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1392 条记录 (耗时 0.034 秒)

    METHOD OF PRODUCTION OF GRAFT CO-POLYMER EXCIPIENT WITH A SUPERIOR PEPTIDE AND PROTEIN BINDING PROPERTY
    83.
    发明申请
    METHOD OF PRODUCTION OF GRAFT CO-POLYMER EXCIPIENT WITH A SUPERIOR PEPTIDE AND PROTEIN BINDING PROPERTY 审中-公开
    生产具有高级肽和蛋白质结合性质的共聚合物共聚物的方法

    公开(公告)号：US20160362523A1

    公开(公告)日：2016-12-15

    申请号：US15036762

    申请日：2015-11-03

    申请人： PHARMAIN CORPORATION

    发明人： Cynthia C. JONES ,  Joshua F. ALFARO ,  Gerardo M. CASTILLO

    IPC分类号： C08G81/00 ,  A61K47/34

    CPC分类号： C08G81/00 ,  A61K47/34 ,  C08G69/10 ,  C08G69/48 ,  C08G73/02 ,  C08G81/025

    摘要： Provided herein is a process of preparing a semi-random graft co-polymer, the product of which is difficult to fully characterize chemically. The product of the present disclosure has unique and useful properties of 1) binding to a peptide and 2) upon co-administration of the product and the peptide into animals the product prolongs the blood circulation time and elevates the level of the peptide, compared to the peptide alone without the product of the disclosure.

    摘要翻译： 本文提供了制备半随机接枝共聚物的方法，其产物难以完全表征化学性质。 本公开的产品具有独特且有用的特性，1）与肽的结合，2）当将产物和肽共同给予动物时，产物延长血液循环时间并提高肽的水平，与 单独的肽而不具有本公开的产物。

    CATIONIC MATERIALS AND FORMULATIONS FOR DRUG DELIVERY
    85.
    发明申请
    CATIONIC MATERIALS AND FORMULATIONS FOR DRUG DELIVERY 有权
    用于药物递送的阳离子材料和配方

    公开(公告)号：US20160338970A1

    公开(公告)日：2016-11-24

    申请号：US15107260

    申请日：2014-12-05

    申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

    发明人： Omid FAROKHZAD ,  Jun WU ,  Lili ZHAO

    IPC分类号： A61K9/51 ,  A61K38/28 ,  C08G81/00 ,  A61K38/38

    CPC分类号： A61K9/5153 ,  A61K9/0019 ,  A61K9/5073 ,  A61K9/5078 ,  A61K9/5192 ,  A61K38/28 ,  A61K38/38 ,  A61K38/385 ,  A61K47/593 ,  A61K47/60 ,  A61K47/645 ,  A61K47/6931 ,  A61K47/6937 ,  C08G81/00

    摘要： Cationic polymers are provided for delivering anionic active agents, preferably in the form or nanoparticles and other nanostructures. The polymer can be a polycation homopolymer or a copolymer containing a polycation block. The polycations and polycation containing polymers can contain dicarboxylic acid ester units and units of (a-amino acid)-α, ω-alkylene diester units. The nanoparticles can contain high loadings of anionic active agents, with sustained release of the active agents. Methods of making the polycations and polycation containing polymers are provided. Methods of making the nanoparticles and formulating them for administration to an individual in need thereof are also provided.

    摘要翻译： 提供阳离子聚合物用于递送阴离子活性剂，优选形式或纳米颗粒和其它纳米结构。 聚合物可以是聚阳离子均聚物或含有聚阳离子嵌段的共聚物。 聚阳离子和含聚阳离子的聚合物可以含有二羧酸酯单元和（α-氨基酸）-α，ω-亚烷基二酯单元的单元。 纳米颗粒可含有高负载量的阴离子活性剂，持续释放活性剂。 提供制造聚阳离子和聚阳离子聚合物的方法。 还提供了制备纳米颗粒并将其配制用于给有需要的个体的方法。

    ALIPHATIC/SEMI-AROMATIC BLOCK COPOLYAMIDE
    88.
    发明申请
    ALIPHATIC/SEMI-AROMATIC BLOCK COPOLYAMIDE 有权
    芳香/半芳族嵌段共聚酰胺

    公开(公告)号：US20160272767A1

    公开(公告)日：2016-09-22

    申请号：US14442457

    申请日：2013-11-13

    申请人： RHODIA OPERATIONS ,  CNRS

    发明人： Naji HUSSEIN ,  Didier LONG ,  Louise-Anne FILLOT

    IPC分类号： C08G81/00

    CPC分类号： C08G81/00 ,  C08G69/265 ,  C08G69/28 ,  C08J3/203 ,  C08J2377/00 ,  C08L77/06

    摘要： The invention relates to a method for the melted production, especially by reactive extrusion, of block copolyamide comprising at least one aliphatic polyamide block and at least one semi-aromatic block, especially wherein the aromatic group has at least one hydroxyl or sulfonate function. The invention also relates to the block copolyamide that can be produced by said method; to a composition comprising the block copolyamide; to granules comprising such a copolyamide or such a composition; to a method for producing an item from a copolyamide or a composition of said copolyamide; and to uses of the copolyamide.

    摘要翻译： 本发明涉及包括至少一种脂族聚酰胺嵌段和至少一种半芳族嵌段的嵌段共聚酰胺熔融生产，特别是通过反应挤出的方法，特别是其中芳基具有至少一个羟基或磺酸盐官能团。 本发明还涉及可通过所述方法生产的嵌段共聚酰胺; 涉及包含嵌段共聚酰胺的组合物; 包含这种共聚酰胺或这种组合物的颗粒; 涉及从共聚酰胺或所述共聚酰胺的组合物制备物品的方法; 以及共聚酰胺的用途。