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    Personal care compositions with color changing indicator
    3.
    发明申请
    Personal care compositions with color changing indicator 审中-公开
    具有变色指示剂的个人护理组合物

    公开(公告)号：US20060222675A1

    公开(公告)日：2006-10-05

    申请号：US11391725

    申请日：2006-03-28

    申请人： Ram Sabnis ,  Timothy Kehoe ,  Robert Balchunis

    发明人： Ram Sabnis ,  Timothy Kehoe ,  Robert Balchunis

    IPC分类号： A01N25/00

    CPC分类号： A61Q17/005 ,  A61F13/42 ,  A61K8/0208 ,  A61K8/368 ,  A61K8/40 ,  A61K8/445 ,  A61K8/4926 ,  A61K8/4973 ,  A61K2800/45 ,  A61L15/20 ,  A61L15/56 ,  A61Q17/04 ,  C11D3/2075 ,  C11D3/24 ,  C11D3/26 ,  C11D3/30 ,  C11D3/40 ,  C11D3/48 ,  C11D17/049

    摘要： The invention describes a composition for use in disinfecting a surface for personal use, such as a public restroom facility or telephone. The composition and delivery of the composition provides for the placement of a thin layer of disinfectant which includes a acid-base indicator. The acid-base indicator disappears as the thin layer effects the germicidal activity of the disinfectant. The composition is also rapidly drying, so that the acid-base indicator disappears as well as the disinfecting composition leaving the surface dry. The invention also relates to use of the compositions in a lotion, such as a sunscreen. Use of the acid-base indicator provides a method to visualize where the lotion is applied by color, with the color then later dissipating.

    摘要翻译： 本发明描述了一种用于消毒用于个人使用的表面的组合物，例如公共厕所设施或电话。 组合物的组成和递送提供了包括酸碱指示剂的消毒剂薄层的放置。 酸碱指示剂消失，因为薄层影响消毒剂的杀菌活性。 组合物也快速干燥，使得酸碱指示剂消失，并且消毒组合物离开表面干燥。 本发明还涉及组合物在洗剂如防晒剂中的用途。 酸碱指示剂的使用提供了一种可视化方法，以便通过颜色涂抹洗剂，颜色随后消散。

    Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
    4.
    发明授权
    Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells 失效
    用于分析细胞代谢活性的报道分子的卤代烷基衍生物

    公开(公告)号：US5576424A

    公开(公告)日：1996-11-19

    申请号：US336285

    申请日：1994-11-08

    申请人： Fei Mao ,  Ram Sabnis ,  John Naleway ,  Nels Olson ,  Richard P. Haugland

    发明人： Fei Mao ,  Ram Sabnis ,  John Naleway ,  Nels Olson ,  Richard P. Haugland

    IPC分类号： C12Q1/04 ,  C12Q1/34 ,  G01N33/535 ,  C07H17/00 ,  C07D309/00

    CPC分类号： G01N33/535 ,  C12Q1/04 ,  C12Q1/34 ,  C12Q2334/00 ,  C12Q2334/20 ,  C12Q2334/40 ,  C12Q2337/20 ,  G01N2333/924

    摘要： The subject invention provides substrates useful for analyzing the metabolic activity in cells by improving the retention of a detectable reporter molecule only in intact cells where a particular enzyme is present. In particular, improved retention results from a two part process involving conjugation of haloalkyl-substituted derivatives of a reporter molecule with intracellular cysteine-containing peptides while unblocking the reporter molecule. The substrates have the formXR-SPACER-REPORTER-BLOCKwherein -BLOCK is a group selected to be removable by action of a specific analyte, to give REPORTER spectral properties different from those of the substrate,-REPORTER- is a molecule that, when no longer bound to BLOCK by a BLOCK-REPORTER bond, has spectral properties different from those of the substrate,-SPACER- is a covalent linkage, andXR- is a haloalkyl moiety that can covalently react with an intracellular thiol (Z-S-H) to form a thioether conjugate (Z-S-R-).After the substrate enters the cells, the analyte removes BLOCK to make REPORTER detectable by the change in spectral properties, and the haloalkyl XR reacts with the intracellular thiol to form the thioether conjugate inside the cells, which is well-retained in the cells.

