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公开(公告)号：US08993340B2
公开(公告)日：2015-03-31
申请号：US13051251
申请日：2011-03-18
Applicant: Hun-joo Lee , Jeong-gun Lee , Mi-jeong Song , Jong-myeon Park , Tae-seok Sim , Min-seok S. Kim
Inventor： Hun-joo Lee , Jeong-gun Lee , Mi-jeong Song , Jong-myeon Park , Tae-seok Sim , Min-seok S. Kim
CPC classification number: C12M47/04 , B01L3/502753 , B01L3/502761 , B01L2300/0864 , B03C1/02 , B03C1/14 , B03C1/145 , C12M1/266 , G01N1/4077 , Y10T436/25
Abstract: A cell separation device includes a channel or chamber in which a sample flows or moves, the sample including target cells marked with magnetic particles, and non-target cells, and a magnet which generates a magnetic first force in a first direction with respect to the sample within the channel or chamber. The channel or chamber of the cell separation device is applied with a second force in a second direction opposite to the first direction of the magnetic force. According to the cell separation device and a method of separating cells, the target cells move in the first direction by the magnetic force, and the non-target cells move in the second direction by the second force, by simultaneously applying the magnetic force and the second force in opposing directions, thereby separating the target cells from the non-target cells.
Abstract translation: 细胞分离装置包括样品流动或移动的通道或室，包括标记有磁性颗粒的靶细胞的样品和非靶细胞，以及相对于第一方向产生第一方向的磁性第一力的磁体 样品在通道或室内。 细胞分离装置的通道或腔室以与磁力的第一方向相反的第二方向施加第二力。 根据细胞分离装置和分离细胞的方法，靶细胞通过磁力在第一方向上移动，非靶细胞通过第二力在第二方向上移动，同时施加磁力和 从而将目标细胞与非靶细胞分离。
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公开(公告)号：US20130149774A1
公开(公告)日：2013-06-13
申请号：US13615267
申请日：2012-09-13
Applicant: Min-seok KIM , Tae-seok SIM , Yeon-jeong KIM , Sang-hyun BAEK , Jin-mi OH , Hyo-young JEONG , Jeong-gun LEE
Inventor： Min-seok KIM , Tae-seok SIM , Yeon-jeong KIM , Sang-hyun BAEK , Jin-mi OH , Hyo-young JEONG , Jeong-gun LEE
CPC classification number: G01N15/12 , C12M41/36 , G01N2015/0065 , G01N2015/1081
Abstract: A cell counter system includes an inlet via which a fluid containing a plurality of cells inflows; a channel in which the fluid flows; a valve unit, which controls flow of the fluid in the channel; an electrode unit, which is arranged in the channel for measuring impedance for counting a number of the plurality of cells; and an outlet, which is connected to the channel to drain the fluid.
Abstract translation: 细胞计数器系统包括通过其流入含有多个细胞的流体入口的入口; 流体流动的通道; 阀单元，其控制流体在通道中的流动; 电极单元，布置在通道中用于测量用于对多个单元的数量进行计数的阻抗; 和出口，其连接到通道以排出流体。
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3.发明申请公开(公告)号：US20130086998A1
公开(公告)日：2013-04-11
申请号：US13571202
申请日：2012-08-09
Applicant: June-young LEE , Sang-hyun BAEK , Hyo-young JEONG , Tae-seok SIM , Jeong-gun LEE
Inventor： June-young LEE , Sang-hyun BAEK , Hyo-young JEONG , Tae-seok SIM , Jeong-gun LEE
IPC: G01N1/20
CPC classification number: B01L3/502753 , B01L3/5027 , B01L2200/0621 , B01L2200/141 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2400/0487 , G01N2035/00237 , G01N2035/0437 , Y10T137/4259
Abstract: A fluid controlling apparatus including at least one sample chamber for holding a fluid containing target materials; a cleaning chamber for holding a cleaning solution; a first multi-port connected to the at least one sample chamber through a first channel and connected to the cleaning chamber through a second channel; a filter portion, connected to the first multi-port through a third channel, for filtering the target materials; and a first pump, connected to the filter portion, for applying a pressure; and a method of controlling a fluid using the fluid controlling apparatus, which comprises passing the fluid containing the target materials from the at least one sample chamber to the filter portion; and cleaning a path of the fluid by passing the cleaning solution through the path.
