公开(公告)号：US09055965B2

公开(公告)日：2015-06-16

申请号：US12729109

申请日：2010-03-22

Applicant: John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  John H. Morriss ,  Ketan P. Muni ,  Isaac J. Kim ,  Hung Ha ,  William M. Facteau ,  Amrish Jayprakash Walke

Inventor： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  John H. Morriss ,  Ketan P. Muni ,  Isaac J. Kim ,  Hung Ha ,  William M. Facteau ,  Amrish Jayprakash Walke

IPC: A61M31/00 ,  A61B17/24 ,  A61B17/3207 ,  A61M29/02 ,  A61M29/00 ,  A61B19/00 ,  A61M25/00 ,  A61M25/10

CPC classification number: A61M29/00 ,  A61B1/233 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1657 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/320016 ,  A61B17/320725 ,  A61B34/20 ,  A61B2017/00292 ,  A61B2017/246 ,  A61B2034/2051 ,  A61B2090/3764 ,  A61B2503/40 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0662 ,  A61M25/09 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/0008 ,  A61M2025/1079 ,  A61M2029/025 ,  A61M2210/0618 ,  A61M2210/1028

Abstract: Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.

公开(公告)号：US09039680B2

公开(公告)日：2015-05-26

申请号：US12107005

申请日：2008-04-21

Applicant: Joshua Makower ,  John Y. Chang ,  Julia D. Vrany ,  Amrish Jayprakash Walke

Inventor： Joshua Makower ,  John Y. Chang ,  Julia D. Vrany ,  Amrish Jayprakash Walke

IPC: A61M29/00 ,  A61M31/00 ,  A61B5/06 ,  A61B5/00 ,  A61B17/24 ,  A61M25/10 ,  A61B17/3207 ,  A61B17/34 ,  A61B19/00 ,  A61B17/22 ,  A61F2/18 ,  A61F2/82 ,  A61M25/00

CPC classification number: A61M31/002 ,  A61B5/06 ,  A61B5/064 ,  A61B5/411 ,  A61B17/24 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B34/20 ,  A61B2017/22061 ,  A61F2/18 ,  A61F2/82 ,  A61F2002/825 ,  A61F2250/0039 ,  A61M25/0029 ,  A61M25/007 ,  A61M25/10 ,  A61M2025/0037 ,  A61M2025/105 ,  A61M2025/1052

Abstract: Implantable devices and methods for delivering drugs and other substances to locations within the body of a human or animal subject to treat or diagnose sinusitis and a variety of other disorders. The invention includes implantable substance delivery devices that comprise reservoirs and barriers that control the rate at which substances pass out of the reservoirs. The delivery devices may be advanced into the body using guidewires, catheters, ports, introducers and other access apparatus. In some embodiments the delivery devices may be loaded with one or more desired substance before their introduction into the body. In other embodiments the delivery devices are loaded and/or reloaded with a desired substance after the delivery device has been introduced into the body.

Abstract translation: 用于将药物和其他物质递送到人或动物身体内的位置以进行治疗或诊断鼻窦炎和各种其他疾病的可植入装置和方法。 本发明包括可植入物质输送装置，其包括控制物质从储存器中流出的速率的储存器和屏障。 输送装置可以使用导线，导管，端口，引导器和其它存取装置进入体内。 在一些实施方案中，递送装置可以在引入体内之前装载一种或多种所需物质。 在其他实施方案中，递送装置在输送装置已经被引入体内之后被装载和/或重新加载所需物质。

公开(公告)号：US08905922B2

公开(公告)日：2014-12-09

申请号：US13429857

申请日：2012-03-26

Applicant: Joshua Makower ,  John Y. Chang

Inventor： Joshua Makower ,  John Y. Chang

IPC: A61B1/06 ,  A61B17/3205 ,  A61B17/24 ,  A61B17/34 ,  A61B17/3207 ,  A61B17/22 ,  A61F2/18 ,  A61F2/82

CPC classification number: A61B17/24 ,  A61B1/233 ,  A61B1/313 ,  A61B10/0233 ,  A61B10/06 ,  A61B17/0218 ,  A61B17/1688 ,  A61B17/29 ,  A61B17/3201 ,  A61B17/32053 ,  A61B17/32056 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B18/02 ,  A61B18/042 ,  A61B18/12 ,  A61B18/18 ,  A61B2017/00477 ,  A61B2017/22061 ,  A61B2017/320052 ,  A61B2017/320064 ,  A61B2018/00327 ,  A61B2018/00595 ,  A61B2018/0212 ,  A61B2018/1405 ,  A61B2217/005 ,  A61B2217/007 ,  A61F2/18 ,  A61F2/186 ,  A61F2/82 ,  A61F11/004 ,  A61F13/2005 ,  A61F2250/0039 ,  A61M16/0434 ,  A61M25/10 ,  A61M29/02 ,  A61M31/00 ,  A61M31/005 ,  A61N1/0541

