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公开(公告)号：US08617704B2
公开(公告)日：2013-12-31
申请号：US13273528
申请日：2011-10-14
CPC分类号： A61L27/306 , A61K6/02 , A61K6/0205 , A61L2400/18 , A61L2430/12 , Y10T156/10 , Y10T428/261 , Y10T428/265 , Y10T428/31667 , A61K6/0017 , C08L43/04
摘要： A coated medical implant, such as a coated dental component, is provided, the coated medical implant including a substrate surface formed of a material comprising available hydroxyl groups and a silicon oxide coating layer chemisorbed on the substrate surface. A method for the preparation of such coated implants is also provided, the method involving application of the silicon oxide coating layer to the substrate surface by chemical vapor deposition. A dental structure is also provided, which includes a first dental component having a substrate surface formed of a material comprising available hydroxyl groups; a silicon oxide coating layer chemisorbed on the substrate surface; a silane coupling agent overlying and covalently attached to the silicon oxide layer; a dental cement overlying and coupled to the silane coupling agent; and a second dental component having a surface bonded to the dental cement.
摘要翻译： 提供涂覆的医疗植入物，例如涂覆的牙科部件，涂覆的医疗植入物包括由包含可用羟基的材料形成的基底表面和在基底表面上化学吸附的氧化硅被覆层。 还提供了用于制备这种涂覆植入物的方法，该方法包括通过化学气相沉积将氧化硅涂层施加到基底表面。 还提供牙科结构，其包括具有由包含可用羟基的材料形成的基底表面的第一牙齿部件; 化学吸附在基材表面上的氧化硅涂层; 覆盖并共价连接到氧化硅层上的硅烷偶联剂; 覆盖并与硅烷偶联剂偶联的牙科水泥; 以及具有粘合到所述牙科粘固剂的表面的第二牙齿部件。
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公开(公告)号：US06924921B2
公开(公告)日：2005-08-02
申请号：US10743418
申请日：2003-12-22
申请人： John South Lewis, lll , Scott Halden Goodwin-Johansson , Brian Rhys Stoner , Sonia Grego , David Edward Dausch
发明人： John South Lewis, lll , Scott Halden Goodwin-Johansson , Brian Rhys Stoner , Sonia Grego , David Edward Dausch
CPC分类号： B82Y20/00 , C30B5/00 , C30B7/005 , C30B29/60 , G02B6/1225 , Y10S117/902 , Y10S117/913 , Y10T428/261 , Y10T428/265 , Y10T428/31504
摘要： A three dimensional photonic crystal and layer-by-layer processes of fabricating the photonic crystal. A substrate is exposed to a plurality of first microspheres made of a first material, the first material being of a type that will bond to the templated substrate and form a self-passivated layer of first microspheres to produce a first layer. The first layer is exposed to a plurality of second microspheres made of a second material, the second material being of a type that will bond to the first layer and form a self-passivated layer of second microspheres. This layering of alternating first and second microspheres can be repeated as desired to build a three dimensional photonic crystal of desired geometry. Charged polymers such as polyelectrolyte coatings can be used to create the bonds.
摘要翻译： 一个三维光子晶体和逐层制造光子晶体的过程。 将基底暴露于由第一材料制成的多个第一微球体中，第一材料是将结合到模板底物并形成第一微球的自钝化层以产生第一层的类型。 第一层暴露于由第二材料制成的多个第二微球，第二材料是将结合到第一层并形成第二微球的自钝化层的类型。 交替的第一和第二微球的这种层叠可以根据需要重复以构建所需几何形状的三维光子晶体。 可以使用带电聚合物如聚电解质涂层来形成结合。
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3.发明申请OPTICAL SENSING DEVICE FOR SENSING ANALYTES AND RELATED APPARATUS AND METHODS 审中-公开用于感测分析仪的光学感测装置及相关装置及方法公开(公告)号：US20140080729A1
公开(公告)日：2014-03-20
申请号：US14006430
申请日：2012-03-16
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , B01L3/5027 , G01N21/05 , G01N21/253 , G01N21/7743 , G01N2021/0346 , G01N2021/058
摘要： An optical sensing device and associated apparatus are configured for multiplexed detection of specific analytes in fluid samples. The device has a wavelength-tunable grating-coupler configuration in which a grating is disposed on a surface of a waveguide. Different regions of the grating may be functionalized with different receptors, and may form binding-specific sensors and reference sensors. The receptors are exposed to a fluid sample utilizing a fluidic structure mounted to the device. The device utilizes evanescent waves to sense analytes bound to the waveguide surface. The evanescent wave is sensitive to changes in refractive index at (or near) the waveguide surface. Changes in refractive index occur proportionally to the mass of the bound analyte. The apparatus utilizes a tunable light source to implement swept wavelength interrogation while the input beam is held at a fixed coupling angle relative to the waveguide and grating.
