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公开(公告)号：US20020045629A1
公开(公告)日：2002-04-18
申请号：US09855228
申请日：2001-05-15
Inventor： Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Jeffry L. Vaught
IPC: A61K031/505 , C07D239/02
CPC classification number: C07D495/04 , C07C317/44 , C07C323/60 , C07C2603/18 , C07D207/16 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06
Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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82.发明授权Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands 失效融合的三环杂芳族衍生物作为多巴胺受体亚型配体
公开(公告)号：US6080745A
公开(公告)日：2000-06-27
申请号：US617895
申请日：1996-03-12
Applicant: William Barnaby Davey , Paul David Leeson , Michael Rowley
Inventor： William Barnaby Davey , Paul David Leeson , Michael Rowley
IPC: A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/495 , A61K31/496 , A61P25/00 , A61P25/18 , A61P43/00 , C07D231/54 , C07D239/70 , C07D261/14 , C07D261/20 , C07D401/04 , C07D405/14 , C07D413/04 , C07D471/04 , C07D495/04 , C07D495/14 , A61K31/42 , A61K31/415
CPC classification number: C07D471/04 , C07D231/54 , C07D239/70 , C07D261/20 , C07D495/04
Abstract: A class of fused tricyclic heteroaromatic compounds of formula (I) as defined in claim 1 or a salt thereof or a prodrug thereof, containing a fused pyrazole, oxazole or pyrimidine ring are ligands for dopamine receptor subtypes within the body and are therefore of use in the treatment and/or prevention of disorders of the dopamine system, such as schizophrenia.
Abstract translation: PCT No.PCT / GB94 / 01936 Sec。 371日期：1996年3月12日 102（e）1996年3月12日PCT PCT 1994年9月6日PCT公布。 WO95 / 07893 PCT出版物 日期：1995年3月23日如权利要求1所定义的式（I）的稠合三环杂芳族化合物或其盐或其前药，包含稠合的吡唑，恶唑或嘧啶环，是体内多巴胺受体亚型的配体， 因此可用于治疗和/或预防多巴胺系统疾病如精神分裂症。
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83.发明授权Substituted pyrazolyl benzenesulfonamides for the treatment of gastrointestinal conditions 失效取代的吡唑基苯磺酰胺用于治疗胃肠道疾病
公开(公告)号：US5753688A
公开(公告)日：1998-05-19
申请号：US534757
申请日：1995-09-27
Applicant: John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
Inventor： John J. Talley , Thomas D. Penning , Paul W. Collins , Donald J. Rogier, Jr. , James W. Malecha , Julie M. Miyashiro , Stephen R. Bertenshaw , Ish K. Khanna , Matthew J. Graneto , Roland S. Rogers , Jeffery S. Carter
IPC: A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/505 , A61K31/506 , A61P5/14 , A61P9/00 , A61P19/02 , A61P25/04 , A61P25/06 , A61P29/00 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D495/04 , A61K31/63
CPC classification number: C07D495/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
Abstract translation: 描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I定义：其中（I）或其药学上可接受的盐。
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84.发明授权
公开(公告)号：US5744493A
公开(公告)日：1998-04-28
申请号：US775150
申请日：1996-12-31
Applicant: Robert Boigegrain , Danielle Gully , Francis Jeanjean , Jean-Charles Molimard
Inventor： Robert Boigegrain , Danielle Gully , Francis Jeanjean , Jean-Charles Molimard
IPC: A61K31/415 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P1/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/18 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04 , C07D453/02 , C07D453/06 , C07D495/04
CPC classification number: C07D403/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/06 , Y02P20/55
Abstract: The present invention relates to new pyrazole derivatives possessing an amide group substituted with an amino acid or one of its derivatives at position 3 and variously substituted in positions 1, 2, 4 or 5 of the pyrazole ring, to a process for preparing these and to pharmaceutical compositions containing the said pyrazole derivatives as an active ingredient.
Abstract translation: 本发明涉及具有酰胺基的新的吡唑衍生物，其被取代为吡唑环的氨基酸或其位置3的衍生物，或其取代的吡唑环的第1,2,4或5位，其制备方法和 含有所述吡唑衍生物作为活性成分的药物组合物。
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公开(公告)号：US5612356A
公开(公告)日：1997-03-18
申请号：US295636
申请日：1995-04-25
Applicant: Hiroyuki Yoshimura , Mitsuo Nagai , Shigeki Hibi , Koichi Kikuchi , Ieharu Hishinuma , Junichi Nagakawa , Makoto Asada , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Isao Yamatsu
Inventor： Hiroyuki Yoshimura , Mitsuo Nagai , Shigeki Hibi , Koichi Kikuchi , Ieharu Hishinuma , Junichi Nagakawa , Makoto Asada , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Isao Yamatsu
IPC: C07D335/08 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/403 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/47 , A61K31/473 , A61P1/16 , A61P5/12 , A61P17/00 , A61P17/14 , A61P19/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C69/76 , C07C211/31 , C07D209/56 , C07D209/58 , C07D215/04 , C07D221/06 , C07D221/16 , C07D221/18 , C07D231/54 , C07D235/02 , C07D261/20 , C07D277/60 , C07D307/77 , C07D307/92 , C07D311/92 , C07D333/38 , C07D333/50 , C07D335/06 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC classification number: C07D495/04 , C07D209/56 , C07D221/18 , C07D231/54 , C07D277/60 , C07D307/77 , C07D311/92 , C07D333/38 , C07D333/50 , C07D335/08 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D417/04 , C07D491/04
Abstract: A heterocycle-containing carbonic acid derivative represented by the following general formula (I): ##STR1## or a physiologically acceptable salt thereof which exhibits an excellent preventive and therapeutic effect against various diseases, and an intermediate which is useful for the production of the heterocycle-containing carbonic acid derivative.
