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公开(公告)号：US09309275B2
公开(公告)日：2016-04-12
申请号：US14195388
申请日：2014-03-03
申请人： Idenix Pharmaceuticals, Inc. , Centre National De La Recherche Scientifique , Universite Montpellier 2 Sciences Et Techniques
发明人： Alistair James Stewart , Adel M. Moussa , Benjamin Alexander Mayes , Francois-Rene Alexandre , Dominique Surleraux , Christophe Claude Parsy , Claire Pierra , David Dukhan , Gilles Gosselin
IPC分类号： C07H19/044 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/708 , A61K31/7068 , A61K31/7076 , A61K31/7072 , A61K45/06 , A61K31/40 , A61K31/497 , A61K31/7056 , A61K38/21
CPC分类号： C07H19/207 , A61K31/40 , A61K31/497 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/212 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K2300/00
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-deoxy nucleoside compounds according to Formula 3001a or 3001b: or a pharmaceutically acceptable salts, solvates, stereoisomeric forms, tautomeric forms, or polymorphic forms thereof, wherein PD, Base1 and Base2 are as provided herein.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式3001a或3001b的3'-脱氧核苷化合物：或其药学上可接受的盐，溶剂合物，立体异构形式，互变异构形式或其多晶型，其中PD，碱基和碱基2如本文所提供。
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公开(公告)号：US09296778B2
公开(公告)日：2016-03-29
申请号：US13899487
申请日：2013-05-21
申请人： Idenix Pharmaceuticals, Inc. , Centre National De La Recherche Scientifique , Universite Montpellier 2 Sciences Et Techniques
发明人： Christophe Claude Parsy , Francois-Rene Alexandre , Cyril B. Dousson , David Dukhan , Gilles Gosselin , Houcine Rahali , Dominique Surleraux
IPC分类号： A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/10 , C07H19/20 , C07H19/213 , C07H19/11
CPC分类号： C07H19/20 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/10 , C07H19/11 , C07H19/213
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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3.发明申请SUGAR-ANALOG PHOSPHORUS-CONTAINING HETEROCYCLES HAVING AN ANTI-METASTATIC ACTIVITY 审中-公开具有抗细胞活性的含糖类含磷的杂环化合物公开(公告)号：US20150376216A1
公开(公告)日：2015-12-31
申请号：US14769928
申请日：2014-02-25
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIRIQUE , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIE , UNIVERSITE MONTPELLIER 1 , UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES , UNIVERSITE PARIS-NORD 13 , UNIVERSITE PARIS-SUD 11
发明人： Norbert BAKALARA , Marcel DELAFORGE , Marc LECOUVEY , Jean-Philippe HUGNOT , Philippe LEGRAND , Jean-Luc PIRAT , David VIRIEUX , Jean-Noel VOLLE
IPC分类号： C07F9/6571 , A61K45/06 , A61K31/665
CPC分类号： C07F9/657172 , A61K9/0019 , A61K9/08 , A61K31/665 , A61K31/67 , A61K31/675 , A61K45/06 , A61K47/14 , C07D493/04 , C07F9/6552 , C07F9/65522 , A61K2300/00
摘要： The use of compounds of formula (1) as defined in the description, for reducing or preventing the onset of metastases in a patient suffering from cancer. Pharmaceutical compositions for using in human or veterinary medicine, including at least one compound of formula (1) are also described.
摘要翻译： 使用描述中定义的式（1）化合物，用于减少或预防患有癌症的患者的转移发生。 还描述了用于人或兽医学包括至少一种式（1）化合物的药物组合物。
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公开(公告)号：US20150166464A1
公开(公告)日：2015-06-18
申请号：US14406065
申请日：2013-06-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N. R.S.) , UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES , ECOLE NATIONAL SUPERIEURE DE CHIMIE DE MONTPELLIER
发明人： Marc Taillefer , Florian Monnier , Anis Tlili , Grégory Danoun
IPC分类号： C07C213/04 , C07C45/68
CPC分类号： C07C213/04 , C07B37/04 , C07C37/20 , C07C45/68 , C07C213/06 , C07C39/21 , C07C217/18 , C07C49/784 , C07C49/84 , C07C49/813 , C07C49/83
摘要： The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.
