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    System and method for quantitative or qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy
    81.
    发明申请
    System and method for quantitative or qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy 有权
    使用激光诱导荧光光谱法定量或定性测量组织和其他材料中外源物质的系统和方法

    公开(公告)号：US20040199079A1

    公开(公告)日：2004-10-07

    申请号：US10407848

    申请日：2003-04-03

    Applicant: The Regents of the University of California ,  The University of Southern California

    Inventor： Roy S. Chuck ,  Peter J. McDonnell ,  Ramez Emile Necola Shehada

    IPC: A61B006/00

    CPC classification number: A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/411 ,  A61B5/441 ,  A61B5/7267 ,  G01J3/4406 ,  G01N21/64 ,  G01N21/6402 ,  G01N21/6408 ,  G01N21/645 ,  G01N21/718 ,  G01N2021/1782 ,  G01N2021/6417 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0697 ,  G01N2201/1296

    Abstract: Methods and systems for the quantitative and qualitative determination of one or more exogenous substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thin layer (e.g. null0.3-nullm) of the material using photochemical decomposition. Simultaneously, the laser energy induces the fluorescence of the substance(s) of interest within the ablated layer of the material. The fluorescence emitted by the substance(s) of interest is then received by a device (e.g., a spectrometer), which measures the spectrum (i.e. intensity versus wavelength) of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device (e.g., a microprocessor or computer) which is programmed or otherwise adapted to determine, on the basis of the fluorescence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.

    Abstract translation: 描述了用于定量和定性测定材料内的一种或多种外源物质的方法和系统。 荧光激发/消融能量（例如，激光脉冲，优选在紫外区域（例如193nm））的流动被引导到材料上以消融薄层（例如≈0.3μm） 材料使用光化学分解。 同时，激光能量在材料的烧蚀层内感应感兴趣的物质的荧光。 由感兴趣的物质发射的荧光然后由测量接收的荧光的光谱（即强度对波长）的装置（例如，光谱仪）接收。 然后将荧光光谱传输到频谱处理装置（例如，微处理器或计算机），该处理装置被编程或以其他方式适应于基于荧光光谱来确定目的物质是否存在于 材料和/或感兴趣物质存在于材料中的浓度。 可以针对材料的每层重复该过程以确定材料中感兴趣的物质的浓度梯度。

    Combination reader
    82.
    发明申请
    Combination reader 有权
    组合阅读器

    公开(公告)号：US20040178370A1

    公开(公告)日：2004-09-16

    申请号：US10384995

    申请日：2003-03-10

    Inventor： Mark F. Oldham ,  Howard G. King ,  Douwe D. Haga ,  Tracy L. Ferea

    IPC: G01V008/00 ,  G01N021/86

    CPC classification number: G01N21/76 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0633 ,  G01N2201/0634

    Abstract: An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus includes a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light illuminates the illumination region. Additionally, the apparatus includes an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal has wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.

    Abstract translation: 一种用于对与样本瓦片相关联的多个特征的阵列进行成像的装置。 该装置包括在照明区域中支撑样品瓦的台，以及具有适于发光的多个LED的照明源。 至少一部分光照射照明区域。 另外，该装置包括图像采集装置，适于在照明源照射照明区域时选择性地收集第一信号的图像，或者不存在照明区域的照明的第二信号。 第一信号具有与照亮照明区域的由LED发射的光的部分的波长有效不同的波长。

    Inspection method and inspection device
    83.
    发明授权
    Inspection method and inspection device 有权
    检验方法和检验装置

    公开(公告)号：US06184977B2

    公开(公告)日：2001-02-06

    申请号：US09280990

    申请日：1999-03-30

    Applicant: Futoshi Ishida

    Inventor： Futoshi Ishida

    IPC: G01N2188

    CPC classification number: G01N21/958 ,  G01N21/94 ,  G01N2201/0633

    Abstract: An method and device for inspecting for surface defects, internal defects, and surface-adhered foreign matter on semitransparent materials. An illuminating device transmits light, that is then collimated through a collimating lens unit, through an object to be inspected. The light then transmits through the object to be inspected an eventually is detected by a detector. Any defects in the object to be inspected will be detected.