Abstract translation: 一种流体控制装置，包括用于保持含有目标材料的流体的至少一个样品室; 用于保持清洁溶液的清洁室; 第一多端口，其通过第一通道连接到所述至少一个样品室，并通过第二通道连接到所述清洁室; 过滤器部分，通过第三通道连接到第一多端口，用于过滤目标材料; 以及连接到过滤器部分的用于施加压力的第一泵; 以及使用所述流体控制装置控制流体的方法，所述方法包括将包含所述目标材料的流体从所述至少一个样品室传送到所述过滤器部分; 以及通过使清洁溶液通过路径来清洁流体的路径。
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4.发明申请TARGET PARTICLES-SEPARATING DEVICE AND METHOD USING MULTI-ORIFICE FLOW FRACTIONATION CHANNEL 有权目标颗粒分离装置和使用多元流动分离通道的方法公开(公告)号：US20110303586A1
公开(公告)日：2011-12-15
申请号：US13156630
申请日：2011-06-09
Applicant: Tae-seok SIM , Jeong-gun LEE , Hyo-il JUNG , Ki-ho KWON
Inventor： Tae-seok SIM , Jeong-gun LEE , Hyo-il JUNG , Ki-ho KWON
CPC classification number: B01L3/502761 , B01L3/502753 , B01L2200/0652 , B01L2300/087 , B01L2400/0487
Abstract: A device separating target particles in a fluid sample includes first through third multi-orifice flow fractionation (“MOFF”) channels, each including a multi-orifice segment with an inlet and an outlet at opposite ends, and an alternating series of contraction channels and expansion chambers interconnected in a lengthwise direction; a first separation unit including a first separation channel which is interconnected in fluid communication with a center region of the outlet of the first MOFF channel, and first branch channels which are interconnected in fluid communication with sidewall regions of the outlet of the first MOFF channel, and respectively with inlets of the second and third MOFF channels; and buffer inlets which are connected to the inlets of the second and third MOFF channels and through which a buffer flows into the second and third MOFF channels.
Abstract translation: 分离流体样品中的目标颗粒的装置包括第一至第三多孔流动分馏（“MOFF”）通道，每个通道包括具有相对端的入口和出口的多孔段，以及交替的一系列收缩通道和 膨胀室沿长度方向互相连接; 第一分离单元，包括与第一MOFF通道的出口的中心区域流体连通的第一分离通道和与第一MOFF通道的出口的侧壁区域流体连通地互连的第一分支通道， 并分别具有第二和第三MOFF通道的入口; 以及连接到第二和第三MOFF通道的入口并且缓冲器通过其流入第二和第三MOFF通道的缓冲器入口。
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5.发明授权公开(公告)号：US09238225B2
公开(公告)日：2016-01-19
申请号：US13571202
申请日：2012-08-09
Applicant: June-young Lee , Sang-hyun Baek , Hyo-young Jeong , Tae-seok Sim , Jeong-gun Lee
Inventor： June-young Lee , Sang-hyun Baek , Hyo-young Jeong , Tae-seok Sim , Jeong-gun Lee
CPC classification number: B01L3/502753 , B01L3/5027 , B01L2200/0621 , B01L2200/141 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2400/0487 , G01N2035/00237 , G01N2035/0437 , Y10T137/4259
Abstract: A fluid controlling apparatus including at least one sample chamber for holding a fluid containing target materials; a cleaning chamber for holding a cleaning solution; a first multi-port connected to the at least one sample chamber through a first channel and connected to the cleaning chamber through a second channel; a filter portion, connected to the first multi-port through a third channel, for filtering the target materials; and a first pump, connected to the filter portion, for applying a pressure; and a method of controlling a fluid using the fluid controlling apparatus, which comprises passing the fluid containing the target materials from the at least one sample chamber to the filter portion; and cleaning a path of the fluid by passing the cleaning solution through the path.
