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    Lung targeting dual drug delivery system
    3.
    发明授权
    Lung targeting dual drug delivery system 有权
    肺靶向双药递送系统

    公开(公告)号：US09421194B2

    公开(公告)日：2016-08-23

    申请号：US13080371

    申请日：2011-04-05

    申请人： Robert K. Prud'homme ,  Patrick J. Sinko ,  Howard A. Stone ,  Nathalie M. Pinkerton ,  Lei Shi ,  Jiandi Wan ,  Sherif Ibrahim ,  Dayuan Gao

    发明人： Robert K. Prud'homme ,  Patrick J. Sinko ,  Howard A. Stone ,  Nathalie M. Pinkerton ,  Lei Shi ,  Jiandi Wan ,  Sherif Ibrahim ,  Dayuan Gao

    IPC分类号： A61K31/437 ,  A61K9/00 ,  A61K9/16

    CPC分类号： A61K9/1641 ,  A61K9/0019 ,  A61K9/1635 ,  A61K9/1647 ,  A61K31/437 ,  A61K31/4745

    摘要： The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer. National Cancer Institute assesses, however, that results of standard treatment are generally poor with only a 15 percent 5-year survival rate for combined cancer stages. Challenges facing the current chemotherapy drugs include excessive toxicity to healthy tissues and limited ability to prevent metastases. A dual drug delivery system described herein selectively targets the lung to deliver anti-cancer drugs and inhibit the formation of metastases.

    摘要翻译： 美国癌症协会估计，在2009年，美国将诊断出1,479,350例新的癌症病例，其中219,440例与肺和支气管有关。 NSCLC的标准治疗方法包括手术，化学疗法，放射线，激光和光动力疗法，均取决于癌症的各个阶段。 然而，国家癌症研究所评估标准治疗结果普遍较差，联合癌症阶段的5年生存率只有15％。 目前化疗药物面临的挑战包括对健康组织的过度毒性和预防转移的能力有限。 本文描述的双重药物递送系统选择性地靶向肺以递送抗癌药物并抑制转移的形成。

    Manipulation of particles in channels
    4.
    发明授权
    Manipulation of particles in channels 有权
    在通道中操纵颗粒

    公开(公告)号：US08689981B2

    公开(公告)日：2014-04-08

    申请号：US13262079

    申请日：2010-04-08

    申请人： Howard A. Stone ,  Mara G. Prentiss ,  Pierre Striehl ,  Efraim Feinstein

    发明人： Howard A. Stone ,  Mara G. Prentiss ,  Pierre Striehl ,  Efraim Feinstein

    IPC分类号： B03C1/00

    CPC分类号： B03C1/288 ,  B03C1/01

    摘要： Systems and methods for the manipulation of particles within channels such as microfluidic channels are provided. In one set of embodiments, magnets are positioned around a channel. As a fluid containing magnetic and non-magnetic particles flows through the channel, the magnetic field created by the magnets can be used to transport the magnetic and/or non-magnetic particles to desired locations within the channel, which may useful in some cases for causing some separation of the particles. For example, the magnetic field may be used to transport magnetic or non-magnetic particles from a core fluid to a surrounding sheath fluid. In some cases, the magnetic field is used to transport non-magnetic particles to a small volume within the channel (e.g., a single-file row within the channel). The systems and methods described herein may find application in a variety of fields including, for example, continuous sorting of cells, removal of targeted cells from a stream of blood, or the arrangement of non-magnetic particles in channels for analysis.