    Abstract translation: 用于检查半透明材料表面缺陷，内部缺陷和表面附着异物的方法和装置。 照明装置将通过准直透镜单元准直的光透过待检查物体。 然后，光通过待检查物体传输，最终由检测器检测。 将检测到待检查对象中的任何缺陷。

    Apparatus for filtering a laser beam in an analytical instrument
    84.
    发明授权
    Apparatus for filtering a laser beam in an analytical instrument 失效
    用于在分析仪器中过滤激光束的装置

    公开(公告)号：US5719667A

    公开(公告)日：1998-02-17

    申请号：US692931

    申请日：1996-07-30

    Applicant: David R. Miers

    Inventor： David R. Miers

    IPC: G01N15/14 ,  G01N21/00

    CPC classification number: G01N15/1436 ,  G01N15/1459 ,  G01N2015/1447 ,  G01N2201/0633

    Abstract: An optical illuminator assembly for an analytical instrument, such as a clinical hematology or a flow cytometer instrument, including a laser diode having a diverging laser beam output, a collimating lens to collimate the diverging laser beam, a spatial filter operating on the collimated laser beam to spatially filter the beam, and a focussing lens to focus the spatially filtered beam into a flow cell containing particles suspended in a moving stream. A beam shaping aperture is preferably inserted between the spatial filter and the focussing lens to shape the laser beam. The spatial filter preferably includes an objective lens, a collimating lens, and a filter aperture interposed between the objective and imaging lenses. The filter aperture is preferably rectangular, having a height to width ratio in the range of 1:2 to 1:3 such that each dimension is on the order of tens of micrometers. The beam shaping aperture is preferably a rectangular aperture having a height to width ratio in a range of from 3:1 to 5:1 such that each dimension is on the order of hundreds of micrometers.

    Abstract translation: 用于分析仪器的光学照明器组件，例如临床血液学或流式细胞仪器，包括具有发散激光束输出的激光二极管，准直发散激光束的准直透镜，在准直激光束上操作的空间滤光器 空间上过滤光束，以及聚焦透镜将空间过滤的光束聚焦到包含悬浮在移动流中的颗粒的流动池中。 光束整形孔优选地插入在空间滤光器和聚焦透镜之间以使激光束成形。 空间滤波器优选地包括物镜，准直透镜和介于物镜和成像透镜之间的滤光器孔。 过滤器孔径优选是矩形的，其高度与宽度之比在1:2至1:3的范围内，使得每个尺寸在几十微米的量级上。 光束成形孔优选地是具有在3:1至5:1范围内的高宽比的矩形孔，使得每个尺寸都在数百微米级。

    Integrated cat's-eye tunable laser spectroscopy system and method
    87.
    发明公开
    Integrated cat's-eye tunable laser spectroscopy system and method 审中-公开

    公开(公告)号：US20240019363A1

    公开(公告)日：2024-01-18

    申请号：US18221138

    申请日：2023-07-12

    Applicant: KineoLabs

    Inventor： Walid A. Atia ,  Dale C. Flanders

    IPC: G01N21/39

    CPC classification number: G01N21/39 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636

    Abstract: A spectroscopy system comprises a tunable laser including a gain chip, a collimating lens for collimating light from the gain chip, an end reflector, a focusing lens for focusing the collimated light on the end reflector, a thin film bandpass filter between the collimating lens and the focusing lens, and an angle control actuator for changing the angle of the thin film filter to the collimated light. The light from the laser is coupled into a sample cell providing a sample. An amplitude detector detects light from the tunable laser prior to passing into the sample cell and a sample detector detecting light from the tunable laser after passing through the sample cell. A processor controls the angle control actuator and monitors a time response of the sample detector and the amplitude detector to resolve an absorption spectra of the sample.

    INSPECTION APPARATUS AND INSPECTION METHOD
    88.
    发明公开
    INSPECTION APPARATUS AND INSPECTION METHOD 审中-公开

    公开(公告)号：US20240011915A1

    公开(公告)日：2024-01-11

    申请号：US18323698

    申请日：2023-05-25

    Applicant: SEMES CO., LTD.

    Inventor： Hark Ryong KIM

    IPC: G01N21/88 ,  G01N21/95

    CPC classification number: G01N21/8806 ,  G01N21/9501 ,  G01N2021/8835 ,  G01N2201/025 ,  G01N2201/0633 ,  G01N2201/0638 ,  G01N2201/0668 ,  G01N2201/0636

    Abstract: The present invention relates to an inspection apparatus and an inspection method which selectively adjust a numerical aperture of illuminating light in the form of collimated light when inspecting a target object, such as a wafer or the like, using a spectrum, thereby preventing a diffraction phenomenon caused by the illuminating light. The inspection apparatus may include: a camera unit disposed above a target object; an illumination unit configured to illuminate the target object with illuminating light; and a light detection unit configured to detect reflection light of the target object illuminated with the illuminating light, wherein the illumination unit comprises a numerical aperture adjustment device which has a first optical member having a first numerical aperture that is replaceable with a second optical member having a second numerical aperture different from the first numerical aperture so as to reduce a diffraction phenomenon caused by the illuminating light.

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