摘要翻译： 本发明涉及在含铜催化剂，配体和碱的存在下，通过式（Ⅱ）化合物与式（Ⅲ）化合物反应来制备式（Ⅰ）化合物的方法。 本发明还涉及该方法的实施，用于制备结构单元以制备特别是在药物，农业化学领域等中的目标分子。
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公开(公告)号：US20140099283A1
公开(公告)日：2014-04-10
申请号：US14047862
申请日：2013-10-07
申请人： Idenix Pharmaceuticals, Inc. , Universite Montpellier 2 Sciences Et Techniques , Centre National De La Recherche Scientifique
发明人： Gilles GOSSELIN , Christophe Claude PARSY , Francois-Rene ALEXANDRE , Houcine RAHALI , Jean-Francois GRIFFON , Julien MILHAU , Dominique SURLERAUX , Cyril B. DOUSSON , Claire PIERRA , Adel M. MOUSSA , Benjamin Alexander MAYES
IPC分类号： C07H19/10 , A61K45/06 , A61K38/21 , C07H19/20 , A61K31/7076 , A61K31/708 , C07H19/14 , A61K31/7064 , C07H19/12 , A61K31/706 , A61K31/7068 , A61K31/7072 , C07H19/16
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式2001的2'-氯核苷：或其药学上可接受的盐，溶剂化物，立体异构形式，互变异构形式或其多晶型，其中B，Z和PD如本文所述。
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6.发明申请公开(公告)号：US20130315867A1
公开(公告)日：2013-11-28
申请号：US13899487
申请日：2013-05-21
申请人： Idenix Pharmaceuticals Inc. , Universite Montpellier 2 Sciences Et Techniques , Centre National De La Recherche Scientifique
发明人： Christophe Claude PARSY , Francois-Rene ALEXANDRE , Cyril B. DOUSSON , David DUKHAN , Gilles GOSSELIN , Houcine RAHALI , Dominique SURLERAUX
IPC分类号： C07H19/20 , C07H19/10 , A61K31/7068 , A61K31/7076 , A61K45/06
CPC分类号： C07H19/20 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/10 , C07H19/11 , C07H19/213
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
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公开(公告)号：US10066029B2
公开(公告)日：2018-09-04
申请号：US14905119
申请日：2014-07-15
IPC分类号： A61K36/00 , C08B37/08 , B01J37/36 , B01J23/40 , B09C1/10 , C02F3/32 , B01J37/02 , B01J37/06 , B01J37/08 , B01J37/16 , B01J37/30 , B01J23/42 , B01J23/44 , B01J23/46 , B01J37/00 , C07B37/04 , C22B3/00 , C22B3/18 , B01J27/13 , B01J31/18 , C07C5/03 , C07C45/34 , C07C209/68 , C07C253/16 , C07D207/06 , B01J37/34 , C02F101/10 , C02F101/20
摘要： A composition derived from the acid treatment of ashes obtained after heat treatment of selected plants or plant material is provided. The selected plants accumulate metal from the platinum group (platinoids). The compositions can be used to produce catalysts for performing various organic synthesis reactions.
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公开(公告)号：US09896461B2
公开(公告)日：2018-02-20
申请号：US14412888
申请日：2013-07-08
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER , UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES
IPC分类号： C07F7/18 , C07F9/40 , C07F9/6518
CPC分类号： C07F7/1804 , C07F9/4006 , C07F9/6518
摘要： The invention concerns a mono- or polyfunctional polysilylated organosilane compound, and the method for preparing same.
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公开(公告)号：US20170348646A1
公开(公告)日：2017-12-07
申请号：US15536780
申请日：2015-12-18
申请人： SAINT-GOBAIN CENTRE DE RECHERCHES ET D'ETUDES EUROPEEN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES , ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
发明人： Daniel URFFER , Christian GUIZARD
CPC分类号： B01D71/02 , B01D63/066 , B01D67/0041 , B01D67/0046 , B01D67/0083 , B01D67/0093 , B01D69/02 , B01D2046/2433 , B01D2046/2437 , B01D2323/08 , B01D2325/028 , C04B35/565 , C04B38/0006 , C04B38/0054 , C04B2235/3826 , C04B2235/781 , C04B2235/786 , C04B35/00 , C04B38/0096 , C04B38/0074
摘要： A filter for the filtration of a fluid, such as a liquid, includes or composed of a support element made of a porous ceramic material, the element having a tubular or parallelepipedal shape delimited by an external surface and including, in its internal portion, a set of adjacent channels with axes parallel to one another and separated from one another by walls of the porous inorganic material, wherein at least a portion of the channels and/or at least a portion of the external surface are covered with a porous separating membrane layer, wherein the layer is made of a material essentially composed of sintered grains of silicon carbide (SiC), and the weight content of elemental oxygen of the layer is less than 0.5%.
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10.发明申请AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV 审中-公开用于治疗HCV的2'-CYANO，AZIDO和氨基酸核苷酸的氨基酸磷酸酯原核苷酸公开(公告)号：US20160113956A1
公开(公告)日：2016-04-28
申请号：US14866759
申请日：2015-09-25
申请人： Centre National De La Recherche Scientifique , Universite Montpellier 2 Sciences Et Techniques , Idenix Pharmaceuticals, Inc.
发明人： David DUKHAN , Christophe Claude PARSY , Gilles GOSSELIN , Jean-François GRIFFON , Guillaume BRANDT , Cyril B. DOUSSON , Adel M. Moussa , Benjamin Alexander Mayes , Alistair James Stewart
IPC分类号： A61K31/7072 , A61K9/00 , A61K45/06 , C07H19/20 , A61K31/7076 , C07H19/10 , A61K31/7068
CPC分类号： A61K31/7072 , A61K9/0053 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H17/02 , C07H19/073 , C07H19/10 , C07H19/173 , C07H19/20
摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-cyano, azido or amino nucleosides according to Formula 1001 or 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, W, R1 and R2 are as described herein.
摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式1001或2001的2'-氰基，叠氮基或氨基核苷：或其药学上可接受的盐，溶剂合物，立体异构形式，互变异构形式或其多晶型，其中基团，W，R 1和R 2 如本文所述。
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