公开(公告)号：US08916198B2

公开(公告)日：2014-12-23

申请号：US12211005

申请日：2008-09-15

Applicant: Susmita Bose ,  Amit Bandyopadhyay ,  Weichang Xue

Inventor： Susmita Bose ,  Amit Bandyopadhyay ,  Weichang Xue

IPC: A61K9/14 ,  A61P43/00 ,  A61K47/48 ,  A61L27/30 ,  A61L27/56 ,  A61L27/54 ,  A61K9/51 ,  A61L27/02

CPC classification number: A61L27/025 ,  A61K9/5115 ,  A61K47/6923 ,  A61L27/10 ,  A61L27/306 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2430/02

Abstract: Mesoporous calcium silicate compositions for controlled release of bioactive agents and methods for producing such compositions are disclosed herein. In one embodiment, mesoporous calcium silicate is synthesized by acid modification of wollastonite particles using hydrochloric acid. A hydrated silica gel layer having abundant Si—OH functional groups can be formed on the surface of wollastonite after acid modification. Bruhauer-Emmett-Teller (BET) surface area increased significantly due to acid modification and, in one arrangement, reached over 350 m2/g. Acid modified mesoporous calcium silicate compositions show a higher ability to adsorb protein compared to unmodified particles and demonstrate controlled release kinetics of these proteins.

Abstract translation: 本文公开了用于控制释放生物活性剂的介孔硅酸钙组合物及其制备方法。 在一个实施方案中，介孔硅酸钙通过使用盐酸的硅灰石颗粒的酸改性来合成。 在酸改性后硅灰石表面可以形成含有大量Si-OH官能团的水合硅胶层。 由于酸改性，Bruhauer-Emmett-Teller（BET）表面积显着增加，一种排列达到了350m2 / g以上。 与未改性的颗粒相比，酸改性介孔硅酸钙组合物显示出更高的吸附蛋白质的能力，并且证明了这些蛋白质的控制释放动力学。

公开(公告)号：US20070203584A1

公开(公告)日：2007-08-30

申请号：US11675006

申请日：2007-02-14

Applicant: Amit Bandyopadhyay ,  Susmita Bose

Inventor： Amit Bandyopadhyay ,  Susmita Bose

IPC: A61F2/28

CPC classification number: B23K26/342 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/30942 ,  A61F2/36 ,  A61F2/367 ,  A61F2/3676 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30006 ,  A61F2002/30011 ,  A61F2002/30013 ,  A61F2002/30028 ,  A61F2002/30029 ,  A61F2002/30115 ,  A61F2002/30118 ,  A61F2002/30179 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30322 ,  A61F2002/30593 ,  A61F2002/30616 ,  A61F2002/30677 ,  A61F2002/30838 ,  A61F2002/30909 ,  A61F2002/3093 ,  A61F2002/3097 ,  A61F2002/3692 ,  A61F2230/0006 ,  A61F2230/0058 ,  A61F2230/0069 ,  A61F2250/0014 ,  A61F2250/0023 ,  A61F2250/0026 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00047 ,  A61F2310/00053 ,  A61F2310/00113 ,  A61F2310/00155 ,  A61F2310/00179 ,  A61F2310/00185 ,  A61F2310/00227 ,  A61F2310/00293 ,  A61L27/06 ,  A61L27/42 ,  A61L27/427 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2430/02 ,  B22F3/105 ,  B22F3/1109 ,  B22F3/1146 ,  B22F2998/00 ,  B23K26/0006 ,  B23K26/70 ,  B23K2103/14 ,  B23K2103/16 ,  B33Y10/00 ,  B33Y50/00 ,  B33Y70/00 ,  B33Y80/00 ,  B22F3/1125 ,  B22F2207/17

