-
公开(公告)号：US10392356B2
公开(公告)日：2019-08-27
申请号：US15615408
申请日：2017-06-06
IPC分类号： C07D295/088 , C07D205/04 , C07D207/08 , C07D211/22 , C07D211/42 , C07D211/44 , C07D233/64 , C07D309/10 , C07C219/06 , C07C229/36 , C07C235/06 , C07C237/08 , C07C69/736 , C07H13/04 , A61P25/00
摘要： Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
-
公开(公告)号：US20190194120A1
公开(公告)日：2019-06-27
申请号：US15762559
申请日：2016-09-22
申请人： XW LABORATORIES INC.
发明人： Jia-Ning Xiang , Xuesong Xu , Xuan Zhang
IPC分类号： C07C69/78 , C07D207/16 , C07C255/57 , C07C69/618 , C07C69/612 , C07C69/22 , C07C69/74 , C07C317/14 , C07D213/80 , C07D277/30 , C07D307/68 , C07D333/38 , C07C229/08 , C07C229/34 , C07C233/47 , C07D207/12 , C07D317/64 , C07D309/12 , C07D211/44 , C07C69/34 , C07C69/96 , C07D213/79 , C07C271/22 , C07C271/34
CPC分类号： C07C69/78 , C07B59/001 , C07C69/22 , C07C69/24 , C07C69/28 , C07C69/34 , C07C69/608 , C07C69/612 , C07C69/618 , C07C69/738 , C07C69/74 , C07C69/76 , C07C69/96 , C07C229/08 , C07C229/34 , C07C229/36 , C07C233/47 , C07C255/57 , C07C271/22 , C07C271/34 , C07C317/14 , C07C317/44 , C07C2601/06 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D207/12 , C07D207/16 , C07D211/44 , C07D211/46 , C07D213/79 , C07D213/80 , C07D277/30 , C07D277/56 , C07D307/68 , C07D309/12 , C07D317/64 , C07D333/38
摘要： The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
-
公开(公告)号：US20190152929A1
公开(公告)日：2019-05-23
申请号：US16138374
申请日：2018-09-21
发明人： Teruhiko ISHIKAWA , Morita IWAMI
IPC分类号： C07D261/04 , C07B33/00 , C07D211/74 , C07D211/46 , C07D211/44 , C07D498/04 , C07C225/06 , C07C271/18
摘要： Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.
-
公开(公告)号：US20190152913A1
公开(公告)日：2019-05-23
申请号：US16257591
申请日：2019-01-25
申请人： 89BIO LTD
发明人： Nadine C. Becknell , Reddeppa Reddy Dandu , Bruce D. Dorsey , Dimitar B. Gotchev , Robert L. Hudkins , Linda Weinberg , Craig A. Zificsak , Allison L. Zulli
IPC分类号： C07D211/44 , C07D495/04 , C07D401/14 , C07D211/54 , C07D211/58 , C07D401/04 , C07D495/02 , C07D491/048 , C07D471/08 , C07D471/04 , C07D471/02 , C07D417/14 , C07D417/12 , C07D409/14 , C07D405/12 , C07D405/06 , C07D401/12 , C07D413/14 , C07D405/14 , C07D409/12
摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.
-
85.发明申请公开(公告)号：US20190119202A1
公开(公告)日：2019-04-25
申请号：US16115028
申请日：2018-08-28
发明人： Eric Anderson , Xin Jiang , Melean Visnick
IPC分类号： C07C255/47 , C07D487/08 , C07D295/195 , C07D211/44 , C07D231/12 , C07C311/07 , C07D209/56 , C07J63/00 , C07D307/20 , C07D261/08 , C07C311/09 , C07C275/26 , C07C271/24
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
-
公开(公告)号：US20190023667A1
公开(公告)日：2019-01-24
申请号：US16138303
申请日：2018-09-21
发明人： Teruhiko ISHIKAWA , Morita IWAMI
IPC分类号： C07D261/04 , C07D211/74 , C07D211/46 , C07B33/00 , C07D211/44 , C07C225/06 , C07C271/18 , C07D498/04
摘要： Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.