Abstract: Sinusitis, enlarged nasal turbinates, tumors, infections, hearing disorders, allergic conditions, facial fractures and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches and, in many cases, flexible catheters as opposed to instruments having rigid shafts. Various diagnostic procedures and devices are used to perform imaging studies, mucus flow studies, air/gas flow studies, anatomic dimension studies, endoscopic studies and transillumination studies. Access and occluder devices may be used to establish fluid tight seals in the anterior or posterior nasal cavities/nasopharynx and to facilitate insertion of working devices (e.g., scopes, guidewires, catheters, tissue cutting or remodeling devices, electrosurgical devices, energy emitting devices, devices for injecting diagnostic or therapeutic agents, devices for implanting devices such as stents, substance eluting devices, substance delivery implants, etc.

Abstract translation: 使用微创方法诊断和/或治疗鼻窦炎，扩大的鼻甲，肿瘤，感染，听力障碍，过敏症状，面部骨折和其他疾病，并且在许多情况下，柔性导管与仪器相反 具有刚性轴。 使用各种诊断程序和装置进行成像研究，粘液流研究，空气/气体流动研究，解剖维度研究，内镜研究和透照研究。 可以使用进入和闭塞器装置在前鼻/鼻后鼻/鼻咽中建立流体密封，并且便于插入工作装置（例如，示波器，导丝，导管，组织切割或重塑装置，电外科装置，能量发射装置， 用于注射诊断或治疗剂的装置，用于植入装置如支架，物质洗脱装置，物质输送植入物等的装置

公开(公告)号：US08828041B2

公开(公告)日：2014-09-09

申请号：US12727190

申请日：2010-03-18

Applicant: John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  John H. Morriss ,  Ketan P. Muni ,  Isaac J. Kim ,  Hung Ha ,  William M. Facteau ,  Amrish Jayprakash Walke

Inventor： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  John H. Morriss ,  Ketan P. Muni ,  Isaac J. Kim ,  Hung Ha ,  William M. Facteau ,  Amrish Jayprakash Walke

IPC: A61M29/00

CPC classification number: A61M29/00 ,  A61B1/233 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1657 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/320016 ,  A61B17/320725 ,  A61B34/20 ,  A61B2017/00292 ,  A61B2017/246 ,  A61B2034/2051 ,  A61B2090/3764 ,  A61B2503/40 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0662 ,  A61M25/09 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/0008 ,  A61M2025/1079 ,  A61M2029/025 ,  A61M2210/0618 ,  A61M2210/1028

Abstract: Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.

Abstract translation: 使用具有柔性或刚性器械的微创方法诊断和/或治疗鼻窦炎和其他耳朵，鼻子和喉咙疾病。 各种方法和装置用于重建或改变耳朵，鼻子或喉咙中的窦口或导管或其他解剖结构的形状，尺寸或构型; 植入装置，细胞或组织; 从耳朵，鼻子或喉咙去除物质; 提供诊断或治疗物质或执行其他诊断或治疗程序。 可以使用引入装置（例如，引导导管，管，导线，细长探针，其它细长构件）来促进工作装置（例如，导管例如球囊导管，导线，组织切割或重塑装置，用于植入元件如支架的装置， 电外科装置，能量发射装置，用于递送诊断或治疗剂，物质输送植入物，范围等的装置）到耳鼻窦或耳朵，鼻子或喉咙中的其他结构中。 提供特定装置（例如，管状引导件，导丝，气囊导管，管状护套），制造和使用这种装置来治疗耳朵，鼻子或喉咙的障碍的方法。

公开(公告)号：US08764726B2

公开(公告)日：2014-07-01

申请号：US12543445

申请日：2009-08-18

Applicant: John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  John H. Morriss ,  Ketan P Muni ,  Isaac J Kim ,  Hung Ha ,  William J Facteau ,  Amrish Jayprakash Walke

