Patent search ap:("GILEAD SCIENCES Page INC.") AND inv:"Hyung-Jung Pyun"

81.

发明授权
Substituted 1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections 有权

公开(公告)号：US09663528B2

公开(公告)日：2017-05-30

申请号：US14815504

申请日：2015-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Manoj C. Desai , Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun , James G. Taylor

IPC: A61K31/4985 , C07D241/38 , C07D487/14

CPC classification number: C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

82.

发明申请
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE 有权
Title translation: 多环碳酰亚胺基化合物及其药物用途

公开(公告)号：US20160289246A1

公开(公告)日：2016-10-06

申请号：US15089342

申请日：2016-04-01

Applicant: Gilead Sciences, Inc.

Inventor： Zhenhong R. Cai , Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun

IPC: C07D513/22 , A61K31/4985 , C07D498/22 , C07D498/16 , A61K31/5365 , C07D491/22 , A61K45/06

CPC classification number: C07D513/22 , A61K31/4375 , A61K31/4985 , A61K31/5365 , A61K45/06 , C07D491/14 , C07D491/22 , C07D498/14 , C07D498/16 , C07D498/22

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A, A′, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 包括立体异构体及其药学上可接受的盐，其中A，A'，R 1和R 2如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

83.

发明申请
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE 审中-公开
Title translation: 多环碳酰亚胺基化合物及其药物用途

公开(公告)号：US20160194335A1

公开(公告)日：2016-07-07

申请号：US14849453

申请日：2015-09-09

Applicant: Gilead Sciences, Inc.

Inventor： Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun

IPC: C07D498/04 , C07D471/18 , C07D487/18

CPC classification number: C07D498/18 , C07D471/18 , C07D471/22 , C07D487/18 , C07D498/04 , C07D498/14

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, Z2, or Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。所述化合物具有下式（I）：其包括其立体异构体和药学上可接受的盐，其中R 1，X，W，Y 1，Y 2，Z 1，Z 2或Z 4如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

84.

发明授权
Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepines and methods for treating viral infections 有权
Title translation: 取代的2,3,4,5,7,9,13,13a-八氢吡啶并[1'，2'：4,5]吡嗪并[2,1-b] [1,3]氧氮杂和治疗病毒感染的方法

公开(公告)号：US09216996B2

公开(公告)日：2015-12-22

申请号：US14133858

申请日：2013-12-19

Applicant: Gilead Sciences, Inc.

Inventor： Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun

IPC: A61K31/4985 , C07D241/38 , C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/498 , C07D471/18 , A61K45/06 , C07D498/18

CPC classification number: C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。所述化合物具有下式（I）：其包括立体异构体及其药学上可接受的盐，其中R1，X，W，Y1，Y2，Z1和Z4如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

85.

发明授权
Antiviral phosphonate analogs 有权
Title translation: 抗病毒膦酸酯类似物

公开(公告)号：US09139604B2

公开(公告)日：2015-09-22

申请号：US14309790

申请日：2014-06-19

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Maria Fardis , Haolun Jin , Ralph Hirschmann , Alan X. Huang , Choung U. Kim , Thorsten A. Kirschberg , Christopher P. Lee , William A. Lee , Richard L. Mackman , David Y. Markevitch , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie O'Shea , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang

IPC: A61K31/44 , C07F9/6561 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/48 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/40 , C07F9/572 , C07F9/58 , C07F9/60 , C07F9/6503 , C07F9/6509 , C07F9/653 , C07F9/6539 , C07F9/655 , C07F9/6553 , C07H15/00 , C07H17/00 , C07H21/00 , C07H19/056 , C07H19/10 , C07H19/20

CPC classification number: C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/58 , C07F9/60 , C07F9/65031 , C07F9/650905 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465

Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明涉及具有抗病毒活性的磷取代的化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

86.

发明申请
INHIBITORS OF HEPATITIS C VIRUS 审中-公开
Title translation: HEPATITIS C VIRUS的抑制剂

公开(公告)号：US20150175655A1

公开(公告)日：2015-06-25

申请号：US14412331

申请日：2013-07-02

Applicant: Gilead Sciences, Inc.

Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil Kumar Karki , Ashley Anne Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam James Schrier , Dustin Siegel , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel

IPC: C07K5/08 , A61K38/06 , A61K45/06

Abstract: Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract translation: 公开了式I的化合物，以及其药学上可接受的盐。还公开了使用所述化合物和含有所述化合物的药物组合物的方法。

87.

发明申请
SYK INHIBITORS 有权
Title translation: SYK抑制剂

公开(公告)号：US20150038488A1

公开(公告)日：2015-02-05

申请号：US14448160

申请日：2014-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Kevin S. Currie , Zhimin Du , Julie Farand , Juan A. Guerrero , Ashley A. Katana , Darryl Kato , Scott E. Lazerwith , Jiayao Li , John O. Link , Nicholas Mai , Gregory Notte , Hyung-Jung Pyun , Michael Sangi , Aaron C. Schmitt , Adam J. Schrier , Kirk L. Stevens , Chandrasekar Venkataramani , William J. Watkins , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel

IPC: C07D487/04 , C07D417/04 , C07D417/12 , C07D403/12 , C07D471/04 , C07D401/14

CPC classification number: C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/08 , C07D498/04 , C07D519/00

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract translation: 本公开涉及作为Syk抑制剂的化合物及其在治疗各种疾病状态（包括癌症和炎性病症）中的用途。在具体实施方案中，化合物的结构由式I给出，其中X 1，X 2，X 3，R 2，R 3，R 4，R 5和Y如本文所述。本公开进一步提供包含式I化合物或其药学上可接受的盐的药物组合物，以及使用这些化合物和组合物治疗由Syk介导的病症的方法。