公开(公告)号：US20170114075A1

公开(公告)日：2017-04-27

申请号：US15253369

申请日：2016-08-31

申请人： Xenon Pharmaceuticals Inc.

发明人： Mikhail Chafeev ,  Sultan Chowdhury ,  Lauren Fraser ,  Jianmin Fu ,  Jonathan Langille ,  Shifeng Liu ,  Jianyu Sun ,  Shaoyi Sun ,  Serguei Sviridov ,  Mark Wood ,  Alla Yurevna Zenova ,  Qi Jia ,  Jean-Jacques Alexandre Cadieux ,  Simon J. Gauthier ,  Amy Frances Douglas ,  Tom Hsieh ,  Nagasree Chakka ,  Zoran Cikojevic

IPC分类号： C07D513/22 ,  C07D491/20 ,  C07D495/20 ,  C07D498/20 ,  C07D491/22 ,  C07D513/20 ,  C07D491/107

CPC分类号： C07D513/22 ,  C07D491/10 ,  C07D491/107 ,  C07D491/20 ,  C07D491/22 ,  C07D495/20 ,  C07D498/20 ,  C07D513/20 ,  C07D519/00

摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

公开(公告)号：US09630929B2

公开(公告)日：2017-04-25

申请号：US14355552

申请日：2012-10-30

申请人： XENON PHARMACEUTICALS INC.

发明人： Shaoyi Sun ,  Alla Yurevna Zenova ,  Mikhail Chafeev ,  Qi Jia ,  Zaihui Zhang ,  Renata Marcella Oballa

IPC分类号： C07D417/12 ,  C07D239/42 ,  C07D285/08 ,  C07D401/12 ,  C07D413/12 ,  C07D211/22 ,  C07D257/06 ,  C07D261/14 ,  C07D277/52 ,  C07D285/135

CPC分类号： C07D239/42 ,  C07D211/22 ,  C07D257/06 ,  C07D261/14 ,  C07D277/52 ,  C07D285/08 ,  C07D285/135 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.

公开(公告)号：US20170002017A1

公开(公告)日：2017-01-05

申请号：US15017282

申请日：2016-02-05

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Jean-Christophe Andrez ,  Sultan Chowdhury ,  Shannon Marie Decker ,  Christoph Martin Dehnhardt ,  Thilo Focken ,  Michael Edward Grimwood ,  Ivan William Hemeon ,  Qi Jia ,  Jun Li ,  Daniel F. Ortwine ,  Brian Safina ,  Tao Sheng ,  Shaoyi Sun ,  Daniel P. Sutherlin ,  Michael Scott Wilson ,  Alla Yurevna Zenova

IPC分类号： C07D491/107 ,  C07C311/51 ,  C07D307/12 ,  C07D213/82 ,  C07D205/04 ,  C07D207/48 ,  C07D295/26 ,  C07D257/04 ,  C07D311/58 ,  C07D209/52 ,  C07D307/18 ,  C07D211/22 ,  C07D233/84

CPC分类号： C07D491/107 ,  A61K31/18 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/44 ,  A61K31/5375 ,  C07B2200/05 ,  C07C307/06 ,  C07C311/51 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2602/18 ,  C07C2602/20 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2602/50 ,  C07C2603/66 ,  C07C2603/68 ,  C07C2603/74 ,  C07D205/04 ,  C07D207/46 ,  C07D207/48 ,  C07D209/52 ,  C07D211/22 ,  C07D211/96 ,  C07D213/64 ,  C07D213/82 ,  C07D233/84 ,  C07D257/04 ,  C07D265/30 ,  C07D295/192 ,  C07D295/26 ,  C07D307/12 ,  C07D307/18 ,  C07D309/08 ,  C07D311/58 ,  C07D311/70 ,  C07D311/72 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D451/02 ,  C07D471/08

摘要： The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

摘要翻译： 和其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，B，R1，R2，R3，R4，R5和RN具有本文所述的含义， 化合物和使用这些化合物和组合物的方法。

公开(公告)号：US20160297754A1

公开(公告)日：2016-10-13

申请号：US15133030

申请日：2016-04-19

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Sultan Chowdhury ,  Christoph Martin Dehnhardt ,  Thilo Focken ,  Michael Edward Grimwood ,  Ivan William Hemeon ,  Qi Jia ,  Daniel Ortwine ,  Brian Safina ,  Shaoyi Sun ,  Daniel P. Sutherlin ,  Alla Yurevna Zenova

IPC分类号： C07C311/51 ,  C07D213/82 ,  C07D213/64 ,  C07D205/04 ,  C07D471/08 ,  C07D405/12 ,  C07D295/26 ,  C07D233/84 ,  C07D257/04 ,  C07D207/46 ,  C07C307/06 ,  C07D311/58

CPC分类号： C07D491/107 ,  A61K31/18 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/44 ,  A61K31/5375 ,  C07B2200/05 ,  C07C307/06 ,  C07C311/51 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2602/18 ,  C07C2602/20 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2602/50 ,  C07C2603/66 ,  C07C2603/68 ,  C07C2603/74 ,  C07D205/04 ,  C07D207/46 ,  C07D207/48 ,  C07D209/52 ,  C07D211/22 ,  C07D211/96 ,  C07D213/64 ,  C07D213/82 ,  C07D233/84 ,  C07D257/04 ,  C07D265/30 ,  C07D295/192 ,  C07D295/26 ,  C07D307/12 ,  C07D307/18 ,  C07D309/08 ,  C07D311/58 ,  C07D311/70 ,  C07D311/72 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D451/02 ,  C07D471/08

摘要： The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, B, R1, R2, R3, R4, R5 and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

摘要翻译： 和其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，B，R1，R2，R3，R4，R5和RN具有本文所述的含义， 化合物和使用这些化合物和组合物的方法。

公开(公告)号：US20240342156A1

公开(公告)日：2024-10-17

申请号：US18415139

申请日：2024-01-17

申请人： Xenon Pharmaceuticals Inc.