-
公开(公告)号：US20180370916A1
公开(公告)日：2018-12-27
申请号：US16072482
申请日：2017-01-27
发明人： Shinnosuke Hayashi , Martial Vallet , Shinya Yokosaka , Kazuya Osumi , Takumi Aoki , Hiroyuki Meguro , Mie Kaino , Kozue Takagaki , Takehiro Takahashi
IPC分类号： C07D211/60 , C07D211/96 , C07D211/44 , C07D401/06 , C07D405/06 , C07D413/06 , A61P17/06 , A61P25/00 , A61P37/06
CPC分类号： C07D211/60 , A61K31/451 , A61K31/454 , A61P17/06 , A61P25/00 , A61P37/06 , C07D211/36 , C07D211/38 , C07D211/44 , C07D211/96 , C07D401/06 , C07D405/06 , C07D413/06
摘要： A compound has retinoid-related orphan receptor γ antagonist activity and shows a therapeutic effect or a preventive effect on autoimmune diseases such as multiple sclerosis or psoriasis or allergic diseases, including allergic dermatitis or the like, such as contact dermatitis or atopic dermatitis. The cyclic amine derivative is represented by the formula or a pharmacologically acceptable salt thereof.
-
88.发明申请公开(公告)号：US20180273474A1
公开(公告)日：2018-09-27
申请号：US15995813
申请日：2018-06-01
发明人： Robert Boyd , Gary Lee , Philip J. Rybczynski
IPC分类号： C07D211/46 , A61K31/445 , A61K31/191 , C07D211/44 , A61K31/451 , C07D211/96 , C07D211/60 , A61K45/06
摘要： The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the central nervous system. In particular, the present invention provides methods for preventing and/or treating Parkinson's disease.
-
公开(公告)号：US10059655B2
公开(公告)日：2018-08-28
申请号：US15104736
申请日：2014-12-17
申请人： Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
发明人： Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
IPC分类号： C07C229/12 , C07C229/38 , C07D205/04 , C07D265/30 , C07D207/12 , C07D207/16 , C07D211/22 , C07D295/088 , C07D211/46 , C07D211/60 , C07D211/62 , C07D295/15 , C07C271/20 , C07C219/04 , A61K47/18 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/713 , A61K39/39 , C07C271/22 , C07D211/06 , C07D211/34 , C07D211/44
CPC分类号： C07C229/12 , A61K9/1272 , A61K9/5123 , A61K31/7105 , A61K31/713 , A61K39/12 , A61K39/39 , A61K47/18 , A61K2039/53 , A61K2039/55555 , C07C219/04 , C07C229/38 , C07C271/20 , C07C271/22 , C07D205/04 , C07D207/12 , C07D207/16 , C07D211/06 , C07D211/22 , C07D211/34 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D265/30 , C07D295/088 , C07D295/15 , C12N2760/18534
摘要： This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, n and p are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
-
公开(公告)号：US09809602B2
公开(公告)日：2017-11-07
申请号：US15304612
申请日：2015-04-17
发明人： Marc P. Windisch , Hee-Young Kim , Jaewon Yang , Jong Yeon Hwang , Suyeon Jo , Jeongjin Kwon , Dongsik Park , Jihyun Choi , Jaeheon Lee
IPC分类号： C07D495/04 , A61K45/06 , A61K31/4365 , C07D333/68 , C07D211/44 , C07D295/12 , C07D211/58 , C07D409/14 , C07D401/04 , C07D407/12 , C07D211/14 , C07D487/04 , C07D401/06 , C07D401/12 , C07D409/12
CPC分类号： C07D495/04 , A61K31/4365 , A61K45/06 , C07D211/14 , C07D211/44 , C07D211/58 , C07D295/12 , C07D333/68 , C07D401/04 , C07D401/06 , C07D401/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D487/04
摘要： The present invention relates to small molecule compounds and their use in the treatment of diseases, in particular viral diseases, in particular hepatitis C virus (HCV).
-
-
-
-
-
-
-
-
-
搜索结果
409 条记录 (耗时 0.035 秒)