Inventor： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  John H. Morriss ,  Ketan P Muni ,  Isaac J Kim ,  Hung Ha ,  William J Facteau ,  Amrish Jayprakash Walke

IPC: A61M31/00

CPC classification number: A61M29/00 ,  A61B1/233 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1657 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/320016 ,  A61B17/320725 ,  A61B34/20 ,  A61B2017/00292 ,  A61B2017/246 ,  A61B2034/2051 ,  A61B2090/3764 ,  A61B2503/40 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0662 ,  A61M25/09 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/0008 ,  A61M2025/1079 ,  A61M2029/025 ,  A61M2210/0618 ,  A61M2210/1028

Abstract: Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.

公开(公告)号：US08721591B2

公开(公告)日：2014-05-13

申请号：US13355758

申请日：2012-01-23

Applicant: John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  Amrish Jayprakash Walke

Inventor： John Y. Chang ,  Joshua Makower ,  Julia D. Vrany ,  Amrish Jayprakash Walke

IPC: A61M29/00

CPC classification number: A61M29/02 ,  A61B5/6852 ,  A61B17/24 ,  A61B17/32002 ,  A61B17/3403 ,  A61B17/3421 ,  A61B18/1492 ,  A61B2017/22039 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2018/00327 ,  A61B2018/00595 ,  A61B2034/2051 ,  A61F2/186 ,  A61F2/82 ,  A61F2/90 ,  A61F2/95 ,  A61F2/958 ,  A61M25/0026 ,  A61M25/005 ,  A61M25/0082 ,  A61M25/0102 ,  A61M25/0138 ,  A61M25/0147 ,  A61M25/09 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M2025/0177 ,  A61M2025/1072 ,  A61M2025/1079 ,  A61M2025/109 ,  A61M2029/025 ,  A61M2210/0681 ,  A61M2210/1028

Abstract: Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat.

Abstract translation: 使用具有柔性或刚性器械的微创方法诊断和/或治疗鼻窦炎和其他耳朵，鼻子和喉咙疾病。 各种方法和装置用于重建或改变耳朵，鼻子或喉咙中的窦口或导管或其他解剖结构的形状，尺寸或构型; 植入装置，细胞或组织; 从耳朵，鼻子或喉咙去除物质; 提供诊断或治疗物质或执行其他诊断或治疗程序。 可以使用引入装置（例如，引导导管，管，导线，细长探针，其它细长构件）来促进工作装置（例如，导管例如球囊导管，导线，组织切割或重塑装置，用于植入元件如支架的装置， 电外科装置，能量发射装置，用于递送诊断或治疗剂，物质输送植入物，范围等的装置）到耳鼻窦或耳朵，鼻子或喉咙中的其他结构中。

公开(公告)号：US08672920B2

公开(公告)日：2014-03-18

申请号：US11927888

申请日：2007-10-30

Applicant: Joshua Makower ,  Theodore Lamson ,  J. Christopher Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

Inventor： Joshua Makower ,  Theodore Lamson ,  J. Christopher Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

IPC: A61M31/00

CPC classification number: A61M25/0108 ,  A61B6/12 ,  A61M5/007 ,  A61M25/0084 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2210/12

Abstract: Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessel lumens. A penetrating catheter is inserted into a blood vessel lumen and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the delivery catheter may remain in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member may be advanced into a vein or venule and used to occlude the lumen of the vein or venule during and after injection of a substance such that the substance will not be carried away by normal venous blood flow.

Abstract translation: 用于将物质或设备运送到位于血管内腔外的靶位置的方法和装置。 将穿透性导管插入血管内腔中，并且穿透器沿导向器朝向目标部位的方向前进。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，输送导管可以保持在适当位置以便从目标部位慢慢或连续地输送物质到和/或获得信息或样品。 或者，具有闭塞构件的输送导管可以推入静脉或小静脉中，并用于在注射物质期间和之后闭塞静脉或小静脉的内腔，使得物质不会被正常的静脉血流带走。

公开(公告)号：US08603106B2

公开(公告)日：2013-12-10

申请号：US12791805

申请日：2010-06-01

Applicant: Joseph Catanese, III ,  Matthew McLean ,  Theodore C. Lamson ,  Amik Nagpurkar ,  Daniel Merrick ,  Joshua Makower ,  Claude Vidal ,  Russell J. Redmond ,  Michael Collinson ,  Mitchell C. Barham ,  Scott West

