Composite microneedle array including nanostructures thereon

    公开(公告)号:US10029084B2

    公开(公告)日:2018-07-24

    申请号:US15382774

    申请日:2016-12-19

    摘要: Composite microneedle arrays including microneedles and a film overlaying the microneedles are provided. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Devices may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component.

    Imprint apparatus, and method of manufacturing article

    公开(公告)号:US09927700B2

    公开(公告)日:2018-03-27

    申请号:US14491014

    申请日:2014-09-19

    发明人: Yosuke Murakami

    IPC分类号: B29C59/00 G03F7/00 B29L31/00

    CPC分类号: G03F7/0002 B29L2031/772

    摘要: The present invention provides an imprint apparatus for molding an imprint material on a target region on a substrate using a mold to form a pattern on the target region, the apparatus comprising a heater configured to deform the target region by heating the substrate, a measurement device configured to measure an overlay state between the target region and the mold, and a controller configured to control the heater such that the overlay state falls within a tolerance.

    Flexible Packaging Structure With Built-In Tamper-Evidence Features and Method for Making Same

    公开(公告)号:US20180071974A1

    公开(公告)日:2018-03-15

    申请号:US15804793

    申请日:2017-11-06

    IPC分类号: B29C59/00 B65D75/58

    摘要: A flexible packaging laminate has built-in opening/reclose and tamper-evidence features by forming the laminate from an outer structure joined in face-to-face relation to an inner structure. Score lines are formed in both structures to enable an opening to be formed through the laminate by lifting a flap or the like out of the plane of the laminate. The score line through the outer structure defines a larger opening than the score line through the inner structure, such that a marginal region of the outer structure extends beyond the edge of the opening portion of the inner structure. A pressure-sensitive adhesive is used to re-adhere the marginal region to an underlying surface of the inner structure adjacent the opening through the laminate. The outer score line includes at least one tab positioned within a heat seal region of the laminate.

    Imprint apparatus
    88.
    发明授权

    公开(公告)号:US09851634B2

    公开(公告)日:2017-12-26

    申请号:US14372938

    申请日:2013-01-25

    摘要: An imprint apparatus forms a pattern of a resin on a region to be processed of a substrate using a mold including a pattern region on which a pattern is formed and includes a correction unit configured to correct a shape of a target region that is either the pattern region on the mold or the region to be processed on the substrate, wherein the correction unit further includes: a heating unit configured to heat an object corresponding to the target region of either the mold or the substrate in a heating region having an area smaller than that of the pattern region on the mold; a scanning unit configured to scan the heating region with respect to the target region by changing the relative position of the target region and the heating region; and a control unit configured to acquire information regarding a correction deformation amount of the target region and control the heating unit and the scanning unit based on the information.