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1.发明授权公开(公告)号：US07597932B2
公开(公告)日：2009-10-06
申请号：US11855374
申请日：2007-09-14
Applicant: Jainamma Krotz , Daniel Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
Inventor： Jainamma Krotz , Daniel Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
CPC classification number: C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
Abstract: The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array and providing a polymerization solution that includes a porogen. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker. The porogen is then removed from the permeation layer, thereby creating void spaces in the permeation layer.
Abstract translation: 本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。 本发明包括在微电极阵列上形成渗透层的方法，包括将接头连接到阵列的表面并提供包含致孔剂的聚合溶液的步骤。 然后将阵列的表面与聚合溶液接触，然后聚合溶液在阵列的表面上聚合，形成通过接头连接在阵列表面上的渗透层。 然后从渗透层除去致孔剂，从而在渗透层中产生空隙。
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公开(公告)号：US20060248910A1
公开(公告)日：2006-11-09
申请号：US11485042
申请日：2006-07-11
Applicant: Daniel Smolko , Gregory Kevorkian
Inventor： Daniel Smolko , Gregory Kevorkian
CPC classification number: A45F3/20 , A41D13/0053 , A45F3/04 , A45F3/18 , A47G19/2266 , A47G19/2272 , A47G21/18 , A47G2400/027 , A61J9/04 , A61M2207/00 , B65D1/323 , B65D47/06 , B65D47/242 , B65D47/265 , B65D51/1616 , B65D81/18 , B65D81/3886 , B65D2205/00 , F25D7/00 , F25D2331/803 , F25D2331/806 , F25D2331/808 , F25D2400/26 , F28D5/00
Abstract: Disclosed are self-cooling pouches useful as containers for beverages and other liquids. Such pouches comprise a porous matrix as an element of the pouch body to effect the cooling of the pouch and a liquid contained therein by pervaporation of the liquid.
Abstract translation: 公开了用作饮料和其他液体的容器的自冷却袋。 这种袋包括作为袋体的元件的多孔基质，以通过渗透蒸发液体来实现小袋的冷却和其中所含的液体。
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公开(公告)号：US20060201186A1
公开(公告)日：2006-09-14
申请号：US11434610
申请日：2006-05-16
Applicant: Daniel Smolko , Gregory Kevorkian
Inventor： Daniel Smolko , Gregory Kevorkian
CPC classification number: A41D13/0053 , F25D7/00
Abstract: Disclosed are cooling tubes or straws for beverages and other liquids. The tubes or straws comprise a porous matrix to effect the cooling a liquid contained within by pervaporation.
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4.发明申请公开(公告)号：US20080063794A1
公开(公告)日：2008-03-13
申请号：US11855374
申请日：2007-09-14
Applicant: Jainamma Krotz , Daniel Smolko , Howard Reese , Thomas Onofrey , Daguang Wang , Theodore Winger , John Havens
Inventor： Jainamma Krotz , Daniel Smolko , Howard Reese , Thomas Onofrey , Daguang Wang , Theodore Winger , John Havens
CPC classification number: C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
Abstract: The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The present invention includes methods for forming a permeation layer on an array of microelectrodes including the steps of attaching a linker to the surface of the array and providing a polymerization solution that includes a porogen. The surface of the array is then contacted with the polymerization solution and the polymerization solution is then polymerized on the surface of the array to form a permeation layer that is attached o the surface of the array through the linker. The porogen is then removed from the permeation layer, thereby creating void spaces in the permeation layer.
