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    Apparatus and methods for treating venous occlusive disorders
    1.
    发明授权
    Apparatus and methods for treating venous occlusive disorders 有权

    公开(公告)号：US11154414B2

    公开(公告)日：2021-10-26

    申请号：US16411231

    申请日：2019-05-14

    申请人： NuGyn, Inc.

    发明人： Claire Hovland ,  Curtis Olson

    IPC分类号： A61F5/41 ,  A61H19/00

    摘要： Apparatus, methods and systems for treating venous occlusive disease are provided. Generally, devices include a soft extension member that is adapted to be mounted at a proximal end of a therapeutic vacuum device. The soft extension member includes a proximal end composed of a tissue contacting portion configured to receive a tissue to be treated, and a distal end composed of a collar configured to be mounted onto an exterior surface of a vacuum chamber. Apparatus, methods and systems for increasing clitoral and cavernosal tumescence by application of a vacuum are also provided.

    Nanofibers containing latent reactive groups
    2.
    发明授权
    Nanofibers containing latent reactive groups 有权
    含有潜在反应性基团的纳米纤维

    公开(公告)号：US08709809B2

    公开(公告)日：2014-04-29

    申请号：US12666173

    申请日：2008-06-20

    申请人： Jie Wen ,  Patrick E. Guire

    发明人： Jie Wen ,  Patrick E. Guire

    IPC分类号： C12M1/00 ,  A61L27/34

    CPC分类号： D01D5/003 ,  A61L27/50 ,  A61L29/14 ,  A61L31/14 ,  A61L2400/12 ,  B05D3/067 ,  B29C35/08 ,  C12M23/20 ,  D01D5/0007 ,  D01F1/10 ,  D01F6/625 ,  D06M15/263 ,  D06M15/273 ,  D06M15/285 ,  D06M2400/01

    摘要： A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one of the latent reactive activatable groups to bond the nanofiber to the surface by the formation of a covalent bond between the surface of the substrate and the latent reactive activatable group. Some of the remaining latent reactive activatable group(s) are left accessible on the surface of the substrate, and may be used for further surface modification of the substrate. Biologically active materials may be immobilized on the nanofiber modified surface by reacting with the latent reactive groups that are accessible on the surface of the substrate.

    摘要翻译： 通过组合一种或多种天然或合成聚合物材料和具有至少两个潜在反应性可活化基团的一种或多种交联剂形成纳米纤维。 潜在的可反应活化的纳米纤维可用于通过活化至少一个潜在的反应性可活化基团来修饰底物的表面，以通过在基材的表面和潜在的反应性之间形成共价键将纳米纤维结合到表面 可激活组。 剩余的潜在反应性可活化基团中的一些在基材的表面上是可接近的，并且可以用于基材的进一步的表面改性。 生物活性物质可以通过与底物表面上可触及的潜在反应性基团反应而固定在纳米纤维改性表面上。

    Coatings for controlled release of water soluble drugs
    9.
    发明授权
    Coatings for controlled release of water soluble drugs 有权

    公开(公告)号：US10098989B2

    公开(公告)日：2018-10-16

    申请号：US15730006

    申请日：2017-10-11

    申请人： INNOVATIVE SURFACE TECHNOLOGIES, INC.

    发明人： Kristin Taton ,  Laurie Lawin ,  Patrick Guire

    IPC分类号： A61L29/08 ,  A61L29/06 ,  A61L29/16 ,  A61L29/10 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16

    摘要： The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.