发明人： James Philip Johnson, JR. ,  Gregory N. Beatch

IPC分类号： A61K31/472 ,  A61K9/00 ,  A61P23/00

CPC分类号： A61K31/472 ,  A61K9/0053 ,  A61P23/00

摘要： In certain embodiments, the present disclosure is directed to methods for treating pain in a subject, such as a human, wherein the methods comprise orally administering a therapeutically effective amount of N-[4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide (Compound A), to the subject in need thereof. The present disclosure is further directed to various improved methods of therapy and administration of Compound A.

公开(公告)号：US20240101531A1

公开(公告)日：2024-03-28

申请号：US18330100

申请日：2023-06-06

申请人： Xenon Pharmaceuticals Inc.

发明人： Paul Scott Charifson ,  Christoph Martin Dehnhardt ,  Julien A. Delbrouck ,  Thilo Focken ,  Wei Gong ,  Shawn Johnstone ,  Xiangyu Li ,  Jia Yi Mo ,  Juliette Sabbatani ,  Hong Wang ,  Steven Sigmund Wesolowski ,  Alla Yurevna Zenova ,  Wei Zhang

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D495/04 ,  C07D513/04 ,  C07D471/04 ,  C07D491/048 ,  C07D491/107 ,  C07D498/04 ,  C07D413/14 ,  C07D487/04 ,  C07D417/14 ,  C07D409/14 ,  C07B59/00 ,  A61P25/08

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D495/04 ,  C07D513/04 ,  C07D471/04 ,  C07D491/048 ,  C07D491/107 ,  C07D498/04 ,  C07D413/14 ,  C07D487/04 ,  C07D417/14 ,  C07D409/14 ,  C07B59/002 ,  A61P25/08 ,  C07B2200/05

摘要： The present disclosure is directed to compounds of Formula (1):




wherein m, n, Y, R1, R2, R3, R4 and R5 are each as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of Formula (I), as described herein, which are useful as voltage-gated potassium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

公开(公告)号：US20220288057A1

公开(公告)日：2022-09-15

申请号：US17668316

申请日：2022-02-09

申请人： XENON PHARMACEUTICALS INC.

发明人： James Philip JOHNSON, JR.

IPC分类号： A61K31/472 ,  A61K31/19 ,  A61K31/4015 ,  A61K31/4166 ,  A61K31/165 ,  A61K31/41 ,  A61P25/08

摘要： In certain embodiments, the present disclosure is directed to methods and uses for treating seizure disorders in a human in need thereof, wherein the methods and uses comprise conjointly administering N-[4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide (Compound A) and an antiseizure medication (ASM) to the human in amounts that are therapeutically effective when conjointly administered. The present disclosure is further directed to various improved methods of therapy and administration of Compound A.

公开(公告)号：US20220055977A1

公开(公告)日：2022-02-24

申请号：US17396283

申请日：2021-08-06

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Ivan William HEMEON ,  Brian SAFINA ,  Daniel SUTHERLIN

IPC分类号： C07C62/38 ,  C07C62/34 ,  C07C229/48 ,  C07D211/22 ,  C07C317/44 ,  C07C323/61 ,  C07C69/757 ,  A61P25/00 ,  A61P29/00 ,  A61P17/04 ,  C07C313/04

摘要： The invention provides a method of treating a disease or condition in a mammal by administering a compound having the general formula I: or a pharmaceutically acceptable salt thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein.

公开(公告)号：US20210253548A1

公开(公告)日：2021-08-19

申请号：US17152185

申请日：2021-01-19

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Chien-an CHEN ,  Sultan CHOWDHURY ,  Shannon Marie DECKER ,  Christoph Martin DEHNHARDT ,  Ivan William HEMEON ,  Steven MCKERRALL ,  Brian SAFINA ,  Tao SHENG ,  Dan SUTHERLIN

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D231/56 ,  C07D403/04 ,  C07D405/04 ,  C07D403/06 ,  C07D403/12 ,  A61P29/00

摘要： The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, n, ring A, X2, L, m, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US11091441B2

公开(公告)日：2021-08-17

申请号：US17069386

申请日：2020-10-13

申请人： Xenon Pharmaceuticals Inc.

发明人： Paul Robert Bichler ,  Jean-Jacques Alexandre Cadieux ,  Matthew David Tandy ,  Gregory N. Beatch

IPC分类号： C07D217/04

摘要： The present disclosure provides solid state forms of a selective potassium channel modulator and pharmaceutical compositions comprising the solid state crystalline forms and pharmaceutically acceptable excipients, and methods for preparing and using the solid state forms and the pharmaceutical compositions thereof.