Abstract translation: 一种流体控制装置，包括用于保持含有目标材料的流体的至少一个样品室; 用于保持清洁溶液的清洁室; 第一多端口，其通过第一通道连接到所述至少一个样品室，并通过第二通道连接到所述清洁室; 过滤器部分，通过第三通道连接到第一多端口，用于过滤目标材料; 以及连接到过滤器部分的用于施加压力的第一泵; 以及使用所述流体控制装置控制流体的方法，所述方法包括将包含所述目标材料的流体从所述至少一个样品室传送到所述过滤器部分; 以及通过使清洁溶液通过路径来清洁流体的路径。
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Patent Agency Ranking
6.发明授权Target particles-separating device and method using multi-orifice flow fractionation channel 有权目标颗粒分离装置和使用多孔流量分馏通道的方法公开(公告)号：US08590710B2
公开(公告)日：2013-11-26
申请号：US13156630
申请日：2011-06-09
Applicant: Tae-seok Sim , Jeong-gun Lee , Hyo-il Jung , Ki-ho Kwon
Inventor： Tae-seok Sim , Jeong-gun Lee , Hyo-il Jung , Ki-ho Kwon
IPC: B07C5/00
CPC classification number: B01L3/502761 , B01L3/502753 , B01L2200/0652 , B01L2300/087 , B01L2400/0487
Abstract: A device separating target particles in a fluid sample includes first through third multi-orifice flow fractionation (“MOFF”) channels, each including a multi-orifice segment with an inlet and an outlet at opposite ends, and an alternating series of contraction channels and expansion chambers interconnected in a lengthwise direction; a first separation unit including a first separation channel which is interconnected in fluid communication with a center region of the outlet of the first MOFF channel, and first branch channels which are interconnected in fluid communication with sidewall regions of the outlet of the first MOFF channel, and respectively with inlets of the second and third MOFF channels; and buffer inlets which are connected to the inlets of the second and third MOFF channels and through which a buffer flows into the second and third MOFF channels.
Abstract translation: 分离流体样品中的目标颗粒的装置包括第一至第三多孔流动分馏（“MOFF”）通道，每个通道包括具有相对端的入口和出口的多孔段，以及交替的一系列收缩通道和 膨胀室沿长度方向互相连接; 第一分离单元，其包括与第一MOFF通道的出口的中心区域流体连通的第一分离通道和与第一MOFF通道的出口的侧壁区域流体连通地互连的第一分支通道， 并分别具有第二和第三MOFF通道的入口; 以及连接到第二和第三MOFF通道的入口并且缓冲器通过其流入第二和第三MOFF通道的缓冲器入口。
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7.发明申请HYDRODYNAMIC FILTER UNIT, HYDRODYNAMIC FILTER INCLUDING THE HYDRODYNAMIC FILTER UNIT, AND METHOD OF FILTERING TARGET MATERIAL BY USING THE HYDRODYNAMIC FILTER UNIT AND THE HYDRODYNAMIC FILTER 有权水力过滤装置，包括水力过滤装置的水力过滤器，以及使用水力过滤装置和水力过滤器过滤目标材料的方法公开(公告)号：US20120325749A1
公开(公告)日：2012-12-27
申请号：US13434252
申请日：2012-03-29
Applicant: Minseok S. KIM , Won-ho LEE , Sun-soo KIM , Jin-hoon KIM , Jeong-gun LEE , Tae-seok SIM
Inventor： Minseok S. KIM , Won-ho LEE , Sun-soo KIM , Jin-hoon KIM , Jeong-gun LEE , Tae-seok SIM
CPC classification number: B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/086
Abstract: A hydrodynamic filter unit includes an inlet channel connected to a fluid chamber, into which a fluid including a target material is introduced, and a plurality of outlet channels connected to the fluid chamber, through which the fluid is discharged. A filtering method includes introducing a fluid including a target material into the hydrodynamic filter unit through the inlet channel, capturing the target material in the hydrodynamic filter unit, and discharging a remaining part of the fluid outside of the hydrodynamic filter unit through an outlet channel.
