公开(公告)号：US20190008963A1

公开(公告)日：2019-01-10

申请号：US16081526

申请日：2017-03-01

申请人： Trustees of Boston University

发明人： Xue HAN ,  Richie E. KOHMAN ,  Susie S. CHA

IPC分类号： A61K41/00 ,  C07H21/00 ,  C07C247/10 ,  A61K47/54 ,  A61N5/06

摘要： The invention provides oligonucleotide conjugates including a photolabile crosslinker attached to a cargo moiety, e.g., a therapeutic or diagnostic agent. The invention further provides reagents useful in the preparation of such conjugates and methods of their use.

公开(公告)号：US20240287463A1

公开(公告)日：2024-08-29

申请号：US17793287

申请日：2021-01-22

申请人： Massachusetts Institute of Technology ,  TRUSTEES OF BOSTON UNIVERSITY

发明人： Christopher S. Chen ,  Sangeeta N. Bhatia ,  Arnav Chhabra ,  Amanda Chen ,  Hyun Ho Song

IPC分类号： C12N5/071 ,  A61L27/38 ,  C12N5/00 ,  C12N5/077 ,  C12N9/64

CPC分类号： C12N5/0671 ,  A61L27/3886 ,  A61L27/3895 ,  C12N5/0062 ,  C12N5/0656 ,  C12N9/6472 ,  C12Y304/22062 ,  C12N2502/1323 ,  C12N2513/00

摘要： Inducible engineered tissue constructs comprising at least one cell population comprising a genetic construct are provided. Methods of making and using said constructs are also provided.

公开(公告)号：US20240263193A1

公开(公告)日：2024-08-08

申请号：US18392928

申请日：2023-12-21

申请人： TRUSTEES OF BOSTON UNIVERSITY

发明人： Alexander Michael Marzilli ,  John Tuan Ngo

IPC分类号： C12N15/87 ,  C07K14/005 ,  C12N9/78 ,  C12N15/11

CPC分类号： C12N15/87 ,  C07K14/005 ,  C12N9/78 ,  C12N15/11 ,  C12Y305/04 ,  C12N2310/20 ,  C12N2310/531 ,  C12N2795/18022

摘要： The technology described herein is directed to compositions, kits, systems and methods related to an engineered, inducible adenosine deaminase (iAD) enzymes, including but not limited to, an engineered inducible adenosine deaminase acting on RNA (ADAR) enzyme, which can be activated in the presence of an inducer. Also described are synthetic RNA molecules, to which the iAD can be specifically recruited to edit at least one target codon, leading to decreased or increased translation of the RNA molecules depending on the specific construct. The technology described herein is also directed to systems comprising the iAD and synthetic RNA molecule, nucleic acids and vectors encoding the iAD and synthetic RNA molecule, and methods of using such systems, nucleic acids, and vectors.

公开(公告)号：US12055536B2

公开(公告)日：2024-08-06

申请号：US18317637

申请日：2023-05-15

申请人： Trustees of Boston University ,  Northwestern University

发明人： Ji-Xin Cheng ,  Junjie Li ,  Yuying Tan ,  Daniela Matei ,  Guangyuan Zhao

IPC分类号： G01J3/44 ,  G01N27/30 ,  G01N27/416 ,  G01N33/487 ,  G01N33/49 ,  G01Q60/60 ,  G16H20/10 ,  G16H50/30 ,  G01N21/65

CPC分类号： G01N33/492 ,  G01N27/30 ,  G01N27/416 ,  G01N33/48735 ,  G01Q60/60 ,  G16H20/10 ,  G16H50/30 ,  G01N21/65 ,  G01N2800/52

摘要： Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

公开(公告)号：US20240218194A1

公开(公告)日：2024-07-04

申请号：US18394639

申请日：2023-12-22

申请人： Trustees of Boston University

发明人： John William Boley ,  Javier M. Morales Ferrer ,  Stephanie Flores Zopf ,  Chloe Grace Kekedjian ,  Ramon Enrique Sanchez Cruz

