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1.发明公开公开(公告)号：US20240328995A1
公开(公告)日：2024-10-03
申请号：US18738534
申请日：2024-06-10
发明人： Wei Zhang , Kevin Horan
IPC分类号： G01N27/416 , G01N27/333 , G01N33/49
CPC分类号： G01N27/4163 , G01N27/333 , G01N33/49 , G01N2496/00
摘要： Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof.
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公开(公告)号：US20240320962A1
公开(公告)日：2024-09-26
申请号：US18576256
申请日：2022-07-06
发明人： Venkatesh NarasimhaMurthy , Vivek Singh , Yao-Jen Chang , Benjamin S. Pollack , Ankur Kapoor , Rayal Raj Prasad Nalam Venkat
IPC分类号： G06V10/776 , G06V10/778 , G06V10/94 , G06V20/69 , G16H50/20
CPC分类号： G06V10/776 , G06V10/778 , G06V10/945 , G06V20/698 , G16H50/20
摘要： Methods of characterizing a sample container or a biological sample in an automated diagnostic analysis system using an artificial intelligence (AI) algorithm include retraining of the AI algorithm in response to characterization confidence levels determined to be unsatisfactory. The AI algorithm is retrained with data (including image data and/or non-image data) having features prevalent at the site where the automated diagnostic analysis system is operated, which were not sufficiently or at all included in training data used to initially train the AI algorithm. Systems for characterizing a sample container or a biological sample using an AI algorithm are also provided, as are other aspects.
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公开(公告)号：US12064765B2
公开(公告)日：2024-08-20
申请号：US17264487
申请日：2019-07-31
发明人： Kalpesh Mehta , Mohiudeen Azhar
CPC分类号： B01L3/502753 , B01L3/502761 , B03C5/005 , B03C5/024 , G01N21/1717 , G01N21/31 , G01N27/44721 , G01N27/44791 , G01N33/4925 , B01L2300/0645 , B01L2300/0822 , B01L2400/0424 , G01N2021/1721
摘要： A method and system for determining a concentration of one or more analytes in whole blood is provided. In one aspect of the invention, the system includes a channel configured to carry whole blood. The system further includes a light source configured to emit light on the channel. Additionally, the system includes an actuation module associable with the channel, wherein the actuation module is configured to generate a cell-free plasma layer in the channel. Furthermore, the system includes an optical module associable with the channel.
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公开(公告)号：US12031890B2
公开(公告)日：2024-07-09
申请号：US18007058
申请日：2021-07-23
发明人： Jeffrey R. Jasperse , Peter Paulicka , Paul Benson
IPC分类号： G01N1/28 , B01L3/00 , G01N29/036 , G01N29/34
CPC分类号： G01N1/286 , B01L3/502715 , G01N29/036 , G01N29/348 , B01L2300/0627 , B01L2300/0861 , B01L2300/12 , B01L2400/0436
摘要： A lysis device including a sample vessel, at least one piezo element, and a controller is disclosed. The sample vessel has a microchannel formed therein. The sample vessel has at least one port extending through a surface to the microchannel. The piezo element is attached to the surface of the sample vessel. The controller has logic to cause the controller to emit a first signal including a series of frequencies to the at least one piezo element to cause the at least one piezo element to generate ultrasonic acoustic standing waves in the sample vessel, to receive a second signal indicative of measured vibration signals from the sample vessel detected by the at least one piezo element, and to determine a resonant frequency of the sample vessel using the measured vibration signals.
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公开(公告)号：US12005027B2
公开(公告)日：2024-06-11
申请号：US17755894
申请日：2020-11-10
发明人： Heiko Kalbfell , Joachim Bernhard
CPC分类号： A61J1/1418 , G01N15/0806 , G01N35/10 , B01L2200/026 , B01L2200/0689 , B01L2400/0487 , G01N2035/0403 , G01N2035/0429
摘要： The invention relates to a system with a seal between a manifold and a liquid container in which a sealing without an elastomer material is used, wherein the sealing properties of the seal are independent of the rotational position of the manifold in relation to the container.
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6.发明公开公开(公告)号：US20240133908A1
公开(公告)日：2024-04-25
申请号：US18546160
申请日：2022-02-10
CPC分类号： G01N35/00732 , G01N35/04 , G06T7/0012 , G06T7/60 , G06T7/97 , G01N2035/0406
摘要： A method of determining a 3D center location of a specimen container on a track. The method includes providing a calibration object on the track; providing an initially calibrated image capture device adjacent to the track; moving the calibration object to at least two different longitudinal positions along the track; capturing a first image with the calibration object located at the first longitudinal position; capturing a second image with the calibration object located at the second longitudinal position; and determining a three-dimensional path trajectory of a center location along the track based at least upon the first image and the second image. The method can be used to determine a 3D center location of a specimen container imaged anywhere within a viewing area. Characterization apparatus and specimen testing apparatus adapted to carry out the methods are described, as are other aspects.
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公开(公告)号：US11935655B2
公开(公告)日：2024-03-19
申请号：US17812476
申请日：2022-07-14
发明人： Poikavila Ullaskrishnan , Ralf Krumtünger , Teodora-Vanessa Liliac , Larisa Micu , Ingo Schmuecking , Puneet Sharma
CPC分类号： G16H50/20 , G06F16/322 , G06F16/367 , G16H10/60
摘要： Systems and methods for determining an evaluation of one or more patients is provided. User input for evaluating one or more patients is received. A commit bundle is retrieved from a commit database. An evaluation of the one or more patients is determined based on the user input using a medical ontology configured with the retrieved commit bundle. The medical ontology is separate from the commit database. Results of the evaluation of the one or more patients are output.
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公开(公告)号：US11913965B2
公开(公告)日：2024-02-27
申请号：US17249767
申请日：2021-03-12
发明人： Tie Wei
IPC分类号： G01N33/94 , G01N33/531
CPC分类号： G01N33/9493 , G01N33/531 , G01N2470/04
摘要： Methods are disclosed for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,500. The method comprises the use of a first antibody that binds to the small molecule and a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a hapten that is not the small molecule or a derivative of the small molecule wherein the hapten comprises a moiety that is structurally similar to that of the second portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.
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9.发明公开公开(公告)号：US20240010841A1
公开(公告)日：2024-01-11
申请号：US18255654
申请日：2021-11-10
发明人： Yali Yang , David Wen , Bogdan Draghici , Yi Feng Zheng , Raphael Bartz , Qingping Jiang , Roland Janzen , Joshua Whalen , Ling Ngo , William Bedzyk
CPC分类号： C09B62/125 , G01N33/582 , C07K16/28 , G01N33/6872 , G01N2333/99
摘要： Labels that include dibromopyridazinedione attached to signal molecules are disclosed, along with methods of producing and using same. Also disclosed are conjugates of the label attached to an analyte-specific binder, as well as methods of producing and using same. Kits containing the labels and/or conjugates are also disclosed, along with microfluidics devices containing same.
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公开(公告)号：US11850585B2
公开(公告)日：2023-12-26
申请号：US17035919
申请日：2020-09-29
发明人： Jennifer A. Samproni
IPC分类号： B01L3/00 , G01N33/487
CPC分类号： B01L3/502707 , B01L3/5027 , G01N33/48707 , B01L2300/0645 , B01L2300/088 , B01L2300/0816 , B01L2300/0887
摘要： In one aspect, the inventive concepts disclosed herein are directed to a sensor assembly which contains a first planar substrate and a second planar substrate which respectively support opposing sensor arrays and contains an integrated flow path extending between the first and second substrates.
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