摘要翻译： 光学感测装置和相关联的装置被配置用于多次检测流体样品中的特定分析物。 该器件具有波长可调光栅耦合器配置，其中光栅设置在波导的表面上。 光栅的不同区域可以用不同的受体功能化，并且可以形成结合特异性传感器和参考传感器。 使用安装到该装置的流体结构将受体暴露于流体样品。 该器件利用ev逝波来感测与波导表面结合的分析物。 ev逝波对波导表面（或附近）的折射率变化敏感。 折射率的变化与结合的分析物的质量成比例地发生。 该设备利用可调谐光源实现扫描波长询问，同时输入光束相对于波导和光栅保持固定的耦合角度。
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4.发明申请CANTILEVER-BASED MEMS OPTICAL SCANNING APPARATUS, SYSTEM AND METHOD 有权基于CANTILEVER的MEMS光学扫描装置，系统和方法公开(公告)号：US20120080612A1
公开(公告)日：2012-04-05
申请号：US13259791
申请日：2010-02-26
CPC分类号： G02B23/2423 , A61B1/0008 , A61B1/00096 , A61B1/00172 , A61B1/043 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/0205 , G01B9/02091 , G01B2290/65 , G02B26/0858 , G02B26/101
摘要： The present invention relates to an optical scanning apparatus and an optical scanning system The optical system includes an optical engine connected to an optical scanning probe The optical scanning probe images a sample at different lateral positions of the sample The optical scanning probe includes a housing having a longitudinal axis extending in a direction towards a sample to be scanned, a first base having a first moveable mirror supported thereon by a first cantilever connecting the first moveable mirror to the first base, a second base having a second moveable mirror supported thereon by a second cantilever connecting the second moveable mirror to the second base, and a support attaching the first and second bases so that the first moveable mirror and the second moveable mirror are disposed along the longitudinal axis apart from each other
摘要翻译： 光学扫描装置和光学扫描系统本发明涉及光学扫描装置和光学扫描系统。该光学系统包括连接到光学扫描探针的光学引擎。光学扫描探针对样品的不同侧向位置成像样品。光学扫描探针包括具有 纵向轴线沿着待扫描样品的方向延伸;第一基座，其具有由第一悬臂支撑在其上的第一可移动反射镜，第一悬臂将第一可移动反射镜连接到第一基座;第二基座，其具有由第二可移动反射镜 将所述第二可移动反射镜连接到所述第二基座的悬臂，以及附接所述第一和第二基座的支撑件，使得所述第一可移动反射镜和所述第二可动反射镜沿着彼此分开的纵向轴线设置
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公开(公告)号：US06752868B2
公开(公告)日：2004-06-22
申请号：US10210010
申请日：2002-07-31
申请人： John South Lewis, III , Scott Halden Goodwin-Johansson , Brian Rhys Stoner , Sonia Grego , David Edward Dausch
发明人： John South Lewis, III , Scott Halden Goodwin-Johansson , Brian Rhys Stoner , Sonia Grego , David Edward Dausch
IPC分类号： C30B2954
CPC分类号： B82Y20/00 , C30B5/00 , C30B7/005 , C30B29/60 , G02B6/1225 , Y10S117/902 , Y10S117/913 , Y10T428/261 , Y10T428/265 , Y10T428/31504
摘要： A three dimensional photonic crystal and layer-by-layer processes of fabricating the photonic crystal. A templated substrate is exposed to a plurality of first microspheres made of a first material, the first material being of a type that will bond to the templated substrate and form a self-passivated layer of first microspheres to produce a first layer. The first layer is exposed to a plurality of second microspheres made of a second material, the second material being of a type that will bond to the first layer and form a self-passivated layer of second microspheres. This layering of alternating first and second microspheres can be repeated as desired to build a three dimensional photonic crystal of desired geometry.