    摘要翻译： 提供了用于操纵诸如微流体通道的通道内的颗粒的系统和方法。 在一组实施例中，磁体围绕通道定位。 当含有磁性和非磁性颗粒的流体流过通道时，由磁体产生的磁场可用于将磁性和/或非磁性颗粒传送到通道内的所需位置，这在某些情况下可能有用 导致颗粒的一些分离。 例如，磁场可以用于将磁性或非磁性颗粒从芯流体输送到周围的鞘液。 在一些情况下，磁场用于将非磁性颗粒传输到通道内的小体积（例如，通道内的单个文件行）。 本文所述的系统和方法可以应用于各种领域，包括例如细胞的连续分选，从血液流中去除靶细胞，或者在通道中排列非磁性粒子进行分析。

    NANO-OTOLOGIC PROTECTIVE EQUIPMENT FOR IMPACT NOISE TOXICITY AND/OR BLAST OVERPRESSURE EXPOSURE
    5.
    发明申请
    NANO-OTOLOGIC PROTECTIVE EQUIPMENT FOR IMPACT NOISE TOXICITY AND/OR BLAST OVERPRESSURE EXPOSURE 审中-公开
    影响噪声和/或爆发过度暴露的纳米生物防护设备

    公开(公告)号：US20110197899A1

    公开(公告)日：2011-08-18

    申请号：US12160558

    申请日：2007-01-10

    申请人： Rick Rogers ,  Brendan Clifford ,  Robert M. Westervelt ,  John W. Hutchinson ,  Howard A. Stone

    发明人： Rick Rogers ,  Brendan Clifford ,  Robert M. Westervelt ,  John W. Hutchinson ,  Howard A. Stone

    IPC分类号： A61F11/06

    CPC分类号： A61F11/08 ,  A61N1/36036

    摘要： An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent one of the ends of the body with the acoustically limp material having a hole therein aligned with the channel extending through the body, and a component film, disc or other structure covering or sealing the opening in the acoustically limp material. The film or disc may be formed of a high-strength polymer material and may be less than 10 micrometers in thickness. Rather than having a single channel extending through the body, a plurality of channels may extend therethrough and a plurality of corresponding holes may be provided in the acoustically limp material. The film, disc or other structure covers or seals the plurality of holes in the acoustically limp material. The film, disc or other structure may be attached in such a fashion as to behave like a flap whose operation is to close in response to high energy sound waves. The flap is pressed shut from the high intensity shock wave itself. The body may cylindrical in shape or may have another shape to fit snugly in a human ear canal.

    摘要翻译： 一种用于防止听力损失的装置，具有由具有第一和第二端的柔性柔性材料制成的主体和延伸穿过其中的通道，与身体的一个端部相邻的声学瑕疵材料，其中具有孔的声lim材料与 通道延伸穿过身体，以及覆盖或密封声学柔软材料中的开口的部件膜，盘或其他结构。 膜或盘可以由高强度聚合物材料形成，并且厚度可以小于10微米。 不是具有延伸穿过主体的单个通道，而是可以在多个通道中延伸通过，并且可以在声学柔软的材料中设置多个对应的孔。 胶片，碟片或其他结构覆盖或密封声lim材料中的多个孔。 胶片，碟片或其他结构可以以与其操作以响应于高能量声波而关闭的片状的方式附接。 从高强度冲击波本身关闭襟翼。 身体可以是圆柱形的或者可以具有另一形状以适合贴合在人耳道中。

    Pressure Determination In Microfludic Systems
    7.
    发明申请
    Pressure Determination In Microfludic Systems 审中-公开
    微流体系统中的压力测定

    公开(公告)号：US20100064780A1

    公开(公告)日：2010-03-18

    申请号：US11989344

    申请日：2006-07-27

    申请人： Howard A Stone

    发明人： Howard A Stone

    IPC分类号： G01L7/18 ,  G01N7/00

    CPC分类号： G01L7/187 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0647 ,  B01L2200/146 ,  B01L2300/0627 ,  G01N11/08

