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公开(公告)号：US10071957B2
公开(公告)日：2018-09-11
申请号：US14413218
申请日：2013-07-05
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Christoph Martin Dehnhardt , Sultan Chowdhury , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Brian Safina , Daniel P. Sutherlin
IPC: C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12 , C07C307/06
CPC classification number: C07C307/06 , A61K31/44 , A61K31/4439 , A61K31/444 , C07C2601/04 , C07D205/04 , C07D209/08 , C07D213/63 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/20 , C07D217/02 , C07D231/56 , C07D277/24 , C07D277/34 , C07D277/62 , C07D305/08 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, ring D, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10005724B2
公开(公告)日：2018-06-26
申请号：US15321335
申请日：2015-07-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C235/54 , C07D207/16 , C07D405/10 , C07D401/12 , C07D471/08 , C07D403/14 , C07D401/10 , C07D413/12 , C07D413/14 , C07D277/06
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US20180162868A1
公开(公告)日：2018-06-14
申请号：US15600612
申请日：2017-05-19
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , David Earl Bogucki , Kristen Nicole Burford , Sultan Chowdhury , Charles Jay Cohen , Shannon Marie Decker , Christoph Martin Dehnhardt , Robert Joseph Devita , James Roy Empfield , Thilo Focken , Michael Edward Grimwood , Syed Abid Hasan , Qi Jia , James Philip Johnson, JR. , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D491/107 , C07D277/52 , C07D417/12 , C07D213/76 , C07D285/08 , C07D401/12 , C07D403/12 , C07D275/03 , C07D239/69 , C07D261/16 , C07D413/12 , C07D263/50 , C07D487/10
Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.
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公开(公告)号：US20170190662A1
公开(公告)日：2017-07-06
申请号：US15321335
申请日：2015-07-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC: C07D207/16 , C07C235/54 , C07D401/12 , C07D277/06 , C07D403/14 , C07D401/10 , C07D413/12 , C07D413/14 , C07D405/10 , C07D471/08
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2103/74 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US09695185B2
公开(公告)日：2017-07-04
申请号：US14989600
申请日：2016-01-06
Applicant: XENON PHARMACEUTICALS INC.
Inventor： Jean-Jacques Alexandre Cadieux , Mikhail Chafeev , Sultan Chowdhury , Jianmin Fu , Qi Jia , Stefanie Abel , Emad El-Sayed , Elke Huthmann , Thomas Isarno
IPC: C07D491/20 , C07D405/04
CPC classification number: C07D491/20 , C07D405/04
Abstract: This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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Patent Agency Ranking
公开(公告)号：US20170087136A1
公开(公告)日：2017-03-30
申请号：US15275131
申请日：2016-09-23
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: A61K31/445 , A61K31/4545 , A61K31/4523
CPC classification number: A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variablesRA, RAA, subscipt n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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87.发明申请ENANTIOMERS OF SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS 审中-公开螺旋体化合物的使用者及其作为治疗剂的用途公开(公告)号：US20170073351A1
公开(公告)日：2017-03-16
申请号：US15278759
申请日：2016-09-28
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Jianmin Fu , Jean-Jacques Alexandre Cadieux
IPC: C07D491/20 , C07B57/00
CPC classification number: C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
Abstract: This invention is directed to the (S)-enantiomer of the compound of formula (I): or a pharmaceutically acceptable solvate or prodrug thereof. This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.
Abstract translation: 或其药学上可接受的溶剂合物或前药。 该（S） - 对映体可用于治疗通过调节电压门控钠通道而改善或缓解的疾病或病症，例如疼痛。
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公开(公告)号：US09458178B2
公开(公告)日：2016-10-04
申请号：US14542367
申请日：2014-11-14
Applicant: Xenon Pharmaceuticals Inc.
Inventor： Mikhail Chafeev , Sultan Chowdhury , Lauren Fraser , Jianmin Fu , Jonathan Langille , Shifeng Liu , Jianyu Sun , Shaoyi Sun , Serguei Sviridov , Mark Wood , Alla Yurevna Zenova , Qi Jia , Jean-Jacques Alexandre Cadieux , Simon J. Gauthier , Amy Frances Douglas , Tom Hsieh , Nagasree Chakka , Zoran Cikojevic
IPC: C07D513/20 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D519/00
CPC classification number: C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
Abstract: This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Abstract translation: 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：US20150252038A1
公开(公告)日：2015-09-10
申请号：US14603273
申请日：2015-01-22
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe ANDREZ , Paul Robert BICHLER , Chien-An CHEN , Sultan CHOWDHURY , Shannon Marie DECKER , Christoph Martin DEHNHARDT , Thilo FOCKEN , Michael Edward GRIMWOOD , Ivan William HEMEON , Qi JIA , Jun LI , Zhiguo LIU , Daniel F. ORTWINE , Brian SAFINA , Daniel SUTHERLIN , Tao SHENG , Shaoyi SUN , Andrew D. WHITE , Michael Scott WILSON , Alla Yurevna ZENOVA , Jiuxiang ZHU
IPC: C07D453/02 , C07D205/04 , C07D401/06 , C07D403/12 , C07D401/12 , C07D211/42
CPC classification number: A61K31/445 , A61K31/337 , A61K31/397 , A61K31/4015 , A61K31/415 , A61K31/4412 , A61K31/4523 , A61K31/4545 , A61K31/495 , C07D205/04 , C07D207/12 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/54 , C07D211/60 , C07D233/68 , C07D237/08 , C07D241/04 , C07D265/30 , C07D305/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D453/02 , C07D487/08 , C07F7/0812
Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compactions.
Abstract translation: 本发明提供具有通式I的化合物及其药学上可接受的盐，其中变量RA，RAA，下标n，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5和RN 具有本文所述的含义，以及含有这些化合物的组合物和使用这些化合物和组合物的方法。
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公开(公告)号：US08952169B2
公开(公告)日：2015-02-10
申请号：US13899526
申请日：2013-05-21
Applicant: Genentech, Inc. , Xenon Pharmaceuticals Inc.
Inventor： Jean-Christophe Andrez , Sultan Chowdhury , Shannon Marie Decker , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Ivan William Hemeon , Qi Jia , Jun Li , Daniel F. Ortwine , Brian Safina , Tao Sheng , Shaoyi Sun , Daniel P. Sutherlin , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C311/51 , C07D403/12 , C07D213/82 , C07D213/64 , C07D205/04 , C07D311/58 , A61K31/445 , A61K31/44 , A61K31/18 , C07D265/30 , C07D233/84 , C07D257/04 , C07C307/06 , C07D295/26 , C07D207/48 , C07D311/70 , C07D413/12 , C07D451/02 , C07D307/12 , C07D309/08 , C07D311/72 , C07D405/12 , C07D491/107 , C07D211/22 , C07D295/192 , C07D211/96 , C07D307/18
CPC classification number: C07D491/107 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/44 , A61K31/5375 , C07B2200/05 , C07C307/06 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/10 , C07C2602/18 , C07C2602/20 , C07C2602/42 , C07C2602/44 , C07C2602/50 , C07C2603/66 , C07C2603/68 , C07C2603/74 , C07D205/04 , C07D207/46 , C07D207/48 , C07D209/52 , C07D211/22 , C07D211/96 , C07D213/64 , C07D213/82 , C07D233/84 , C07D257/04 , C07D265/30 , C07D295/192 , C07D295/26 , C07D307/12 , C07D307/18 , C07D309/08 , C07D311/58 , C07D311/70 , C07D311/72 , C07D403/12 , C07D405/12 , C07D413/12 , C07D451/02 , C07D471/08
Abstract: The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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