Abstract translation: PCT No.PCT / JP93 / 01841 Sec。 371日期1995年04月25日 102（e）日期1995年4月25日PCT提交1993年12月20日PCT公布。 公开号WO94 / 14777 日期：1994年7月7日由以下通式（I）表示的含杂环的碳酸衍生物：对各种疾病具有优异的预防和治疗作用的中间体 可用于制备含杂环的碳酸衍生物。
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Patent Agency Ranking
公开(公告)号：US5591764A
公开(公告)日：1997-01-07
申请号：US468394
申请日：1995-06-06
Applicant: Mohamed A. H. Fahmy, deceased , Charles R. Harrison , George P. Lahm , Thomas M. Stevenson
Inventor： Mohamed A. H. Fahmy, deceased , Charles R. Harrison , George P. Lahm , Thomas M. Stevenson
IPC: A01N47/38 , C07D231/06 , C07D231/54 , A01N43/56
CPC classification number: C07D231/06 , A01N47/38 , C07D231/54
Abstract: N-sulfenylated and N-acylated pyrazoline arthropodicides, compositions containing them and methods for controlling arthropods by applying compounds of the invention to them or to their environment. The pyrazolines are selected from those of Formulae I to III wherein R.sub.1, R.sub.2, R.sub.3, Q, A, B, J, K, Y, m, n and p are as defined in the text: ##STR1##
Abstract translation: N-亚磺酰化和N-酰化的吡唑啉节肢动物杀虫剂，含有它们的组合物和通过将本发明的化合物施用于它们或其环境来控制节肢动物的方法。 吡唑啉选自式I至III的那些，其中R 1，R 2，R 3，Q，A，B，J，K，Y，m，n和p如文中所定义：
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87.发明授权
公开(公告)号：US5521207A
公开(公告)日：1996-05-28
申请号：US223629
申请日：1994-04-06
Applicant: Matthew J. Graneto
Inventor： Matthew J. Graneto
IPC: A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04 , A61K43/56
CPC classification number: C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1##
Abstract translation: 描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I定义：（I）
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88.发明授权Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole intermediate compounds 失效四氢吲唑，四氢环戊吡唑和六氢环庚吡唑中间体化合物
公开(公告)号：US5387693A
公开(公告)日：1995-02-07
申请号：US176391
申请日：1993-12-30
Applicant: Peter J. Connolly , Michael P. Wachter
Inventor： Peter J. Connolly , Michael P. Wachter
IPC: C07D231/54 , C07D231/56
CPC classification number: C07D231/56 , C07D231/54
Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
Abstract translation: 公开了通式I：IMA的化合物可用于治疗或预防高胆固醇血症，高脂蛋白血症和动脉粥样硬化。 还公开了用于制备式I化合物的新型中间体化合物。
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89.发明授权Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds 失效四氢吲唑，四氢环吡唑和六氢环庚吡唑类化合物
公开(公告)号：US5315012A
公开(公告)日：1994-05-24
申请号：US98536
申请日：1993-09-09
Applicant: Peter J. Connolly , Michael P. Wachter
Inventor： Peter J. Connolly , Michael P. Wachter
IPC: A61K31/415 , A61K31/416 , A61P3/06 , A61P9/10 , A61P31/00 , A61P43/00 , C07D231/54 , C07D231/56 , C07D405/06 , C12N9/99
CPC classification number: C07D231/56 , C07D231/54
Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
Abstract translation: 公开了通式I：IMA的化合物可用于治疗或预防高胆固醇血症，高脂蛋白血症和动脉粥样硬化。 还公开了用于制备式I化合物的新型中间体化合物。
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90.发明授权Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors 失效四氢吲唑，四氢环吡唑和六氢环庚吡唑化合物及其作为HMG-COA还原酶抑制剂的用途
公开(公告)号：US5250561A
公开(公告)日：1993-10-05
申请号：US886569
申请日：1992-05-20
Applicant: Peter J. Connolly , Michael P. Wachter
Inventor： Peter J. Connolly , Michael P. Wachter
IPC: C07D231/54 , C07D231/56 , A61K31/415 , C07D405/06
CPC classification number: C07D231/56 , C07D231/54
Abstract: Compounds of the general formula I: ##STR1## are disclosed as useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis. Novel intermediate compounds used to make the compound of formula I are also disclosed.
Abstract translation: 公开了通式I：IMA的化合物可用于治疗或预防高胆固醇血症，高脂蛋白血症和动脉粥样硬化。 还公开了用于制备式I化合物的新型中间体化合物。
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