IPC分类号： C09D11/023 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/10 ,  C09D11/102 ,  C09D11/14 ,  B22D23/00 ,  C08K3/04 ,  C08K3/105 ,  C08K3/36

CPC分类号： C09D11/023 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/10 ,  C09D11/102 ,  C09D11/14 ,  B22D23/003 ,  C08K3/04 ,  C08K3/041 ,  C08K3/105 ,  C08K3/36 ,  C08K2201/001

摘要： Methods and compositions for 3D and 4D printing inks exhibit desirable electrical and rheological properties. The compositions disclosed include a 3D printing ink employing a liquid metal emulsion and a method of creating a stretchable electronic device using the same. The compositions also include 4D printing inks and methods of tuning said inks to have desirable properties.

公开(公告)号：US20240173383A1

公开(公告)日：2024-05-30

申请号：US18215317

申请日：2023-06-28

申请人： Beth Israel Deaconess Medical Center, Inc. ,  Trustees of Boston University

发明人： Ara Nazarian ,  Edward K. Rodriguez ,  Mark Grinstaff

IPC分类号： A61K38/22 ,  A61K9/00 ,  A61K9/16 ,  A61K47/42 ,  A61K47/60 ,  A61K47/69 ,  A61M3/00 ,  A61P19/02

CPC分类号： A61K38/2221 ,  A61K9/0019 ,  A61K9/16 ,  A61K47/42 ,  A61K47/60 ,  A61K47/6903 ,  A61M3/005 ,  A61P19/02 ,  A61M2202/07 ,  C07K14/575

摘要： The present invention provides methods for treating a stiffened joint in a subject that comprise administering relaxin, e.g., a PEGylated relaxin-2, to the subject. The relaxin may be administered intra-articularly as a sustained release formulation. The present invention also provides sustained release formulations in the form of a hydrogel for administering polypeptides that are covalently attached to a polymer, e.g., PEG.

公开(公告)号：US11977076B2

公开(公告)日：2024-05-07

申请号：US16579798

申请日：2019-09-23

申请人： Trustees of Boston University

发明人： Jerome S. Brody ,  Avrum Spira ,  Jeffrey S. Berman ,  Anthony W. O'Regan

IPC分类号： C12Q1/6886 ,  G01N33/574

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer.

公开(公告)号：US20240131029A1

公开(公告)日：2024-04-25

申请号：US18275731

申请日：2022-02-03

申请人： President and Fellows of Harvard College ,  Trustees of Boston University

发明人： Esak Lee ,  Christopher S. Chen

IPC分类号： A61K31/517 ,  A61P7/10

CPC分类号： A61K31/517 ,  A61P7/10

摘要： The present disclosure provides methods and compositions for treating a condition associated with impaired lymphatic drainage.

公开(公告)号：US11946928B2

公开(公告)日：2024-04-02

申请号：US17748404

申请日：2022-05-19

申请人： TRUSTEES OF BOSTON UNIVERSITY ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Ke Xu ,  Marc E. Lenburg ,  Ehab Billatos ,  Alejandro A. Diaz

IPC分类号： G01N33/50 ,  C12Q1/6883

CPC分类号： G01N33/5023 ,  C12Q1/6883 ,  C12Q2539/10 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/50

摘要： Described herein are methods relating to the diagnosis, prognosis, and treatment of airway dysfunction, e.g., bronchiectasis by detecting gene expression in a sample obtained from a subject. Exemplary samples include a bronchial brushing, nasal brushing, sputum, or peripheral blood sample.

公开(公告)号：US20240099614A1

公开(公告)日：2024-03-28

申请号：US18462190

申请日：2023-09-06

申请人： Trustees of Boston University

发明人： James Galagan ,  Uros Kuzmanovic ,  Abdurrahman Addokhi

IPC分类号： A61B5/145 ,  A61B5/1477 ,  A61B5/1486

CPC分类号： A61B5/14546 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/1477 ,  A61B5/1486

摘要： Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.