Inventor： Joseph Catanese, III ,  Matthew McLean ,  Theodore C. Lamson ,  Amik Nagpurkar ,  Daniel Merrick ,  Joshua Makower ,  Claude Vidal ,  Russell J. Redmond ,  Michael Collinson ,  Mitchell C. Barham ,  Scott West

IPC: A61B17/10

CPC classification number: A61B17/0401 ,  A61B17/00234 ,  A61B17/0218 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/0625 ,  A61B17/10 ,  A61B17/32 ,  A61B17/3468 ,  A61B17/3478 ,  A61B17/42 ,  A61B2017/00022 ,  A61B2017/00274 ,  A61B2017/0046 ,  A61B2017/00792 ,  A61B2017/00796 ,  A61B2017/00805 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/045 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/06052 ,  A61B2017/06176 ,  A61B2017/0688 ,  A61B2018/00547 ,  A61F2/0022 ,  A61F2/0045 ,  A61F2/0063

Abstract: Integrated systems and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device configured to deploy and implant anchor devices for such purposes.

Abstract translation: 用于在医疗应用中操纵组织和解剖结构或其他结构以用于治疗疾病或障碍或其它目的的综合系统和相关方法。 在一个方面，该系统包括被配置为部署和植入用于这些目的的锚定装置的输送装置。

公开(公告)号：US08556925B2

公开(公告)日：2013-10-15

申请号：US11974444

申请日：2007-10-11

Applicant: Joshua Makower ,  Theodore M. Bender ,  Brian K. Shiu ,  Pablo G. Acosta ,  Shuji Uemura ,  Josef L. Friedmann ,  Crystine Lee

Inventor： Joshua Makower ,  Theodore M. Bender ,  Brian K. Shiu ,  Pablo G. Acosta ,  Shuji Uemura ,  Josef L. Friedmann ,  Crystine Lee

IPC: A61M29/00

CPC classification number: A61F5/0073

Abstract: Implantable devices, methods of implantation and tools for performing the implantations. A device includes a volume occupying member having a working configuration such that, when the device is implanted into the abdominal cavity of the patient, the device performs at least one of: prevention of expansion of the stomach of the patient into a space occupied by the volume occupying member in the abdominal cavity; and compression of a portion of the stomach. A device is configured to have substantially neutral buoyancy or a slightly positive buoyancy when implanted in the abdominal cavity external of the stomach. An attachment member is connected to the volume occupying member, and at least a portion of the attachment member is configured to encourage tissue ingrowth from at least one internal abdominal structure when held in contact therewith.

公开(公告)号：US20130211489A1

公开(公告)日：2013-08-15

申请号：US13578555

申请日：2011-02-08

Applicant: Joshua Makower ,  Earl A. Bright, II ,  Theodore M. Bender ,  Joseph Cantanese, III ,  John Y. Chang ,  Thomas King ,  Clinton Slone ,  Theodore C. Lamson ,  Aziz Imraan

Inventor： Joshua Makower ,  Earl A. Bright, II ,  Theodore M. Bender ,  Joseph Cantanese, III ,  John Y. Chang ,  Thomas King ,  Clinton Slone ,  Theodore C. Lamson ,  Aziz Imraan

IPC: A61F2/06

CPC classification number: A61F2/06 ,  A61F2/885 ,  A61F2/89 ,  A61F2/915 ,  A61F2002/825 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0054

Abstract: Methods and devices for relieving stenoses in, or otherwise improving blood flow through, body lumens. Although applicable in a variety of different body lumens, the methods and devices of this invention are specifically useable for relieving stenoses in, or otherwise improving blood flow through, veins which drain blood from the brain for treatment of multiple sclerosis or other neurodegenerative disorders that are caused, triggered or exacerbated by venous occlusion or venous insufficiency.

Abstract translation: 用于减轻体液流经或以其他方式改善身体流明的血流的方法和装置。 尽管适用于各种不同的体腔，本发明的方法和装置特别可用于缓解静脉中的狭窄或改善通过静脉的血液，所述静脉排出来自脑的血液用于治疗多发性硬化症或其它神经变性疾病 导致，触发或加重静脉闭塞或静脉功能不全。