Abstract: Particular aspects provide novel devices for bone tissue engineering, comprising a metal or metal-based composite member/material comprising an interior macroporous structure in which porosity may vary from 0-90% (v), the member comprising a surface region having a surface pore size, porosity, and composition designed to encourage cell growth and adhesion thereon, to provide a device suitable for bone tissue engineering in a recipient subject. In certain aspects, the device further comprises a gradient of pore size, porosity, and material composition extending from the surface region throughout the interior of the device, wherein the gradient transition is continuous, discontinuous or seamless and the growth of cells extending from the surface region inward is promoted. Additional aspects provide a device for bone tissue engineering, comprising a metal or metal-based composite member/material comprising an interior porous structure, wherein the pore size, porosity and material composition is selected to provide a device having an optimal density and/or elastic modulus and/or compression strength for a specific recipient. Novel methods for fabricating the devices are also provided.

Abstract translation: 特定方面提供了用于骨组织工程的新型装置，其包括金属或金属基复合材料/材料，其包含孔隙度可以在0-90％（v）之间变化的内部大孔结构，所述构件包括具有表面孔 设计用于促进细胞生长和粘附的大小，孔隙率和组成，以提供适合受试者的骨组织工程的装置。 在某些方面，该装置进一步包括从装置的整个内部的表面区域延伸的孔径，孔隙率和材料组成的梯度，其中梯度过渡是连续的，不连续的或无缝的，并且细胞从表面延伸的生长 地区内向推动。 另外的方面提供了一种用于骨组织工程的装置，其包括金属或金属基复合材料/材料，其包括内部多孔结构，其中选择孔径，孔隙率和材料组成以提供具有最佳密度和/或弹性的装置 模数和/或压缩强度。 还提供了用于制造器件的新颖方法。

公开(公告)号：US06571008B1

公开(公告)日：2003-05-27

申请号：US09369961

申请日：1999-08-06

Applicant: Amit Bandyopadhyay ,  Jonathan C. Christensen

Inventor： Amit Bandyopadhyay ,  Jonathan C. Christensen

IPC: G06K900

CPC classification number: G06T17/10 ,  B33Y80/00

Abstract: A reverse engineering technique allows the creation of 3-D CAD files from a solid model. A solid model of a part to be reverse engineered is created from polymers having an index of refraction matching that of an immersion liquid. Over the immersion liquid is a masking liquid that is substantially opaque. The generally clear polymeric model of the part is moved through the immersion/masking layer interface while images of the cross section of the model are acquired at the interface layer. The images are then used to create digital solid models from a physical model or to compare an existing physical model with its digital model.

Abstract translation: 逆向工程技术允许从实体模型创建3-D CAD文件。 要反向工程的零件的实体模型由具有与浸入液体的折射率相匹配的折射率的聚合物产生。 在浸没液体之上是基本上不透明的掩蔽液体。 该部分的通常清晰的聚合物模型通过浸入/掩蔽层界面移动，同时在界面层获取模型横截面的图像。 然后，图像用于从物理模型创建数字实体模型，或者将现有物理模型与其数字模型进行比较。

公开(公告)号：US6049160A

公开(公告)日：2000-04-11

申请号：US114267

申请日：1998-07-13

Applicant: Ahmad Safari ,  Stephen C. Danforth ,  Amit Bandyopadhyay ,  Thomas McNulty ,  Rajesh K. Panda

Inventor： Ahmad Safari ,  Stephen C. Danforth ,  Amit Bandyopadhyay ,  Thomas McNulty ,  Rajesh K. Panda

IPC: H01L41/08 ,  H01L41/083 ,  H01L41/18 ,  H01L41/22

CPC classification number: H01L41/183 ,  H01L41/37 ,  B29C67/0055

Abstract: This invention relates to a new class of piezoelectric composites with a radial design. More particularly, the radial design of these new ceramic/polymer composites show a higher sensitivity in the radial direction than conventional tube structured devices. Devices made utilizing this novel design will therefore show significantly enhanced performance in many applications.