Abstract translation: 本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。 本发明包括在微电极阵列上形成渗透层的方法，包括将接头连接到阵列的表面并提供包含致孔剂的聚合溶液的步骤。 然后将阵列的表面与聚合溶液接触，然后聚合溶液在阵列的表面上聚合，形成通过接头连接在阵列表面上的渗透层。 然后从渗透层除去致孔剂，从而在渗透层中产生空隙。
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公开(公告)号：US20060201187A1
公开(公告)日：2006-09-14
申请号：US11435154
申请日：2006-05-16
Applicant: Daniel Smolko , Gregory Kevorkian
Inventor： Daniel Smolko , Gregory Kevorkian
IPC: F28C1/00
CPC classification number: A41D13/0053 , F25D7/00
Abstract: Disclosed are cooling jackets for containers for beverages and other liquids. Such a jacket comprises a porous matrix as an element of the jacket body to effect the cooling of the jacket by pervaporation of a liquid contained within the jacket body. The jacket therefore cools a liquid within a container maintained in direct contact with the jacket.
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Patent Agency Ranking
公开(公告)号：US20050263480A1
公开(公告)日：2005-12-01
申请号：US11194660
申请日：2005-08-02
Applicant: Daniel Smolko , Gregory Kevorkian
Inventor： Daniel Smolko , Gregory Kevorkian
IPC: A41D13/005 , A45F3/20 , A47G19/22 , A47G21/18 , A61J1/14 , A61J9/04 , B65D1/32 , B65D47/06 , B65D47/24 , B65D47/26 , B65D51/16 , B65D81/18 , B65D81/38 , C08J9/00 , F25D7/00 , F28D5/00
CPC classification number: A45F3/20 , A47G19/2266 , A47G19/2272 , A47G21/18 , A47G2400/027 , A61J9/04 , A61M2207/00 , B65D1/323 , B65D47/06 , B65D47/242 , B65D47/265 , B65D51/1616 , B65D81/18 , B65D81/3886 , B65D2205/00 , C02F1/003 , C02F2307/02 , F25D7/00 , F25D2331/803 , F25D2331/806 , F25D2331/808 , F25D2400/26 , F28D5/00
Abstract: Disclosed are beverage containers and closures for beverage containers that are vented for the purpose of reducing negative pressure or vacuum that builds up inside the container when a beverage is being consumed therefrom. Also disclosed are closures which provide for chemical treatment of a liquid by a porous treatment matrix when the liquid is dispensed through the closure.
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7.发明授权公开(公告)号：US06960298B2
公开(公告)日：2005-11-01
申请号：US10014895
申请日：2001-12-10
Applicant: Jainamma Krotz , Daniel Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
Inventor： Jainamma Krotz , Daniel Smolko , Howard R. Reese , Thomas J. Onofrey , Daguang Wang , Theodore M. Winger , John R. Havens
IPC: G01N33/53 , A61K20060101 , B01D29/00 , B01D39/14 , B01D63/08 , B01J19/00 , C08J5/12 , C12M1/34 , C12Q1/68 , G01N27/26 , G01N27/30 , G01N27/447 , G01N33/543 , G01N33/547 , G01N33/566
CPC classification number: C12Q1/002 , B01D67/003 , B01D69/125 , B01D2323/18 , B01D2323/34 , B01D2323/42 , C09D123/26 , C12Q1/003 , G01N33/5438 , G01N33/545
Abstract: The present invention provides improved synthetic polymer hydrogel permeation layers for use on active electronic matrix devices for biological assays. The permeation layers have a defined porous character, with mesopores in a size range between about 100 nanometers and about 1000 nanometers, and may also have micropores in the micrometer size range. The mesoporous synthetic hydrogel permeation layers demonstrate improved signal intensity and linearity characteristics as compared to nanoporous synthetic hydrogel permeation layers on active electronic matrix devices. In addition, the present invention also provides synthetic polymer hydrogel permeation layers which contain copolymerized attachment sites for nucleic acid probes or other biomolecules.