    摘要翻译： 本发明提供了用于通过仅在存在特定酶的完整细胞中改善可检测报道分子的保留来分析细胞中代谢活性的底物。 特别地，涉及将报道分子的卤代烷基取代的衍生物与含细胞内半胱氨酸的肽结合的两部分方法的改进的保留结果，同时解除报道分子的阻断。 底物具有形式XR-SPACER-REPORTER-BLOCK，其中-BLOCK是选择通过特定分析物的作用可除去的基团，使得REPORTER光谱性质与底物不同，-REPORTER-是不再存在的分子 通过BLOCK-REPORTER键与BLOCK结合，具有与底物不同的光谱性质，-SPACER-是共价连接，XR-是可与胞内硫醇（ZSH）共价反应形成硫醚的卤代烷基部分 缀合物（ZSR-）。 在底物进入细胞后，分析物除去BLOCK以通过光谱性质的变化使REPORTER可检测到，并且卤代烷基XR与细胞内硫醇反应以在细胞内形成硫醚缀合物，其在细胞中良好保留。

    Composition and method for producing colored bubbles
    5.
    发明申请
    Composition and method for producing colored bubbles 有权
    彩色气泡的组成和方法

    公开(公告)号：US20060004110A1

    公开(公告)日：2006-01-05

    申请号：US11150975

    申请日：2005-06-13

    申请人： Ram Sabnis ,  Timothy Kehoe

    发明人： Ram Sabnis ,  Timothy Kehoe

    IPC分类号： B01F17/00 ,  A63H33/28

    CPC分类号： C11D3/40 ,  C11D1/146 ,  C11D1/523 ,  C11D1/652 ,  C11D1/90 ,  C11D1/94 ,  C11D3/2065 ,  C11D11/0094

    摘要： Compositions and methods for producing substantially uniformly colored bubbles are described. The composition comprises at least one surfactant mixed with at least one colorant, the colorant forming at least approximately 10% of the composition. The surfactant, or surface-active agent, forms the bubble while the colorant, or pigment, provides the color. Generally, the composition may comprise 10-99% colorant to produce varying degrees of opacity. In addition, glycerin, fragrance, propylene glycol, sodium lauryl sulfate, potassium hydroxide, or other additives may be included.

    摘要翻译： 描述了用于制备基本上均匀着色的气泡的组合物和方法。 该组合物包含至少一种与至少一种着色剂混合的表面活性剂，着色剂形成至少约10％的组合物。 表面活性剂或表面活性剂形成气泡，而着色剂或颜料提供颜色。 通常，组合物可以包含10-99％的着色剂，以产生不同程度的不透明度。 此外，可以包括甘油，香料，丙二醇，月桂基硫酸钠，氢氧化钾或其它添加剂。

    Lithography pattern shrink process and articles
    6.
    发明申请
    Lithography pattern shrink process and articles 失效
    平版印刷图案收缩工艺和文章

    公开(公告)号：US20050147901A1

    公开(公告)日：2005-07-07

    申请号：US11063411

    申请日：2005-02-23

    申请人： Ram Sabnis ,  James Lamb

    发明人： Ram Sabnis ,  James Lamb

    IPC分类号： H01L21/28 ,  B32B3/10 ,  G03C5/00 ,  G03F7/00 ,  G03F7/16 ,  G03F7/40 ,  H01L21/00 ,  H01L21/027 ,  H01L21/312 ,  H01L21/768

    CPC分类号： H01L21/02274 ,  G03F7/40 ,  H01L21/02118 ,  H01L21/0212 ,  H01L21/312 ,  H01L21/76816 ,  H01L21/76885 ,  Y10T428/24331 ,  Y10T428/24562