Abstract translation: 本发明涉及一种具有径向设计的新型压电复合材料。 更具体地，这些新型陶瓷/聚合物复合材料的径向设计显示出比常规管结构设备更高的径向灵敏度。 因此，使用这种新颖设计的设备将在许多应用中显示出显着增强的性能。

公开(公告)号：US6004500A

公开(公告)日：1999-12-21

申请号：US81308

申请日：1998-05-19

Applicant: Ahmad Safari ,  Victor F. Janas ,  Amit Bandyopadhyay ,  Rajesh K. Panda ,  Mukesh Agarwala ,  Stephen C. Danforth

Inventor： Ahmad Safari ,  Victor F. Janas ,  Amit Bandyopadhyay ,  Rajesh K. Panda ,  Mukesh Agarwala ,  Stephen C. Danforth

IPC: H01L41/18 ,  H01L41/22 ,  C04B33/32

CPC classification number: H01L41/37 ,  H01L41/183

Abstract: A process for making ceramic composites includes the steps of: a) forming a polymer composition into a three-dimensional mold; b) filling said three-dimensional mold with one or more ceramic containing compositions; c) heating said filled mold to dry and sinter the ceramic; d) removing at least a portion of said three-dimensional mold thereby forming voids; and e) filling the voids with a second composition which has a piezoelectric coefficient which is substantially different from the piezoelectric coefficient of said ceramic structure. Steps a through e yield a controlled, non-random piezoelectric ceramic composite having 2-3, 3-2 or 3--3 connectivity with respect to the sintered ceramic and the second composition throughout the composite.

Abstract translation: 制备陶瓷复合材料的方法包括以下步骤：a）将聚合物组合物形成为三维模具; b）用一种或多种含陶瓷的组合物填充所述三维模具; c）加热所述填充的模具以干燥并烧结陶瓷; d）去除所述三维模具的至少一部分，从而形成空隙; 以及e）用具有与所述陶瓷结构的压电系数基本不同的压电系数的第二组合物填充所述空隙。 步骤a至e产生相对于烧结陶瓷和第二组合物在整个复合材料中具有2-3，3-2或3-3连通性的受控非随机压电陶瓷复合材料。

公开(公告)号：US5997795A

公开(公告)日：1999-12-07

申请号：US86847

申请日：1998-05-29

Applicant: Stephen C. Danforth ,  Ahmad Safari ,  John Ballato ,  Remco Van Weeren ,  Amit Bandyopadhyay

Inventor： Stephen C. Danforth ,  Ahmad Safari ,  John Ballato ,  Remco Van Weeren ,  Amit Bandyopadhyay

IPC: B29C33/38 ,  B29C67/00 ,  C04B38/00 ,  C30B5/00 ,  G02B6/122 ,  B29C35/08 ,  B29C41/02 ,  C04B35/00

CPC classification number: B29C67/0081 ,  B29C33/3842 ,  B29C67/0062 ,  B29C67/0092 ,  B82Y20/00 ,  C04B38/00 ,  C30B29/60 ,  C30B5/00 ,  G02B6/1225 ,  C04B2111/00181

Abstract: Solid freeform fabrication techniques are used in direct methods to form photonic bandgap structures, and in indirect methods to form molds for photonic bandgap structures. In the direct methods, solid particulate materials are mixed with a binder and, through a computer-controlled process, are built layer by layer to form the structure. In the indirect methods, unfilled polymeric materials are built layer by layer to form a negative mold for the photonic bandgap structure. The cavities within the mold may then be filled with a slurry incorporating solid particulate materials. Subsequent processing may include mold removal, binder removal, densification and secondary infiltration steps to form a photonic bandgap structure having the desired properties.