    摘要： Methods and apparatus for measuring changes in pressure in a fluidic system are described. In one aspect, an apparatus for measuring pressure as described herein includes a test channel (e.g., a first fluidic channel (120)) and a control channel (e.g., a second fluidic channel (125)) that join a measuring region (130) downstream of the test and control channels. In some embodiments, fluid flowing in the test and control channels can be laminar and form a stable fluid interface in the measuring region. A property of the fluid interface, such as the position of the fluid interface, e.g., relative to a width of the measuring region, may be measured, in some cases visually. In some embodiments, introduction of a component (e.g., a cell) into the test channel can cause a change in pressure drop in the test channel. This change in pressure drop can cause a deflection of the fluid interface. The amplitude of deflection of the fluid interface can be correlated with the change in pressure caused by the introduction of the component in the test channel. In some cases, changes in pressure can be associated with a characteristic (e.g., a mechanical property) of the component. Advantageously, changes in pressure can be measured dynamically and in real time.

    摘要翻译： 描述了用于测量流体系统中的压力变化的方法和装置。 一方面，如本文所述的用于测量压力的装置包括连接测量区域（130）的测试通道（例如，第一流体通道（120））和控制通道（例如，第二流体通道（125））， 测试和控制渠道的下游。 在一些实施例中，在测试和控制通道中流动的流体可以是层流的并且在测量区域中形成稳定的流体界面。 流体界面的特性，例如流体界面的位置，例如相对于测量区域的宽度，可以在某些情况下在视觉上被测量。 在一些实施例中，将组件（例如，单元）引入测试通道可导致测试通道中的压降的变化。 压差的这种变化可能导致流体界面的偏转。 流体界面的偏转幅度可以与由测试通道中的部件引入引起的压力变化相关。 在一些情况下，压力的变化可以与部件的特性（例如，机械特性）相关联。 有利地，可以动态地和实时地测量压力的变化。

    MANIPULATION OF PARTICLES IN CHANNELS
    9.
    发明申请
    MANIPULATION OF PARTICLES IN CHANNELS 有权
    管道中的颗粒的操作

    公开(公告)号：US20120080360A1

    公开(公告)日：2012-04-05

    申请号：US13262079

    申请日：2010-04-08

    申请人： Howard A. Stone ,  Mara G. Prentiss ,  Pierre Striehl ,  Efraim Feinstein

    发明人： Howard A. Stone ,  Mara G. Prentiss ,  Pierre Striehl ,  Efraim Feinstein

    IPC分类号： B03C1/32 ,  B81B7/00 ,  B03C1/00

    CPC分类号： B03C1/288 ,  B03C1/01

    摘要： Systems and methods for the manipulation of particles within channels such as microfluidic channels are provided. In one set of embodiments, magnets are positioned around a channel. As a fluid containing magnetic and non-magnetic particles flows through the channel, the magnetic field created by the magnets can be used to transport the magnetic and/or non-magnetic particles to desired locations within the channel, which may useful in some cases for causing some separation of the particles. For example, the magnetic field may be used to transport magnetic or non-magnetic particles from a core fluid to a surrounding sheath fluid. In some cases, the magnetic field is used to transport non-magnetic particles to a small volume within the channel (e.g., a single-file row within the channel). The systems and methods described herein may find application in a variety of fields including, for example, continuous sorting of cells, removal of targeted cells from a stream of blood, or the arrangement of non-magnetic particles in channels for analysis.

    摘要翻译： 提供了用于操纵诸如微流体通道的通道内的颗粒的系统和方法。 在一组实施例中，磁体围绕通道定位。 当含有磁性和非磁性颗粒的流体流过通道时，由磁体产生的磁场可用于将磁性和/或非磁性颗粒传输到通道内的所需位置，这在某些情况下可能有用 导致颗粒的一些分离。 例如，磁场可以用于将磁性或非磁性颗粒从芯流体输送到周围的鞘液。 在一些情况下，磁场用于将非磁性颗粒传输到通道内的小体积（例如，通道内的单个文件行）。 本文所述的系统和方法可以应用于各种领域，包括例如细胞的连续分选，从血液流中去除靶细胞，或者在通道中排列非磁性粒子进行分析。