摘要翻译： 一个三维光子晶体和逐层制造光子晶体的过程。 模板化的衬底暴露于由第一材料制成的多个第一微球体中，第一材料是将结合到模板衬底并形成第一微球的自钝化层以产生第一层的类型。 第一层暴露于由第二材料制成的多个第二微球，第二材料是将结合到第一层并形成第二微球的自钝化层的类型。 交替的第一和第二微球的这种层叠可以根据需要重复以构建所需几何形状的三维光子晶体。
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公开(公告)号：US08700134B2
公开(公告)日：2014-04-15
申请号：US13259791
申请日：2010-02-26
IPC分类号： A61B6/00
CPC分类号： G02B23/2423 , A61B1/0008 , A61B1/00096 , A61B1/00172 , A61B1/043 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/0205 , G01B9/02091 , G01B2290/65 , G02B26/0858 , G02B26/101
摘要： The present invention relates to an optical scanning apparatus and an optical scanning system The optical system includes an optical engine connected to an optical scanning probe The optical scanning probe images a sample at different lateral positions of the sample The optical scanning probe includes a housing having a longitudinal axis extending in a direction towards a sample to be scanned, a first base having a first moveable mirror supported thereon by a first cantilever connecting the first moveable mirror to the first base, a second base having a second moveable mirror supported thereon by a second cantilever connecting the second moveable mirror to the second base, and a support attaching the first and second bases so that the first moveable mirror and the second moveable mirror are disposed along the longitudinal axis apart from each other.
摘要翻译： 光学扫描装置和光学扫描系统本发明涉及光学扫描装置和光学扫描系统。该光学系统包括连接到光学扫描探针的光学引擎。光学扫描探针对样品的不同侧向位置成像样品。光学扫描探针包括具有 纵向轴线沿着待扫描样品的方向延伸;第一基座，其具有由第一悬臂支撑在其上的第一可移动反射镜，第一悬臂将第一可移动反射镜连接到第一基座;第二基座，其具有由第二可移动反射镜 将第二可移动反射镜连接到第二基座的悬臂，以及附接第一和第二基座的支撑件，使得第一可移动反射镜和第二可移动反射镜沿着彼此分开的纵向轴线设置。
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公开(公告)号：US20120034572A1
公开(公告)日：2012-02-09
申请号：US13273528
申请日：2011-10-14
IPC分类号： A61C8/00 , A61C13/007 , A61C5/04 , A61C5/00 , B32B37/12 , A61C7/14 , C23C16/40 , B32B37/14 , C23C16/02 , A61C5/08 , A61C5/02
CPC分类号： A61L27/306 , A61K6/02 , A61K6/0205 , A61L2400/18 , A61L2430/12 , Y10T156/10 , Y10T428/261 , Y10T428/265 , Y10T428/31667 , A61K6/0017 , C08L43/04
摘要： A coated medical implant, such as a coated dental component, is provided, the coated medical implant including a substrate surface formed of a material comprising available hydroxyl groups and a silicon oxide coating layer chemisorbed on the substrate surface. A method for the preparation of such coated implants is also provided, the method involving application of the silicon oxide coating layer to the substrate surface by chemical vapor deposition. A dental structure is also provided, which includes a first dental component having a substrate surface formed of a material comprising available hydroxyl groups; a silicon oxide coating layer chemisorbed on the substrate surface; a silane coupling agent overlying and covalently attached to the silicon oxide layer; a dental cement overlying and coupled to the silane coupling agent; and a second dental component having a surface bonded to the dental cement.
摘要翻译： 提供涂覆的医疗植入物，例如涂覆的牙科部件，涂覆的医疗植入物包括由包含可用羟基的材料形成的基底表面和在基底表面上化学吸附的氧化硅被覆层。 还提供了一种用于制备这种涂覆植入物的方法，该方法包括通过化学气相沉积将氧化硅涂层施加到基底表面。 还提供牙科结构，其包括具有由包含可用羟基的材料形成的基底表面的第一牙齿部件; 化学吸附在基材表面上的氧化硅涂层; 覆盖并共价连接到氧化硅层上的硅烷偶联剂; 覆盖并与硅烷偶联剂偶联的牙科水泥; 以及具有粘合到所述牙科粘固剂的表面的第二牙齿部件。
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