摘要:
The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.
摘要:
A device for monitoring the boron content of the borophosphosilicate, BPSG. The BPSG is obtained by the oxidation of silane, of diborane and of phosphine in a reactor, starting with a first, diborane/silane gas mixture and a second, phosphine/silane gas mixture by monitoring the ratio .rho.=diborane/(diborane+silane) of the mixture resulting from the mixing of the first and second gas mixtures. Monitoring of the boron content is obtained by measuring the density of the first mixture, determining the amount of residual hydrogen in the first mixture and modulating the mass flow rate of the first mixture in response to the calculated ratio .rho..
摘要:
A method and apparatus for measuring particulates in a combustion gas is accomplished by dividing the combustion gas into a first and second sample gas. The first sample gas is filtered to remove particulates to create a reference gas sample. A combustion furnace can heat both the reference gas sample and the sample gas to oxidize any particulates in the sample gas. A gas analyzer that is connected to the furnace can detect the gas components in, respectively, the reference gas sample and the sample gas, and a comparison of the detected results can determine the concentration of particulates.
摘要:
A method and an apparatus for measuring the concentration values of constituents of urine collected in a toilet bowl. A conduit extends from the urine-collecting portion of the bowl to a concentration-measuring device. A gas injector is mounted beside the conduit to intermittently inject gas into the conduit, for dividing the urine contained in the conduit into aliquots. The concentration values of urinary constituents of each aliquot are measured.
摘要:
Apparatus and method for the separation of immiscible liquids are provided, and comprise the use of separator means having a surface which is preferentially "wettable" by one of the liquids to the substantial exclusion of another of the liquids. In use, the liquids are flowed from a common liquid source onto said surface with the one liquid being sorbed thereby to the substantial exclusion of the other liquid to thus substantially separate the liquids. The separator means surface may be maintained essentially level to retain the substantially separated liquid thereon, or may be inclined to result in the flow of the same therefrom under the influence of the force of gravity. Alternatively, the separator means may be made of a liquid-permeable material to permit the flow of the substantially separated liquid therethrough and therefrom under the influence of the force of gravity. The apparatus and method are particularly adapted to the substantial separation of aqueous sample liquids from hydrophobic isolation liquids which encapsulate the same; and are readily combinable with a sample liquid reaction device to effectively combine the sample liquid separation and reaction operations. The material of the separator means may be inherently hydrophobic, or may be rendered super-hydrophobic by the surface coating thereof with a super-hydrophobic coating material.
摘要:
Automatic dilution apparatus and method are provided, and are operable in conjunction with automated sample liquid analysis systems to automatically dilute sample liquids as supplied thereby to automated sample liquid analysis apparatus. One embodiment of the dilution apparatus operates to dilute the sample liquids by flowing the sample liquids from the analysis system sample liquid supply conduit, diluting the same, and returning the diluted sample liquids to the supply conduit for flow therethrough to the sample analysis apparatus for sample liquid analysis. Flow of undiluted sample liquids through the supply conduit is prevented attendant operation of the dilution apparatus. A second embodiment of the dilution apparatus operates to remove predetermined volumes of the sample liquids from the supply conduit, and to replace the same with like volumes of a diluent liquid; thereby diluting the sample liquids in the supply conduit for continued flow to the sample liquid analysis apparatus. Both embodiments of the dilution apparatus are operable on demand; and the second apparatus embodiment is additionally operable to dilute the sample liquids to a varying degree throughout a predetermined dilution range.
摘要:
A continuous flow analyzer of the type which introduces continuously a carrier liquid into a single tubular conduit to form a stable main carrier stream and injects predetermined volumes of reagent liquid and sample liquid in series into the main carrier stream. The analyzer reduces the consumption of the reagent and can form a stable continuous flow.
摘要:
An analyzing apparatus for the analysis of liquid samples is provided with a single sample input unit and a serial sample input unit which may alternatively be connected to a joint evaluation unit by means of a change-over switch. This will permit the measurement of single samples during a serial sample run by interrupting the automated process, additional provisions ensuring an automatic return to the serial sample mode.
摘要:
A sample analyzing system features a number of discrete sample segments continuously conveyed along a conduit. Each sample segment receives a precise aliquot of one or more reagents on a selective basis, and in any particular sequence. Selective injection of the reagent into the moving stream of sample segments allows for an increase in the efficiency and throughput of the sample processing.
摘要:
An automated method for the determination of uric acid in biological fluids utilizing a benzidine or diphenyline and peroxidase as the color indicator.