Abstract translation: 固体自由形成技术用于形成光子带隙结构的直接方法，以及用于形成光子带隙结构的模具的间接方法。 在直接方法中，将固体颗粒材料与粘合剂混合，并通过计算机控制的方法逐层地构建以形成结构。 在间接方法中，未填充的聚合物材料逐层地构建，以形成用于光子带隙结构的负模具。 然后可以用包含固体颗粒材料的浆料填充模具内的空腔。 随后的处理可以包括脱模，粘合剂去除，致密化和二次渗透步骤以形成具有期望性质的光子带隙结构。

公开(公告)号：US09028871B2

公开(公告)日：2015-05-12

申请号：US12298012

申请日：2007-04-25

Applicant: Susmita Bose ,  Amit Bandyopadhyay

Inventor： Susmita Bose ,  Amit Bandyopadhyay

IPC: A61F2/28 ,  A61K9/00 ,  A61L27/58 ,  A61L27/12 ,  A61L27/32 ,  A61L27/42 ,  C04B35/447 ,  C04B35/626

CPC classification number: A61L27/58 ,  A61L27/10 ,  A61L27/12 ,  A61L27/306 ,  A61L27/32 ,  A61L27/425 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  A61L2420/06 ,  A61L2430/02 ,  A61L2430/12 ,  C04B35/447 ,  C04B35/6261 ,  C04B2235/3201 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3212 ,  C04B2235/3213 ,  C04B2235/3232 ,  C04B2235/3272 ,  C04B2235/3281 ,  C04B2235/3284 ,  C04B2235/3291 ,  C04B2235/34 ,  C04B2235/3418 ,  C04B2235/442 ,  C04B2235/445 ,  C04B2235/5445 ,  C04B2235/608 ,  C04B2235/77 ,  C04B2235/786 ,  C04B2235/80 ,  C04B2235/96

Abstract: Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion or ion dopants and metal oxide dopants, wherein the composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled strength loss, depending on dopant composition, under body, body fluid or simulated body fluid conditions. Preferably, the at least one dopant is selected from the group consisting of Zn2+, Mg2+, Si2+, Na+, K+, Sr2+, Cu2+, Fe3+/Fe2+, Ag+, Ti4+, CO32−, F−, MgO, ZnO, NaF, KF, FeO/Fe2O3, SrO, CuO, SiO2, TiO2, Ag2O and CaCO3, present in an amount between 0 and about 10 w %, from about 0.5 to about 5 w %, or from about 1 to about 3 w %, and methods of using same.

Abstract translation: 具体方面提供用于生物工程，恢复或再生组织或骨的生物可再吸收和生物相容性组合物，其包含三维多孔或非多孔支架材料，其包含其中选自金属离子或离子掺杂剂的至少一种掺杂剂的磷酸钙基陶瓷，以及 金属氧化物掺杂剂，其中所述组合物具有足够的生物相容性以提供细胞或组织支架，并且根据体内，体液或模拟体液条件下的掺杂剂组成，以受控的吸收速率可再吸收受控的强度损失。 优选地，所述至少一种掺杂剂选自Zn2 +，Mg2 +，Si2 +，Na +，K +，Sr2 +，Cu2 +，Fe3 + / Fe2 +，Ag +，Ti4 +，CO32-，F-，MgO，ZnO，NaF， FeO / Fe 2 O 3，SrO，CuO，SiO 2，TiO 2，Ag 2 O和CaCO 3以0至约10重量％，约0.5至约5重量％，或约1至约3重量％的量存在，以及 使用相同。

公开(公告)号：US08545559B2

公开(公告)日：2013-10-01

申请号：US12246455

申请日：2008-10-06

Applicant: Amit Bandyopadhyay ,  Susmita Bose

Inventor： Amit Bandyopadhyay ,  Susmita Bose

IPC: A61F2/28

CPC classification number: C23C28/00 ,  A61F2/30767 ,  A61F2002/3093 ,  A61L27/306 ,  A61L27/32 ,  A61L27/54 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/624 ,  A61L2400/12 ,  B22F1/025 ,  B22F7/08 ,  C23C28/042 ,  C23C28/048