Abstract translation: 本发明提供了用于生物测定的活性电子基质装置上的改进的合成聚合物水凝胶渗透层。 渗透层具有限定的多孔性质，其中介孔的尺寸范围在约100纳米至约1000纳米之间，并且也可以具有微米尺寸范围内的微孔。 与有源电子矩阵器件上的纳米多孔合成水凝胶渗透层相比，介孔合成水凝胶渗透层显示出改进的信号强度和线性特性。 此外，本发明还提供含有用于核酸探针或其他生物分子的共聚附着位点的合成聚合物水凝胶渗透层。
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公开(公告)号：US20070187248A1
公开(公告)日：2007-08-16
申请号：US11638093
申请日：2006-12-12
Applicant: Dalibor Hodko , Ying Huang , Daniel Smolko
Inventor： Dalibor Hodko , Ying Huang , Daniel Smolko
IPC: B03C5/02
CPC classification number: G01N27/447 , B03C5/005 , B03C5/026
Abstract: Devices and methods for performing separation of cell particles by dielectrophoresis in three dimensions. In one embodiment the device comprises a flow chamber having microfabricated chip with a plurality of vertical and horizontal electrodes, which may be coated with a protective layer to prevent direct contact between any electrode and a sample. The horizontal electrodes are in electrical communication with a DC or an AC power source, while the vertical electrodes are in electrical communication with an AC power source.
Abstract translation: 用于通过介电电泳在三维中进行细胞颗粒分离的装置和方法。 在一个实施例中，该装置包括具有多个垂直和水平电极的微加工芯片的流动室，其可以涂覆有保护层，以防止任何电极和样品之间的直接接触。 水平电极与DC或AC电源电连通，而垂直电极与AC电源电连通。
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公开(公告)号：US20060201178A1
公开(公告)日：2006-09-14
申请号：US11434998
申请日：2006-05-16
Applicant: Daniel Smolko , Gregory Kevorkian
Inventor： Daniel Smolko , Gregory Kevorkian
CPC classification number: A41D13/0053 , F25D7/00
Abstract: Disclosed are self-cooling garments comprising a porous matrix as an element of the garment body to effect the cooling of the garment by pervaporation of a liquid contained within the garment body. The garment thereby provides cooling for the wearer.
Abstract translation: 本发明公开了一种自冷衣服，其包括作为衣物的元件的多孔基质，以通过渗透汽化包含在衣服体内的液体来实现衣服的冷却。 因此，衣服为穿戴者提供冷却。
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10.发明申请公开(公告)号：US20060134657A1
公开(公告)日：2006-06-22
申请号：US11140555
申请日：2005-05-27
Applicant: Dalibor Hodko , Daniel Smolko , Stuart Duffy
Inventor： Dalibor Hodko , Daniel Smolko , Stuart Duffy
IPC: C12Q1/68
CPC classification number: C12Q1/6825 , B01L3/5027 , B01L9/527 , G01N27/3278 , C12Q2563/155 , C12Q2563/137 , C12Q2565/607 , C12Q2565/501
Abstract: A new, extremely sensitive, and rapid electronic detection method for direct detection of hybridized genomic targets to specific probes on the microarray is proposed. The method consists of fast electronic accumulation of the DNA target on a particular electrode site at the micro-electrode array, sequential electronic hybridization of oligonucleotide labeled metallic (nano)particles on the target DNA and monitoring the electrochemical AC impedance changes at the electrode site. The method is enhanced by electroplating over the DNA target which serves as the metallization template and over the particles which provide seeds for rapid electroplating. The AC impedance changes are monitored during the electroplating over the DNA target and between the array electrodes sites. The signal in the absence and presence of the target DNA is a difference between “no connection” and a “short” between the array electrodes
Abstract translation: 提出了一种用于将杂交的基因组靶基因直接检测到微阵列上的特异性探针的新的，非常灵敏和快速的电子检测方法。 该方法包括在微电极阵列上的特定电极部位上DNA靶的快速电子积累，寡核苷酸标记的金属（纳米）粒子在靶DNA上的顺序电子杂交，并监测电极部位的电化学AC阻抗变化。 该方法通过电镀在用作金属化模板的DNA靶上和提供用于快速电镀的种子的颗粒上而得到增强。 在DNA靶标和阵列电极位置之间的电镀期间监测AC阻抗变化。 目标DNA不存在和存在时的信号是阵列电极之间的“无连接”和“短”之间的差异
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