Abstract translation: 流体动力过滤器单元包括连接到流体室的入口通道，包括目标材料的流体被引入到该流体室中，以及连接到流体室的多个出口通道，流体被排出。 过滤方法包括通过入口通道将包括目标材料的流体引入到流体动力过滤器单元中，捕获流体动力过滤器单元中的目标材料，以及通过出口通道将流体动力过滤器单元外剩余部分排出。
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公开(公告)号：US20100204063A1
公开(公告)日：2010-08-12
申请号：US12619067
申请日：2009-11-16
Applicant: Tae-seok SIM
Inventor： Tae-seok SIM
CPC classification number: B01L3/5085 , B01J2219/00533 , B01J2219/00608 , B01J2219/00722 , B01L3/5088 , B01L2300/0636 , B01L2300/0887 , B01L2300/089
Abstract: A DNA chip package includes; a base substrate, a photoresist layer disposed on the base substrate, at least one DNA chip mounting groove disposed in the photoresist layer and exposing the base substrate therethrough, and at least one DNA chip mounted in the at least one DNA chip mounting groove.
Abstract translation: DNA芯片封装包括： 基底基板，设置在基底基板上的光致抗蚀剂层，设置在光致抗蚀剂层中的至少一个DNA芯片安装槽，并使基板穿过其中;以及安装在至少一个DNA芯片安装槽中的至少一个DNA芯片。
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9.发明授权Hydrodynamic filter unit, hydrodynamic filter including the hydrodynamic filter unit, and method of filtering target material by using the hydrodynamic filter unit and the hydrodynamic filter 有权流体动力过滤器单元，包括流体动力过滤器单元的流体动力过滤器，以及通过使用流体动力过滤器单元和流体动力过滤器过滤目标材料的方法公开(公告)号：US09421543B2
公开(公告)日：2016-08-23
申请号：US13434252
申请日：2012-03-29
Applicant: Minseok S. Kim , Won-ho Lee , Sun-soo Kim , Jin-hoon Kim , Jeong-gun Lee , Tae-seok Sim
Inventor： Minseok S. Kim , Won-ho Lee , Sun-soo Kim , Jin-hoon Kim , Jeong-gun Lee , Tae-seok Sim
CPC classification number: B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/086
Abstract: A hydrodynamic filter unit includes an inlet channel connected to a fluid chamber, into which a fluid including a target material is introduced, and a plurality of outlet channels connected to the fluid chamber, through which the fluid is discharged. A filtering method includes introducing a fluid including a target material into the hydrodynamic filter unit through the inlet channel, capturing the target material in the hydrodynamic filter unit, and discharging a remaining part of the fluid outside of the hydrodynamic filter unit through an outlet channel.
Abstract translation: 流体动力过滤器单元包括连接到流体室的入口通道，包括目标材料的流体被引入到该流体室中，以及连接到流体室的多个出口通道，流体被排出。 过滤方法包括通过入口通道将包括目标材料的流体引入到流体动力过滤器单元中，捕获流体动力过滤器单元中的目标材料，以及通过出口通道将流体动力过滤器单元外剩余部分排出。
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10.发明申请FLUID CONTROLLING APPARATUS AND FILTER AND BIOCHIP INCLUDING THE FLUID CONTROLLING APPARATUS 有权流体控制装置和过滤器和生物技术包括流体控制装置公开(公告)号：US20130079248A1
公开(公告)日：2013-03-28
申请号：US13584552
申请日：2012-08-13
Applicant: Minseok S. KIM , Sun-soo KIM , Jin-hoon KIM , Won-ho LEE , Jeong-gun LEE , Tae-seok SIM , Sang-hyun BAEK , Hyo-young JEONG
Inventor： Minseok S. KIM , Sun-soo KIM , Jin-hoon KIM , Won-ho LEE , Jeong-gun LEE , Tae-seok SIM , Sang-hyun BAEK , Hyo-young JEONG
CPC classification number: B01L3/502753 , B01L3/502746 , B01L2200/10 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/0887 , B01L2400/0487 , B01L2400/086 , G01N21/05 , G01N2001/4088 , G01N2021/0325 , G01N2021/0346
Abstract: A fluid controlling apparatus including an inlet through which a fluid is introduced, a channel portion connected to the inlet, an outlet that is connected to the channel portion and through which the fluid is discharged, and at least one fluid resisting portion disposed between the inlet and the outlet, as well as a filter and a biochip including the fluid controlling apparatus.
Abstract translation: 一种流体控制装置，其包括入口，流体通过该入口，与入口连接的通道部分，连接到通道部分并且流体被排出的出口以及设置在入口之间的至少一个流体阻力部分 和出口，以及包括流体控制装置的过滤器和生物芯片。
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