公开(公告)号：US20230405586A1

公开(公告)日：2023-12-21

申请号：US18240904

申请日：2023-08-31

Applicant: WAINAMICS, INC.

Inventor： Arturo M. Escajeda ,  Huyen Tran ,  Ming X. Tan

IPC: B01L3/00 ,  C12Q1/6844

CPC classification number: B01L3/502715 ,  C12Q1/6844 ,  B01L2200/04 ,  B01L2300/08 ,  B01L2200/0689 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2200/0605

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

公开(公告)号：US10105083B1

公开(公告)日：2018-10-23

申请号：US16018409

申请日：2018-06-26

Applicant: Wainamics, Inc.

Inventor： Ming Tan ,  Frank Zaugg ,  Peter Kernen

IPC: B01L1/00 ,  A61B5/15 ,  A61M1/34 ,  A61J1/05 ,  B01L3/00 ,  B01L3/02 ,  G01N33/49

CPC classification number: A61B5/150022 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150343 ,  A61J1/05 ,  A61J1/06 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3496 ,  A61M2205/3331 ,  B01L3/0217 ,  B01L3/502 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0832 ,  G01N33/491

Abstract: The invention is directed to methods and devices for efficient separation of plasma from whole blood which are suitable for point of care use in resource poor environments. In some embodiments, elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port; (b) a filter chamber having an inlet and an outlet, and containing at least one filter capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in fluid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber for (i) drawing a predetermined volume of sample into the SCR by a first user action and (ii) driving the predetermined volume at a substantially constant linear flow under a pressure not exceeding 2 psi from the SCR through the filter chamber and the outlet of the filter chamber by a second user action.

公开(公告)号：US11904314B2

公开(公告)日：2024-02-20

申请号：US17129783

申请日：2020-12-21

Applicant: WAINAMICS, INC.

Inventor： Arturo M. Escajeda ,  Huyen Tran ,  Ming X. Tan

IPC: C12Q1/6844 ,  B01L3/00

CPC classification number: B01L3/502715 ,  C12Q1/6844 ,  B01L2200/04 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/08

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

公开(公告)号：US20220032294A1

公开(公告)日：2022-02-03

申请号：US17158130

申请日：2021-01-26

Applicant: WAINAMICS, INC.

Inventor： Arturo M. Escajeda ,  Huyen Tran ,  Ming X. Tan

IPC: B01L3/00 ,  C12Q1/6844

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.

公开(公告)号：US20200030792A1

公开(公告)日：2020-01-30

申请号：US16491295

申请日：2018-03-14

Applicant: Wainamics, Inc.

Inventor： Hrair Kirakossian ,  Ming Tan

IPC: B01L3/00

Abstract: The invention, is directed to devices and methods for low cost and convenient separation, of plasma from whole blood. In some embodiments, devices of the invention comprise an integrated collection of channels and chambers m a body that permit acquisition of a blood sample by capillary action, centrifugal separation of cells from plasma, and manual dispensing of purified plasma by simple pinching of a bellows chamber to force air into plasma-holding channels which thereby expels a predetermined volume of the purified plasma.

公开(公告)号：US10111610B2

公开(公告)日：2018-10-30

申请号：US15521221

申请日：2015-11-03

Applicant: Wainamics, Inc.

Inventor： Ming Tan ,  Frank Zaugg ,  Peter Kernen

IPC: G01N1/00 ,  A61B5/15 ,  A61M1/34 ,  G01N33/49 ,  A61J1/05 ,  B01L3/02 ,  B01L3/00 ,  A61J1/06

Abstract: The invention is directed to methods and devices for efficient separation of plasma irons whole blood which are suitable for point of care use in resource poor environments, in some embodiments, elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port; (b) a filter chamber having an inlet and an outlet, and containing at least one filter capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in Quid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber for (i) drawing a predetermined volume of sample into ore SCR by a first user action and (ii) driving the predetermined volume at a substantially constant linear flow under a pressure not exceeding 2 psi from the SCR through the filter chamber and the outlet of the filter chamber by a second user action.

公开(公告)号：US20180303395A1

公开(公告)日：2018-10-25

申请号：US16018409

申请日：2018-06-26

Applicant: Wainamics, Inc.

Inventor： Ming Tan ,  Frank Zaugg ,  Peter Kernen

IPC: A61B5/15 ,  G01N33/49 ,  A61J1/05 ,  B01L3/02 ,  A61M1/34 ,  B01L3/00

CPC classification number: A61B5/150022 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150343 ,  A61J1/05 ,  A61J1/06 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3496 ,  A61M2205/3331 ,  B01L3/0217 ,  B01L3/502 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0832 ,  G01N33/491

Abstract: The invention is directed to methods and devices for efficient separation of plasma from whole blood which are suitable for point of care use in resource poor environments. In some embodiments, elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port; (b) a filter chamber having an inlet and an outlet, and containing at least one filter capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in fluid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber for (i) drawing a predetermined volume of sample into the SCR by a first user action and (ii) driving the predetermined volume at a substantially constant linear flow under a pressure not exceeding 2 psi from the SCR through the filter chamber and the outlet of the filter chamber by a second user action.

公开(公告)号：US20240416345A1

公开(公告)日：2024-12-19

申请号：US18702705

申请日：2022-11-01

Applicant: WAINAMICS, INC.

Inventor： Ming Xiao Tan ,  Huyen Tran ,  Jonathan Diver

IPC: B01L3/00 ,  G01N15/10 ,  G01N15/14

Abstract: The invention provides microfluidics devices, methods and kits employing expandable gels in a sample chamber for translocating cells or particles in a sample solution to an observation plane to facilitate counting and analysis.

公开(公告)号：US20240416340A1

公开(公告)日：2024-12-19

申请号：US18699972

申请日：2022-10-07

Applicant: Wainamics, Inc.

Inventor： Arturo Escajeda ,  Amanda Giacobbe ,  Ming X. Tan

IPC: B01L3/00

Abstract: The invention is directed to an input module for microfluidic cartidges comprising: (a) a container for holding a fluid, the container comprising an interior and an inlet thereto; (b) a cap comprising a tubular body with an axial passage such that a first end of the axial passage is capable of being sealingly connected to the inlet of the container and a second end of the axial passage is sealingly covered with a pierceable film and comprises a cap fitting; and (c) an inlet operationally associated with a microfluidic device.

公开(公告)号：US20240360497A1

公开(公告)日：2024-10-31

申请号：US18437399

申请日：2024-02-09

Applicant: WAINAMICS, INC.

Inventor： Arturo M. Escajeda ,  Huyen Tran ,  Ming X. Tan

IPC: C12Q1/6844 ,  B01L3/00 ,  B01L7/00

CPC classification number: C12Q1/6844 ,  B01L3/502715 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/049 ,  B01L2400/0677

Abstract: The invention is directed to devices and methods for performing rapid low-cost bioassays in self-contained disposable cartridges that provide efficient mixing of sample and reactants under a layer of liquid wax. Some embodiments additionally use gravity assisted distribution of sample and assay reagents in conjunction with an appliance containing all necessary valves, pneumatic sources, heat sources and detection stations.