011/10

CPC classification number: G01N3/24 ,  G01N11/16 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0623

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine Theological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.

Abstract translation: 本发明涉及微型流变仪，平行流变仪和改进的力传感器元件，其可有利地与微型流变仪和平行流变仪组合使用。 微型流变仪适用于确定以少量样品形式提供的材料的神学特性。 微型流变仪包括致动元件，感测元件和反馈电路，以提供由样品施加到感测元件的剪切力的重新平衡，这确保了确定剪切应变的特殊刚度，从而允许高精度的测量。 本发明的并行流变仪允许多个样本的同时测量，以便在短时间内允许多个样本。 根据本发明的力传感器元件允许同时测量施加到传感器元件的剪切力和法向力。 此外，提供了一种流变仪，其包括基于应力光学材料的力传感器。

公开(公告)号：US20030000291A1

公开(公告)日：2003-01-02

申请号：US10163064

申请日：2002-06-05

Applicant: Symyx Technologies, Inc.

Inventor： Oleg Kolosov ,  Leonid Matsiev ,  Miroslav Petro

IPC: G01N030/00

CPC classification number: G01N29/4427 ,  G01N9/002 ,  G01N9/32 ,  G01N11/167 ,  G01N29/022 ,  G01N29/036 ,  G01N29/348 ,  G01N29/46 ,  G01N30/16 ,  G01N30/76 ,  G01N35/085 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2030/765

Abstract: An improved system, device and method for characterizing a fluid sample that includes injecting a fluid sample into a mobile phase of a flow characterization system, and detecting a property of the fluid sample or of a component thereof with a flow detector comprising a mechanical resonator, preferably one that is operated at a frequency less than about 1 MHz, such as a tuning fork resonator.

Abstract translation: 一种用于表征流体样品的改进的系统，装置和方法，其包括将流体样品注入到流动表征系统的流动相中，以及用包括机械共振器的流动检测器检测流体样品或其组分的性质， 优选以小于约1MHz的频率操作的音调，例如音叉谐振器。

公开(公告)号：US20020142912A1

公开(公告)日：2002-10-03

申请号：US09992630

申请日：2001-11-06

Applicant: Symyx Technologies, Inc.

Inventor： Thomas R. Boussie ,  Gary M. Diamond ,  Christopher Goh ,  Keith A. Hall ,  Anne M. LaPointe ,  Margarete K. Leclerc ,  Cheryl Lund ,  Vince Murphy

IPC: C07F001/00 ,  B01J031/00

CPC classification number: C07D213/74 ,  B01J2219/00722 ,  C07B2200/11 ,  C07D213/38 ,  C07D213/61 ,  C07D213/68 ,  C07F7/00 ,  C07F7/003 ,  C07F9/58 ,  C08F4/65908 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/06 ,  C08F210/02 ,  C08F210/16 ,  C40B40/14 ,  C08F4/659 ,  C08F4/65904 ,  C08F2500/15 ,  C08F2500/02 ,  C08F210/10 ,  C08F212/08 ,  C08F210/14 ,  C08F4/64144 ,  C08F4/64113 ,  C08F4/64044

Abstract: New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with hafnium metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, isobutylene or styrene. Certain of the catalysts are particularly effective at polymerizing propylene to high molecular weight isotactic polypropylene in a solution process at a variety of polymerization conditions.

Abstract translation: 公开了新配体，组合物，金属 - 配体络合物和具有吡啶基 - 胺配体的阵列，其催化单体聚合成聚合物。 这些具有铪金属中心的这些催化剂中的某些具有高性能特征，包括较高的共聚单体引入到乙烯/烯烃共聚物中，其中这种烯烃是例如1-辛烯，异丁烯或苯乙烯。 某些催化剂在各种聚合条件下在溶液过程中将丙烯聚合成高分子量全同立构聚丙烯是特别有效的。

公开(公告)号：US20020124897A1

公开(公告)日：2002-09-12

申请号：US10092035

申请日：2002-03-06

Applicant: Symyx Technologies, Inc.

Inventor： H. Sam Bergh ,  Daniel M. Pinkas

IPC: F16K031/12

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K7/14 ,  F16K27/003 ,  F16K99/0015 ,  F16K99/0023 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/008 ,  G01N30/20 ,  G01N2030/205 ,  Y10T137/87893

Abstract: A novel gas injection valve for injecting discrete charges of gas into a mobile phase or carrier stream is provided. Injection valves of the invention comprise a plurality of microvalves capable of receiving gas at different pressures and emitting discrete charges of gas at approximately the same pressure. The invention further provides for parallel injection valve arrays capable of injecting multiple samples substantially simultaneously and a method of injecting discrete gas samples at a controlled pressure to a high-resolution gas chromatograph.

Abstract translation: 提供了一种用于将离散的气体注入流动相或载流子的新颖的气体注入阀。 本发明的注射阀包括能够接收不同压力的气体并以大致相同的压力发射离散的气体的多个微型阀。 本发明还提供了能够基本上同时喷射多个样品的平行喷射阀阵列以及将受控压力的离散气体样品注入高分辨率气相色谱仪的方法。

公开(公告)号：US20020110925A1

公开(公告)日：2002-08-15

申请号：US10116805

申请日：2002-04-05

Applicant: Symyx Technologies, Inc.

Inventor： Paul Mansky ,  Richard Tiede ,  Steve Havadtoy

IPC: B01L003/00

CPC classification number: B01L3/5023 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00315 ,  B01J2219/00484 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00704 ,  B01L3/5025 ,  B01L3/50255 ,  B01L2400/0481 ,  B01L2400/049 ,  G01N33/36 ,  G01N33/367 ,  G01N35/028 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

Abstract: An apparatus for use in testing a plurality of compositions in parallel. The apparatus includes an upper plate having a plurality of openings extending therethrough to form upper fluid chambers and a lower plate having a plurality of openings extending at least partially therethrough to form cavities. A central plate having a plurality of openings extending therethrough to form central fluid chambers is positioned between the upper and lower plates with the central chambers in alignment with the upper chambers and the cavities. A porous sheet is interposed between the upper and central plates such that an upper surface of the sheet is in contact with fluid within the upper chamber and a lower surface of the sheet is in contact with fluid within the central chamber. The apparatus further includes a flexible membrane positioned between the lower and central plates such that changes in pressure within the cavities or fluid chambers cause deflection of the membrane to force fluid to pass through the porous sheet.

Abstract translation: 用于并行测试多种组合物的装置。 该装置包括具有延伸穿过其中以形成上流体室的多个开口的上板，以及具有至少部分地穿过其延伸以形成空腔的多个开口的下板。 具有贯穿其中以形成中心流体室的多个开口的中心板位于上板和下板之间，中心室与上室和空腔对准。 多孔片介于上板和中板之间，使得片的上表面与上室内的流体接触，并且片的下表面与中心室内的流体接触。 该装置还包括位于下板和中心板之间的柔性膜，使得空腔或流体室内的压力变化导致膜的偏转以迫使流体通过多孔板。