    摘要： Novel processes of applying a thin, uniform, conformal organic polymeric film by a wide variety of deposition processes into lithography pattern substrates are provided. The inventive processes result in shrinking of the gaps in the lithography pattern equally, thus producing a smaller dimension. The amount of pattern shrinkage is selectively controlled by controlling the deposition rate to provide the desired final structure dimension. A wide variety of organic films is used as materials for these films. The inventive methods are applicable to any patterning technique used in lithography to provide a reduction in pattern sizes. Examples of the applicable device levels include the production of gate layers, ion implantation of active device layers and substantive metal layers, dielectric patterning, interconnect processes produced by damascene, dual damascene, backend packaging layers, and devices requiring multiple layers deposited by electrodeposition, CVD or sputtering. The inventive methods are useful for providing highly conformal coatings on large surface substrates having super submicron (i.e., 0.15 μm or smaller) features. The process is environmentally friendly and relatively low cost compared to other options.

    摘要翻译： 提供了通过各种各样的沉积工艺将薄的，均匀的共形有机聚合物膜应用于光刻图案衬底的新方法。 本发明的方法导致平版印刷图案中间隙的缩小，从而产生更小的尺寸。 通过控制沉积速率以提供期望的最终结构尺寸来选择性地控制图案收缩量。 使用各种有机薄膜作为这些薄膜的材料。 本发明的方法适用于在光刻中使用的任何图案化技术以提供图案尺寸的减小。 可应用的器件级别的实例包括栅极层的生产，有源器件层的离子注入和实质金属层，电介质图案化，由镶嵌生成的互连工艺，双镶嵌，后端封装层以及需要通过电沉积沉积多层的器件 或溅射。 本发明的方法可用于在具有超亚微米（即0.15μm或更小）特征的大表面基底上提供高保形涂层。 与其他选项相比，该过程是环保的，成本相对较低。

    Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
    9.
    再颁专利
    Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells 失效
    用于分析细胞代谢活性的报道分子的卤代烷基衍生物

    公开(公告)号：USRE38723E1

    公开(公告)日：2005-04-12

    申请号：US08910090

    申请日：1997-08-12

    申请人： Fei Mao ,  Ram Sabnis ,  John Naleway ,  Nels Olson ,  Richard P. Haugland

    发明人： Fei Mao ,  Ram Sabnis ,  John Naleway ,  Nels Olson ,  Richard P. Haugland

    IPC分类号： C12Q1/04 ,  C12Q1/34 ,  G01N33/535 ,  C07H17/00 ,  C07D309/00

    CPC分类号： G01N33/535 ,  C12Q1/04 ,  C12Q1/34 ,  C12Q2334/00 ,  C12Q2334/20 ,  C12Q2334/40 ,  C12Q2337/20 ,  G01N2333/924

    摘要： The subject invention provides substrates useful for analyzing the metabolic activity in cells by improving the retention of a detectable reporter molecule only in intact cells where a particular enzyme is present. In particular, improved retention results from a two part process involving conjugation of haloalkyl-substituted derivatives of a reporter molecule with intracellular cysteine-containing peptides while unblocking the reporter molecule. The substrates have the form XR-SPACER-REPORTER-BLOCK wherein -BLOCK is a group selected to be removable by action of a specific analyte, to give REPORTER spectral properties different from those of the substrate, -REPORTER- is a molecule that, when no longer bound to BLOCK by a BLOCK-REPORTER bond, has spectral properties different from those of the substrate, -SPACER- is a covalent linkage, and XR- is a haloalkyl moiety that can covalently react with an intracellular thiol (Z-S-H) to form a thioether conjugate (Z-S-R). After the substrate enters the cells, the analyte removes BLOCK to make REPORTER detectable by the change in spectral properties, and the haloalkyl XR reacts with the intracellular thiol to form the thioether conjugate inside the cells, which is well-retained in the cells.