Abstract: The present disclosure is directed to modified metal materials for implantation and/or bone replacement, and to methods for modifying surface properties of metal substrates for enhancing cellular adhesion (tissue integration) and providing antimicrobial properties. Some embodiments comprise surface coatings for metal implants, such as titanium-based materials, using (1) electrochemical processing and/or oxidation methods, and/or (2) laser processing, in order to enhance bone cell-materials interactions and achieve improved antimicrobial properties. One embodiment comprises the modification of a metal surface by growth of in situ nanotubes via anodization, followed by electrodeposition of silver on the nanotubes. Other embodiments include the use of LENS™ processing to coat a metal surface with calcium-based bioceramic composition layers. These surface treatment methods can be applied as a post-processing operation to metallic implants such as hip, knee and spinal devices as well as screws, pins and plates.

Abstract translation: 本公开涉及用于植入和/或骨置换的改性金属材料以及用于改善金属基底的表面性质以增强细胞粘附（组织整合）并提供抗微生物性质的方法。 一些实施方案包括使用（1）电化学加工和/或氧化方法和/或（2）激光加工的金属植入物的表面涂层，例如钛基材料，以增强骨细胞 - 材料相互作用并获得改进的抗微生物剂 属性。 一个实施方案包括通过阳极氧化原位纳米管的生长，随后在纳米管上电沉积银，来改变金属表面。 其他实施方案包括使用LENS TM处理以用钙基生物陶瓷组合物层涂覆金属表面。 这些表面处理方法可以作为后处理操作应用于金属植入物，例如髋，膝和脊柱装置，以及螺钉，销和板。

公开(公告)号：US5796207A

公开(公告)日：1998-08-18

申请号：US847901

申请日：1997-04-28

Applicant: Ahmad Safari ,  Stephen C. Danforth ,  Amit Bandyopadhyay ,  Victor F. Janas ,  Rajesh Kumar Panda

Inventor： Ahmad Safari ,  Stephen C. Danforth ,  Amit Bandyopadhyay ,  Victor F. Janas ,  Rajesh Kumar Panda

IPC: H01L41/18 ,  H01L41/08

CPC classification number: H01L41/18 ,  H01L41/183

Abstract: This invention relates to novel oriented piezoelectric ceramic and ceramic/polymer composites. More particularly, it provides a novel piezoelectric composite design wherein the ceramic piezoelectric phase is oriented at an angle with respect to the direction of applied stress, thus giving improved electromechanical properties.

Abstract translation: 本发明涉及新型取向压电陶瓷和陶瓷/聚合物复合材料。 更具体地，它提供了一种新颖的压电复合材料设计，其中陶瓷压电相位相对于所施加的应力方向成一定角度定向，从而提供改善的机电性能。

公开(公告)号：US20140010856A1

公开(公告)日：2014-01-09

申请号：US14006941

申请日：2012-03-26

Applicant: Amit Bandyopadhyay ,  Susmita Bose

Inventor： Amit Bandyopadhyay ,  Susmita Bose

IPC: A61L27/04

CPC classification number: A61L27/306 ,  A61L27/04 ,  A61L27/047 ,  A61L27/50 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  A61L2430/02

Abstract: Various embodiments of surface-modified devices, components, and associated methods of manufacturing are described herein. In one embodiment, an implantable device suitable for being implanted in a patient includes an implantable material having a utile shape and a surface and a modification material deposited on at least a portion of the surface of the implantable material. The modification material has a release rate in an implantation environment in the patient. The modification material at the release rate is effective as bactericidal without being cytotoxic to the patient.

Abstract translation: 本文描述了表面改性的器件，部件和相关的制造方法的各种实施例。 在一个实施例中，适于植入患者的可植入装置包括具有钝化形状和表面的可植入材料和沉积在可植入材料表面的至少一部分上的修饰材料。 修饰材料在患者的植入环境中具有释放速率。 在释放速率下的改性材料是有效的杀菌剂，而不会对患者造成细胞毒性。